\uff0d\u6587\u732e\u540d\uff0d
\nCurrow D, Louw S, McCloud P, Fazekas B, Plummer J, McDonald CF, Agar M, Clark K, McCaffery N, Ekstrom MP; Australian National Palliative Care Clinical Studies Collaborative (PaCCSC).
\nRegular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial.
\nThorax. 2020 Jan;75(1):50-56. doi: 10.1136\/thoraxjnl-2019-213681. Epub 2019 Sep 26.<\/p>\n
\uff0d\u8981\u7d04\uff0d
\n\u3010\u76ee\u7684\u3011
\n\u3000\u30e2\u30eb\u30d2\u30cd\u306f\u6162\u6027\u7684\u306a\u547c\u5438\u56f0\u96e3\u611f\u3092\u7de9\u548c\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u304c\u3001\u5927\u304d\u306aRCT\u306b\u3088\u308b\u30c7\u30fc\u30bf\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3002\u6162\u6027\u7684\u306a\u547c\u5438\u56f0\u96e3\u611f\u306b\u5bfe\u3059\u308b\u4f4e\u7528\u91cf\u306e\u30e2\u30eb\u30d2\u30cd\u5f90\u653e\u88fd\u5264\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306b\u3088\u308a\u691c\u8a3c\u3059\u308b\u3002
\n\u3010\u65b9\u6cd5\u3011
\n\u3000\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u547c\u5438\u5668\u30fb\u5faa\u74b0\u5668\u30fb\u7de9\u548c\u30b1\u30a2\u306e\u5165\u9662\u30fb\u5916\u6765\u30b5\u30fc\u30d3\u30b914\u65bd\u8a2d\u3067\u4e8c\u91cd\u76f2\u691c\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u884c\u3063\u305f\u3002\u4fee\u6b63\u7248MRC\u606f\u5207\u308c\u30b9\u30b1\u30fc\u30eb\u30672\u4ee5\u4e0a\u306e\u547c\u5438\u56f0\u96e3\u611f\u3092\u6709\u3059\u308b\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u4ecb\u5165\u7fa4\u306f\u7d4c\u53e3\u30e2\u30eb\u30d2\u30cd\u5f90\u653e\u88fd\u526420mg\/\u65e5\u3068\u4e0b\u5264\u3001\u5bfe\u7167\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u4e0b\u5264\u3092\u305d\u308c\u305e\u308c7\u65e5\u9593\u670d\u85ac\u3057\u305f\u3002\u4e21\u7fa4\u3068\u3082\u5fc5\u8981\u6642\u306b\u30e2\u30eb\u30d2\u30cd\u901f\u653e\u88fd\u52642.5mg\/\u56de\u30921\u65e56\u56de\u307e\u3067\u4f7f\u7528\u53ef\u3068\u3057\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u73fe\u5728\u306e\u547c\u5438\u56f0\u96e3\u611f\u306eVAS\u8a55\u4fa1\u306e\u524d\u5f8c\u3067\u306e\u5909\u5316\u3068\u3057\u305f\u3002\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f24\u6642\u9593\u524d\u3068\u4eca\u306b\u304a\u3051\u308b\u547c\u5438\u56f0\u96e3\u611f\u306e\u6700\u4f4e\u30fb\u6700\u9ad8\u30fb\u5e73\u5747\u5f37\u5ea6\u3068\u60a3\u8005\u306eQOL\u3001\u4ecb\u8b77\u8005\u306eQOL\u3001\u60a3\u8005\u306e\u6cbb\u7642\u3078\u306e\u597d\u307f\u3092\u8a55\u4fa1\u3057\u305f\u3002
\n\u3010\u7d50\u679c\u3011
\n\u3000\u4ecb\u5165\u7fa4\u306b145\u540d\u3001\u5bfe\u7167\u7fa4\u306b139\u540d\u304c\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b\u73fe\u5728\u306e\u547c\u5438\u56f0\u96e3\u8a55\u4fa1\u306e\u5909\u5316\u306b\u6709\u610f\u5dee\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u5909\u5316\u306e\u5dee-0.15 mm, 95%\u4fe1\u983c\u533a\u9593 -4.59 to 4.29; p=0.95\uff09\u3002\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3067\u3082\u4ecb\u5165\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0824\u6642\u9593\u3067\u6700\u60aa\u306e\u547c\u5438\u56f0\u96e3\u611f, p=0.064; 24\u6642\u9593\u3067\u6700\u826f\u306e\u547c\u5438\u56f0\u96e3\u611f, p=0.207; 24\u6642\u9593\u306e\u5e73\u5747\u7684\u306a\u547c\u5438\u56f0\u96e3\u611f, p=0.355; \u73fe\u5728\u306e\u547c\u5438\u56f0\u96e3\u306e\u4e0d\u5feb\u611f, p=0.338; \u5026\u6020\u611f, p\uff1c0.001, \u4ecb\u5165\u7fa4\u306e\u65b9\u304c\u5026\u6020\u611f\u5897\u60aa; QOL, p=0.880; \u5168\u8eab\u72b6\u614b, p=0.260\uff09\u3002\u4ecb\u5165\u7fa4\u306f\u4fbf\u79d8\uff08p=0.001\uff09\u3001\u75b2\u52b4\uff08p<0.001\uff09\u3001\u60aa\u5fc3\u30fb\u5614\u5410\uff08p=0.008\uff09\u304c\u6709\u610f\u306b\u591a\u304b\u3063\u305f\u3002\u30e2\u30eb\u30d2\u30cd\u306e\u30ec\u30b9\u30ad\u30e5\u30fc\u4f7f\u7528\u306f\u5bfe\u7167\u7fa4\u3067\u3088\u308a\u591a\u304b\u3063\u305f\uff08\u4ecb\u5165\u7fa4, \u5e73\u57475.8\u56de, \u5bfe\u7167\u7fa4, 8.7\u56de; p=0.001\uff09\u3002\n\u3010\u7d50\u8ad6\u3011\n\u3000\u6162\u6027\u7684\u306a\u547c\u5438\u56f0\u96e3\u611f\u306b\u5bfe\u3059\u308b\u30e2\u30eb\u30d2\u30cd\u5f90\u653e\u88fd\u5264\u306e\u5b9a\u671f\u670d\u7528\u306e\u4ecb\u5165\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u304c\u3001\u30ec\u30b9\u30ad\u30e5\u30fc\u4f7f\u7528\u306f\u5bfe\u7167\u7fa4\u3088\u308a\u5c11\u306a\u304b\u3063\u305f\u3002\n\n\u3010\u958b\u50ac\u65e5\u30112020\u5e743\u670811\u65e5\uff08\u6c34\uff09\n<\/p>\n","protected":false},"excerpt":{"rendered":"