{"id":1690,"date":"2019-06-13T16:29:16","date_gmt":"2019-06-13T07:29:16","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1690"},"modified":"2019-06-13T16:29:16","modified_gmt":"2019-06-13T07:29:16","slug":"%e7%89%87%e9%a0%ad%e7%97%9b%e3%82%82%e3%81%a1%e3%81%ae%e5%a5%b3%e6%80%a7%e3%81%ae%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%a8%e4%bd%8e%e5%ae%b9%e9%87%8f%e3%83%94%e3%83%ab%e3%81%ae%e9%96%a2%e4%bf%82","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1690","title":{"rendered":"\u7247\u982d\u75db\u3082\u3061\u306e\u5973\u6027\u306e\u8133\u5352\u4e2d\u3068\u4f4e\u5bb9\u91cf\u30d4\u30eb\u306e\u95a2\u4fc2"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nHuma. U. Sheikh. Risk of Stroke Associated With Use of Estrogen Containing Contraceptives in Women With Migraine: A Systematic Review. Headache. 2018 Jan; 58(1): 5-21.
\n\uff0d\u8981\u7d04\uff0d
\nIntroduction\uff1a\u8457\u8005\u305f\u3061\u304c\u306a\u305c\u3053\u306e\u7814\u7a76\u3092\u884c\u3063\u305f\u306e\u304b\u3001\u3053\u308c\u307e\u3067\u306b\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u306a\u3069\u524d\u63d0\u3068\u306a\u3063\u305f\u4e8b\u67c4\u3092\u8a18\u8f09\u3059\u308b\u3002
\n\u7247\u982d\u75db\u306f\u3001\u598a\u5a20\u53ef\u80fd\u306a\u5e74\u9f62\u306e\u5973\u6027\u304c\u7f79\u60a3\u3059\u308bcommon disease\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u7247\u982d\u75db\u306f\u8133\u5352\u4e2d\u3092\u542b\u3080\u69d8\u3005\u306a\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u8a00\u308f\u308c\u3066\u304a\u308a\u3001\u7279\u306b\u524d\u5146\u3092\u4f34\u3046\u7247\u982d\u75db\u3067\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002\u5148\u884c\u7814\u7a76\u3067\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u306e\u7d4c\u53e3\u907f\u598a\u85ac\u3068\u8133\u5352\u4e2d\u306b\u306f\u95a2\u9023\u304c\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u306f\u6539\u826f\u3092\u91cd\u306d\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u3082\u3069\u3093\u3069\u3093\u6e1b\u3063\u3066\u304d\u3066\u3044\u308b\u3002\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u306e\u5c11\u306a\u3044\u73fe\u5728\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u7d4c\u53e3\u907f\u598a\u85ac\u3068\u3001\u8133\u5352\u4e2d\u767a\u751f\u30ea\u30b9\u30af\u306e\u9593\u306b\u306f\u95a2\u9023\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\uff08\u2192\u7d4c\u53e3\u907f\u598a\u85ac\u4e00\u89a7\u3078\uff09<\/p>\n

Method\uff1a\u3069\u306e\u3088\u3046\u306a\u65b9\u6cd5\u3092\u7528\u3044\u305f\u306e\u304b\u3001\u7279\u6b8a\u306a\u65b9\u6cd5\u3067\u3042\u308c\u3070\u9069\u5b9c\u89e3\u8aac\u3092\u5165\u308c\u308b\u3002
\n\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc
\nPubMed\u3001Cochrane Library\u3001\u304a\u3088\u3073EMBASE\u30922016\u5e741\u6708\u307e\u3067\u691c\u7d22\u3057\u300118\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u82f1\u8a9e\u306eRCT\u3082\u3057\u304f\u306f\u89b3\u5bdf\u7814\u7a76\u3092\u53ce\u96c6\u3057\u305f\u3002\u4ecb\u5165\u306f\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u5185\u670d(\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u5358\u5264\u3082\u3057\u304f\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u30fb\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u306e\u5408\u5264)\u3092\u3001\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u865a\u8840\u6027\u30fb\u51fa\u8840\u6027\u8133\u5352\u4e2d\u3068\u3057\u305f\u3002
\n\u7814\u7a76\u306e\u8cea\u306fGRADE\u3068Newcastle Ottawa\u30b9\u30b1\u30fc\u30eb\u3067\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

Results\uff1a\u8868\u3084\u30b0\u30e9\u30d5\u304c\u3042\u308c\u3070\u9069\u5b9c\u7d39\u4ecb\u3059\u308b\u3002
\n\u30007\u672c\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u306b\u3066\u7247\u982d\u75db\u3092\u6709\u3059\u308b\u5973\u6027\u3067\u7d4c\u53e3\u907f\u598a\u85ac\u3092\u5185\u670d\u3057\u305f\u4eba\u3046\u3061\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3092\u8d77\u3053\u3057\u305f\u4eba\u306eOR\u306f2.08-16.0\u3068\u5831\u544a\u3055\u308c\u305f\u304c\u3001\u3044\u305a\u308c\u3082\u5c0f\u898f\u6a21\u3067\u4fe1\u983c\u533a\u9593\u304c\u5e83\u3044\u3002
\n\u3000\u7247\u982d\u75db\u3092\u6709\u3059\u308b\u5973\u6027\u306b\u304a\u3051\u308b\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u3068\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u5831\u544a\u306f\u306a\u3044\u3002\uff08\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u306e\u8a18\u8f09\u306f\u3042\u308b\u304c\u3001\u95a2\u4fc2\u6027\u306f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u306a\u3044\uff09\u7247\u982d\u75db\u3068\u95a2\u9023\u306a\u304f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u3068\u8133\u5352\u4e2d\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306f\u3001\u30b0\u30eb\u30fc\u30d7\u9593\u6bd4\u8f03(\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf50\u03bcg\u300130-40\u300120)\u306b\u304a\u3044\u3066\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u306b\u5bb9\u91cf\u4f9d\u5b58\u7684\u306a\u5909\u5316\u304c\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u305f\u7814\u7a76\u3082\u3042\u3063\u305f\u3002
\n\u3000\u305d\u306e\u4ed6\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u3001\u7247\u982d\u75db\u3068\u55ab\u7159\u3068\u4f4e\u7528\u91cf\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u76f8\u4e57\u52b9\u679c\u7684\u306b\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002OR34.4(CI 3.27-361)
\n \u524d\u5146\u306e\u6709\u7121\u3067\u306e\u6bd4\u8f03\u306b\u3064\u3044\u3066\u306f\u30011884\u4f8b\u3092\u96c6\u3081\u305f\u7814\u7a76\u304c\u3042\u308a\u3001\u524d\u5146\u3092\u4f34\u3046\u3082\u306e\u3067OR6.1(CI3.1-12.1)\u3001\u4f34\u308f\u306a\u3044\u3082\u306e\u3067OR1.7(1.09-2.88)\u3068\u3044\u3046\u7d50\u679c\u3067\u3042\u3063\u305f\u3002 <\/p>\n

Discussion\uff1a\u4eca\u56de\u306e\u7814\u7a76\u306e\u9650\u754c\u3001\u6b8b\u3055\u308c\u305f\u8ab2\u984c\u306a\u3069\u3092\u8a18\u8f09\u3059\u308b\u3002
\n \u307b\u3068\u3093\u3069\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u7247\u982d\u75db\u306e\u8a3a\u65ad\u57fa\u6e96\u304c\u66d6\u6627\u3067\u3042\u308b\u3053\u3068\u3001\u524d\u5146\u306e\u3042\u308b\u306a\u3057\u3067\u5c64\u5225\u5316\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u7a2e\u985e\u3084\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u542b\u6709\u91cf\u306e\u8a18\u8f09\u304c\u306a\u3044(\u30ab\u30c3\u30c8\u30aa\u30d5\u309250\u03bcg\u4ee5\u4e0b\u3068\u8a18\u8f09\u3057\u3066\u3044\u308b\u3082\u306e\u306f\u591a\u3044\u304c\u3001\u73fe\u5728\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u4f4e\u7528\u91cf\u7d4c\u53e3\u907f\u598a\u85ac\u306f30-40\u03bcg\u304c\u307b\u3068\u3093\u3069\u300110-20\u03bcg\u3068\u3044\u3046\u3082\u306e\u3082\u3042\u308a\u3001\u73fe\u72b6\u306b\u306f\u3042\u307e\u308a\u5373\u3057\u3066\u3044\u306a\u3044\u7d50\u679c\u3067\u3042\u3063\u305f)\u3053\u3068\u304climitation\u3068\u3057\u3066\u3042\u3052\u3089\u308c\u305f\u3002
\n \u7d50\u8ad6\u3068\u3057\u3066\u306f\u3001\u4f4e\u7528\u91cf\u7d4c\u53e3\u907f\u598a\u85ac\u3068\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u306f\u8cea\u306e\u9ad8\u3044\u7814\u7a76\u306b\u4e4f\u3057\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u524d\u5146\u306e\u3042\u308b\u7247\u982d\u75db\u3082\u3061\u306e\u5973\u6027\u306e\u7d4c\u53e3\u907f\u598a\u85ac\u5185\u670d\u3068\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306f\u95a2\u9023\u304c\u3042\u308a\u305d\u3046\u3060\u304c\u3001\u4f4e\u7528\u91cf\u7d4c\u53e3\u907f\u598a\u85ac\u3067\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3002\u55ab\u7159\u3068\u306e\u4f75\u7528\u306f\u30ea\u30b9\u30af\u304c\u500d\u5897\u3059\u308b\u306e\u3067\u6ce8\u610f\u3002\u5c11\u306a\u304f\u3068\u308250\u03bcg\u4ee5\u4e0a\u306e\u9ad8\u5bb9\u91cf\u306e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88fd\u5264\u3068\u306f\u95a2\u9023\u304c\u3042\u308a\u305d\u3046\u306a\u306e\u3067\u3001\u3088\u308a\u5c11\u306a\u3044\u542b\u6709\u91cf\u306e\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u4f7f\u7528\u304c\u59a5\u5f53\u3060\u308d\u3046\u30fb\u30fb\u30fb\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112019\u5e746\u67085\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Huma. U. Sheikh. Risk of Stroke Associated With Use of Estrogen Containing Contraceptives in Women With … \u7d9a\u304d\u3092\u8aad\u3080 \u7247\u982d\u75db\u3082\u3061\u306e\u5973\u6027\u306e\u8133\u5352\u4e2d\u3068\u4f4e\u5bb9\u91cf\u30d4\u30eb\u306e\u95a2\u4fc2<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-1690","post","type-post","status-publish","format-standard","hentry","category-13"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1690"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1690\/revisions"}],"predecessor-version":[{"id":1691,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1690\/revisions\/1691"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1690"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}