{"id":1198,"date":"2016-11-07T11:52:01","date_gmt":"2016-11-07T02:52:01","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1198"},"modified":"2016-11-07T11:52:01","modified_gmt":"2016-11-07T02:52:01","slug":"af%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%8a%97%e5%87%9d%e5%9b%ba%e8%96%ac%e3%81%ae%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%a8%e5%ae%89%e5%85%a8%e6%80%a7%e3%81%ae%e6%af%94%e8%bc%83","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1198","title":{"rendered":"Af\u306b\u5bfe\u3059\u308b\u6297\u51dd\u56fa\u85ac\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u6bd4\u8f03"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nTorben Bjerregaard Larsen, Flemming Skj\u00f8th, Peter Br\u00f8nnum Nielsen, Jette Nordstr\u00f8m Kj\u00e6ldgaard, Gregory Y H Lip.
\nComparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study. BMJ 2016; 353<\/p>\n

\uff0d\u8981\u7d04\uff0d
\nObjective<\/strong>
\n\u3000\u6297\u51dd\u56fa\u85ac\u3092\u521d\u3081\u3066\u958b\u59cb\u3059\u308b\u5fc3\u623f\u7d30\u52d5\u306e\u60a3\u8005\u3055\u3093\u3067\u3001\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3\uff08\u30d7\u30e9\u30b6\u30ad\u30b5\uff09\u3001\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3\uff08\u30a4\u30b0\u30b6\u30ec\u30eb\u30c8\uff09\u3001\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3\uff08\u30a8\u30ea\u30ad\u30e5\u30fc\u30b9\uff09\u3068\u3044\u3063\u305fNOACs\u306e\u6709\u52b9\u6027\u3084\u5b89\u5168\u6027\u3092\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n

Design<\/strong>
\n\u3000\u89b3\u5bdf\u7684\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u7814\u7a76 <\/p>\n

Setting<\/strong>
\n\u30003\u3064\u306e\u30c7\u30f3\u30de\u30fc\u30af\u306e\u5168\u56fd\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u30012011\u5e748\u6708\u304b\u30892015\u5e7410\u6708<\/p>\n

Participants<\/strong>
\n\u300061,678\u4eba\u306e\u7d4c\u53e3\u6297\u51dd\u56fa\u85ac\u3092\u521d\u3081\u3066\u51e6\u65b9\u3055\u308c\u305f\u975e\u5f01\u819c\u75c7\u6027\u5fc3\u623f\u7d30\u52d5\u306e\u60a3\u8005\u3067\u3001\u5f01\u819c\u75c7\u6027\u5fc3\u623f\u7d30\u52d5\u3084\u9759\u8108\u8840\u6813\u75c7\u306e\u65e2\u5f80\u304c\u306a\u3044\u60a3\u8005\u3002\u6cbb\u7642\u306e\u9078\u629e\u306f\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3(n=35,436\u300157%)\u3001\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3 150mg (n=12,701\u300121%)\u3001\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3 20mg (n=7,129\u300112%)\u3001\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3 5mg (n=6,349\u300110%)\u306b\u5206\u3051\u3089\u308c\u305f\u3002<\/p>\n

Main outcome measures<\/strong>
\n\u3000\u865a\u8840\u6027\u8133\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u6897\u585e\u3082\u3057\u304f\u306f\u5168\u8eab\u6027\u585e\u6813\u75c7\u306e\u5408\u8a08\u3001\u6b7b\u4ea1\u3001\u865a\u8840\u6027\u8133\u6897\u585e\u3082\u3057\u304f\u306f\u5168\u8eab\u6027\u585e\u6813\u75c7\u3082\u3057\u304f\u306f\u6b7b\u4ea1\u306e\u5408\u8a08\u3092\u6709\u52b9\u6027\u306e\u7d50\u679c\u3068\u5b9a\u7fa9\u3057\u305f\u3002\u5b89\u5168\u6027\u306e\u7d50\u679c\u306f\u3042\u3089\u3086\u308b\u51fa\u8840\u3001\u8133\u5185\u51fa\u8840\u3001\u5927\u51fa\u8840\u3068\u3057\u305f\u3002<\/p>\n

Results<\/strong>
\n\u3000\u5206\u6790\u3092\u865a\u8840\u6027\u8133\u6897\u585e\u306b\u9650\u5b9a\u3059\u308b\u3068\u3001NOACs\u306f\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u30021\u5e74\u306e\u30d5\u30a9\u30ed\u30fc\u306e\u4e2d\u3067\u306f\u3001\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3\u306f\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6bd4\u3079\u3066\u865a\u8840\u6027\u8133\u6897\u585e\u3068\u5168\u8eab\u6027\u585e\u6813\u75c7\u306e\u5e74\u9593\u767a\u75c7\u7387\u306e\u6e1b\u5c11\uff08\u305d\u308c\u305e\u308c3.0%\u30683.3%\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f0.83\uff0895%\u4fe1\u983c\u533a\u9593\u306f0.69-0.99\uff09\u3002\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3\u3068\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3\uff08\u305d\u308c\u305e\u308c\u5e74\u95932.8%\u30684.9%\uff09\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6bd4\u3079\u3066\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002\u5e74\u9593\u6b7b\u4ea1\u7387\u306f\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3(5.2%)\u3068\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3(2.7%)\uff08\u305d\u308c\u305e\u308c0.65,0.56-0.75\u30010.63,0.48-0.82\uff09\u3068\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3(8.5%)\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u304c\u3001\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3(7.7%)\u306f\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002\u3042\u3089\u3086\u308b\u51fa\u8840\u306e\u7d44\u307f\u5408\u308f\u3055\u308c\u305f\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u306f\u3001\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3(3.3%)\u3068\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3(2.4%)\uff080.62,0.51-0.74\uff09\u3068\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3(5.0%)\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u30ea\u30d0\u30fc\u30ed\u30ad\u30b5\u30d0\u30f3\u306e\u5e74\u9593\u306e\u51fa\u8840\u7387\uff085.3%\uff09\u306f\u540c\u3058\u3067\u3042\u3063\u305f\u3002<\/p>\n

Conclusion<\/strong>
\n\u3000\u901a\u5e38\u306e\u8a3a\u7642\u3067\u306f\u3001\u3059\u3079\u3066\u306eNOACs\u304c\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6bd4\u3079\u3066\u5b89\u5168\u6027\u3082\u6709\u52b9\u6027\u3082\u4ee3\u66ff\u3067\u304d\u308b\u3082\u306e\u3067\u3042\u308b\u3068\u8003\u3048\u308b\u3002\u865a\u8840\u6027\u8133\u6897\u585e\u306b\u3064\u3044\u3066\u306fNOACs\u3068\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u306b\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u6b7b\u4ea1\u7387\u3001\u3042\u3089\u3086\u308b\u51fa\u8840\u3001\u5927\u51fa\u8840\u306b\u95a2\u3057\u3066\u306f\u30ef\u30fc\u30d5\u30a1\u30ea\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30a2\u30d4\u30ad\u30b5\u30d0\u30f3\u3068\u30c0\u30d3\u30ac\u30c8\u30e9\u30f3\u304c\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002<\/p>\n

\uff0d\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\uff0d
\n\u3000\u3053\u306e\u6587\u732e\u3092\u8aad\u3093\u3067\u3001NOACs\u306b\u3064\u3044\u3066\u306e\u77e5\u8b58\u304c\u5897\u3048\u3066\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u304c\u81ea\u5206\u306e\u4e2d\u3067\u3088\u308a\u8eab\u8fd1\u306b\u611f\u3058\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002
\n\u3000\u4eca\u5f8c\u3082\u65b0\u3057\u3044\u85ac\u5264\u306e\u51e6\u65b9\u306f\u8e8a\u8e87\u3059\u308b\u3068\u601d\u308f\u308c\u308b\u304c\u3001\u305d\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8abf\u3079\u3066\u3001\u4f7f\u3044\u3053\u306a\u305b\u308b\u3088\u3046\u306b\u3057\u3066\u3044\u304d\u305f\u3044\u3002<\/p>\n

\u3010\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3011<\/strong>
\n\u30001.\u307f\u306a\u3055\u3093\u306fNOACs\u3092\u65b0\u898f\u306b\u51e6\u65b9\u3059\u308b\u969b\u306b\u8e8a\u8e87\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304b\uff1f
\n\u3000\uff08\u4f7f\u3044\u3053\u306a\u3057\u3066\u3044\u308b\u65b9\u306f\u6c17\u6301\u3061\u306e\u5909\u9077\u306a\u3069\u304c\u3042\u308c\u3070\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\uff09
\n\u30002. \u65b0\u3057\u3044\u85ac\u5264\u306e\u77e5\u8b58\u3092\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u624b\u306b\u5165\u308c\u3066\u3044\u307e\u3059\u304b\uff1f<\/p>\n

\u3010\u958b\u50ac\u65e5\u3011
\n\u30002016\u5e7411\u67082\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Torben Bjerregaard Larsen, Flemming Skj\u00f8th, Peter Br\u00f8nnum Nielsen, Jette Nordstr\u00f8m Kj\u00e6ldgaard, Gregory Y … \u7d9a\u304d\u3092\u8aad\u3080 Af\u306b\u5bfe\u3059\u308b\u6297\u51dd\u56fa\u85ac\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306e\u6bd4\u8f03<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1198","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1198"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1198\/revisions"}],"predecessor-version":[{"id":1200,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1198\/revisions\/1200"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}