{"id":1252,"date":"2017-02-06T13:30:55","date_gmt":"2017-02-06T04:30:55","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1252"},"modified":"2017-02-06T13:30:55","modified_gmt":"2017-02-06T04:30:55","slug":"%e3%80%90ebm%e3%81%ae%e5%ad%a6%e3%81%b3%e3%80%91%e3%83%a9%e3%83%a1%e3%83%ab%e3%83%86%e3%82%aa%e3%83%b3%e3%81%ae%e5%8a%b9%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1252","title":{"rendered":"\u3010EBM\u306e\u5b66\u3073\u3011\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\u306e\u52b9\u679c"},"content":{"rendered":"<p><strong>STEP1\u3000\u81e8\u5e8a\u60a3\u8005\u306b\u5373\u3057\u305fPI(E)CO<\/strong><br \/>\n\u3010\u8a55\u4fa1\u3092\u884c\u3063\u305f\u65e5\u4ed8\u3011<br \/>\n\u30002016\u5e7412\u670811\u65e5<br \/>\n\u3010\u81e8\u5e8a\u72b6\u6cc1\u306e\u30b5\u30de\u30ea\u30fc\u3011<br \/>\n\u3000\u7247\u5074\u819d\u95a2\u7bc0\u6c34\u816b\u306b\u3088\u308bADL\u4f4e\u4e0b\u306e\u305f\u3081\u8a2a\u554f\u8a3a\u7642\u3092\u958b\u59cb\u3057\u305f\u3070\u304b\u308a\u306e93\u6b73\u5973\u6027\u3002\u95a2\u7bc0\u6c34\u816b\u306f\u6574\u5f62\u5916\u79d1\u3067\u8a3a\u65ad\u30fb\u6cbb\u7642\u3092\u53d7\u3051\u3001\u8a2a\u554f\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u3082\u884c\u3044\u72ec\u6b69\u304c\u53ef\u80fd\u306a\u7a0b\u5ea6\u306b\u306f\u56de\u5fa9\u50be\u5411\u3002\u8a8d\u77e5\u75c7\uff08\u8a73\u7d30\u306f\u672a\u8a55\u4fa1\u3060\u304c\u91cd\u5ea6\u306b\u306f\u76f8\u5f53\uff09\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3001\u9ad8\u8840\u5727\u306f\u3042\u308b\u304c\u8a2a\u554f\u958b\u59cb\u6642\u70b9\u3067\u5185\u670d\u85ac\u306f\u306a\u3057\u3002\u96a3\u306e\u5bb6\u306b\u4f4f\u3080\u5a18\u304c\u4ecb\u8b77\u3057\u306a\u304c\u3089\u72ec\u5c45\u3067\u751f\u6d3b\u3057\u3066\u3044\u308b\u3002\u5a18\u304c\u76e3\u8996\u30ab\u30e1\u30e9\u3067\u69d8\u5b50\u3092\u898b\u5b88\u3063\u3066\u3044\u308b\u304c\u3001\u591c\u9593\u4e0d\u7720\u304c\u3042\u308a\u4e00\u6669\u4e2d\u3046\u308d\u3046\u308d\u52d5\u3044\u3066\u3044\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u5a18\u3082\u5fc3\u914d\u3067\u7720\u308c\u306a\u3044\u3068\u306e\u3053\u3068\u3067\u4ee5\u524d\u52b9\u679c\u304c\u3042\u3063\u305f\u3068\u3044\u3046\u30ec\u30f3\u30c9\u30eb\u30df\u30f3\u51e6\u65b9\u3092\u5e0c\u671b\u3055\u308c\u305f\u3002\u30ec\u30f3\u30c9\u30eb\u30df\u30f3\u3092\u958b\u59cb\u3057\u305f\u304c\u52b9\u679c\u304c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u7761\u7720\u30ea\u30ba\u30e0\u3092\u6574\u3048\u308b\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\u3067\u3042\u308c\u3070\u8ee2\u5012\u306e\u5927\u304d\u306a\u30ea\u30b9\u30af\u306b\u306f\u306a\u3089\u305a\u306b\u72b6\u6cc1\u3092\u6539\u5584\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3068\u8003\u3048\u8ad6\u6587\u3092\u8abf\u3079\u305f\u3002<\/p>\n<p>\u3000\u3000P\uff1b\u9ad8\u9f62\uff0865\u6b73\u4ee5\u4e0a\uff09\u306e\u4e0d\u7720\u75c7\u60a3\u8005\u306b<br \/>\n\u3000\u3000I(E)\uff1b\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068<br \/>\n\u3000\u3000C\uff1b\u30d7\u30e9\u30bb\u30dc\u85ac\u3092\u6295\u4e0e\u3057\u305f\u3068\u304d\u3068\u6bd4\u3079<br \/>\n\u3000\u3000O\uff1a\u7761\u7720\u6642\u9593\u306f\u5897\u3048\u308b\u304b \/ \u8ee2\u5012\u306a\u3069\u6709\u5bb3\u306a\u526f\u4f5c\u7528\u306f\u5897\u3048\u308b\u304b<\/p>\n<p><strong>STEP2\u3000\u691c\u7d22\u3057\u3066\u898b\u3064\u3051\u305f\u6587\u732e\u306e\u540d\u524d<\/strong><br \/>\n\u3010\u898b\u3064\u3051\u305f\u8ad6\u6587\u3011<br \/>\nA 2-night, 3-period, crossover study of ramelteon\u2019s efficacy and safety in older adults with chronic insomnia<\/p>\n<p><strong>STEP3\uff1b\u8ad6\u6587\u306e\u8a55\u4fa1<br \/>\nSTEP3-1.\u8ad6\u6587\u306ePECO\u306f\u60a3\u8005\u306ePECO\u3068\u5408\u81f4\u3059\u308b\u304b\uff1f<\/strong><br \/>\n\u3000P\uff1b65\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u8005\u306b<br \/>\n\u3000\u3000\u7d44\u307f\u5165\u308c\u57fa\u6e96\u2026\u6700\u4f4e3\u304b\u6708\u7d9a\u304f\u90313-4\u6669\u306e\u4e0d\u7720\u3092\u4f34\u3046DSM-\u2163\u3067\u8a3a\u65ad\u3055\u308c\u308b\u7279\u767a\u6027\u4e0d\u7720\u75c7\u60a3\u8005\u3067\u3001\u4e0d\u7720\u306b\u8d77\u56e0\u3059\u308b\u65e5\u4e2d\u306e\u969c\u5bb3\u3084\u60a9\u307f\u3092\u62b1\u3048\u3001<br \/>\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000BMI18\uff5e34\u3001\u81ea\u5df1\u7533\u544a\u306e\u5c31\u5bdd\u6642\u9593\u304c\u5348\u5f8c8:30\uff5e\u5348\u524d12\u6642\u306e\u8005<br \/>\n\u3000\u3000\u9664\u5916\u57fa\u6e96\u20261\u5e74\u4ee5\u5185\u306b\u91cd\u5927\u306a\u7cbe\u795e\u307e\u305f\u306f\u533b\u5b66\u7684\u75be\u60a3\u30015\u65e5\u4ee5\u5185\u306b\u7761\u7720\u30b5\u30a4\u30af\u30eb\u306b\u5f71\u97ff\u3057\u3046\u308b\u85ac\u30fb\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u670d\u7528\u30013\u9031\u9593\u4ee5\u5185\u306b\u4ed6\u306b\u4e2d\u67a2\u795e\u7d4c\u306b<br \/>\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u4f5c\u7528\u3059\u308b\u85ac\u3092\u670d\u7528\u30013\u304b\u6708\u4ee5\u5185\u306b\u7761\u7720\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3046\u308b\u98df\u4e8b\u3084\u904b\u52d5\u3084\u5c31\u52b4\u72b6\u6cc1\u306e\u8457\u3057\u3044\u5909\u5316\u30017\u65e5\u4ee5\u5185\u306b3\u56de\u4ee5\u4e0a\u6642\u5dee\u306e\u5883\u754c\u7dda\u3092\u8d8a\u3048\u305f<br \/>\n\u3000I(E)\uff1b\u30e9\u30e1\u30eb\u30c6\u30aa\u30f34mg\u307e\u305f\u306f8mg\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001<br \/>\n\u3000C\uff1b\u30d7\u30e9\u30bb\u30dc\u85ac\u3092\u6295\u4e0e\u3057\u305f\u5834\u5408\u306b\u6bd4\u3079\u3001<br \/>\n\u3000O\uff1b\u6cbb\u7642\u52b9\u679c\u2026\u5165\u7720\u307e\u3067\u306b\u304b\u304b\u3063\u305f\u6642\u9593\u3001\u5168\u7761\u7720\u6642\u9593\u3001\u7761\u7720\u52b9\u7387\u3001\u4e2d\u9014\u899a\u9192\u306e\u56de\u6570\u3001\u7761\u7720\u958b\u59cb\u304b\u3089\u899a\u9192\u307e\u3067\u306e\u6642\u9593\u3001\u81ea\u5df1\u7533\u544a\u306e\u8a55\u4fa1\uff08sSL,sTST,sNAW,<br \/>\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u7761\u7720\u306b\u623b\u308b\u307e\u3067\u306e\u56f0\u96e3\u3055\u3001\u4e3b\u89b3\u7684\u7761\u7720\u306e\u8cea\uff09\u304c\u6539\u5584\u3059\u308b\u304b<br \/>\n\u3000\u3000\u3000\u526f\u4f5c\u7528\u2026\u6b8b\u5b58\u85ac\u7406\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306f\u5897\u52a0\u3059\u308b\u304b<br \/>\n\u2192\u60a3\u8005\u306ePECO\u3068\u3000(\u5408\u81f4\u3059\u308b\u3000\u30fb\u3000<span style=\"text-decoration: underline;\"><strong>\u591a\u5c11\u7570\u306a\u308b\u304cOK<\/strong><\/span>\u3000\u30fb\u3000\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u4e0d\u9069\u5207)<\/p>\n<p><strong>STEP3-2\u3000\u8ad6\u6587\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u8a55\u4fa1\uff1b\u5185\u7684\u59a5\u5f53\u6027\u306e\u8a55\u4fa1<\/strong><br \/>\n\u2460\u7814\u7a76\u65b9\u6cd5\u304cRCT\u306b\u306a\u3063\u3066\u3044\u308b\u304b\uff1f\u96a0\u853d\u5316\u3068\u76f2\u691c\u5316\u306f\u3055\u308c\u3066\u3044\u308b\u304b\uff1f<br \/>\n\u3000\u2192\u30e9\u30f3\u30c0\u30e0\u5272\u308a\u4ed8\u3051\u304c\u3000\uff08\u3000<span style=\"text-decoration: underline;\"><strong>\u3055\u308c\u3066\u3044\u308b<\/strong><\/span>\u3000\u30fb\u3000\u3000\u3055\u308c\u3066\u3044\u306a\u3044\u3000\uff09\u203b\u305f\u3060\u3057\u65b9\u6cd5\u306f\u8a18\u8f09\u306a\u3057<br \/>\n\u3000\u2192\u96a0\u853d\u5316\u304c\uff08\u3000\u3055\u308c\u3066\u3044\u308b\u3000\u30fb\u3000\u3000<span style=\"text-decoration: underline;\"><strong>\u3055\u308c\u3066\u3044\u306a\u3044<\/strong><\/span>\u3000\u30fb\u3000\u4e0d\u660e \uff09<br \/>\n\u3000\u2192\u76f2\u691c\u5316\u304c\uff08\u3000<span style=\"text-decoration: underline;\"><strong>\u3055\u308c\u3066\u3044\u308b<\/strong><\/span>\u3000\u30fb\u3000\u4e00\u90e8\u3055\u308c\u3066\u3044\u308b\u3000\u30fb\u3000\u3000\u3055\u308c\u3066\u3044\u306a\u3044\u3000\u30fb\u8a18\u8f09\u306a\u3057\u3000\uff09\u203b\u305f\u3060\u3057\u76f2\u691c\u306e\u5bfe\u8c61\u304c\u4f55\u306a\u306e\u304b\u8a18\u8f09\u306a\u3057<br \/>\n\u5b9f\u969b\u306eTable\u3067\u4ecb\u5165\u7fa4\u3068\u5bfe\u7167\u7fa4\u306f\u540c\u3058\u3088\u3046\u306a\u96c6\u56e3\u306b\u306a\u3063\u3066\u3044\u308b\u304b\uff1f<br \/>\n\u3000\u2192\uff08\u3000<strong><span style=\"text-decoration: underline;\">\u4ecb\u5165\u7fa4\u30fb\u5bfe\u7167\u7fa4\u306e\u691c\u8a0e\u306a\u3057<\/span><\/strong>\u3000\uff09<br \/>\n\u2461 \u89e3\u6790\u65b9\u6cd5\u306fITT(intention to treat)\u304b\uff1f<br \/>\n\u3000\u2192\u305d\u3082\u305d\u3082\u8131\u843d\u8005\u306a\u3057<\/p>\n<p><strong>STEP3-3\u3000\u8ad6\u6587\u3067\u898b\u3044\u3060\u3055\u308c\u305f\u7d50\u679c\u306e\u8a55\u4fa1<\/strong><br \/>\nOutcome\u306b\u3064\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u5024\u3092\u78ba\u8a8d\u3059\u308b<br \/>\n\u3010\u2460 \u6cbb\u7642\u52b9\u679c\u306e\u6709\u7121\uff1b P\u5024\u3092\u78ba\u8a8d\u3059\u308b\u3011<br \/>\n\u3000\u6cbb\u7642\u52b9\u679c\u2026\u5ba2\u89b3\u7684\u6307\u6a19\u306eLPS\uff1a\u7761\u7720\u6f5c\u6642\u3001TST\uff1a\u7761\u7720\u6642\u9593\u3001Sleep efficiency\uff1a\u7761\u7720\u52b9\u7387\u306ep\u5024\u306f\u3044\u305a\u308c\u3082\uff1c0.05\u3001<br \/>\n\u3000\u3000\u3000\u3000\u3000 \u4e3b\u89b3\u7684\u6307\u6a19\u306e\u307b\u3068\u3093\u3069\uff08ramelteon4mg\u306esSL\u4ee5\u5916\uff09\u306ep\u5024\u306f\uff1e0.05<br \/>\n\u3000\u6b8b\u5b58\u85ac\u7406\u52b9\u679c\u3001\u526f\u4f5c\u7528\u2026\u6b8b\u5b58\u85ac\u7406\u52b9\u679c\u306b\u512a\u4f4d\u5dee\u306f\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u308b\u304cp\u5024\u306f\u3044\u305a\u308c\u3082\uff1e0.05\u3001\u526f\u4f5c\u7528\u306f\u7d71\u8a08\u5b66\u7684\u306a\u8a55\u4fa1\u304c\u3055\u308c\u3066\u3044\u306a\u3044<\/p>\n<p>\u3010\u2461\u6cbb\u7642\u52b9\u679c\u306e\u5927\u304d\u3055\uff1b\u6bd4\u306e\u6307\u6a19\u3068\u5dee\u306e\u6307\u6a19\u3092\u78ba\u8a8d\u3059\u308b\u3011<br \/>\n\u25cfRR(\u3042\u308b\u3044\u306fHR\u30fbOR)\u3092\u78ba\u8a8d\u3059\u308b<br \/>\n\u25cfARR\u3068NNT\u3092\u8a08\u7b97\u3059\u308b<br \/>\n\u3000\u203bP\u5024\u3067\u6709\u610f\u5dee\u304c\u51fa\u305f\u3082\u306e\u306b\u3064\u3044\u3066\u8a08\u7b97<br \/>\n\u3000\u6cbb\u7642\u52b9\u679c\u306f\u8a08\u7b97\u3067\u304d\u306a\u3044<\/p>\n<p>\u3010\u2462\u6cbb\u7642\u52b9\u679c\u306e\u3086\u3089\u304e\uff1b\u4fe1\u983c\u533a\u9593\u3092\u78ba\u8a8d\u3059\u308b\u3011<br \/>\n\u3000\u4fe1\u983c\u533a\u9593\u306e\u8a18\u8f09\u306a\u3057<\/p>\n<p><strong>STEP4\u3000\u60a3\u8005\u3078\u306e\u9069\u7528<\/strong><br \/>\n\u3010\u2460\u8ad6\u6587\u306e\u60a3\u8005\u3068\u3001\u76ee\u306e\u524d\u306e\u60a3\u8005\u304c\u3001\u7d50\u679c\u304c\u9069\u7528\u3067\u304d\u306a\u3044\u307b\u3069\u7570\u306a\u3063\u3066\u3044\u306a\u3044\u304b\uff1f\u3011<br \/>\n\u3000\u7761\u7720\u30ea\u30ba\u30e0\u304c\u5927\u304d\u304f\u640d\u306a\u308f\u308c\u305f\u8d85\u9ad8\u9f62\u8a8d\u77e5\u75c7\u60a3\u8005\u306b\u5bfe\u3057\u3066\u52b9\u679c\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306f\u65ad\u8a00\u3067\u304d\u306a\u3044\u304c\u3001\u53c2\u8003\u306b\u306f\u306a\u308b\u3002<\/p>\n<p>\u3010\u2461\u6cbb\u7642\u305d\u306e\u3082\u306e\u306f\u5fe0\u5b9f\u306b\u5b9f\u884c\u53ef\u80fd\u304b\uff1f\u3011<br \/>\n\u3000\u751f\u6d3b\u6307\u5c0e\u306f\u56f0\u96e3<br \/>\n\u3000\u670d\u85ac\u7ba1\u7406\u306f\u5a18\u304c\u884c\u3063\u3066\u304a\u308a\u5185\u670d\u53ef\u80fd<\/p>\n<p>\u3010\u2462\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u30b3\u30b9\u30c8\u3084\u5bb3\u3092\u542b\u3081\u3066\u5168\u3066\u8a55\u4fa1\u3055\u308c\u305f\u304b\uff1f\u3011<br \/>\n\u3000\u30b3\u30b9\u30c8\uff1a\u30e9\u30e1\u30eb\u30c6\u30aa\u30f38mg82.5\u5186\/\u9320\u3068\u6bd4\u8f03\u7684\u9ad8\u4fa1\uff08\u4e00\u822c\u7684\u306a\u7761\u7720\u85ac\u306e\u5185\u30de\u30a4\u30b9\u30ea\u30fc\u4ee5\u5916\u306f1\u932020\u5186\u53f0\u4ee5\u4e0b\u304c\u591a\u3044<br \/>\n\u3000\u3000\u3000\u3000\u3000Ex. \u30ec\u30f3\u30c9\u30eb\u30df\u30f30.25mg27.5\u5186\/\u9320\u3001\u30de\u30a4\u30b9\u30ea\u30fc5mg49.6\u5186\/\u9320\uff09<br \/>\n\u3000\u526f\u4f5c\u7528\uff1a\u691c\u8a0e\u304c\u4e0d\u5341\u5206\u3002\u672c\u60a3\u8005\u3067\u91cd\u8981\u3068\u601d\u308f\u308c\u308b\u8ee2\u5012\u30ea\u30b9\u30af\u3001\u9577\u671f\u9593\u670d\u7528\u3057\u305f\u5834\u5408\u306e\u30ea\u30b9\u30af\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n<p>\u3010\u2463\u60a3\u8005\u306e\u8003\u3048\u30fb\u55dc\u597d\u306f\u3069\u3046\u306a\u306e\u304b\uff1f\u3011<br \/>\n\u3000\u7d71\u8a08\u7684\u306b\u5ba2\u89b3\u7684\u7761\u7720\u3092\u6539\u5584\u3059\u308b\u3068\u3057\u3066\u3082\u305d\u306e\u52b9\u679c\u81ea\u4f53\u306f\u5c0f\u3055\u304f\u3001\u6700\u3082\u610f\u5473\u306e\u3042\u308b\u4e3b\u89b3\u7684\u7761\u7720\u306f\u307b\u3068\u3093\u3069\u6539\u5584\u3057\u306a\u3044\u3002<br \/>\n\u6b8b\u5b58\u85ac\u7406\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306f\u5341\u5206\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3068\u306f\u3044\u3044\u304c\u305f\u3044\u304c\u3001\u51e6\u65b9\u3057\u306a\u3044\u6839\u62e0\u306b\u306a\u308b\u307b\u3069\u5927\u304d\u306a\u30ea\u30b9\u30af\u306f\u306a\u3055\u305d\u3046\u3002<br \/>\n\u305f\u3060\u3057\u672c\u75c7\u4f8b\u306e\u771f\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u300c\u5a18\u306e\u5fc3\u914d\u3084\u7761\u7720\u6642\u9593\u306e\u6539\u5584\u300d\u304b\u3082\u3057\u308c\u306a\u3044\u306e\u3067\u3001\u591a\u5c11\u306a\u308a\u3068\u3082\u5ba2\u89b3\u7684\u7761\u7720\u3092\u6539\u5584\u3059\u308b\u306e\u3067\u3042\u308c\u3070\u6295\u4e0e\u3092\u8a66\u3059\u610f\u7fa9\u306f\u3042\u308b\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n<p>\uff0a\u7565\u8a9e<br \/>\n\u3000LPS\uff08Latency to Onset of Persistent Sleep\uff09\uff1a\u7761\u7720\u6f5c\u6642\u2026\u5bdd\u5165\u308a\u307e\u3067\u306e\u6642\u9593<br \/>\n\u3000TST\uff08Total Sleep Time\uff09\uff1a\u5168\u7761\u7720\u6642\u9593<br \/>\n\u3000Sleep efficiency\uff1a\u7761\u7720\u52b9\u7387\u2026\u5c31\u5e8a\u6642\u9593\u4e2d\u306e\u7761\u7720\u6642\u9593\u306e\u5272\u5408<br \/>\n\u3000WASO\uff08Waking After Sleep Onset\uff09\uff1a\u4e2d\u9014\u899a\u9192\u6642\u9593<br \/>\n\u3000SL\uff08Sleep Time\uff09\uff1a\u5165\u7720\u6f5c\u6642\u2026\u5c31\u5e8a\u304b\u3089\u5165\u7720\u307e\u3067\u306e\u6642\u9593<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n2016\u5e7412\u670814\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STEP1\u3000\u81e8\u5e8a\u60a3\u8005\u306b\u5373\u3057\u305fPI(E)CO \u3010\u8a55\u4fa1\u3092\u884c\u3063\u305f\u65e5\u4ed8\u3011 \u30002016\u5e7412\u670811\u65e5 \u3010\u81e8\u5e8a\u72b6\u6cc1\u306e\u30b5\u30de\u30ea\u30fc\u3011 \u3000\u7247\u5074\u819d\u95a2\u7bc0\u6c34\u816b\u306b\u3088\u308bADL\u4f4e\u4e0b\u306e\u305f\u3081\u8a2a\u554f\u8a3a\u7642\u3092\u958b\u59cb\u3057\u305f\u3070\u304b\u308a\u306e93\u6b73\u5973\u6027\u3002\u95a2\u7bc0\u6c34\u816b\u306f\u6574\u5f62\u5916\u79d1\u3067\u8a3a\u65ad\u30fb\u6cbb &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1252\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u3010EBM\u306e\u5b66\u3073\u3011\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\u306e\u52b9\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-1252","post","type-post","status-publish","format-standard","hentry","category-15"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1252","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1252"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1252\/revisions"}],"predecessor-version":[{"id":1254,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1252\/revisions\/1254"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1252"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1252"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1252"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}