\uff0d\u6587\u732e\u540d\uff0d
\nThe effect of anti-dementia drugs on\u00a0Alzheimer disease-induced\u3000cognitive impairment: A network meta-analysis.
\nCui CC 1 ,\u00a0Sun Y,\u00a0Wang XY,\u00a0Zhang Y,\u00a0Xing Y.
\nMedicine (Baltimore).\u00a02019 Jul;98(27):e16091. doi: 10.1097\/MD.0000000000016091.<\/p>\n
\uff0d\u8981\u7d04\uff0d
\nIntroduction\uff1a
\n\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e3b\u75c7\u72b6\u3067\u3042\u308b\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u306e\u305f\u3081\u306e\u81e8\u5e8a\u63a8\u5968\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u65bd\u3057\u3066\u3001
\n\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u69d8\u3005\u306a\u6297\u8a8d\u77e5\u75c7\u85ac\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f<\/p>\n
Method\uff1a
\n\u95a2\u9023\u3059\u308b\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306fPubmed database, Web of Science, Clinical Trials, Embase,
\nCohranne library, Chinese National Knowledge Infrastructure database, CBM databases,
\nWanfang\u3092\u4ecb\u3057\u3066\u898b\u3064\u3051\u3089\u308c\u305f\u3002\u5408\u8a0833\u306e\u8ad6\u6587\u304c\u96c6\u3081\u3089\u308c\u3001\u6700\u3082\u65e9\u304f\u96c6\u3081\u3089\u308c\u305f\u8ad6\u6587\u306f2017\u5e742\u6708\u306b\u767a\u520a\u3055\u308c\u305f\u3002
\n\u96c6\u3081\u3089\u308c\u305f\u8ad6\u6587\u306f\u53b3\u683c\u306ainclusion criteria\u3068exclusion criteria\u306b\u3088\u3063\u3066\u8ad6\u6587\u306e\u8cea\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u3002
\n\u5168\u3066\u306e\u5206\u6790\u306f\u4ee5\u524d\u306b\u767a\u884c\u3055\u308c\u305f\u7279\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002\u305d\u308c\u3086\u3048\u502b\u7406\u7684\u627f\u8a8d\u307e\u305f\u306f\u60a3\u8005\u306e\u540c\u610f\u306f\u5fc5\u8981\u306a\u304b\u3063\u305f\u3002
\nMMSE\u306e\u30b9\u30b3\u30a2\u306733\u306e\u8ad6\u6587\u309211\u306e\u8ad6\u6587\u3068\u30d7\u30e9\u30bb\u30dc\u4ee5\u5916\u306e12\u306e\u85ac\u3092\u7279\u8272\u3068\u3057\u305f\u8efd\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3001
\n17\u306e\u8ad6\u6587\u3068\u30d7\u30e9\u30bb\u30dc\u4ee5\u5916\u306b15\u306e\u5185\u670d\u3092\u7279\u8272\u3068\u3057\u305f\u4e2d\u7b49\u5ea6\u306e\u4efb\u5730\u6a5f\u80fd\u969c\u5bb3\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u30015\u3064\u306e\u8ad6\u6587\u3068\u30d7\u30e9\u30bb\u30dc\u4ee5\u5916\u306b\uff13\u3064\u306e\u5185\u670d\u3092\u7279\u5fb4\u3068\u3059\u308b\u91cd\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3057\u305f\u3002
\nResults\uff1a
\n\u30c9\u30cd\u30da\u30b8\u30eb(\u30a2\u30ea\u30bb\u30d7\u30c8)\u3001\u30ac\u30e9\u30f3\u30bf\u30df\u30f3\uff08\u30ec\u30df\u30cb\u30fc\u30eb\uff09\u3001\u30d5\u30da\u30eb\u30b8\u30f3\uff08\u30b3\u30b0\u30cb\u30a2\u30c3\u30d7\u65e5\u672c\u3067\u306f\u672a\u627f\u8a8d\uff09\u306f\u8efd\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u6700\u3082\u9ad8\u3044\u6709\u52b9\u6027\u3092\u793a\u3057\u305f\uff08\u305d\u308c\u305e\u308c\u5e73\u5747\u5dee5.2,2.5\u304a\u3088\u30732.4\uff09\u3002
\n\u30c9\u30cd\u30da\u30b8\u30eb\u3001\u30d5\u30da\u30eb\u30b8\u30f3\u3001\u30ea\u30d0\u30b9\u30c1\u30b0\u30df\u30f3\uff08\u30a4\u30af\u30bb\u30ed\u30f3\u30d1\u30c3\u30c1\/\u30ea\u30d0\u30b9\u30bf\u30c3\u30c1\uff09\u306f\u4e2d\u7b49\u5ea6\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u30b0\u30eb\u30fc\u30d7\u306b\u304a\u3044\u3066\u6700\u3082\u6709\u610f\u306a\u7d50\u679c\u3092\u793a\u3057\u305f\uff08\u305d\u308c\u305e\u308c\u5e73\u5747\u5dee3.8.2.9\u304a\u3088\u30733.0\uff09
\n\u91cd\u5ea6\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u30c9\u30cd\u30da\u30b8\u30eb\u306f\u660e\u3089\u304b\u306b\u30e1\u30de\u30f3\u30c1\u30f3\u3088\u308a\u512a\u308c\u3066\u3044\u305f\u3002\u305d\u308c\u6545\u30c9\u30cd\u30da\u30b8\u30eb\u306f\u8a8d\u77e5\u6a5f\u80fd\u306e\u7a0b\u5ea6\u306b\u95a2\u308f\u3089\u305a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306b\u5bfe\u3057\u3066\u52b9\u679c\u7684\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002
\nConclusion\uff1a
\n\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u7528\u3044\u305f\u81e8\u5e8a\u7684\u306b\u4e00\u822c\u7684\u306a\u6297\u8a8d\u77e5\u75c7\u85ac\u306e\u8a55\u4fa1\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306e\u7de9\u548c\u306b\u30b3\u30ea\u30f3\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\u963b\u5bb3\u85ac\u3001\u7279\u306b\u30c9\u30cd\u30da\u30b8\u30eb\u306e\u6709\u52b9\u6027\u3092\u78ba\u8a8d\u3057\u305f\u3002
\n\u3057\u305f\u304c\u3063\u3066\u3053\u306e\u7814\u7a76\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306b\u5bfe\u3057\u3066\u306e\u85ac\u7269\u7684\u4ecb\u5165\u306e\u9078\u629e\u306b\u5bfe\u3057\u3066\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b<\/p>\n
\u3010\u958b\u50ac\u65e5\u30112019\u5e748\u67087\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"