{"id":182,"date":"2014-03-04T13:40:44","date_gmt":"2014-03-04T04:40:44","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=182"},"modified":"2015-08-06T13:41:36","modified_gmt":"2015-08-06T04:41:36","slug":"%e3%83%ac%e3%83%9c%e3%83%81%e3%83%ad%e3%82%ad%e3%82%b7%e3%83%b3%ef%bc%88%e3%83%81%e3%83%a9%e3%83%bc%e3%83%82%e3%83%b3%ef%bd%93%ef%bc%89%e3%81%ae%e5%86%85%e6%9c%8d%e6%99%82%e9%96%93","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=182","title":{"rendered":"\u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\uff08\u30c1\u30e9\u30fc\u30c2\u30f3\uff33\uff09\u306e\u5185\u670d\u6642\u9593"},"content":{"rendered":"

\u2015\u3000\u6587\u732e\u540d\u3000\u2015\u3000
\n\u3000Thien-Giang Bach-Huynh,\u00a0Bindu Nayak,\u00a0Jennifer Loh,\u00a0Steven Soldin, and\u00a0Jacqueline Jonklaas<\/p>\n

Timing of Levothyroxine Administration Affects Serum Thyrotropin Concentration
\nJ Clin Endocrinol Metab.\u00a02009 October;\u00a094(10):905-3912.
\nhttp:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2758731\/<\/a><\/p>\n

\u2015\u3000\u8981\u7d04\u3000\u2015<\/p>\n

Context: \u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u306f\u3001\u98df\u4e8b\u306b\u3088\u308b\u5438\u53ce\u963b\u5bb3\u3092\u9632\u3050\u305f\u3081\u671d\u98df\u524d\u306b\u5185\u670d\u3055\u308c\u3066\u3044\u308b\u3002TSH\u6fc3\u5ea6\u306f\u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u306e\u52b9\u679c\u306e\u6307\u6a19\u3067\u3042\u308b\u3002<\/p>\n

Objective: \u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u306eTSH\u6fc3\u5ea6\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u3001\u98df\u4e8b\u6442\u53d6\u3068\u95a2\u9023\u3057\u305f\u5185\u670d\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u5909\u5316\u3059\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b
\nDesign: \u53c2\u52a0\u8005\u306f\u30e9\u30f3\u30c0\u30e0\u306b\uff16\u3064\u306b\u632f\u308a\u5206\u3051\u3089\u308c\u3001\u305d\u308c\u305e\u308c\u304c\uff18\u9031\u9593\u306e\u30ec\u30b8\u30e1\u30f3\u3092\uff13\u30bf\u30fc\u30e0\u884c\u3046\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u30c7\u30b6\u30a4\u30f3\u3067\u5b9f\u65bd\u3055\u308c\u308b\u3002\uff13\u30bf\u30fc\u30e0\u306e\u30ec\u30b8\u30e1\u30f3\u306f\u305d\u308c\u305e\u308c\u671d\u98df\u524d\u30fb\u5c31\u5bdd\u524d\u30fb\u671d\u98df\u6642\u3067\u306e\u5185\u670d\u3002TSH\u30fbfreeT4\u30fbfreeT3\u6fc3\u5ea6\u304c\u5404\u30ec\u30b8\u30e1\u30f3\u3067\u6e2c\u5b9a\u3055\u308c\u308b\u3002
\n\u53c2\u52a0\u8005\u306e\u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u306e\u6295\u4e0e\u91cf\u306f\u5909\u66f4\u305b\u305a\u306b\u5b9f\u65bd\u3055\u308c\u305f\uff0e
\nPrimary outcome\u306f\u3001\u4ed6\u306e\u30ec\u30b8\u30e1\u30f3\u3068\u671d\u98df\u524d\u306e\u30ec\u30b8\u30e1\u30f3\u3068\u306eTSH\u6fc3\u5ea6\u306e\u76f8\u9055\u3002<\/p>\n

Setting: academic medical center\u3067\u5b9f\u65bd\u3055\u308c\u305f<\/p>\n

Participants: \u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u307e\u305f\u306f\u7532\u72b6\u817a\u764c\u306e\u6cbb\u7642\u306e\u305f\u3081\u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u3092\u5185\u670d\u3057\u3066\u3044\u308b\u60a3\u8005<\/p>\n

Results: 65\u4eba\u306e\u60a3\u8005\u304c\u53c2\u52a0\u3002\u671d\u98df\u524d\u5185\u670d\u306e\u5e73\u5747TSH\u6fc3\u5ea6\u306f1.06 \u00b1 1.23 mIU\/L\u3002\u671d\u98df\u6642\u5185\u670d\u306e\u5e73\u5747TSH\u6fc3\u5ea6\u306f\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f(2.93 \u00b1 3.29 mIU\/L). \u5c31\u5bdd\u524d\u5185\u670d\u306e\u5e73\u5747TSH\u6fc3\u5ea6\u3082\u307e\u305f\u512a\u4f4d\u306b\u9ad8\u304b\u3063\u305f(2.19 \u00b1 2.66 mIU\/L)\u3002<\/p>\n

Conclusion: \u671d\u98df\u524d\u4ee5\u5916\u306e\u30ec\u30b8\u30e1\u30f3\u3067\u306f\u3001TSH\u6fc3\u5ea6\u304c\u9ad8\u304f\u3001\u307e\u305f\u3070\u3089\u3064\u304d\u304c\u5927\u304d\u304b\u3063\u305f\u3002\u7279\u5b9a\u306eTSH\u306e\u76ee\u6a19\u5024\u304c\u671b\u307e\u308c\u3001\u305d\u308c\u306b\u3088\u308a\u533b\u539f\u6027\u306e\u6f5c\u5728\u6027\u7532\u72b6\u817a\u75be\u60a3\u3092\u907f\u3051\u308b\u306a\u3089\u3070\u3001\u671d\u98df\u524d\u306e\u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\u5185\u670d\u306b\u3088\u308a\u6700\u3082\u72ed\u3044\u76ee\u6a19\u7bc4\u56f2\u3067\u306eTSH\u6fc3\u5ea6\u304c\u78ba\u4fdd\u3055\u308c\u308b\u3060\u308d\u3046\u3002<\/p>\n

\u2015\u3000\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3000\u2015<\/p>\n

\u3053\u306e\u7814\u7a76\u3067\u306f\uff18\u9031\u9593\u306e\u30ec\u30b8\u30e1\u30f3\u306a\u306e\u3067\u3001\u9577\u671f\u9593\u306e\u52b9\u679c\u306f\u4e0d\u660e\u3067\u3042\u3063\u305f\u3002
\n\u3057\u304b\u3057\u3001\u81ea\u5206\u81ea\u8eab\u3067\u306f\u98f2\u307f\u3084\u3059\u3055\u304b\u3089\u98df\u5f8c\u3067\u51e6\u65b9\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u591a\u3044\u306e\u3067\u3001\u8abf\u6574\u304c\u3088\u308a\u56f0\u96e3\u306a\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u306f\u3001\u671d\u98df\u524d\uff08\u305d\u308c\u304c\u96e3\u3057\u3051\u308c\u3070\u5c31\u5bdd\u6642\uff09\u306b\u51e6\u65b9\u5909\u66f4\u3059\u308b\u3053\u3068\u3092\u691c\u8a0e\u3057\u305f\u3044\u3002<\/p>\n

\u958b\u50ac\u65e5\uff1a\u5e73\u621026\u5e742\u670819\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"

\u2015\u3000\u6587\u732e\u540d\u3000\u2015\u3000 \u3000Thien-Giang Bach-Huynh,\u00a0Bindu Nayak,\u00a0Jennifer Loh,\u00a0Steven Soldin, and\u00a0Jacqueline Jonklaas Timing of … \u7d9a\u304d\u3092\u8aad\u3080 \u30ec\u30dc\u30c1\u30ed\u30ad\u30b7\u30f3\uff08\u30c1\u30e9\u30fc\u30c2\u30f3\uff33\uff09\u306e\u5185\u670d\u6642\u9593<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-182","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=182"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/182\/revisions"}],"predecessor-version":[{"id":183,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/182\/revisions\/183"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}