{"id":1643,"date":"2019-02-20T10:43:50","date_gmt":"2019-02-20T01:43:50","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1643"},"modified":"2019-02-20T10:43:50","modified_gmt":"2019-02-20T01:43:50","slug":"ace%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%a8%e8%82%ba%e7%99%8c%e3%83%aa%e3%82%b9%e3%82%af","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1643","title":{"rendered":"ACE\u963b\u5bb3\u85ac\u3068\u80ba\u764c\u30ea\u30b9\u30af"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nBl\u00e1naid M Hicks, et. al. Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study BMJ 2018;363:k4209<\/p>\n

-\u8981\u7d04-
\nIntroduction\uff1a
\n\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20\u963b\u5bb3\u5264\uff08\u4ee5\u964d\u3001ACEI\uff09\u306f\u77ed\u671f\u7684\u306b\u306f\u6bd4\u8f03\u7684\u5b89\u5168\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u9577\u671f\u4f7f\u7528\u304c\u764c\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u308b\u3002\u3044\u304f\u3064\u304b\u306e\u751f\u7269\u5b66\u7684\u7814\u7a76\u304cACEI\u3068\u80ba\u764c\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306e\u53ef\u80fd\u6027\u306e\u305f\u3081\u306b\u5b58\u5728\u3059\u308b\u3002ACEI\u306e\u4f7f\u7528\u306f\u80ba\u306b\u30d6\u30e9\u30b8\u30ad\u30cb\u30f3\u306e\u84c4\u7a4d\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u80ba\u304c\u3093\u306e\u5897\u6b96\u3092\u523a\u6fc0\u3057\u3046\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u30025\u307e\u305f\u3001\u30b5\u30d6\u30b9\u30bf\u30f3\u30b9\uff30\u306e\u84c4\u7a4d\u3092\u3082\u305f\u3089\u3057\u3001\u3053\u308c\u306f\u80ba\u764c\u7d44\u7e54\u306b\u304a\u3044\u3066\u767a\u73fe\u3055\u308c\u3001\u305d\u3057\u3066\u816b\u760d\u5897\u6b96\u304a\u3088\u3073\u8840\u7ba1\u65b0\u751f\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002
\n\u3044\u307e\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001ACEI\u306b\u3088\u308b\u304c\u3093\u306e\u767a\u751f\u7387\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u306a\u304b\u3063\u305f\u304c\u3001\u307b\u3068\u3093\u3069\u306e\u30b5\u30f3\u30d7\u30eb\u304c\u6bd4\u8f03\u7684\u5c0f\u898f\u6a21\u3067\u8ffd\u8de1\u671f\u9593\u304c\u77ed\u304b\u3063\u305f\uff08\u4e2d\u592e\u50243.5\u5e74\uff09\u3002\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\uff08\u4ee5\u4e0b\u3001ARB\uff09\u306e\u4f7f\u7528\u3068\u6bd4\u8f03\u3057\u3066ACEI\u306e\u4f7f\u7528\u304c\u80ba\u764c\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304b\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u5927\u898f\u6a21\u306a\u96c6\u56e3\u30d9\u30fc\u30b9\u8a66\u9a13\u3092\u884c\u3063\u305f\u3002
\nMethod\uff1a
\n\u3053\u306e\u7814\u7a76\u306f1500\u4e07\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u542b\u3080\u7d04700\u306e\u4e00\u822c\u8a3a\u7642\u304b\u3089\u306e\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u308b\u3001\u82f1\u56fd\u81e8\u5e8a\u8a3a\u7642\u7814\u7a76\u30c7\u30fc\u30bf\u30ea\u30f3\u30af\uff08CPRD\uff09\u3092\u4f7f\u7528\u3057\u305f\u3002\u964d\u5727\u85ac\uff08\u03b2\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\u3001\u03b1\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\u3001ACEI\u3001ARB\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30f3\u30cd\u30eb\u906e\u65ad\u85ac\u3001\u8840\u7ba1\u62e1\u5f35\u85ac\u3001\u4e2d\u67a2\u6027\u964d\u5727\u85ac\u3092\u542b\u3080\uff09\u3067\u65b0\u305f\u306b\u6cbb\u7642\u958b\u59cb\u3055\u308c\u305f18\u6b73\u4ee5\u4e0a\u306e\u5168\u60a3\u8005\u306e\u57fa\u672c\u30b3\u30db\u30fc\u30c8\u3092\u7279\u5b9a\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u5c11\u306a\u304f\u3068\u30821\u5e74\u9593\u306e\u75c5\u6b74\u304cCPRD\u306b\u3042\u308b\u3053\u3068\u3092\u8981\u6c42\u3057\u305f\uff08\u5229\u5c3f\u85ac\u3001\u795e\u7d4c\u7bc0\u906e\u65ad\u85ac\u3001\u304a\u3088\u3073\u30ec\u30cb\u30f3\u963b\u5bb3\u85ac\uff09\u3002
\n\u4e0a\u8a18\u3067\u5b9a\u7fa9\u3055\u308c\u305f\u57fa\u672c\u30b3\u30db\u30fc\u30c8\u304b\u3089\u30011995\u5e741\u67081\u65e5\u4ee5\u964d\uff08\u82f1\u56fd\u3067ACEI\u3068ARB\u306e\u4e21\u65b9\u304c\u51e6\u65b9\u53ef\u80fd\u3068\u306a\u3063\u305f\u6700\u521d\u306e\u5e74\uff09\u306e12\u670831\u65e5\u307e\u3067\u306b\u65b0\u898f\u964d\u5727\u85ac\u3092\u670d\u7528\u3057\u59cb\u3081\u305f\u5168\u60a3\u8005\u306e\u8a66\u9a13\u30b3\u30db\u30fc\u30c8\u3092\u7279\u5b9a\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306b\u306f\u3001\u65b0\u305f\u306b\u964d\u5727\u85ac\u3067\u6cbb\u7642\u958b\u59cb\u3055\u308c\u305f\u60a3\u8005\u3001\u306a\u3089\u3073\u306b\u4ee5\u524d\u306e\u6cbb\u7642\u6b74\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u306a\u3044\u964d\u5727\u85ac\u3092\u8ffd\u52a0\u307e\u305f\u306f\u5207\u308a\u66ff\u3048\u305f\u60a3\u8005\u304c\u542b\u307e\u308c\u305f\u3002\u764c\u3068\u8a3a\u65ad\u3092\u3046\u3051\u305f\u3053\u3068\u306e\u3042\u308b\u60a3\u8005\uff08\u975e\u9ed2\u8272\u816b\u76ae\u819a\u764c\u4ee5\u5916\uff09\u304a\u3088\u3073\u30b3\u30db\u30fc\u30c8\u306b\u5165\u308b\u524d\u306e\u4efb\u610f\u306e\u6642\u70b9\u3067\u764c\u6cbb\u7642\uff08\u5316\u5b66\u7642\u6cd5\u307e\u305f\u306f\u653e\u5c04\u7dda\u7642\u6cd5\uff09\u3092\u53d7\u3051\u305f\u3053\u3068\u306e\u3042\u308b\u60a3\u8005\u306f\u9664\u5916\u3057\u305f\u3002\u6f5c\u4f0f\u671f\u9593\u306e\u8003\u616e\u3068\u8ffd\u8de1\u8abf\u67fb\u306e\u9593\u306e\u5076\u767a\u7684\u4e8b\u8c61\u306e\u540c\u5b9a\u3092\u78ba\u5b9f\u306b\u3059\u308b\u305f\u3081\u306b\u30b3\u30db\u30fc\u30c8\u767b\u9332\u5f8c\u306e\u8ffd\u8de1\u8abf\u67fb1\u5e74\u672a\u6e80\u306e\u60a3\u8005\u3092\u9664\u5916\u3057\u305f\u3002
\n\u3059\u3079\u3066\u306e\u89e3\u6790\u30e2\u30c7\u30eb\u3067\u306f\u3001\u30b3\u30db\u30fc\u30c8\u53c2\u52a0\u6642\u306b\u6e2c\u5b9a\u3055\u308c\u305f\u4ee5\u4e0b\u306e\u5909\u6570\u306b\u3064\u3044\u3066\u8abf\u6574\u3055\u308c\u305f\uff1a\u5e74\u9f62\u3001\u6027\u5225\u3001\u30b3\u30db\u30fc\u30c8\u53c2\u52a0\u5e74\u3001BMI\u3001\u55ab\u7159\u72b6\u614b\uff08\u55ab\u7159\u7d99\u7d9a\u4e2d\u3001\u7981\u7159\u5f8c\u3001\u975e\u55ab\u7159\uff09\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u6027\u75be\u60a3\uff08\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u786c\u5909\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u708e\u3001\u809d\u4e0d\u5168\u3092\u542b\u3080\uff09\u3001\u304a\u3088\u3073\u80ba\u75be\u60a3\u306e\u65e2\u5f80\u6b74\uff08\u80ba\u708e\u3001\u7d50\u6838\u3001\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u3092\u542b\u3080\uff09\u3002\u3055\u3089\u306b\u7814\u7a76\u30e2\u30c7\u30eb\u306b\u306f\u6cbb\u7642\u3055\u308c\u305f\u9ad8\u8840\u5727\u306e\u671f\u9593\uff08\u964d\u5727\u85ac\u306e\u6700\u521d\u306e\u51e6\u65b9\u304b\u3089\u30b3\u30db\u30fc\u30c8\u53c2\u52a0\u3068\u306e\u9593\u306e\u6642\u9593\u3068\u3057\u3066\u5b9a\u7fa9\uff09\u304a\u3088\u3073\u30b3\u30db\u30fc\u30c8\u306b\u53c2\u52a0\u524d\u306e\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u304c\u542b\u307e\u308c\u305f\u3002
\n\u5404\u66dd\u9732\u7fa4\u306b\u3064\u3044\u3066\u3001\u30dd\u30a2\u30bd\u30f3\u5206\u5e03\u306b\u57fa\u3065\u3044\u3066\u3001\u80ba\u764c\u306e\u7c97\u767a\u751f\u7387\u304a\u3088\u307395\uff05\u4fe1\u983c\u533a\u9593\u3092\u8a08\u7b97\u3057\u305f\u3002\u6b20\u640d\u5024\u3092\u6301\u3064\u5909\u6570\u306e\u591a\u91cd\u4ee3\u5165\u3092\u4f7f\u7528\u3057\u3066\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\u306e\u4f7f\u7528\u3068\u6bd4\u8f03\u3057\u305fACEI\u306e\u4f7f\u7528\u306b\u95a2\u9023\u3059\u308b\u80ba\u304c\u3093\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u304a\u3088\u307395\uff05\u4fe1\u983c\u533a\u9593\u3092\u63a8\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u6642\u9593\u4f9d\u5b58Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u305f\u3002
\nResults\uff1a
\n\u30b3\u30db\u30fc\u30c8\u306b\u306f992 061\u4eba\u306e\u60a3\u8005\u304c\u542b\u307e\u308c\u30011\u5e74\u5f8c\u306e\u30b3\u30db\u30fc\u30c8\u53c2\u52a0\u6e96\u5099\u671f\u9593\u3092\u8d85\u3048\u3066\u5e73\u57476.4\uff08SD 4.7\uff09\u5e74\u9593\u8ffd\u8de1\u3055\u308c\u305f\u3002\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u4e2d\u3001335,135\u4eba\u306e\u60a3\u8005\u304cACEI\u3067\u6cbb\u7642\u3055\u308c\u300129,008\u4eba\u304cARB\u3001\u305d\u3057\u306610 1,637\u4eba\u304cACEI\/ARB\u4f75\u7528\u3067\u6cbb\u7642\u3055\u308c\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u30017952\u4eba\u306e\u60a3\u8005\u304c\u80ba\u764c\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u65b0\u305f\u306b\u8a3a\u65ad\u3055\u308c\u30011000\u4eba\u5e74\u5f53\u305f\u308a1.3\u306e\u7c97\u767a\u751f\u73871.3\uff0895\uff05\u4fe1\u983c\u533a\u95931.2\u301c1.3\uff09\u3068\u306a\u3063\u305f\u3002<\/p>\n

\"20190220\u4e0a\u91ce\uff11\"<\/a><\/p>\n

\u8868\uff11\u306f\u3001\u30b3\u30db\u30fc\u30c8\u5168\u4f53\u306eACEI\u3001ARB\u3001\u304a\u3088\u3073\u4ed6\u306e\u964d\u5727\u85ac\u306e\u4f7f\u7528\u306b\u3088\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u3092\u793a\u3059\u3002\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\u306e\u4f7f\u7528\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001ACEI\u670d\u7528\u7fa4\u306f\u7537\u6027\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u95a2\u9023\u969c\u5bb3\u3001\u73fe\u5728\u55ab\u7159\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u304a\u3088\u3073\u3088\u308a\u9ad8\u3044BMI\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001ACEI\u670d\u7528\u7fa4\u306f\u6cbb\u7642\u3055\u308c\u305f\u9ad8\u8840\u5727\u306e\u671f\u9593\u304c\u3088\u308a\u77ed\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u3084\u4ed6\u306e\u51e6\u65b9\u85ac\u3092\u4f7f\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3088\u308a\u9ad8\u304b\u3063\u305f\u3002ACEI\u304a\u3088\u3073ARB\u670d\u7528\u8005\u306f\u3001\u80ba\u708e\u3001\u7d50\u6838\u3001\u304a\u3088\u3073\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u306e\u985e\u4f3c\u3057\u305f\u75c5\u6b74\u3092\u6301\u3063\u3066\u3044\u305f\u3002<\/p>\n

\"20190220\u4e0a\u91ce\uff12\"<\/a><\/p>\n

ARB\u3068\u6bd4\u8f03\u3057\u3066\u3001ACEI\u306f14\uff05\u306e\u80ba\u764c\u30ea\u30b9\u30af\u5897\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff081000\u4eba\u5e74\u3042\u305f\u308a1.6v1.2 \u30cf\u30b6\u30fc\u30c9\u6bd41.14\u300195\uff05\u4fe1\u983c\u533a\u95931.01\u301c1.29\uff09\u30025\u5e74\u672a\u6e80\u306eACEI\u306e\u4f7f\u7528\u306f\u80ba\u304c\u3093\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.10\u30010.96\u304b\u30891.25\uff09\u3002\u3057\u304b\u30575\u301c10\u5e74\u306e\u4f7f\u7528\uff081.22\u30011.06\u301c1.40\uff09\u3067\u4e0a\u6607\u3057\u300110\u5e74\u4ee5\u4e0a\u306e\u4f7f\u7528\uff081.31\u30011.08\u301c1.59\uff09\u3067\u3082\u5897\u52a0\u3057\u7d9a\u3051\u305f\u3002ACEI\u958b\u59cb\u4ee5\u964d\u306e\u671f\u9593\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u95a2\u9023\u6027\u304c\u89b3\u5bdf\u3055\u308c\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u958b\u59cb\u5f8c\u3088\u308a\u9577\u3044\u6642\u9593\u3067\u5897\u52a0\u3057\u3001\u958b\u59cb\u5f8c10\u5e74\u4ee5\u4e0a\u3067\u30d4\u30fc\u30af\u306b\u9054\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.29\u30011.10\u304b\u30891.51\uff09\u3002<\/p>\n

\"20190220\u4e0a\u91ce\uff13\"<\/a><\/p>\n

Discussion\uff1a
\n\u7d04100\u4e07\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u5927\u898f\u6a21\u306a\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u7814\u7a76\u3067\u306f\u3001ACEI\u306e\u4f7f\u7528\u306f\u5168\u4f53\u306714\uff05\u306e\u80ba\u304c\u3093\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u95a2\u9023\u6027\u306f5\u5e74\u9593\u306e\u4f7f\u7528\u5f8c\u306b\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u7279\u306b10\u5e74\u9593\u4ee5\u4e0aACEI\u3092\u4f7f\u7528\u3057\u305f\u60a3\u8005\u306e\u9593\u3067\u306f\u3001\u9577\u671f\u9593\u306e\u4f7f\u7528\u3067\u5897\u52a0\u3057\u305f\uff0831\uff05\u306e\u30ea\u30b9\u30af\u5897\u52a0\uff09\u3002\u82f1\u56fd\u3067\u306f\u3001\u6bce\u5e747,010\u4e07\u4ef6\u306e\u964d\u5727\u85ac\u304c\u6295\u4e0e\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u3061\u7d0432\uff05\u304cACEI\u3067\u3042\u308b\u3002
\n\u4ee5\u524d\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001ACEI\u670d\u7528\u3068\u764c\u5168\u4f53\u307e\u305f\u306f\u80ba\u764c\u3068\u306e\u9593\u306b\u95a2\u9023\u306f\u898b\u3064\u304b\u3089\u306a\u304b\u3063\u305f\u304c\u3001\u6bd4\u8f03\u7684\u77ed\u671f\u9593\u306e\u8ffd\u8de1\u671f\u9593\uff08\u4e2d\u592e\u5024\u671f\u95933.5\u5e74\uff081.3\u301c5.1\u5e74\uff09\uff09\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u764c\u306a\u3069\u306e\u9577\u671f\u306e\u6709\u5bb3\u4e8b\u8c61\u3092\u8a55\u4fa1\u3059\u308b\u306e\u306b\u5341\u5206\u306a\u8ffd\u8de1\u671f\u9593\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u672c\u7814\u7a76\u30675\u5e74\u9593\u306e\u4f7f\u7528\u5f8c\u306bACEI\u3068\u80ba\u764c\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u306f\u7279\u306b\u91cd\u8981\u3067\u3042\u308b\u3002
\n\u3053\u306e\u7814\u7a76\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u5236\u9650\u304c\u3042\u308b\u3002\u307e\u305a\u3001\u91cd\u8981\u306a\u4ea4\u7d61\u56e0\u5b50\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u305f\u304c\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u5730\u4f4d\u3001\u98df\u4e8b\u3001\u30e9\u30c9\u30f3\u307e\u305f\u306f\u30a2\u30b9\u30d9\u30b9\u30c8\u3078\u306e\u66dd\u9732\u3001\u80ba\u304c\u3093\u306e\u5bb6\u65cf\u6b74\u306a\u3069\u3001\u4ed6\u306e\u6f5c\u5728\u7684\u306a\u4ea4\u7d61\u56e0\u5b50\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u6b20\u3051\u3066\u3044\u305f\u3002\u3055\u3089\u306b\u3001\u55ab\u7159\u72b6\u614b\u3092\u8abf\u6574\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u55ab\u7159\u306e\u671f\u9593\u3068\u5f37\u5ea6\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306a\u60c5\u5831\u304c\u4e0d\u8db3\u3057\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u975e\u55ab\u7159\u8005\u5185\u3067\u884c\u308f\u308c\u305f\u5206\u6790\u306f\u3001\u660e\u3089\u304b\u306a\u6301\u7d9a\u6642\u9593- \u53cd\u5fdc\u306e\u95a2\u9023\u6027\u3068\u3068\u3082\u306b\u3001\u4e00\u6b21\u5206\u6790\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3059\u308b\u7d50\u679c\u3092\u751f\u307f\u51fa\u3057\u3001\u55ab\u7159\u5f37\u5ea6\u306b\u3088\u308b\u4ea4\u7d61\u304c\u4eca\u56de\u306e\u8abf\u67fb\u7d50\u679c\u306b\u91cd\u5927\u306a\u5f71\u97ff\u306f\u53ca\u307c\u3055\u306a\u3044\u3060\u308d\u3046\u3002\u7b2c\u4e8c\u306b\u3001CPRD\u306e\u51e6\u65b9\u306f\u4e00\u822c\u958b\u696d\u533b\u306b\u3088\u3063\u3066\u66f8\u304b\u308c\u305f\u51e6\u65b9\u3092\u8868\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u60a3\u8005\u304c\u6cbb\u7642\u8a08\u753b\u306b\u5f93\u308f\u306a\u304b\u3063\u305f\u308a\u3001\u5c02\u9580\u5bb6\u304b\u3089\u51e6\u65b9\u3092\u53d7\u3051\u305f\u308a\u3057\u305f\u5834\u5408\u3001\u3070\u304f\u9732\u306e\u8aa4\u5206\u985e\u304c\u8d77\u3053\u308a\u5f97\u308b\u3002\u3057\u304b\u3057\u3001\u30b3\u30db\u30fc\u30c8\u306b\u5165\u308b\u3059\u3079\u3066\u306e\u60a3\u8005\u304c\u964d\u5727\u85ac\u3067\u65b0\u305f\u306b\u6cbb\u7642\u3055\u308c\u305f\u60a3\u8005\u3067\u3042\u3063\u305f\u306e\u3067\u3001\u975e\u9075\u5b88\u306b\u3088\u308b\u8aa4\u5206\u985e\u306f\u6700\u5c0f\u9650\u3067\u3042\u308a\u3001ACEI\u3068ARB\u306e\u9593\u3067\u306f\u304a\u305d\u3089\u304f\u5dee\u304c\u306a\u3044\u306f\u305a\u3067\u3042\u308b\u3002
\n\u6700\u5f8c\u306b\u3001\u6301\u7d9a\u6027\u54b3\u55fd\u306fACEI\u306e\u4e00\u822c\u7684\u3067\u3088\u304f\u77e5\u3089\u308c\u305f\u526f\u4f5c\u7528\u3067\u3042\u308a\u3001\u89b3\u5bdf\u3055\u308c\u305f\u95a2\u9023\u6027\u304c\u691c\u51fa\u30d0\u30a4\u30a2\u30b9\u306b\u8d77\u56e0\u3059\u308b\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u3002ACEI\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u80f8\u90e8\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u65ad\u5c64\u64ae\u5f71\u306a\u3069\u306e\u8a3a\u65ad\u7684\u8a55\u4fa1\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u524d\u81e8\u5e8a\u80ba\u764c\u306e\u691c\u51fa\u7387\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002CPRD\u306b\u80f8\u90e8\u691c\u67fb\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u5341\u5206\u306b\u8a18\u9332\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u5206\u6790\u3067\u3053\u306e\u53ef\u80fd\u6027\u3092\u8aac\u660e\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001ACEI\u3068\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u958b\u59cb\u5f8c\u306e\u80f8\u90e8\u691c\u67fb\u3067\u306e\u9055\u3044\u306f\u3054\u304f\u308f\u305a\u304b\u306a\u3082\u306e\u3068\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3055\u3089\u306b\u3001\u80ba\u764c\u306e\u904e\u5270\u691c\u51fa\u306f\u6cbb\u7642\u958b\u59cb\u5f8c\u6bd4\u8f03\u7684\u65e9\u304f\u89b3\u5bdf\u3055\u308c\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u3001\u305d\u308c\u304c\u6211\u3005\u306e\u8ffd\u8de1\u8abf\u67fb\u30921\u5e74\u9045\u308c\u3089\u305b\u305f\u7406\u7531\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001ACEI\u306e\u4f7f\u7528\u3068\u80ba\u764c\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u3001\u4f7f\u7528\u671f\u9593\u306e\u5897\u52a0\uff08\u5c11\u306a\u304f\u3068\u30825\u5e74\u9593\u306e\u4f7f\u7528\u5f8c\uff09\u306b\u3088\u3063\u3066\u306e\u307f\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u307e\u3068\u3081\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u80ba\u764c\u306e\u904e\u5270\u691c\u51fa\u306e\u4eee\u8aac\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002
\nConclusion\uff1a
\n\u3053\u306e\u5927\u898f\u6a21\u306a\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u7814\u7a76\u3067\u306f\u3001ACEI\u306e\u4f7f\u7528\u306f\u3001\u671f\u9593\u3068\u53cd\u5fdc\u306e\u95a2\u4fc2\u306e\u8a3c\u62e0\u3068\u3068\u3082\u306b\u3001\u5168\u4f53\u3068\u3057\u3066\u80ba\u304c\u3093\u306e\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u89b3\u6e2c\u3055\u308c\u305f\u63a8\u5b9a\u5024\u306f\u63a7\u3048\u3081\u3060\u304c\u3001\u80ba\u764c\u30ea\u30b9\u30af\u304c\u3042\u308b\u591a\u6570\u306e\u60a3\u8005\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u4eca\u56de\u306e\u77e5\u898b\u306f\u4ed6\u306e\u72b6\u6cc1\u3067\u3082\u518d\u73fe\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112019\u5e742\u670820\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

-\u6587\u732e\u540d- Bl\u00e1naid M Hicks, et. al. Angiotensin converting enzyme inhibitors and risk of lung cancer: population ba … \u7d9a\u304d\u3092\u8aad\u3080 ACE\u963b\u5bb3\u85ac\u3068\u80ba\u764c\u30ea\u30b9\u30af<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1643","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1643"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1643\/revisions"}],"predecessor-version":[{"id":1648,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1643\/revisions\/1648"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}