{"id":1793,"date":"2020-01-16T10:04:23","date_gmt":"2020-01-16T01:04:23","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1793"},"modified":"2020-02-05T12:39:08","modified_gmt":"2020-02-05T03:39:08","slug":"%e4%bd%93%e7%a9%8d%e9%aa%a8%e5%af%86%e5%ba%a6%e3%81%8a%e3%82%88%e3%81%b3%e9%aa%a8%e5%bc%b7%e5%ba%a6%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e9%ab%98%e7%94%a8%e9%87%8f%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1793","title":{"rendered":"\u4f53\u7a4d\u9aa8\u5bc6\u5ea6\u304a\u3088\u3073\u9aa8\u5f37\u5ea6\u306b\u5bfe\u3059\u308b\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u52b9\u679c"},"content":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d<br \/>\nLauren A. Burt, PhD. Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength A Randomized Clinical Trial. JAMA. 2019 Aug 27;322(8):736-745.<\/p>\n<p>\uff0d\u8981\u7d04\uff0d<br \/>\n<strong><span style=\"text-decoration: underline;\">\u80cc\u666f<\/span><\/strong><br \/>\n12\u30f6\u6708\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u8a31\u5bb9\u4e0a\u9650\u6442\u53d6\u91cf\u4ee5\u4e0a\u3067\u30d3\u30bf\u30df\u30f3D\u6295\u4e0e\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u304c\u3001\u7c73\u56fd\u6210\u4eba\u306e3\uff05\u304c\u5c11\u306a\u304f\u3068\u30824000IU\/day\u306e\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u3092\u5831\u544a\u3057\u3066\u3044\u308b\u3002<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u76ee\u7684<\/strong><\/span><br \/>\n\u4f53\u7a4d\u9aa8\u5bc6\u5ea6\uff08BMD\uff09\u304a\u3088\u3073\u5f37\u5ea6\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u7528\u91cf\u4f9d\u5b58\u52b9\u679c\u306e\u8a55\u4fa1<br \/>\n\u30c7\u30b6\u30a4\u30f3<br \/>\n\u30ab\u30ca\u30c0\u30fb\u30ab\u30eb\u30ac\u30ea\u30fc\u306e\u5358\u4e00\u65bd\u8a2d\u30672013\u5e748\u6708\u301c2017\u5e7412\u6708\u307e\u3067\u306b\u5b9f\u65bd\u3055\u308c\u305f3\u5e74\u9593\u306e\u4e8c\u91cd\u76f2\u691cRCT\u3002<br \/>\n55\u301c70\u6b73\u307e\u3067\u306e311\u4eba\u306e\u9aa8\u7c97\u9b06\u75c7\u306e\u306a\u3044\u5065\u5eb7\u306a\u6210\u4eba\u300125[OH]D\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ec\u30d9\u30eb\u306f30\u301c125nmol\/L\u3002<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u4ecb\u5165<\/strong><\/span><br \/>\n400IU\uff08n = 109\uff09\u30014000IU\uff08n = 100\uff09\u300110000IU\uff08n = 102\uff09\u3067\u306e3\u5e74\u9593\u306e\u30d3\u30bf\u30df\u30f3D3\u306e1\u65e5\u91cf\u3002<br \/>\n\u30ab\u30eb\u30b7\u30a6\u30e0\u6442\u53d6\u306f\u3001\u98df\u4e8b\u30671200mg\/day\u672a\u6e80\u306e\u4eba\u306b\u63d0\u4f9b\u3002<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u7d50\u679c<\/strong><\/span><br \/>\nHR-pQCT\uff08high-resolution peripheral quantitative CT\uff1aDEXA\u3088\u308a\u6b63\u78ba\u306b\u9aa8\u5bc6\u5ea6\u3092\u6e2c\u5b9a\u3057\u3001\u304b\u3064\u9aa8\u5f37\u5ea6\u3092\u6e2c\u5b9a\u3067\u304d\u308b\u3082\u306e\uff09\u3067\u6a48\u9aa8\u30fb\u811b\u9aa8\u306e\u9aa8\u5bc6\u5ea6\uff08BMD\uff1abone mineral density\uff09\u3092\u8a55\u4fa1\u3001\u304a\u3088\u3073\u8981\u7d20\u89e3\u6790\u306b\u3088\u308b\u9aa8\u5f37\u5ea6\u306e\u63a8\u5b9a\u3002<br \/>\n\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f311\u4eba\u306e\u53c2\u52a0\u8005\uff0853\uff05\u304c\u7537\u6027\u3001\u5e73\u5747\u5e74\u9f6262.2\u6b73\uff09\u306e\u3046\u3061287\u4eba\uff0892\uff05\uff09\u304c\u7814\u7a76\u3092\u5b8c\u4e86\u3002<br \/>\n25(OH)D\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30013\u304b\u6708\u30013\u5e74\u5f8c\u306e\u5024\u306f\u3001400IU\u30b0\u30eb\u30fc\u30d7\u306776.3\u300176.7\u300177.4nmol\/L\u3002<br \/>\n4000IU\u30b0\u30eb\u30fc\u30d7\u306781.3\u3001115.3\u3001\u304a\u3088\u3073132.2\u3002<br \/>\n10000IU\u30b0\u30eb\u30fc\u30d7\u306778.4\u3001188.0\u3001\u304a\u3088\u3073144.4\u3002<br \/>\n\u7d42\u4e86\u6642\u3067\u306e\u6a48\u9aa8\u306e\u9aa8\u5bc6\u5ea6\u306f400IU\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u30014000IU\u30b0\u30eb\u30fc\u30d7\uff08\u22123.9 mg HA\/cm3 [95% CI, \u22126.5 to \u22121.3]\uff09\u304a\u3088\u307310,000IU\u30b0\u30eb\u30fc\u30d7\uff08\u22127.5 mg HA\/cm3 [95% CI, \u221210.1 to \u22125.0]) \u3067\u4f4e\u304b\u3063\u305f\u3002<br \/>\n\u4f53\u7a4dBMD\u306e\u5e73\u5747\u5909\u5316\u7387\u306f-1.2\uff05\uff08400 IU\u30b0\u30eb\u30fc\u30d7\uff09\u3001-2.4\uff05\uff084000 IU\u30b0\u30eb\u30fc\u30d7\uff09\u3001\u304a\u3088\u3073-3.5\uff05\uff08 10000 IU\u30b0\u30eb\u30fc\u30d7\uff09\u3067\u3042\u3063\u305f\u3002<br \/>\n400 IU\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u811b\u9aa8\u306e\u9aa8\u5bc6\u5ea6\u306e\u5dee\u306f\u30014000IU\u30b0\u30eb\u30fc\u30d7\u3067-1.8 mg HA \/cm\u00b3\uff0895\uff05CI\u3001-3.7\u301c0.1\uff09\u300110000 IU\u30b0\u30eb\u30fc\u30d7\u3067-4.1 mg HA \/cm\u00b3\uff0895\uff05CI\u3001- 6.0\u301c-2.2\uff09\u3001\u5e73\u5747\u5909\u5316\u5024\u306f-0.4\uff05\uff08400IU\uff09\u3001-1.0\uff05\uff084000IU\uff09\u3001\u304a\u3088\u3073-1.7\uff05\uff0810000IU\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u7d50\u8ad6\u3068\u95a2\u9023\u6027<\/strong><\/span><br \/>\n\u5065\u5eb7\u6210\u4eba\u3067\u306f\u30011\u65e5\u3042\u305f\u308a4000IU\u307e\u305f\u306f10,000IU\u306e\u30d3\u30bf\u30df\u30f3D\u30923\u5e74\u9593\u6295\u4e0e\u3059\u308b\u3068\u3001400IU\u3068\u6bd4\u8f03\u3057\u3066\u9aa8\u5bc6\u5ea6\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002\u811b\u9aa8\u3067\u306f\u300110000IU\u3067\u306e\u307f\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002\u6a48\u9aa8\u3067\u3082\u811b\u9aa8\u3067\u3082\u9aa8\u5f37\u5ea6\u306b\u306f\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u3002\u8abf\u67fb\u7d50\u679c\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u306e\u305f\u3081\u306e\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u5229\u70b9\u3092\u652f\u6301\u3057\u306a\u304b\u3063\u305f\u3002\u6709\u5bb3\u304b\u3069\u3046\u304b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u53c2\u52a0\u8005\u306e\u30d5\u30ed\u30fc<\/strong><\/span><br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff11.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff11-1024x1022.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff11\" width=\"640\" height=\"639\" \/><\/a><\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u6bcd\u96c6\u56e3<\/strong><\/span><br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff12.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff12-657x1024.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff12\" width=\"640\" height=\"998\" \/><\/a><\/p>\n<p>\uff1c\u9664\u5916\uff1e<br \/>\n\u9aa8\u7c97\u9b06\u75c7\uff08\u9aa8\u91cf\u4f4e\u4e0b\u306f\u542b\u3080\uff09<br \/>\n\u8840\u6e0525(OH)\u5024\u306e\u9ad8\u5024\u3001\u4f4e\u5024<br \/>\n\u8840\u6e05Ca\u5024\u306e\u9ad8\u5024\u3001\u4f4e\u5024<br \/>\n\u534a\u5e74\u4ee5\u5185\u306b\u9ad8\u5bb9\u91cf\u30d3\u30bf\u30df\u30f3D\u670d\u7528<br \/>\n2\u5e74\u4ee5\u5185\u306b\u9aa8\u7c97\u9b06\u75c7\u306e\u6cbb\u7642\u4ecb\u5165<br \/>\n\u30d3\u30bf\u30df\u30f3D\u4ee3\u8b1d\u306b\u5f71\u97ff\u3059\u308b\u75be\u60a3(\u30b5\u30eb\u30b3\u306a\u3069)<br \/>\n\u814e\u969c\u5bb3<br \/>\n\u5438\u53ce\u4e0d\u826f<br \/>\n2\u5e74\u4ee5\u5185\u306e\u814e\u7d50\u77f3<br \/>\n\u65e5\u713c\u3051\u30b5\u30ed\u30f3\u306b\u901a\u3063\u3066\u3044\u308b<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>A\uff08\u8840\u6e0525(OH)D\uff09\u3001B\uff08\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\uff09\u3001C\uff08\u30bf\u30a4\u30d7\uff11\u30b3\u30e9\u30fc\u30b2\u30f3C\u30c6\u30ed\u30da\u30d7\u30c1\u30c9\uff09\u306e\u5206\u5e03<\/strong><\/span><br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff13.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff13-459x1024.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff13\" width=\"459\" height=\"1024\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff14.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff14-459x1024.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff14\" width=\"459\" height=\"1024\" \/><\/a><\/p>\n<p>\u8840\u6e0525(OH)D\u5024\u306f\u9ad8\u5bb9\u91cf\u6295\u4e0e\u3067\u4e0a\u6607\u3059\u308b\u304c\u3001\u526f\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3001\u9aa8\u4ee3\u8b1d\u30de\u30fc\u30ab\u30fc\u306b\u306f\u5f71\u97ff\u306a\u3057<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Primary Outcome\u3000\uff1c\u9aa8\u5bc6\u5ea6\u306e\u5909\u5316\uff1e<\/strong><\/span><br \/>\n<span style=\"text-decoration: underline;\"><strong> <a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff15.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff15-861x1024.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff15\" width=\"640\" height=\"761\" \/><\/a><\/strong><\/span><br \/>\n\u6295\u4e0e\u3059\u308c\u3070\u6295\u4e0e\u3059\u308b\u307b\u3069\u9aa8\u5bc6\u5ea6\u304c\u4e0b\u304c\u3063\u3066\u3044\u308b<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>\u670d\u4f5c\u7528\u983b\u5ea6<\/strong><\/span><br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff161.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2020\/01\/\uff2a\uff23201912\u5927\u897f\uff161-1024x351.png\" alt=\"\uff2a\uff23201912\u5927\u897f\uff16\" width=\"640\" height=\"219\" \/><\/a><br \/>\n\u9ad8Ca\u8840\u75c7\u3068\u9ad8Ca\u5c3f\u75c7\u3067\u6709\u610f\u5dee\u3042\u308a<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112019\u5e7412\u67084\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d Lauren A. Burt, PhD. Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone S &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=1793\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u4f53\u7a4d\u9aa8\u5bc6\u5ea6\u304a\u3088\u3073\u9aa8\u5f37\u5ea6\u306b\u5bfe\u3059\u308b\u9ad8\u7528\u91cf\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306e\u52b9\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,11],"tags":[],"class_list":["post-1793","post","type-post","status-publish","format-standard","hentry","category-5","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1793"}],"version-history":[{"count":7,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1793\/revisions"}],"predecessor-version":[{"id":1864,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1793\/revisions\/1864"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}