{"id":1807,"date":"2020-01-24T16:57:33","date_gmt":"2020-01-24T07:57:33","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=1807"},"modified":"2020-01-24T17:08:01","modified_gmt":"2020-01-24T08:08:01","slug":"%e8%96%ac%e5%89%a4%e6%ba%b6%e5%87%ba%e3%82%b9%e3%83%86%e3%83%b3%e3%83%88%e3%82%92%e7%94%a8%e3%81%84%e3%81%9fpci%e5%be%8c%e3%81%ae%e6%8a%97%e8%a1%80%e5%b0%8f%e6%9d%bf%e8%96%ac2%e5%89%a4%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=1807","title":{"rendered":"\u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\u3092\u7528\u3044\u305fPCI\u5f8c\u306e\u6297\u8840\u5c0f\u677f\u85ac2\u5264\u6cbb\u7642\u306e\u671f\u9593"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nDuration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis. BMJ 2019; 365: l2222<\/p>\n

\uff0d\u8981\u7d04\uff0d
\n\u3010Introduction\u3011
\n\u30a2\u30b9\u30d4\u30ea\u30f3\u3068P2Y12\u53d7\u5bb9\u4f53\u963b\u5bb3\u5264\uff08\u30c1\u30af\u30ed\u30d4\u30b8\u30f3\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\uff09\u3092\u4f7f\u7528\u3057\u305f2\u91cd\u6297\u8840\u5c0f\u677f\u7642\u6cd5\uff08DAPT\uff09\u306f\u3001\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u5f8c\u306e\u60a3\u8005\u30b1\u30a2\u306e\u57fa\u790e\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\uff08DES\uff09\u79fb\u690d\u5f8c\u306e\u60a3\u8005\u306b\u5bfe\u3059\u308bDAPT\u306e\u63a8\u5968\u671f\u9593\u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u3067\u306f12\u30f6\u6708\u4ee5\u4e0a\u3001\u5b89\u5b9a\u3057\u305f\u51a0\u52d5\u8108\u75be\u60a3\u306e\u60a3\u8005\u3067\u306f6\u30f6\u6708\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u3060\u304c\u3001DES\u6280\u8853\u306e\u6539\u826f\u3068\u5f37\u529b\u306aP2Y12\u53d7\u5bb9\u4f53\u963b\u5bb3\u5264\u306e\u51fa\u73fe\u306b\u3088\u308a\u3001DAPT\u304b\u3089\u5358\u4e00\u306e\u6297\u8840\u5c0f\u677f\u7642\u6cd5\u3078\u5207\u308a\u66ff\u3048\u308b\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u306f\u8b70\u8ad6\u306e\u4f59\u5730\u304c\u3042\u308b\u3002
\n\u904e\u53bb\u306e\u7814\u7a76\u3067\u306f\u300112\u30f6\u6708\u4ee5\u4e0a\u306eDAPT\u306f\u30013\uff5e6\u30f6\u6708\u306eDAPT\u3068\u6bd4\u8f03\u3057\u3066\u975e\u512a\u8d8a\u6027\u304c\u8a3c\u660e\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001DAPT\u306e\u671f\u9593\u304c\u77ed\u3044\u65b9\u304c\u3001\u51fa\u8840\u306b\u95a2\u9023\u3057\u305f\u6b7b\u4ea1\u7387\u306e\u4f4e\u4e0b\u306b\u3088\u308a\u3001\u5168\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u4f4e\u304f\u306a\u3063\u305f\u3002\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u7814\u7a76\u3067\u306f\u77ed\u671fDAPT\u304c\u5f93\u6765\u306e\u6a19\u6e96\u671f\u9593\u306b\u53d6\u3063\u3066\u4ee3\u308f\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u306f\u7d50\u8ad6\u3065\u3051\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u30013\u30f6\u6708\u306eDAPT\u304cACS\u60a3\u8005\u306e\u865a\u8840\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u305f\u3002
\n\u672c\u7814\u7a76\u3067\u306f\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u3001DAPT\u306e\u7d99\u7d9a\u671f\u9593\u3092\u3088\u308a\u5b9a\u91cf\u5316\u3057\u3001\u5305\u62ec\u7684\u306a\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002<\/p>\n

\u3010Method\u3011
\n\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff1aMedline\u3001Embase\u3001Cochrane Library for clinical trials\u3001PubMed\u3001Web of Science\u3002ClinicalTrials.gov\u3001Clinicaltrialsregister.eu\u3082\u691c\u7d22\u3057\u305f\u3002
\n\u57fa\u6e96\uff1a\u5bfe\u8c61\u8005\u306fDES\u3092\u4f7f\u7528\u3057\u305fPCI\u5f8c\u306bDAPT\u3092\u53d7\u3051\u305f\u6210\u4eba\uff0818\u6b73\u4ee5\u4e0a\uff09\u3002\u4ecb\u5165\u306fDAPT\u306e\u5019\u88dc\u671f\u9593\uff08\u77ed\u671f\uff1b6\u30f6\u6708\u4ee5\u4e0b\u3001\u6a19\u6e96\u671f\u9593\uff1b12\u30f6\u6708\u3001\u9577\u671f\uff1b\uff1e12\u30f6\u6708\uff09\u3002\u4ed6\u306e\u5019\u88dc\u671f\u9593\u3068\u306e\u6bd4\u8f03\u3092\u884c\u3063\u305f\u3002\u7d50\u679c\u306b\u306f\u6b7b\u4ea1\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u51fa\u8840\u304c\u542b\u307e\u308c\u308b\u3002\u9664\u5916\u57fa\u6e96\uff1a\u22661\u30f6\u6708\u306eDAPT\u3001\u975e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u5206\u6790\u3001\u6a2a\u65ad\u7814\u7a76\u3001\u75c7\u4f8b\u5831\u544a\u30fb\u75c7\u4f8b\u30b7\u30ea\u30fc\u30ba\u3001\u9032\u884c\u4e2d\u306e\u8a66\u9a13\u3001\u307e\u305f\u306f\u5143\u306e\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u3002<\/p>\n

\u3010Results\u3011
\n2010\u5e74\uff5e2018\u5e74\u307e\u3067\u306e17\u306e\u7814\u7a76\u300146,864\u540d\u306e\u53c2\u52a0\u8005\u304c\u542b\u307e\u308c\u305f\u3002DAPT\u306e\u6700\u77ed\u671f\u9593\u306f3\u30f6\u6708\u3067\u3001\u6700\u9577\u671f\u9593\u306f48\u30f6\u6708\u3002\u5168\u4f53\u3068\u3057\u306613,234\u540d\u306e\u53c2\u52a0\u8005\u304c\u77ed\u671fDAPT\u306b\u300118,473\u540d\u304c\u6a19\u6e96\u671f\u9593DAPT\u306b\u300115,157\u540d\u304c\u9577\u671fDAPT\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002\u5168\u3066\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u3001\u5b8c\u5168\u306a\u81e8\u5e8a\u7684\u304a\u3088\u3073\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u7279\u6027\u304c\u5831\u544a\u3055\u308c\u305f\u3002
\n\u77ed\u671fDAPT\u3068\u6bd4\u8f03\u3057\u3066\u3001\u9577\u671fDAPT\u306f\u5927\u51fa\u8840\uff08\u30aa\u30c3\u30ba\u6bd41.78\u300195\uff05\u4fe1\u983c\u533a\u95931.27\uff5e2.49\uff09\u3001\u975e\u5fc3\u81d3\u6b7b\uff08\u30aa\u30c3\u30ba\u6bd41.63\u300195\uff05\u4fe1\u983c\u533a\u95931.03\uff5e2.59\uff09\u304c\u591a\u304f\u307f\u3089\u308c\u305f\u3002\u6a19\u6e96\u671f\u9593DAPT\u306f\u51fa\u8840\u7387\u306e\u9ad8\u3055\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u30aa\u30c3\u30ba\u6bd41.39\u300195\uff05\u4fe1\u983c\u533a\u95931.01\uff5e1.92\uff09\u3002\u4ed6\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u306f\u9855\u8457\u306a\u5dee\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u611f\u5ea6\u5206\u6790\u306b\u3088\u308a\u3001\u77ed\u671f\u307e\u305f\u306f\u6a19\u6e96\u671f\u9593DAPT\u3068\u6bd4\u8f03\u3057\u3066\u300118\u30f6\u6708\u4ee5\u4e0a\u306eDAPT\u3067\u306f\u975e\u5fc3\u81d3\u6b7b\u304a\u3088\u3073\u51fa\u8840\u30ea\u30b9\u30af\u304c\u3055\u3089\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001\u65b0\u3057\u3044\u4e16\u4ee3\u306eDES\u304c\u79fb\u690d\u3055\u308c\u305f\u60a3\u8005\u3067\u306f\u3001\u9577\u671fDAPT\u3067\u77ed\u671fDAPT\u3088\u308a\u3082\u5168\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u304c\u9ad8\u304f\u306a\u3063\u305f\uff08\u30aa\u30c3\u30ba\u6bd41.99\u300195\uff05\u4fe1\u983c\u533a\u95931.04\uff5e3.81\uff09\u3002ACS\u306b\u5bfe\u3057\u3066\u65b0\u4e16\u4ee3\u306eDES\u3092\u4f7f\u7528\u3055\u308c\u305f\u60a3\u8005\u306b\u3064\u3044\u3066\u3001\u77ed\u671fDAPT\u306f\u6a19\u6e96\u671f\u9593DAPT\u3068\u540c\u69d8\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u793a\u3057\u305f\u3002<\/p>\n

\"JC20200115\u4e2d\u5cf6\uff11\"<\/a><\/p>\n

Fig2\uff1aNetwork meta-analysis results of all endpoints between two pairs of duration of DAPT<\/p>\n

\"JC20200115\u4e2d\u5cf6\uff12\"<\/a><\/p>\n

Fig3\uff1aNetwork meta-analysis results of all endpoints between two pairs of duration of DAPT<\/p>\n

\u3010Discussion\u3011
\nDAPT\u306e\u6700\u9069\u306a\u671f\u9593\u306f\u3001\u500b\u4eba\u306e\u865a\u8840\u304a\u3088\u3073\u51fa\u8840\u306e\u30ea\u30b9\u30af\u3092\u8003\u616e\u306b\u5165\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u304c\u3001\u3053\u306e\u7814\u7a76\u306f\u3001\u76f4\u63a5\u304a\u3088\u3073\u9593\u63a5\u6bd4\u8f03\u304b\u3089\u306e\u6839\u62e0\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001DES\u3092\u4f7f\u7528\u3057\u305fPCI\u5f8c\u306e\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u3067\u77ed\u671fDAPT\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002
\n\u672c\u7814\u7a76\u306e\u9650\u754c\u3068\u3057\u3066\u3001\u7b2c\u4e00\u306b\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u3092\u30d9\u30fc\u30b9\u306bDAPT\u306e\u671f\u9593\u3092\u8a55\u4fa1\u3057\u305f\u305f\u3081\u3001\u30d7\u30e9\u30b9\u30b0\u30ec\u30eb\u3084\u30c1\u30ab\u30b0\u30ec\u30ed\u30fc\u30eb\u306a\u3069\u4ed6\u306eP2Y12\u963b\u5bb3\u5264\u3092\u9069\u7528\u3057\u305f\u5834\u5408\u306f\u7d50\u8ad6\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u7b2c\u4e8c\u306b\u3001\u30d7\u30fc\u30eb\u3055\u308c\u305f\u5b9a\u7fa9\u3067\u7570\u306a\u308b\u8a66\u9a13\u306e\u7d50\u679c\u5206\u6790\u3092\u884c\u3063\u305f\u70b9\u3067\u3042\u308b\u3002\u7b2c\u4e09\u306b\u3001\u5fc3\u81d3\u6b7b\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u8a66\u9a13\u3067\u306f\u3044\u304f\u3064\u304b\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c\u5831\u544a\u3055\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u983b\u5ea6\u4e3b\u7fa9\u3068\u30d9\u30a4\u30ba\u4e3b\u7fa9\u306e\u67a0\u7d44\u307f\u3067\u306e\u7d50\u679c\u306e\u308f\u305a\u304b\u306a\u76f8\u9055\u304c\u90e8\u5206\u7684\u306b\u8aac\u660e\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112019\u5e7412\u670811\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: … \u7d9a\u304d\u3092\u8aad\u3080 \u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\u3092\u7528\u3044\u305fPCI\u5f8c\u306e\u6297\u8840\u5c0f\u677f\u85ac2\u5264\u6cbb\u7642\u306e\u671f\u9593<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1807","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1807"}],"version-history":[{"count":3,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1807\/revisions"}],"predecessor-version":[{"id":1863,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1807\/revisions\/1863"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}