{"id":1662,"date":"2019-03-20T11:46:34","date_gmt":"2019-03-20T02:46:34","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1662"},"modified":"2019-03-20T11:46:34","modified_gmt":"2019-03-20T02:46:34","slug":"2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e5%8f%8a%e3%81%b3%e8%85%8e%e6%a9%9f%e8%83%bd%e3%81%ae1%e6%ac%a1%e4%ba%88%e9%98%b22%e6%ac%a1","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1662","title":{"rendered":"2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u53ca\u3073\u814e\u6a5f\u80fd\u306e1\u6b21\u4e88\u9632\/2\u6b21\u4e88\u9632\u306b\u5bfe\u3057\u7528\u3044\u3089\u308c\u308bSGLT2\u963b\u5bb3\u85ac"},"content":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015<br \/>\nThomas A Zelniker, Stephen D Wiviott, et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet 2018 Nov 9.<\/p>\n<p>\u2015\u8981\u7d04\u2015<br \/>\n\u25ce\u80cc\u666f<br \/>\nSGLT2\u963b\u5bb3\u85ac\u306b\u95a2\u3057\u3066\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u306b\u5bfe\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u30022\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fSGLT2\u963b\u5bb3\u85ac\u306e\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u306b\u95a2\u3057\u3066\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u4e26\u3073\u306b\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u65bd\u3057\u305f\u3002\u201918\u5e749\u670824\u65e5\u307e\u3067\u306b\u516c\u958b\u3055\u308c\u305f\u8a66\u9a13\u306b\u95a2\u3057\u3001PubMed\u53ca\u3073Embase\u3092\u691c\u7d22\u3057\u3066\u3044\u308b\u3002\u6709\u52b9\u6027\u306e\u7d50\u679c\u306f\u3001\u4e3b\u8981\u306a\u6709\u5bb3\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8(\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u5fc3\u8840\u7ba1\u6b7b)\u3001\u5fc3\u8840\u7ba1\u6b7b\u3082\u3057\u304f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u814e\u81d3\u75c5\u306e\u9032\u884c\u3092\u542b\u3093\u3067\u3044\u308b\u3002<\/p>\n<p>\u25ce\u7d50\u679c<br \/>\n\u25bc 3\u3064\u306e\u8a66\u9a13(\u2460 EMPA-REG OUTCOME\u3001\u2461 CANVAS program\u3001\u2462 DECLARE-TIMI 58)\u3092\u5bfe\u8c61\u3068\u3057\u305f<br \/>\n\u2460 Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015; 373: 2117\u201328.<br \/>\n\u300042\u30ab\u56fd\u3001590\u65bd\u8a2d\u3067\u300118\u6b73\u4ee5\u4e0a\u3001BMI\u226645kg\/\u33a1\u3001eGFR\u226730\u3092\u6e80\u305f\u3059\u60a3\u8005<br \/>\n\u2461 Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 2017; 377: 644\u201357<br \/>\n\u300030\u30ab\u56fd\u3067\u3001HbA1c 7.0\uff5e10.5%\u300130\u6b73\u4ee5\u4e0a\u3067\u75c7\u72b6\u3092\u6709\u3059\u308b\u52d5\u8108\u786c\u5316\u6027\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6301\u3064\u304b\u300150\u6b73\u4ee5\u4e0a\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u30922\u9805\u76ee\u4ee5\u4e0a\u6e80\u305f\u3059\u60a3\u8005<br \/>\n\u2462 Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2018; published online Nov 10. DOI: 10. 1056\/ NEJMoa1812389.<br \/>\n\u3000(\u5bfe\u8c61\u60a3\u8005\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u691c\u7d22\u3067\u304d\u305a)<\/p>\n<p>\u30fb\u5408\u308f\u305b\u306634322\u540d\u306e\u60a3\u8005(\u3046\u306160.2%\u304c\u52d5\u8108\u786c\u5316\u6027\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6709\u3057\u3066\u3044\u308b)\u306e\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3057\u305f\u3002\u5e73\u5747\u5e74\u9f62\u306f63.5\u6b73\u300135.1%\u306f\u5973\u6027\u3067\u3042\u3063\u305f\u30023342\u540d\u306b\u6709\u5bb3\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u30012028\u540d\u306b\u5fc3\u8840\u7ba1\u6b7b\u3082\u3057\u304f\u306f\u5fc3\u4e0d\u5168\u306b\u56e0\u308b\u5165\u9662\u3092\u3001766\u540d\u306b\u814e\u81d3\u75c5\u306e\u9032\u884c\u3092\u8a8d\u3081\u305f\u3002<br 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srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75302-1024x437.png 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75302-300x128.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75302.png 1606w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n(\u56f31) \u5fc3\u7b4b\u6897\u585e\u3001\u8133\u6897\u585e\u3001\u5fc3\u8840\u7ba1\u6b7b\u306b\u95a2\u3059\u308b\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002<\/p>\n<p> <a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75303.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75303-1024x452.png\" alt=\"20190320\u5bcc\u75303\" width=\"640\" height=\"283\" class=\"alignleft size-large wp-image-1665\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75303-1024x452.png 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75303-300x133.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75303.png 1612w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n(\u56f32) \u5fc3\u4e0d\u5168\u306b\u56e0\u308b\u5165\u9662\u53ca\u3073\u5fc3\u8840\u7ba1\u6b7b\u306b\u95a2\u3057\u3066\u3001\u52d5\u8108\u786c\u5316\u6027\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6301\u3064\u304b\u3001<br \/>\n\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u306e\u307f\u306b\u3068\u3069\u307e\u308b\u304b\u306e\u89b3\u70b9\u304b\u3089\u691c\u8a0e\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75304.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75304-1024x442.png\" alt=\"20190320\u5bcc\u75304\" width=\"640\" height=\"276\" class=\"alignleft size-large wp-image-1666\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75304-1024x442.png 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75304-300x130.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75304.png 1611w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n(\u56f33) \u5fc3\u4e0d\u5168\u306b\u56e0\u308b\u5165\u9662\u53ca\u3073\u5fc3\u8840\u7ba1\u6b7b\u306b\u95a2\u3057\u3066\u3001\u5fc3\u4e0d\u5168\u65e2\u5f80\u306e\u6709\u7121\u3067\u691c\u8a0e\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75305.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75305-1024x451.png\" alt=\"20190320\u5bcc\u75305\" width=\"640\" height=\"282\" class=\"alignleft size-large wp-image-1667\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75305-1024x451.png 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75305-300x132.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75305.png 1600w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n(\u56f34) \u814e\u6a5f\u80fd\u306e\u60aa\u5316\u3001\u672b\u671f\u814e\u4e0d\u5168\u3001\u814e\u6b7b\u306b\u95a2\u3057\u3066\u3001\u52d5\u8108\u786c\u5316\u6027\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6709\u7121\u306e\u89b3\u70b9\u304b\u3089<br \/>\n\u691c\u8a0e\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9<\/p>\n<p> <a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75306.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75306-760x1024.png\" alt=\"20190320\u5bcc\u75306\" width=\"640\" height=\"862\" class=\"alignleft size-large wp-image-1668\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75306-760x1024.png 760w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75306-223x300.png 223w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2019\/03\/20190320\u5bcc\u75306.png 880w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><br \/>\n(\u56f35) (A)\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3001\u672b\u671f\u814e\u4e0d\u5168\u3001\u814e\u6b7b\u306b\u3064\u3044\u3066\u3001(B)\u5fc3\u4e0d\u5168\u306b\u56e0\u308b\u5165\u9662\u306b\u3064\u3044\u3066\u3001<br \/>\n(C)\u5927\u304d\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u3064\u3044\u3066\u3001\u305d\u308c\u305e\u308c\u814e\u6a5f\u80fd\u306e\u89b3\u70b9\u304b\u3089\u691c\u8a0e\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112019\u5e743\u670820\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015 Thomas A Zelniker, Stephen D Wiviott, et al. SGLT2 inhibitors for primary and secondary prevention of ca &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1662\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u53ca\u3073\u814e\u6a5f\u80fd\u306e1\u6b21\u4e88\u9632\/2\u6b21\u4e88\u9632\u306b\u5bfe\u3057\u7528\u3044\u3089\u308c\u308bSGLT2\u963b\u5bb3\u85ac<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1662","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1662"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1662\/revisions"}],"predecessor-version":[{"id":1669,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1662\/revisions\/1669"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}