{"id":1301,"date":"2017-03-23T12:01:09","date_gmt":"2017-03-23T03:01:09","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1301"},"modified":"2017-03-23T12:01:09","modified_gmt":"2017-03-23T03:01:09","slug":"%e3%83%97%e3%83%a9%e3%82%a4%e3%83%9e%e3%83%aa%e3%83%bb%e3%82%b1%e3%82%a2%e3%81%a7%e3%81%ae%e5%ae%b6%e6%97%8f%e6%80%a7%e9%ab%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e8%a1%80","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1301","title":{"rendered":"\u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2\u3067\u306e\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nDavid S. Wald, et al. Child\u2013Parent Familial Hypercholesterolemia Screening in Primary Care.N Engl J Med 2016;375:1628-37.<\/p>\n

\uff0d\u8981\u7d04\uff0d
\n\u62bc\u898b\u5148\u751f\u306e\u672c\uff08www.amazon.co.jp\/dp\/4758309604<\/a>\uff09\u306b\u3042\u3063\u305f10\u306e\u30b9\u30c6\u30c3\u30d7\u306b\u6cbf\u3063\u3066\u307f\u307e\u3059\u3002<\/p>\n

Step1\uff1a\u7d50\u8ad6\u3092\u985e\u63a8\u3057\u306a\u304c\u3089\u30bf\u30a4\u30c8\u30eb\u3092\u78ba\u8a8d\u3059\u308b<\/span><\/strong>
\n\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u63a8\u5968\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u3060\u308d\u3046<\/p>\n

Step2\uff1a\u7814\u7a76\u898f\u6a21\u3092\u77e5\u308b\u305f\u3081\u306b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u540d\u3068\u8457\u8005\u306e\u6240\u5c5e\u6a5f\u95a2\u3092\u78ba\u8a8d\u3059\u308b<\/span><\/strong>
\n\"\u677e\u5cf6\u5148\u751f\u56f3\uff11\"<\/a>
\nWolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry\uff08http:\/\/www.wolfson.qmul.ac.uk\/about-us<\/a>\uff091991\u5e74\u8a2d\u7acb
\nNorth East Thames Molecular Genetics Laboratory, Great Ormond Street Hospital\uff08http:\/\/www.gosh.nhs.uk\/<\/a>\uff09\u3053\u3069\u3082\u75c5\u9662
\n\u3069\u3061\u3089\u3082\u30a4\u30ae\u30ea\u30b9\u3001\u30ed\u30f3\u30c9\u30f3<\/p>\n

Step3\uff1a\u7d50\u8ad6\u306e\u771f\u9ac4\u3092\u898b\u308b\uff08conclusion\uff09<\/span><\/strong>
\nChild\u2013parent screening was feasible in primary care practices at routine child immunization visits.
\n\u3000\u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2\u533b\u3092\u30ef\u30af\u30c1\u30f3\u3067\u53d7\u8a3a\u3057\u305f\u3068\u304d\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u53ef\u80fd
\nFor every 1000 children screened, 8 persons (4 children and 4 parents) were identified as having positive screening results for familial hypercholesterolemia and were consequently at high risk for cardiovascular disease.
\n\u30001000\u4eba\u306e\u5b50\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3066\u30014\u4eba\u306e\u5b50\u30684\u4eba\u306e\u89aa\u304cFH\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3002<\/p>\n

Step4\uff1aBackground\u3092\u898b\u3066\u7814\u7a76\u306e\u65b0\u898f\u6027\u30fb\u72ec\u81ea\u6027\u3092\u78ba\u8a8d\u3059\u308b<\/span><\/strong>
\n\u30fbWhat is known?
\n\u3000FH\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\u907a\u4f1d\u306e\u75be\u60a3\u3067\u30011000\u4eba\u306b2\u4eba\u306e\u983b\u5ea6\uff08BMJ2007\u3088\u308a\uff09\u30022007\u5e74\u306eBMJ\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u3001FH\u306ePopulation-Based child-parent screening\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u30021-9\u6b73\u5150\u3067\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6e2c\u5b9a\u3057\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u304c\u3042\u3063\u305f\u5834\u5408\u306b\u4e21\u89aa\u3082\u6e2c\u5b9a\u3059\u308b\u300220-39\u6b73\u306eFH\u60a3\u8005\u306f\u3001\u540c\u4e16\u4ee3\u306e\u5065\u5e38\u8005\u306e100\u500d\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8d77\u3053\u3057\u3084\u3059\u3044\u3002\u4e21\u89aa\u3068\u3001\u601d\u6625\u671f\u306b\u306a\u3063\u305f\u5b50\u306b\u306f\u30b9\u30bf\u30c1\u30f3\u304c\u52e7\u3081\u3089\u308c\u308b\u3002
\n\u3000FH\u306e\u8a3a\u65ad\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u884c\u3046\u304c\u3001\u5168\u3066\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u307e\u305fFH\u5909\u7570\u304c\u3042\u3063\u3066\u3082\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u304f\u306a\u3044\u5834\u5408\u3082\u3042\u308b\u3002\u4ee5\u524d\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u898b\u7a4d\u3082\u308a\u3067\u306f\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08T-Chol\uff09\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u306f\u4e2d\u592e\u5024\u306e1.53\u500d\uff08multiples of the median\uff1bMoM\uff09\u225299.9\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3067\u30011\u301c9\u6b73\u5150\u306eFH\u60a3\u8005\u309288%\u62fe\u3044\u4e0a\u3052\u3089\u308c\u308b
\n\u30fbWhat is unknown, Purpose of the study
\n\u3000We assessed the efficacy and feasibility of such screening in primary care practice.<\/p>\n

Step5\uff1aMethods\u304b\u3089\u7814\u7a76\u65b9\u6cd5\u3092\u540c\u5b9a\u3057\u3001PICO\u3092\u7528\u3044\u3066\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b<\/span><\/strong>
\n\u30fb\u30a8\u30d3\u30c7\u30f3\u30b9\u30d4\u30e9\u30df\u30c3\u30c9\u306e\u3069\u3053\u306b\u4f4d\u7f6e\u3059\u308b\u306e\u304b
\n\u3000\u8a3a\u65ad\u306e\u6709\u76ca\u6027\u3092\u898b\u308b\u3001\u6a2a\u65ad\u7814\u7a76\uff1f
\n\u30fbPICO\u306f\uff1f
\n\u3000\u306a\u3057<\/p>\n

\uff1cMethods\uff1e
\n\u30002012\u5e743\u6708\u301c2015\u5e743\u6708\u3000\u30a4\u30ae\u30ea\u30b9\u306e92\u7b87\u6240\u306egeneral medical practices\u3067\u304a\u3088\u305d13\u304b\u6708\u3067\u5b50\u4f9b\u306e\u4e88\u9632\u63a5\u7a2e\u3067\u6765\u9662\u3057\u305f\u6642\u306b\u3001\u89aa\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u308b\u304b\u78ba\u8a8d
\n13097\u5150\u306e\u89aa\u306e\u3046\u306111010\u5150\u306e\u89aa\uff0884%\uff09\u304c\u540c\u610f\u3057\u305f\u3002
\n\u3000\u4e88\u9632\u63a5\u7a2e\u306e\u6642\u306b\u3001heel-stick capillary blood sample\u3092\u63a1\u53d6\u3057\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u6e2c\u5b9a\u3068FH\u5909\u7570\u306e\u6709\u7121\u3092\u78ba\u8a8d\u3057\u305f\u3002\u826f\u597d\u306a\u691c\u4f53\u306f10118\u5150\u3067\u5f97\u3089\u308c\u305f\u3002T-Chol, HDL, TG\u306fthe Cholestech LDX point-of-care analyzer (Alere)\u3067\u6e2c\u5b9a\u3055\u308c\u305f\u3002
\ncoefficients of variation\uff08\u5909\u52d5\u4fc2\u6570\uff09\u3001\u3001\u3001
\n\u3000LDL\u306fthe Friedewald equation\u3067\u8a08\u7b97\u3002\u6700\u7d42\u7684\u306b10095\u5150\u304c\u89e3\u6790\u3055\u308c\u305f\u3002
\n\u3000\u8a08\u6e2c\u3055\u308c\u305fFH\u5909\u7570\u306f\u3001FH48\u3068\u3044\u304648\u7a2e\u985e\u306e\u3082\u306e\u3001c.10580G\u2192A (p.Arg3527Gln) mutation in APOB\u3001c.1120G\u2192T (p.Asp374Tyr) mutation in PCSK9
\n\u3000DNA\u306fthe QuickGene-810 (AutoGen)\u3067\u62bd\u51fa\u3055\u308cTaqMan single-nucleotide polymorphism (SNP) genotyping (Life Technologies) on the Fluidigm Biomark platform\u3067\u6e2c\u5b9a\u3055\u308c\u305f\u3002FH48\u306f\u306a\u3044\u304cTC\u304c\u9ad8\u5024\uff08230mg\/dl\u4ee5\u4e0a\uff09\u306e\u3082\u306e\u306fthe BigDye Terminator, v. 3.1, Cycle Sequencing Kit (Applied Biosystems)\u3092\u7528\u3044\u3066Sanger sequencing of LDLR (all exons, boundary and promoter regions), APOB (exon 26), and PCSK9 (exon 7)\u3092\u8abf\u3079\u305f\u3002\u305d\u308c\u3067\u3082\u7570\u5e38\u304c\u306a\u3044\u5834\u5408\u306f\u30013\u304b\u6708\u4ee5\u964d\u7d4c\u3063\u3066\u304b\u3089\u518d\u5ea6\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u8abf\u3079\u305f\u3002<\/p>\n

\u3000\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3042\u308aFH\u5909\u7570\u304c\u3042\u308b\u304b\u30013\u304b\u6708\u4ee5\u964d\u306b\u518d\u5ea6\u9ad8\u304b\u3063\u305f\u5834\u5408\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u967d\u6027\u3068\u3059\u308b\u3002\u305d\u306e\u89aa\u3082\u540c\u3058\u5909\u7570\u3092\u3082\u3066\u3070\u967d\u6027\u3068\u3059\u308b\u3002\u5909\u7570\u304c\u306a\u3044\u5834\u5408\u3001\u4e21\u89aa\u306e\u3046\u3061\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306a\u65b9\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u967d\u6027\u8005\u3068\u3059\u308b\u3002<\/p>\n

Step6\uff1a\u6bd4\u3001\u4fe1\u983c\u533a\u9593\u3001P\u5024\u3092\u78ba\u8a8d\u3057\u3066\u7d50\u679c\u3092\u8a55\u4fa1\u3059\u308b<\/span>
\n\"\u677e\u5cf6\u5148\u751f\u56f3\uff12\"<\/a>
\n\uff08\u79c1\u898b\uff09
\n\u30fb\u5fc3\u7b4b\u6897\u585e\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u7387\u304c\u3001\u65e5\u672c\u3067\u306e\u5b9f\u611f\u3068\u6bd4\u3079\u3066\u304b\u306a\u308a\u9ad8\u3044\u3002
\n\u30fb\u6bcd\u89aa\u306e\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u304c31\u6b73\u3001\u7236\u89aa\u304c34\u6b73\u3001\u82f1\u56fd\u3082\u6669\u5a5a\u5316\u3057\u3066\u3044\u308b\u306e\u304b\u3002<\/p>\n

\"\u677e\u5cf6\u5148\u751f\u56f3\uff13\"<\/a>
\n\u3000FH+\u306f\u5168\u54e1\u30d8\u30c6\u30ed\u578b\u3060\u3063\u305f<\/p>\n

\"\u677e\u5cf6\u5148\u751f\u56f3\uff14\"<\/a>
\n\u3000FH\u5909\u7570\uff0b\u306e\u3046\u30611\/3\u306f\u6b63\u5e38\u5024\uff081\/6\u306f\u6b63\u5e38\u4e2d\u592e\u5024\u4ee5\u4e0b\uff09<\/p>\n

\"\u677e\u5cf6\u5148\u751f\u56f3\uff15\"<\/a>
\n\u3000FH\u3068\u8a3a\u65ad\u3055\u308c\u305f\u89aa\u306f\u30b9\u30bf\u30c1\u30f3\u5185\u670d\u3092\u958b\u59cb\u3057\u305f\u3002
\n\u3000\u8a3a\u65ad\u306b\u3064\u3044\u3066\u30cd\u30ac\u30c6\u30a3\u30d6\u306a\u5370\u8c61\u3092\u6301\u3063\u305f\u89aa\u306f\u3044\u306a\u304b\u3063\u305f\u3002\u4e88\u9632\u63a5\u7a2e\u306e\u59a8\u3052\u306b\u306a\u308b\u3053\u3068\u3082\u306a\u304b\u3063\u305f\u3002
\n
\nStep7\uff1a\u8003\u5bdf\u90e8\u5206\u304b\u3089\u30d1\u30e9\u30b0\u30e9\u30d5\u30ea\u30fc\u30c7\u30a3\u30f3\u30b0\u30b9\u30ad\u30eb\u3092\u7528\u3044\u3066\u7d50\u679c\u306e\u89e3\u91c8\u3068\u9650\u754c\u3092\u540c\u5b9a\u3059\u308b<\/span><\/strong>
\n\u30fbSummary of Main Findings
\n\u30fbInterpretation
\n\u3000\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u304f\u306a\u3044\u5150\u3067\u3082\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u304a\u3053\u306a\u3063\u305f\u3053\u3068\u3067\u308f\u304b\u3063\u305f\u3053\u3068
\n\u3000\u3000FH\u5909\u7570\uff0b\u306e\u3046\u30611\/3\u306f\u6b63\u5e38\u5024\uff081\/6\u306f\u6b63\u5e38\u4e2d\u592e\u5024\u4ee5\u4e0b\uff09
\n\u3000\u3000\u540c\u3058\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u3066\u3082\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u306f\u5e45\u304c\u3042\u308b\u2192\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u767a\u8a00\u306b\u306f\u4ed6\u306e\u56e0\u5b50\u304c\u91cd\u8981
\n\u3000\u3000\u3000\u2192\u30db\u30e2\u578b\u3068\u30d8\u30c6\u30ed\u578b\u306e\u9055\u3044
\n\u3000\u3000\u3000\u2192\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u5b9a\u7fa9\u81ea\u4f53\u304c\u96e3\u3057\u3044\uff1a\u5909\u7570\u3092\u91cd\u8981\u8996\u3059\u308b\u306e\u304b\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u91cd\u8981\u8996\u3059\u308b\u306e\u304b
\n\u3000\u305d\u306e\u89e3\u6c7a\u6cd5\u3068\u3057\u3066\u63d0\u6848\u3057\u3066\u3044\u308b\u306e\u306f\u3001FH\u3092\u65e9\u767a\u51a0\u52d5\u8108\u75be\u60a3\u306e\u30ea\u30b9\u30af\u8981\u56e0\u3068\u3057\u3066\u6349\u3048\u308b\u3053\u3068\u3002
\n\u3000\uff08\u4f8b\u3048\u3070BRCA1\u306e\u5909\u7570\u306f\u3001\u75be\u60a3\u3067\u306a\u304f\u3001\u4e73\u304c\u3093\u3084\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u3068\u3057\u3066\u6349\u3048\u3089\u308c\u3066\u3044\u308b\uff09
\n\u3000Figure4\u306b\u793a\u3059population-based screening policy\u306b\u3088\u3063\u3066\u3001\u5076\u7136\u306e\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u9664\u5916\u3067\u304d\u3001
\n\u3000\u672a\u77e5\u306e\u5909\u7570\u3082\u542b\u3093\u3060\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u62fe\u3044\u4e0a\u3052\u3001\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002
\n\u30fbGeneralizability
\n\u3000\u3053\u306e\u7814\u7a76\u3067\u306f\u5168\u54e1\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u884c\u3063\u305f\u304c\u3001\u5b9f\u969b\u306f\u9650\u3089\u308c\u305f\u4eba\uff081.35MoM\u306e\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u4eba\uff09\u3057\u304b\u9069\u5fdc\u306b\u306a\u3089\u306a\u3044\u3002
\n\u3000Reflex DNA testing\uff08http:\/\/www.lmsalpha.com\/features\/ReflexDNA\uff09\u304c\u51fa\u6765\u308c\u3070\u3001\u5e83\u307e\u308b\u304b\u3082\u3057\u308c\u306a\u3044
\n\u30fbConclusions
\n\u3000\u3053\u306e\u3084\u308a\u65b9\u304c\u5c0e\u5165\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3060\u304c\u3001\u6709\u7528\u3067\u3042\u308b\u3002<\/p>\n

Step8\uff1aEditorial\uff08\u7de8\u96c6\u5f8c\u8a18\uff09\u3092\u4f7f\u3063\u3066\u7814\u7a76\u9818\u57df\u3067\u306e\u8ad6\u6587\u306e\u4fa1\u5024\u3092\u540c\u5b9a\u3059\u308b<\/span><\/strong>
\n\u3000\u4e21\u89aa\u4e16\u4ee3\u306f\u5065\u8a3a\u3084\u533b\u7642\u6a5f\u95a2\u53d7\u8a3a\u304c\u6700\u3082\u5c11\u306a\u3044\u6642\u671f\u306a\u306e\u3067\u3001\u3053\u306echild-parent\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u3088\u3044\u6a5f\u4f1a\u306b\u306a\u308b\u304b\u3082\u3002\u5c0f\u5150\u671f\uff0810\u6b73\uff09\u304b\u3089\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3059\u308b\u3053\u3068\u3067\u3001\u51a0\u52d5\u8108\u75be\u60a3\u30ea\u30b9\u30af\u3092\u6b63\u5e38\u4eba\u3068\u540c\u7b49\u307e\u3067\u6e1b\u3089\u305b\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002
\n\u3000\u3053\u308c\u307e\u3067\u884c\u308f\u308c\u3066\u3044\u308bCascade screening\u3067\u306f\u3001\u9ad8\u5ea6\u306e\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u3042\u308b\u6210\u4eba\u3092\u6a5f\u8ee2\u306b\u3001\u5bb6\u65cf\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u304b\u3051\u3066\u3044\u304f\u65b9\u6cd5\u3067\u3001\u30b3\u30b9\u30c8\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306f\u3088\u3044\u304c\u3001\u3059\u3067\u306b\u52d5\u8108\u786c\u5316\u304c\u9032\u884c\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u591a\u3044\u3002Universal screening\u304c\u6c42\u3081\u3089\u308c\u308b\u3002Pediatrics 2011\u306b\u3042\u3063\u305fExpert panel\u306e\u767a\u8868\u3067\u306f\u30019-11\u6b73\u306817-21\u6b73\u3067\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u304c\u3001\u3088\u308a\u65e9\u3044\u6642\u671f\u306b\u884c\u3046\u3053\u3068\u3067\u6f0f\u308c\u3092\u5c11\u306a\u304f\u3057\u305f\u308a\u65e9\u671f\u304b\u3089\u306e\u751f\u6d3b\u6307\u5c0e\u3084\u6cbb\u7642\u3092\u59cb\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n

Step9\uff1aCorrespondence\u3092\u4f7f\u3063\u3066\u95a2\u9023\u3059\u308b\u7814\u7a76\u3092\u8a55\u4fa1\u3059\u308b<\/span><\/p>\n

Step10\uff1aConference report\u3092\u4f7f\u3063\u3066\u8ad6\u6587\u304c\u793e\u4f1a\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8003\u3048\u308b<\/span><\/strong><\/p>\n

\u3010\u958b\u50ac\u65e5\u3011
\n2017\u5e743\u670815\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d David S. Wald, et al. Child\u2013Parent Familial Hypercholesterolemia Screening in Primary Care.N Engl J Med … \u7d9a\u304d\u3092\u8aad\u3080 \u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2\u3067\u306e\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1301","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1301"}],"version-history":[{"count":4,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1301\/revisions"}],"predecessor-version":[{"id":1310,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1301\/revisions\/1310"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}