{"id":1375,"date":"2017-08-25T12:20:28","date_gmt":"2017-08-25T03:20:28","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1375"},"modified":"2017-08-25T12:20:28","modified_gmt":"2017-08-25T03:20:28","slug":"%e5%b0%8f%e5%85%90%e3%81%ae%e6%80%a5%e6%80%a7%e4%b8%ad%e8%80%b3%e7%82%8e%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e6%8a%97%e7%94%9f%e5%89%a4%e3%81%af1%e3%80%9c2%e5%9b%9e%e6%97%a5%e3%81%a7%e8%89%af","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1375","title":{"rendered":"\u5c0f\u5150\u306e\u6025\u6027\u4e2d\u8033\u708e\u306b\u5bfe\u3059\u308b\u6297\u751f\u5264\u306f1\u301c2\u56de\/\u65e5\u3067\u826f\u3044\u306e\u304b\uff1f"},"content":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015<br \/>\nThanaviratananich, S., Laopaiboon, M., &#038; Vatanasapt, P. Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. The Cochrane Library.2013.<\/p>\n<p>\u2015\u8981\u7d04\u2015<br \/>\n<strong>\u3010Introduction\u3011<\/strong><br \/>\n\u3000\u6025\u6027\u4e2d\u8033\u708e\u306f\u5c0f\u5150\u306e\u826f\u304f\u3042\u308b\u554f\u984c\u3067\u3042\u308b\u3002CVA\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305aAMPC\u306f\u983b\u7e41\u306b\u9078\u629e\u3055\u308c\u308b\u6cbb\u7642\u3068\u3057\u3066\u51e6\u65b9\u3055\u308c\u308b\u3002\u5f93\u6765\u306e\u63a8\u5968\u306f1\u65e5\u306b3\u56de\u3042\u308b\u3044\u306f4\u56de\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u4eca\u65e51\u65e5\u306b1\u56de\u3042\u308b\u3044\u306f2\u56de\u6295\u4e0e\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u3002<br \/>\n\u3000\u3082\u3057\u30011\u65e51\u56de\u3042\u308b\u3044\u306f2\u56de\u6295\u4e0e\u304c3\u56de\u3042\u308b\u3044\u306f4\u56de\u6295\u4e0e\u3068\u540c\u7b49\u306e\u52b9\u679c\u3067\u3042\u308c\u3070\u3001\u4fbf\u5229\u3067\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u5411\u4e0a\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n<p><strong>\u3010Method\u3011<\/strong><br \/>\n\u3000\uff15\u3064\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30e1\u30bf\u5206\u6790\u3002<\/p>\n<p>\u3000\u25cf\u53c2\u52a0\u8005\uff1a12\u6b73\u4ee5\u4e0b\u306e\u6025\u6027\u4e2d\u8033\u708e\u60a3\u8005\u3002\u6025\u6027\u4e2d\u8033\u708e\u306f\u6025\u6027\u306e\u8033\u75db\u3068\u3001\u9f13\u819c\u7a7f\u523a\u3042\u308b\u3044\u306f\u30c6\u30a3\u30f3\u30d1\u30ce\u30b0\u30e9\u30e0\u306eB\u578bC\u578b\u3067\u8a3a\u65ad\u3055\u308c\u305f\u3082\u306e\u3002<br \/>\n\u3000\u3000\u3000\u3000\u3000\uff08B\u578b\u306f\u4e2d\u8033\u306efluid\u3092\u793a\u5506\u3057\u3001C\u578b\u306f\u4e2d\u8033\u5185\u306e\u5727\u529b\u304c\u5927\u6c17\u5727\u3088\u308a\u4f4e\u3044\u4e8b\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff09<br \/>\n\u3000\u25cf\u4ecb\u5165\u306e\u30bf\u30a4\u30d7\uff1aCVA\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305aAMPC1\u301c2\u56de\uff0f\u65e5\u30683\u301c4\u56de\uff0f\u65e5\u3068\u6bd4\u8f03\u3059\u308b\u3002<br \/>\n\u3000\u25cfPrimary outcomes\uff1a\u30c7\u30fc\u30bf\u304c\u3042\u308b\u5834\u5408\u3001\u8033\u75db\u306e\u6539\u5584\u30fb\u89e3\u71b1\u30fb\u7d30\u83cc\u5b66\u7684\u6cbb\u7652\u306b\u3088\u308b\u3001\u6297\u751f\u5264\u7d42\u4e86\uff087\u301c15\u65e5\u76ee\uff09\u306e\u81e8\u5e8a\u7684\u6cbb\u7642\u7387\u3002<br \/>\n\u3000\u25cfSecondary outcomes\uff1a\u8033\u75db\u306e\u6539\u5584\u3068\u89e3\u71b1\u306b\u3088\u308b\u81e8\u5e8a\u7684\u6cbb\u7652\u7387\u3002\u518d\u767a\u6027\u4e2d\u8033\u708e\u306e\u306a\u3044AOM\u6cbb\u7642\u5f8c\u60a3\u8005\u306e\u307f\u306b\u304a\u3044\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3001<br \/>\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u6cbb\u7652\u5f8c\uff081\u301c3\u30f6\u6708\u5f8c\uff09\u3001\u30c6\u30a3\u30f3\u30d1\u30ce\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u308b\u4e2d\u8033\u6d78\u51fa\u6db2\u306e\u6539\u5584\u3002AOM\u306e\u5408\u4f75\u75c7\uff08\u518d\u767a\u3001\u4e73\u69d8\u7a81\u8d77\u708e\uff09\u3002<br \/>\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u6295\u85ac\u3078\u306e\u6709\u5bb3\u4e8b\u8c61\u3002<\/p>\n<p>\u30002\u4eba\u306e\u8457\u8005\u306f\u72ec\u7acb\u3057\u3066\u305d\u308c\u305e\u308c\u306e\u8a66\u9a13\u304b\u3089\u6cbb\u7642\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u3092\u62bd\u51fa\u3057\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u3001\u65bd\u884c\u30d0\u30a4\u30a2\u30b9\u3001\u691c\u51fa\u30d0\u30a4\u30a2\u30b9\u3001\u75c7\u4f8b\u6e1b\u5c11\u30d0\u30a4\u30a2\u30b9\u3001\u5831\u544a\u30d0\u30a4\u30a2\u30b9\u3001\u53ca\u3073\u305d\u306e\u4ed6\u306e\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002<br \/>\n\u3000\u30d0\u30a4\u30a2\u30b9\u306e\u4f4e\u30ea\u30b9\u30af\u30fb\u9ad8\u30ea\u30b9\u30af\u30fb\u4e0d\u78ba\u5b9f\u306a\u30ea\u30b9\u30af\u3068\u3057\u3066\u3001\u8cea\u306e\u683c\u4ed8\u3051\u3092\u5b9a\u7fa9\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u309295\uff05\u4fe1\u983c\u533a\u9593\u306eRR\u3068\u3057\u3066\u307e\u3068\u3081\u305f\u3002<\/p>\n<p><strong>\u3010Main Results\u3011<\/strong><br \/>\n\u30001601\u4eba\u306e\u5c0f\u5150\u3092\u542b\u30805\u3064\u306e\u7814\u7a76\u304c\u542b\u307e\u308c\u305f\u3002<\/p>\n<p>\u3000\u6cbb\u7642\u7d42\u4e86\u6642\uff08RR1.03,95\uff05\u4fe1\u983c\u533a\u9593 0.99\u301c1.07\uff09 Fig.3<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f31.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f31.png\" alt=\"\u8cb4\u5cf6\u5148\u751f\u56f31\" width=\"894\" height=\"208\" class=\"aligncenter size-full wp-image-1376\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f31.png 894w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f31-300x70.png 300w\" sizes=\"auto, (max-width: 894px) 100vw, 894px\" \/><\/a><br \/>\n\u3000\u3000<strong>Figure 3. Forest plot of comparison: Clinical cure rate at the end of therapy.<br \/>\n<\/strong><br \/>\n\u3000\u6cbb\u7642\u4e2d \u3000\u3000(RR 1.06, 95%\u4fe1\u983c\u533a\u9593 0.85 to 1.33)\u3000Fig.4<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f32.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f32.png\" alt=\"\u8cb4\u5cf6\u5148\u751f\u56f32\" width=\"898\" height=\"160\" class=\"aligncenter size-full wp-image-1377\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f32.png 898w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f32-300x53.png 300w\" sizes=\"auto, (max-width: 898px) 100vw, 898px\" \/><\/a><br \/>\n\u3000\u3000<strong>Figure 4. Forest plot of comparison: Clinical cure rate during therapy. <\/strong><\/p>\n<p>\u3000\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u671f\u9593 \uff081\u301c3\u30f6\u6708\uff09(RR 1.02, 95%\u4fe1\u983c\u533a\u9593 0.95 to 1.09)\u3000Fig.5<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f33.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f33.png\" alt=\"\u8cb4\u5cf6\u5148\u751f\u56f33\" width=\"870\" height=\"192\" class=\"aligncenter size-full wp-image-1378\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f33.png 870w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f33-300x66.png 300w\" sizes=\"auto, (max-width: 870px) 100vw, 870px\" \/><\/a><br \/>\n\u3000\u3000<strong>Figure 5. Forest plot of comparison: Clinical cure at post-treatment (one to three months). <\/strong><\/p>\n<p>\u3000\u518d\u767a\u6027\u4e2d\u8033\u708e(RR 1.21, 95%\u4fe1\u983c\u533a\u9593 0.52 to 2.81)Fig.6<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f34.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f34.png\" alt=\"\u8cb4\u5cf6\u5148\u751f\u56f34\" width=\"870\" height=\"176\" class=\"aligncenter size-full wp-image-1379\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f34.png 870w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2017\/08\/\u8cb4\u5cf6\u5148\u751f\u56f34-300x61.png 300w\" sizes=\"auto, (max-width: 870px) 100vw, 870px\" \/><\/a><br \/>\n\u3000\u3000<strong>Figure 6. Forest plot of comparison: AOM complications: Recurrent AOM after completion of therapy. <\/strong><\/p>\n<p>\u3000AMPC\u306e\u307f\u3001\u307e\u305f\u306fAMPC\/CVA\u3067\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3092\u5225\u3005\u306b\u884c\u3063\u305f\u7d50\u679c\u3001\u3059\u3079\u3066\u306e\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u304a\u3044\u30661\u65e51\u301c2\u56de\u30681\u65e53\u56de\u306e\u7fa4\u3067\u5dee\u304c\u306a\u304b\u3063\u305f\u3002<br \/>\n\u3000\u307e\u305f\u3001\u5185\u670d\u9075\u5b88\u7387(RR 1.04, 95%\u4fe1\u983c\u533a\u9593 0.98 to 1.10)\u3001\u4e0b\u75e2\u3084\u76ae\u819a\u969c\u5bb3\u306a\u3069\u306e\u5168\u6709\u5bb3\u4e8b\u8c61 (RR 0.92, 95%\u4fe1\u983c\u533a\u9593 0.52 to 1.63)\u3068\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002\uff08\u7d4c\u53e3\u6297\u751f\u7269\u8cea\u306e1\u65e51\u56de\u307e\u305f\u306f2\u56de\u306e\u6295\u4e0e\u306f\u30011\u65e53\u56de\u306e\u6295\u4e0e\u3088\u308a\u9ad8\u3044\u9075\u5b88\u7387\u3092\u6709\u3059\u308b\u5831\u544a\u304c\u3042\u308b\uff08Kardas 2007; Pechere 2007\uff09\uff09<\/p>\n<p><strong>\u3010\u8457\u8005\u3089\u306e\u7d50\u8ad6\u3011<\/strong><br \/>\n\u3000\u672c\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001CVA\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305aAMPC\u306e1\u65e51\u56deor2\u56de\u306e\u7528\u91cf\u3092\u4f7f\u7528\u3057\u305f\u7d50\u679c\u306f\u3001AOM\u306e\u6cbb\u7642\u30673\u56de\u6295\u4e0e\u306e\u7d50\u679c\u306b\u5339\u6575\u3059\u308b\u4e8b\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u4e21\u65b9\u306e\u6295\u85ac\u304c\u540c\u3058\u6709\u52b9\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3001\u307e\u305f\u306f\u8907\u96d1\u3067\u306a\u3044AOM\u304c\u81ea\u7136\u6cbb\u7652\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u5f97\u308b\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\u30002017\u5e748\u670823\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015 Thanaviratananich, S., Laopaiboon, M., &#038; Vatanasapt, P. Once or twice daily versus three times dail &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1375\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u5c0f\u5150\u306e\u6025\u6027\u4e2d\u8033\u708e\u306b\u5bfe\u3059\u308b\u6297\u751f\u5264\u306f1\u301c2\u56de\/\u65e5\u3067\u826f\u3044\u306e\u304b\uff1f<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,17],"tags":[],"class_list":["post-1375","post","type-post","status-publish","format-standard","hentry","category-10","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1375"}],"version-history":[{"count":5,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1375\/revisions"}],"predecessor-version":[{"id":1384,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1375\/revisions\/1384"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}