{"id":1604,"date":"2018-11-21T10:04:46","date_gmt":"2018-11-21T01:04:46","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1604"},"modified":"2018-11-21T10:04:46","modified_gmt":"2018-11-21T01:04:46","slug":"%e3%82%a8%e3%83%80%e3%83%a9%e3%83%9c%e3%83%b3%ef%bc%88%e3%83%a9%e3%82%b8%e3%82%ab%e3%83%83%e3%83%88%ef%bc%89%e3%81%aeals%e9%80%b2%e8%a1%8c%e6%8a%91%e5%88%b6%e5%8a%b9%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1604","title":{"rendered":"\u30a8\u30c0\u30e9\u30dc\u30f3\uff08\u30e9\u30b8\u30ab\u30c3\u30c8\u00ae\uff09\u306eALS\u9032\u884c\u6291\u5236\u52b9\u679c"},"content":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015<br \/>\nK.Abe. et al. Safety and efficacy of edaravone in well defined patients<br \/>\nwith amyotrophic lateral sclerosis: a randomised,<br \/>\ndouble-blind, placebo-controlled trial. Lancet Neurol 2017; 16: 505\u201312<\/p>\n<p>\u2015\u8981\u7d04\u2015<br \/>\n\u2605Introduction\uff1a ALS\u306e\u539f\u56e0\u306f\u3044\u307e\u3060\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u304c\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff083-Nitrotyrosine\u3001coenzyme Q10\u30018-hydroxydeoxyguanosine\u30014-Hydroxy-2,3-nonenal\uff09\u304c\u75be\u60a3\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u30a8\u30c0\u30e9\u30dc\u30f3\u306f\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u3092\u6d88\u53bb\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u8131\u843d\u3092\u963b\u6b62\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u3002\u30a8\u30c0\u30e9\u30dc\u30f3\u306fALS\u306e\u9032\u884c\u3092\u6539\u5584\u3055\u305b\u308b\u50cd\u304d\u304c\u3042\u308b\u3068\u4e88\u60f3\u3055\u308c\u3001\u5bfe\u30d7\u30e9\u30bb\u30dc\u306e\u7b2c3\u76f8\u8a66\u9a13\u3092\u884c\u3063\u305f\u304c\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3042\u308bALSFRS-R\u30b9\u30b3\u30a2\u306b\u6709\u610f\u5dee\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30a8\u30c0\u30e9\u30dc\u30f3\u304c\u75be\u60a3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u306e\u306b\u52b9\u679c\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u60a3\u8005\u5c64\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u76ee\u7684\u3067\u591a\u91cd\u6bd4\u8f03\u691c\u5b9a\u3092\u884c\u3063\u305f\u3002\u3059\u308b\u3068ALSFRS-R\u30b9\u30b3\u30a2\u304c\u5168\u9805\u76ee2\u70b9\u4ee5\u4e0a\u3001\u52aa\u529b\u6027\u80ba\u6d3b\u91cf80%\u4ee5\u4e0a\u3001\u91cd\u75c7\u5ea6\u5206\u985e1\u5ea6\u30012\u5ea6\u3001\u7f79\u75c5\u6a5f\u95a22\u5e74\u4ee5\u5185\u306e\u6761\u4ef6\u304c\u30a8\u30c0\u30e9\u30dc\u30f3\u306e\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n<p>\u2605Method\uff1aa randomized, double blind, parallel-group, placebo-controlled study<br \/>\n\u3010\u9078\u629e\u57fa\u6e96\u3011 20-75\u6b73\u3001ALS\u91cd\u75c7\u5ea6\u5206\u985e1\u30012\u5ea6\u300112\u9031\u9593\u306e\u89b3\u5bdf\u6a5f\u95a2\u306e\u9593\u306bALSFRS-R\u30b9\u30b3\u30a2\u5909\u5316\u304c-1\uff5e-4\u70b9\u3001ALSFRS-R\u30b9\u30b3\u30a2\u5168\u9805\u76ee2\u70b9\u4ee5\u4e0a\u3001\u52aa\u529b\u6027\u80ba\u6d3b\u91cf80%\u4ee5\u4e0a\u3001El Escoria\u6539\u8a02Airlie House\u8a3a\u65ad\u57fa\u6e96\u3067\u300cDefinite\u300d\u300cProbable\u300d\u3001\u7f79\u60a3\u671f\u9593\u304c2\u5e74\u4ee5\u5185<br \/>\n\u3010\u9664\u5916\u57fa\u6e96\u3011ALSFRS-R\u304c\u547c\u5438\u56f0\u96e3\u3001\u8d77\u5750\u547c\u5438\u3001\u547c\u5438\u4e0d\u5168\u30673\u70b9\u672a\u6e80\u3001ALS\u767a\u75c7\u5f8c\u306e\u810a\u9ac4\u624b\u8853\u6b74\u3001\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u30af\u30ea\u30a2\u30e9\u30f3\u30b950ml\/min\u4ee5\u4e0b\u3000\uff08\u65e2\u306b\u30ea\u30eb\u30be\u30fc\u30eb\u3092\u5185\u670d\u3057\u3066\u3044\u305f\u60a3\u8005\u306f\u7d99\u7d9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304c\u3001\u89b3\u5bdf\u671f\u9593\u5f8c\u306b\u30ea\u30eb\u30be\u30fc\u30eb\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3068\u3057\u305f\uff09<br \/>\n\u3010\u65b9\u6cd5\u3011\u30e9\u30f3\u30c0\u30e0\u5316\u306e\u524d\u306b12\u9031\u9593\u306e\u89b3\u5bdf\u671f\u9593\u3092\u8a2d\u3051\u3066\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3059\u88ab\u9a13\u8005\u306b\u3064\u3044\u3066\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u4e8c\u91cd\u76f2\u691c\u4e0b\u3067\u5272\u308a\u4ed8\u3051\u300124\u9031\u9593\uff086\u30b5\u30a4\u30af\u30eb\uff09\u306e\u6cbb\u7642\u3092\u884c\u3063\u305f\u3002\u7b2c1\u30b5\u30a4\u30af\u30eb\u306f14\u65e5\u9593\u9023\u65e5\u6295\u4e0e\u3057\u305f\u5f8c14\u65e5\u9593\u4f11\u85ac\u3057\u3001\u7b2c2\u30b5\u30a4\u30af\u30eb\u4ee5\u964d\u306f14\u65e5\u9593\u306e\u3046\u306110\u65e5\u9593\u6295\u4e0e\u3057\u305f\u5f8c14\u65e5\u9593\u4f11\u85ac\u3057\u305f\u3002<br \/>\n\u3010End point\u3011<br \/>\n\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u958b\u59cb\u304b\u30896\u30b5\u30a4\u30af\u30eb\u7d42\u4e86\u5f8c\u306eALSFRS-R\u30b9\u30b3\u30a2\u306e\u5909\u5316<br \/>\n\u526f\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u52aa\u529b\u6027\u80ba\u6d3b\u91cf\u3001Modified Norris Scale\u3001ALSAQ-40\u30b9\u30b3\u30a2\u3001ALS\u91cd\u75c7\u5ea6\u3001\u63e1\u529b\u3001\u3064\u307e\u3080\u529b\u3001\u6b7b\u4ea1\u307e\u305f\u306f\u4e00\u5b9a\u306e\u75c5\u52e2\u9032\u884c\u307e\u3067\u306e\u671f\u9593<\/p>\n<p>\u2605Result\uff1a\u6295\u4e0e\u958b\u59cb\u6642\u3068\u7b2c6\u30b5\u30a4\u30af\u30eb\u7d42\u4e86\u6642\u306eALSFRS-R\u30b9\u30b3\u30a2\u5909\u5316\u91cf\u306b\u304a\u3051\u308b\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u306f2.49\u70b9\u3067\u30a8\u30c0\u30e9\u30dc\u30f3\u7fa4\u306e\u65b9\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u30b9\u30b3\u30a2\u306e\u4f4e\u4e0b\u304c\u7de9\u3084\u304b\u3060\u3063\u305f\u3002\uff0895%CI 0.99-3.98 p=0.0013\uff09<br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff11.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff11.png\" alt=\"201811\u795e\u7530\uff11\" width=\"507\" height=\"459\" class=\"alignleft size-full wp-image-1605\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff11.png 507w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff11-300x272.png 300w\" sizes=\"auto, (max-width: 507px) 100vw, 507px\" \/><\/a><\/p>\n<p>\u526f\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u6709\u610f\u5dee\u304c\u3067\u305f\u306e\u306fModified Norris Scale\u30b9\u30b3\u30a2\u3068ALSAQ-40\u30b9\u30b3\u30a2\u3060\u3063\u305f\u3002\u5c11\u3057\u3067\u3082\u526f\u4f5c\u7528\u3092\u8d77\u3053\u3057\u305f\u75c7\u4f8b\u306f\u30a8\u30c0\u30e9\u30dc\u30f3\u7fa4\u306758\u75c7\u4f8b\uff0884%\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306757\u75c7\u4f8b\uff0884%\uff09\u3001\u91cd\u75c7\u526f\u4f5c\u7528\u306f\u30a8\u30c0\u30e9\u30dc\u30f3\u7fa4\u306711\u75c7\u4f8b\uff0816%\uff09\uff08\u56a5\u4e0b\u969c\u5bb3\u3001\u547c\u5438\u969c\u5bb3\u3001\u69cb\u97f3\u969c\u5bb3\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306716\u75c7\u4f8b\uff0824%\uff09\u3060\u3063\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff12.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff12.png\" alt=\"201811\u795e\u7530\uff12\" width=\"640\" height=\"359\" class=\"alignleft size-large wp-image-1606\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff12.png 907w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2018\/11\/201811\u795e\u7530\uff12-300x168.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112018\u5e7411\u670821\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015 K.Abe. et al. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral scleros &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1604\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u30a8\u30c0\u30e9\u30dc\u30f3\uff08\u30e9\u30b8\u30ab\u30c3\u30c8\u00ae\uff09\u306eALS\u9032\u884c\u6291\u5236\u52b9\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1604","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1604"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1604\/revisions"}],"predecessor-version":[{"id":1852,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1604\/revisions\/1852"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}