{"id":1097,"date":"2016-08-15T17:19:26","date_gmt":"2016-08-15T08:19:26","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1097"},"modified":"2016-08-15T17:19:26","modified_gmt":"2016-08-15T08:19:26","slug":"a-vaccine-to-prevent-herpes-zoster-and-postherpetic-neuralgia-in-older-adults","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1097","title":{"rendered":"A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults"},"content":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d<br \/>\nOxman MN, et al. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. N Engl J Med. 2005;352(22):2271.<\/p>\n<p>\uff0d\u3053\u306e\u6587\u732e\u3092\u9078\u3093\u3060\u80cc\u666f\u2015<br \/>\n\u3000\u5916\u6765\u5b9a\u671f\u901a\u9662\u4e2d\u306e\u4e2d\u5e74\u5973\u6027\u3088\u308a\u3001\u300c\u7fa9\u7236\u304c\u5e2f\u72b6\u75b1\u75b9\u306b\u306a\u308a\u3001\u5927\u5909\u5f37\u3044\u75db\u307f\u3067\u82e6\u3057\u3093\u3067\u3044\u305f\u3002\u81ea\u5206\u306f\u3042\u3042\u3044\u3046\u98a8\u306b\u306f\u306a\u308a\u305f\u304f\u306a\u3044\u306e\u3067\u3001\u4f55\u3068\u304b\u9632\u304e\u305f\u3044\u3002\u4e88\u9632\u6ce8\u5c04\u304c\u3042\u308b\u3063\u3066\u805e\u3044\u305f\u3053\u3068\u304c\u3042\u308b\u3093\u3060\u3051\u3069\u3001\u3069\u308c\u304f\u3089\u3044\u52b9\u304d\u307e\u3059\u304b\uff1f\u300d\u3068\u805e\u304b\u308c\u305f\u3002\u6210\u4eba\u3078\u306e\u6c34\u75d8\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u5e2f\u72b6\u75b1\u75b9\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u3053\u3068\u306f\u805e\u3044\u305f\u3053\u3068\u304c\u3042\u3063\u305f\u304c\u3001\u52b9\u679c\u306e\u307b\u3069\u306f\u628a\u63e1\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u306e\u3067\u3001\u8abf\u3079\u308b\u3053\u3068\u306b\u3057\u305f\u3002<\/p>\n<p>\uff0d\u8981\u7d04\uff0d<br \/>\nIntroduction\uff1a<br \/>\n\u3000\u5e74\u9f62\u3092\u91cd\u306dVZV\u306b\u5bfe\u3059\u308b\u7d30\u80de\u6027\u514d\u75ab\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u306b\u3057\u305f\u304c\u3063\u3066\u3001\u5e2f\u72b6\u75b1\u75b9\u306e\u7f79\u60a3\u983b\u5ea6\u3084\u91cd\u75c7\u5ea6\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u5e2f\u72b6\u75b1\u75b9\u306b\u3088\u308b\u75db\u307f\u3084\u5e2f\u72b6\u75b1\u75b9\u5f8c\u795e\u7d4c\u75db\u306f\u9ad8\u9f62\u8005\u306eQOL\u3092\u8457\u3057\u304f\u4f4e\u4e0b\u3055\u305b\u308b\u3002\u305d\u3053\u3067\u9ad8\u9f62\u8005\u306b\u5bfe\u3057\u3066VZV\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3059\u308b\u3053\u3068\u3067\u3001\u5e2f\u72b6\u75b1\u75b9\u306e\u7f79\u60a3\u983b\u5ea6\u3084\u91cd\u75c7\u5ea6\u304c\u4e0b\u304c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u3001\u691c\u8a3c\u3057\u305f\u3002<\/p>\n<p>Method\uff1a<br \/>\n\u3000\u6c34\u75d8\u7f79\u60a3\u6b74\u304c\u3042\u308b\u304b\uff0c\u30a2\u30e1\u30ea\u30ab\u306b30\u5e74\u4ee5\u4e0a\u4f4f\u3093\u3067\u3044\u308b60\u6b73\u4ee5\u4e0a\u306e38546\u4eba\u3002\u514d\u75ab\u4e0d\u5168\u60a3\u8005\u306f\u9664\u5916\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3002<br \/>\n\u3000\u4ecb\u5165\u7fa4\u306b\u306f\u65e5\u672c\u56fd\u5185\u3068\u540c\u3058\u5ca1\u682a\u306e\u5f31\u6bd2\u751f\u30ef\u30af\u30c1\u30f30.5ml\u3092\u76ae\u4e0b\u63a5\u7a2e\u3002<br \/>\n\u3000\u5e2f\u72b6\u75b1\u75b9\u306e\u8a3a\u65ad\u306fPCR\u6cd5\u3092\u542b\u3081\u305f\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u5247\u3063\u3066\u884c\u308f\u308c\u3001\u6700\u7d42\u7684\u306b\u6c34\u75d8\u5e2f\u72b6\u75b1\u75b9\u306e\u5c02\u9580\u533b5\u4eba\u304c\u5224\u5b9a\u3002\u5e2f\u72b6\u75b1\u75b9\u306e\u7f79\u60a3\u983b\u5ea6\u3001\u91cd\u75c7\u5ea6\u3001\u75db\u307f\u3084\u4e0d\u5feb\u611f\u304c\u7d9a\u304f\u671f\u9593\u3092\u8a55\u4fa1\u3002\u75db\u307f\u3084\u4e0d\u5feb\u611f\u306e\u7a0b\u5ea6\u306f\u8cea\u554f\u7d19\u7968\u3067\u8a55\u4fa1\u3002<br \/>\n\u3000\u5e73\u57473.13\u5e74\u8ffd\u8de1\u3002<\/p>\n<p>Results\uff1a<br \/>\n\u3000\u3000<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24601.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24601-660x1024.png\" alt=\"\u5ddd\u5408\u5148\u751f\u56f3\u2460\" width=\"640\" height=\"993\" class=\"aligncenter size-large wp-image-1103\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24601-660x1024.png 660w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24601-193x300.png 193w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24601.png 721w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n\u3000\u3000<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24611.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24611.png\" alt=\"\u5ddd\u5408\u5148\u751f\u56f3\u2461\" width=\"730\" height=\"630\" class=\"aligncenter size-full wp-image-1104\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24611.png 730w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24611-300x259.png 300w\" sizes=\"auto, (max-width: 730px) 100vw, 730px\" \/><\/a><br \/>\n<strong>\u7f79\u60a3\u7387\uff1aVaccine\u30000.00542\u3000\u3000Placebo\u30000.01112\u3000\u2192NNP\u3000175<\/strong><\/p>\n<p>\u3000\u3000<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24621.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24621.png\" alt=\"\u5ddd\u5408\u5148\u751f\u56f3\u2462\" width=\"742\" height=\"746\" class=\"aligncenter size-full wp-image-1105\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24621.png 742w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24621-150x150.png 150w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24621-298x300.png 298w\" sizes=\"auto, (max-width: 742px) 100vw, 742px\" \/><\/a><br \/>\n<strong>\u7f79\u60a3\u7387\uff1aVaccine\u30000.00046\u3000\u3000Placebo 0.00138\u3000\u3000\u2192NNP\u30001086<\/strong><\/p>\n<p>\u3000\u3000<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24631.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24631.png\" alt=\"\u5ddd\u5408\u5148\u751f\u56f3\u2463\" width=\"845\" height=\"649\" class=\"aligncenter size-full wp-image-1106\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24631.png 845w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2016\/08\/\u5ddd\u5408\u5148\u751f\u56f3\u24631-300x230.png 300w\" sizes=\"auto, (max-width: 845px) 100vw, 845px\" \/><\/a><\/p>\n<p>\uff0d\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\uff0d<br \/>\n\u3000\u6c34\u75d8\u30ef\u30af\u30c1\u30f3\u306f\u81ea\u8cbb\u30676000\u5186\u304b\u308910000\u5186\u7a0b\u5ea6\u306e\u3088\u3046\u3067\u3059\u3002<br \/>\n\u3000\u3000\u30fb\u6c34\u75d8\u306e\u7f79\u60a3\u6b74\u304c\u3042\u308a\u5e2f\u72b6\u75b1\u75b9\u4e88\u9632\u306e\u305f\u3081\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u5e0c\u671b\u3059\u308b\u4eba\u304c\u3044\u305f\u3089\u3001\u3069\u3046\u8aac\u660e\u3057\u307e\u3059\u304b\uff1f<br \/>\n\u3000\u3000\u30fb\u3042\u308b\u3044\u306f\u62c5\u5f53\u60a3\u8005\u304c\u63a5\u7a2e\u3057\u305f\u7d4c\u9a13\u304c\u3042\u308b\u65b9\u306f\u3044\u307e\u3059\u304b\uff1f<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\u30002016\u5e747\u670820\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d Oxman MN, et al. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. N Engl J &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1097\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1097","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1097"}],"version-history":[{"count":4,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1097\/revisions"}],"predecessor-version":[{"id":1109,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1097\/revisions\/1109"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}