{"id":1737,"date":"2019-10-02T08:27:37","date_gmt":"2019-10-01T23:27:37","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1737"},"modified":"2019-10-02T08:27:37","modified_gmt":"2019-10-01T23:27:37","slug":"cpap%e7%99%82%e6%b3%95%e3%81%ae%e3%82%a2%e3%83%89%e3%83%92%e3%82%a2%e3%83%a9%e3%83%b3%e3%82%b9%e5%90%91%e4%b8%8a%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e3%82%a8%e3%82%b9%e3%82%be%e3%83%94%e3%82%af","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1737","title":{"rendered":"CPAP\u7642\u6cd5\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u5411\u4e0a\u306b\u5bfe\u3059\u308b\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u306e\u77ed\u671f\u4f7f\u7528\u306e\u52b9\u679c"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nChristopher J. et al. Effects of a Short Course of Eszopiclone on Continuous Positive Airway Pressure Adherence. 17
\nNovember 2009 Annals of Internal Medicine Volume 151 \u2022 Number 10<\/p>\n

\uff0d\u8981\u7d04\uff0d
\nIntroduction\uff1a
\n\u672a\u6cbb\u7642\u3078\u306e\u9589\u585e\u578b\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\uff08OSAS\uff09\u3078\u306eCPAP\u7642\u6cd5\u306e\u5c0e\u5165\u306f\u65e5\u4e2d\u306eQOL\u306e\u5411\u4e0a\u3084\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u75c7\u6291\u5236\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u7b2c\u4e00\u6cbb\u7642\u9078\u629e\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002
\nCPAP\u3092\u65b0\u898f\u306b\u5c0e\u5165\u3057\u305f\u60a3\u8005\u306e\u3046\u3061\u3001\u7d0450\uff05\u304c\u6700\u521d\u306e1\u5e74\u4ee5\u5185\u3001\u307b\u3068\u3093\u3069\u304c\u6700\u521d\u306e1\u304b\u6708\u4ee5\u5185\u306b\u4f7f\u7528\u3092\u4e2d\u6b62\u3057\u3066\u3044\u308b\u3002
\n\u9577\u671f\u7684\u306a\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u306e\u4fe1\u983c\u3067\u304d\u308b\u552f\u4e00\u306e\u4e88\u6e2c\u56e0\u5b50\u306f\u3001\u77ed\u671f\u7684\u306a\u6301\u7d9a\u967d\u5727\u547c\u5438\u7642\u6cd5\uff08CPAP\uff09\u3092\u9075\u5b88\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002
\n\u77ed\u671f\u7684\u306a\u6cbb\u7642\u306e\u9075\u5b88\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u6226\u7565\u306f\u3001CPAP\u7642\u6cd5\u306e\u6210\u529f\u306b\u5408\u7406\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002
\n\u7406\u8ad6\u7684\u306b\u306f\u3001\u5fb9\u5e95\u3057\u305f\u60a3\u8005\u6559\u80b2\u3001\u5b9a\u671f\u7684\u306a\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3001\u304a\u3088\u3073\u30c7\u30d0\u30a4\u30b9\u306e\u5feb\u9069\u6027\u306e\u5411\u4e0a\uff08\u305f\u3068\u3048\u3070\u3001\u52a0\u6e29\u52a0\u6e7f\u5668\u3001\u3088\u308a\u9069\u5207\u306a\u30de\u30b9\u30af\u306e\u4f7f\u7528\uff09\u306b\u3088\u308a\u6210\u529f\u7387\u304c\u5897\u52a0\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002
\n\u3057\u304b\u3057\u3053\u306e\u3088\u3046\u306a\u96c6\u4e2d\u7684\u306a\u30b5\u30dd\u30fc\u30c8\u3084\u6280\u8853\u7684\u4ecb\u5165\u306f\u3001\u5b9f\u969b\u306e\u81e8\u5e8a\u3067\u4e00\u8cab\u6027\u3001\u78ba\u5b9f\u6027\u3092\u6301\u3063\u3066\u5b9f\u65bd\u3055\u308c\u3066\u3044\u306a\u3044\u3002
\n\u3069\u306e\u3088\u3046\u306a\u60a3\u8005\u304cCPAP\u7642\u6cd5\u306e\u9577\u671f\u7d99\u7d9a\u306b\u79fb\u884c\u3059\u308b\u304b\u3092\u4e88\u6e2c\u3057\u3001CPAP\u7642\u6cd5\u5c0e\u5165\u66422\u9031\u9593\u306e\u975e\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u93ae\u9759\u50ac\u7720\u6027\uff08\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\uff09\u3092\u4f7f\u7528\u3059\u308b\u307b\u3046\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u9577\u671f\u7684\u306aCPAP\u7642\u6cd5\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u5b9a\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u3092\u884c\u3046\u3002<\/p>\n

Method\uff1a
\n2007\u5e743\u6708\u304b\u30892008\u5e7412\u6708\u307e\u3067\u306b\u65b0\u898f\u306bOSAS\u3068\u8a3a\u65ad\u3055\u308c\u3001\u4ee5\u524d\u306bCPAP\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u306a\u304b\u3063\u305f18\u6b73\u304b\u308964\u6b73\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u3002
\nOSAS\u306f\u3059\u3079\u3066\u306e\u60a3\u8005\u3067\u3001\u591c\u9593\u306e\u7761\u7720\u30dd\u30ea\u30b0\u30e9\u30d5\u691c\u67fb\u306b\u57fa\u3065\u3044\u3066\u8a3a\u65ad\u3055\u308c\u3001\u307e\u305f\u3059\u3079\u3066\u306e\u7761\u7720\u30dd\u30ea\u30b0\u30e9\u30e0\u306f\u3001\u7814\u7a76\u8abf\u67fb\u54e1\u304a\u3088\u3073\u8457\u8005\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002\u8a3a\u65ad\u3092\u78ba\u7acb\u3057\u3001\u7121\u547c\u5438\u4f4e\u547c\u5438\u6307\u6570\u3092\u4f7f\u7528\u3057\u3066\u3001\u7c73\u56fd\u7761\u7720\u533b\u5b66\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u57fa\u6e96\u306b\u5f93\u3063\u3066OSA\u306e\u91cd\u75c7\u5ea6\u3092\u5b9a\u7fa9\u3057\u305f\u3002
\n\u50ac\u7720\u85ac\u3092\u9577\u671f\u9593\u4f7f\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u30011\u6669\u306b2\u676f\u4ee5\u4e0a\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u98f2\u6599\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u60a3\u8005\u3001\u304a\u3088\u3073\u809d\u6a5f\u80fd\u969c\u5bb3\u307e\u305f\u306f\u7814\u7a76\u306e\u5b8c\u4e86\u3092\u59a8\u3052\u308b\u91cd\u5ea6\u306e\u7cbe\u795e\u75be\u60a3\u306e\u3042\u308b\u60a3\u8005\u3001\u598a\u5a66\u3092\u9664\u5916\u3057\u305f\u3002<\/p>\n

\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f33 mg\u3092\u5c31\u7720\u524d\u306b\u670d\u7528\u3059\u308b\u7fa4\uff08n 80\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n 80\uff09\u3092\u7121\u4f5c\u70ba\u306b\u5272\u308a\u5f53\u3066\u305f\u3002
\n\u30e9\u30f3\u30c0\u30e0\u5316\u306f\u3001\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u5316\u3055\u308c\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u65bd\u3055\u308c\u305f\u3002\u85ac\u5c40\u306b\u306f\u6700\u7d42\u30c7\u30fc\u30bf\u304c\u53ce\u96c6\u3055\u308c\u308b\u307e\u3067\u3001\u7121\u4f5c\u70ba\u5316\u3068\u76f2\u691c\u5316\u3092\u7dad\u6301\u3057\u305f\u3002
\nCPAP\u3092\u958b\u59cb\u3059\u308b\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u5305\u62ec\u7684\u306a\u6559\u80b2\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u53c2\u52a0\u3057\u3001\u9069\u5207\u306a\u30de\u30b9\u30af\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u3092\u884c\u3063\u305f\u3002CPAP\u81ea\u4f53\u306f\u5168\u54e1\u304c\u540c\u3058\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3057\u305f\u3002
\n\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u53cd\u5fdc\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u30011\u304b\u6708\u5f8c\u306b\u8a55\u4fa1\u304c\u884c\u308f\u308c\u305f\u3002\u307e\u305f\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001\u8ffd\u52a0\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u63d0\u4f9b\u3055\u308c\u3001\u5727\u529b\u306e\u5909\u5316\u3001\u6f0f\u308c\u306e\u8a55\u4fa1\u3001\u30de\u30b9\u30af\u306e\u5909\u66f4\u3001
\n\u307e\u305f\u306f\u9069\u5207\u306a\u7761\u7720\u885b\u751f\u306a\u3069\u306e\u8abf\u6574\u3068\u6559\u80b2\u3092\u542b\u3080\u975e\u85ac\u7406\u5b66\u7684\u4ecb\u5165\u306f\u3001\u3088\u308a\u826f\u3044\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u5411\u4e0a\u306e\u305f\u3081\u306b\u500b\u5225\u5316\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u7814\u7a76\u306b\u767b\u9332\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u60a3\u8005\u306f\u30013\u30f6\u6708\u304a\u3088\u30736\u30f6\u6708\u306e\u6cbb\u7642\u5f8c\u306b\u3082\u8a55\u4fa1\u3092\u53d7\u3051\u305f\u3002
\nPrimary outcome\u3068\u3057\u3066\u6e2c\u5b9a\u3057\u305f\u3082\u306e\u306f\u300124\u9031\u76ee\u306eCPAP\u7642\u6cd5\u306e\u9075\u5b88\u3067\u3042\u3063\u305f\u3002
\n\u8a73\u7d30\u306b\u306f\u3001\u4f7f\u7528\u3055\u308c\u305f\u591c\u9593\u306e\u5272\u5408\u3001\u5168\u8abf\u67fb\u306e\u591c\u9593\u306e\u5e73\u5747\u591c\u9593\u4f7f\u7528\u6642\u9593\u3001CPAP\u304c\u4f7f\u7528\u3055\u308c\u305f\u591c\u9593\u306e\u5e73\u5747\u6642\u9593\u3092\u8a08\u7b97\u3057\u305f\u3002
\n\u307e\u305f\u3001\u300cCPAP\u306e\u5b9a\u671f\u4f7f\u7528\u300d\u304c\u3067\u304d\u3066\u3044\u308b\u304b\u306e\u5272\u5408\u3092\u6bd4\u8f03\u3057\u305f\u3002\u3053\u308c\u306f\u5168\u4f53\u306e70\uff05\u4ee5\u4e0a\u4f7f\u7528\u5272\u5408\u304c\u3042\u308a\u3001\u304b\u30641\u6669\u30674\u6642\u9593\u4ee5\u4e0a\u306e\u4f7f\u7528\u304c\u3067\u304d\u3066\u3044\u308b\u3082\u306e\u3068\u5b9a\u7fa9\u3057\u305f\u3002
\n\u4e0a\u8a18\u306e\u6e2c\u5b9a\u306b\u306fCPAP\u30e6\u30cb\u30c3\u30c8\u306b\u7d71\u5408\u3055\u308c\u3066\u3044\u308b\u300c\u30b9\u30de\u30fc\u30c8\u30ab\u30fc\u30c9\u300d\u304b\u3089CPAP\u4f7f\u7528\u306e\u5ba2\u89b3\u7684\u306a\u6e2c\u5b9a\u5024\u3092\u53d6\u5f97\u3057\u305f\u3002
\n\u767b\u9332\u6642\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\uff09\u304a\u3088\u3073CPAP\u3092\u958b\u59cb\u3057\u3066\u304b\u30891\u30013\u30016\u304b\u6708\u5f8c\u306b\u6e2c\u5b9a\u3055\u308c\u305f\u5909\u6570\u3092\u3059\u3079\u3066\u53ce\u96c6\u3057\u305f\u3002\u3055\u3089\u306b1\u304b\u6708\u30013\u304b\u6708\u30016\u304b\u6708\u306b\u30b9\u30de\u30fc\u30c8\u30ab\u30fc\u30c9\u3092\u53ce\u96c6\u3057\u3001
\n\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u305f\u30c7\u30fc\u30bf\u30921\u9031\u9593\u5358\u4f4d\u3067\u6bce\u6669\u8a18\u9332\u304a\u3088\u3073\u5206\u6790\u3092\u3057\u305f\u3002
\nSecondary outcome\u306f\u3001CPAP\u4e2d\u65ad\u7387\u3068\u75c7\u72b6\u306e\u6539\u5584\u7387\u3092\u6e2c\u5b9a\u3057\u305f\u3002
\n\u75c7\u72b6\u306e\u6307\u6a19\u306b\u306f\u3001\u30a8\u30d7\u30ef\u30fc\u30b9\u7720\u6c17\u5c3a\u5ea6\uff08ESS\uff09\u30b9\u30b3\u30a2\u3001\u75b2\u52b4\u611f\u3001\u7761\u7720\u30a2\u30f3\u30b1\u30fc\u30c8\u306e\u6a5f\u80fd\u7684\u7d50\u679c\u306e\u5909\u5316\u3092\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u7814\u7a76\u306e\u7d42\u308f\u308a\u3068\u306e\u9593\u3067\u6bd4\u8f03\u3057\u3066\u6c7a\u5b9a\u3057\u305f\u3002<\/p>\n

Results\uff1a
\n\u767b\u9332\u3055\u308c\u305f160\u4eba\u306e\u60a3\u8005\u306e\u3046\u3061\u3001154\u4eba\u304c\u6cbb\u9a13\u85ac\u3092\u53d7\u3051\u53d6\u308a\u3001\u5206\u6790\u3055\u308c\u305f\u3002\u767b\u9332\u3055\u308c\u305f\u60a3\u8005\u306e\u3046\u3061\u30011\u30013\u30016\u30f6\u6708\u3067\u8ffd\u8de1\u8abf\u67fb\u3092\u884c\u3044\u3001\u305d\u306e\u6642\u70b9\u3067150\u3001136\u3001\u304a\u3088\u3073120\u4eba\u304c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u30022\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u60a3\u8005\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u60a3\u8005\u7279\u6027\u306f\u985e\u4f3c\u3057\u3066\u304a\u308a\uff08Table1\uff09\u3001\u6cbb\u9a13\u85ac\u304b\u3089\u5831\u544a\u3055\u308c\u305f\u526f\u4f5c\u7528\u3082\u7a00\u3067\u3001\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u5dee\u306f\u306a\u304b\u3063\u305f\uff08Table2\uff09\u3002
\n\"JC\u897f\u5712\uff11\"<\/a>
\n\"JC\u897f\u5712\uff12\"<\/a><\/p>\n

\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u7fa4\u306f\u3001\u5168\u4f53\u306e64.4\uff05\u3067CPAP\u3092\u4f7f\u7528\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3067\u306f45.2\uff05\u3067\u3042\u308a\u3001\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u306b\u3088\u308aCPAP\u7642\u6cd5\u306e\u9075\u5b88\u304c\u6539\u5584\u3055\u308c\u305f\u3002\u307e\u305f\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u5bfe\u30d7\u30e9\u30bb\u30dc\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3001\u5168\u8abf\u67fb\u306e\u591c\u9593\u306e\u5e73\u5747\u591c\u9593\u4f7f\u7528\u6642\u9593\u306f3.57\u5bfe2.42\u6642\u9593\u3001CPAP\u304c\u4f7f\u7528\u3055\u308c\u305f\u591c\u9593\u306e\u5e73\u5747\u6642\u9593\u306f4.05\u5bfe3.02\u6642\u9593\u3067\u3042\u3063\u305f\u3002<\/p>\n

\"JC\u897f\u5712\uff13\"<\/a><\/p>\n

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\uff0d\u6587\u732e\u540d\uff0d Christopher J. et al. Effects of a Short Course of Eszopiclone on Continuous Positive Airway Pressure Ad … \u7d9a\u304d\u3092\u8aad\u3080 CPAP\u7642\u6cd5\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u5411\u4e0a\u306b\u5bfe\u3059\u308b\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u306e\u77ed\u671f\u4f7f\u7528\u306e\u52b9\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1737","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1737"}],"version-history":[{"count":4,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1737\/revisions"}],"predecessor-version":[{"id":1744,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1737\/revisions\/1744"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}