{"id":2331,"date":"2023-04-25T09:29:14","date_gmt":"2023-04-25T00:29:14","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2331"},"modified":"2023-04-25T09:29:14","modified_gmt":"2023-04-25T00:29:14","slug":"6%e3%83%b6%e6%9c%88%e6%9c%aa%e6%ba%80%e3%81%ae%e4%b9%b3%e5%85%90%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bcovid-19%e9%96%a2%e9%80%a3%e5%85%a5%e9%99%a2%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a6%8a%e5%a8%a0","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2331","title":{"rendered":"6\u30f6\u6708\u672a\u6e80\u306e\u4e73\u5150\u306b\u304a\u3051\u308bCOVID-19\u95a2\u9023\u5165\u9662\u306b\u5bfe\u3059\u308b\u598a\u5a20\u4e2d\u306emRNACOVID-19\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u6bcd\u4f53\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6709\u52b9\u6027-17\u5dde"},"content":{"rendered":"

\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002
\n-\u6587\u732e\u540d-
\nNatasha B. Halasa, MD, Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19\u2013Associated Hospitalization in Infants Aged. MMWR Morb Mortal Wkly Rep. 2022 Feb 18; 71(7): 264\u2013270.<\/p>\n

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\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u7279\u6027\u3001\u81e8\u5e8a\u60c5\u5831\u3001\u304a\u3088\u3073SARS-CoV-2\u691c\u67fb\u5c65\u6b74\u306f\u3001\u5165\u9662\u4e2d\u307e\u305f\u306f\u9000\u9662\u5f8c\u306b\u8a13\u7df4\u3092\u53d7\u3051\u305f\u7814\u7a76\u62c5\u5f53\u8005\u304c\u5b9f\u65bd\u3057\u305f\u89aa\u307e\u305f\u306f\u4fdd\u8b77\u8005\u306e\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u3001\u304a\u3088\u3073\u4e73\u5150\u306e\u8a18\u9332\u306e\u96fb\u5b50\u533b\u7642\u8a18\u9332\u30ec\u30d3\u30e5\u30fc\u3092\u901a\u3058\u3066\u53d6\u5f97\u3055\u308c\u305f\u3002\u6bcd\u89aa\u306fCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6b74\u306b\u3064\u3044\u3066\u5c0b\u306d\u3089\u308c\u305f\u3002\u6295\u4e0e\u56de\u6570\u3001\u598a\u5a20\u4e2d\u306b\u6295\u4e0e\u3092\u53d7\u3051\u305f\u304b\u3069\u3046\u304b\u3001\u30ef\u30af\u30c1\u30f3\u3092\u53d7\u3051\u305f\u5834\u6240\u3001\u30ef\u30af\u30c1\u30f3\u88fd\u9020\u696d\u8005\u3001COVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30ab\u30fc\u30c9\u306e\u5165\u624b\u53ef\u80fd\u6027\u306a\u3069\u304c\u542b\u307e\u308c\u308b\u3002\u7814\u7a76\u62c5\u5f53\u8005\u306f\u3001\u5dde\u306e\u4e88\u9632\u63a5\u7a2e\u767b\u9332\u3001\u96fb\u5b50\u533b\u7642\u8a18\u9332\u3001\u307e\u305f\u306f\u305d\u306e\u4ed6\u306e\u60c5\u5831\u6e90\uff08\u30d7\u30e9\u30a4\u30de\u30ea\u30b1\u30a2\u63d0\u4f9b\u8005\u304b\u3089\u306e\u6587\u66f8\u306a\u3069\uff09\u3092\u542b\u3080\u6587\u66f8\u5316\u3055\u308c\u305f\u60c5\u5831\u6e90\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3066\u3001\u4e88\u9632\u63a5\u7a2e\u306e\u72b6\u614b\u3092\u78ba\u8a8d\u3057\u305f\u3002
\n\u3000\u6bcd\u89aa\u306f\uff0c\u8cc7\u6599\u306b\u57fa\u3065\u3044\u3066\u3001\u307e\u305f\u306f\u3082\u3063\u3068\u3082\u3089\u3057\u3044\u81ea\u5df1\u7533\u544a\uff08\u63a5\u7a2e\u65e5\u304a\u3088\u3073\u5834\u6240\u306e\u63d0\u4f9b\uff09\u306b\u3088\u308a\u3001\u30d5\u30a1\u30a4\u30b6\u30fc\u30fb\u30d0\u30a4\u30aa\u30f3\u30c6\u30c3\u30af\u307e\u305f\u306f\u30e2\u30c7\u30eb\u30ca\u306emRNA COVID-19\u30ef\u30af\u30c1\u30f3\u306e2\u56de\u63a5\u7a2e\u30b7\u30ea\u30fc\u30ba\u3092\u5b8c\u4e86\u3057\u305f\u5834\u5408\u3001COVID-19\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6e08\u307f\u3068\u307f\u306a\u3057\u305f\uff0e\u6bcd\u89aa\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u72b6\u6cc1\u306f\u30011\uff09\u672a\u63a5\u7a2e\uff08\u4e73\u5150\u306e\u5165\u9662\u524d\u306bCOVID-19\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u306a\u304b\u3063\u305f\u6bcd\u89aa\uff09\u30012\uff09\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u2020\u2020\uff08\u598a\u5a20\u4e2d\u306b2\u56de\u5206\u306e\u4e00\u6b21mRNA COVID-19\u30ef\u30af\u30c1\u30f3\u30b7\u30ea\u30fc\u30ba\u3092\u51fa\u7523\u524d14\u65e5\u4ee5\u4e0a\u306b\u5b8c\u4e86\u3057\u305f\u6bcd\u89aa\uff09\u306b\u5206\u985e\u3055\u308c\u305f\u3002\u598a\u5a20\u4e2d\u307e\u305f\u306f\u51fa\u7523\u5f8c\u306e\u6bcd\u89aa\u306e SARS-CoV-2 \u611f\u67d3\u72b6\u6cc1\u306f\u3001\u3053\u306e\u8a55\u4fa1\u3067\u306f\u8a18\u9332\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u6bcd\u89aa\u306f\u3001\u598a\u5a20\u4e2d\u306b\u90e8\u5206\u7684\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3055\u308c\u305f\u5834\u5408\uff08\u598a\u5a20\u4e2d\u306b1\u56de\u63a5\u7a2e\u3057\u3001\u598a\u5a20\u524d\u306b\u306f\u63a5\u7a2e\u3057\u306a\u304b\u3063\u305f\u5834\u5408\uff09\uff0871\u4eba\uff09\u3001Janssen\uff08Johnson\uff06Johnson\uff09COVID-19\u30ef\u30af\u30c1\u30f3\uff084\u4eba\uff09\u3092\u53d7\u3051\u3001COVID-19\u30922\u56de\u63a5\u7a2e\u3057\u305f\u5834\u5408\u3001\u598a\u5a20\u524d\u306bCOVID-19\u30ef\u30af\u30c1\u30f3\u30922\u56de\u63a5\u7a2e\uff087\u4eba\uff09\u3001\u51fa\u7523\u524d14\u65e5\u4ee5\u4e0a\u3067COVID-19\u30ef\u30af\u30c1\u30f3\u30922\u56de\u3088\u308a\u591a\u304f\u63a5\u7a2e\uff0810\u4eba\uff09\u306e\u5834\u5408\u306f\u9664\u5916\u3057\u305f\u3002
\n\u3000\u75c7\u4f8b\u4e73\u5150\u3068\u5bfe\u7167\u4e73\u5150\u306e\u7279\u5fb4\u3092\u6bd4\u8f03\u3059\u308b\u305f\u3081\u306b\u8a18\u8ff0\u7d71\u8a08\uff08\u30ab\u30c6\u30b4\u30ea\u30fc\u5225\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u30d4\u30a2\u30bd\u30f3\u30fb\u30ab\u30a4\u4e8c\u4e57\u691c\u5b9a\u304a\u3088\u3073\u30d5\u30a3\u30c3\u30b7\u30e3\u30fc\u306e\u6b63\u78ba\u691c\u5b9a\u3001\u9023\u7d9a\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u30a6\u30a3\u30eb\u30b3\u30af\u30bd\u30f3\u30fb\u30e9\u30f3\u30af\u30b5\u30e0\u691c\u5b9a\uff09\u3092\u7528\u3044\u305f\u3002\u4e73\u5150\u306e COVID-19 \u5165\u9662\u306b\u5bfe\u3059\u308b\u6bcd\u89aa\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u52b9\u679c\uff08\u3059\u306a\u308f\u3061\u3001\u30ef\u30af\u30c1\u30f3\u52b9\u679c\uff3bVE\uff3d\uff09\u306f\uff0c\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u30e2\u30c7\u30eb\u304b\u3089\u6c42\u3081\u305f VE = 100% \u00d7\uff081-\u75c7\u4f8b\u4e73\u5150\u304a\u3088\u3073\u5bfe\u7167\u4e73\u5150\u306e\u6bcd\u89aa\u304c\u598a\u5a20\u4e2d\u306b COVID-19 mRNA \u30ef\u30af\u30c1\u30f3\u306e 2 \u56de\u6295\u4e0e\u3092\u5b8c\u4e86\u3059\u308b\u8abf\u6574\u30aa\u30c3\u30ba\u6bd4\uff09\u5f0f\u3067\u7b97\u51fa\u3057\u305f\u3002\u30e2\u30c7\u30eb\u306f\u3001\u4e73\u5150\u306e\u5e74\u9f62\u3068\u6027\u5225\u3001\u7c73\u56fd\u56fd\u52e2\u8abf\u67fb\u306e\u5730\u57df\u3001\u5165\u9662\u306e\u66a6\u5e74\u9593\u3001\u304a\u3088\u3073\u4eba\u7a2e\/\u6c11\u65cf\u3067\u8abf\u6574\u3055\u308c\u305f\u3002\u305d\u306e\u4ed6\u306e\u56e0\u5b50\uff08\u4f8b\uff1a\u4e73\u5150\u306e\u57fa\u790e\u75be\u60a3\u3001\u793e\u4f1a\u7684\u8106\u5f31\u6027\u6307\u6570\u3001\u884c\u52d5\u56e0\u5b50\uff09\u3082\u8a55\u4fa1\u3057\u305f\u304c\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30aa\u30c3\u30ba\u6bd4\u30925\uff05\u4ee5\u4e0a\u5909\u5316\u3055\u305b\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u3042\u308b\u3044\u306f\u591a\u304f\u306e\u4e73\u5150\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\uff08\u4f8b\uff1a\u6bcd\u4e73\u6b74\u3001\u672a\u719f\u5150\u3001\u4fdd\u80b2\u53c2\u52a0\uff09\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u6700\u7d42\u30e2\u30c7\u30eb\u306b\u306f\u542b\u307e\u306a\u304b\u3063\u305f\uff0e\u4e8c\u6b21\u89e3\u6790\u3067\u306f\u3001\u6bcd\u89aa\u304c\u598a\u5a20\u521d\u671f\uff08\u6700\u521d\u306e 20 \u9031\u4ee5\u5185\uff09\u304a\u3088\u3073\u598a\u5a20\u5f8c\u671f\uff0821 \u9031\u304b\u3089\u51fa\u7523 14 \u65e5\u524d\u307e\u3067\uff09\u306b 2 \u56de\u76ee\u306e COVID-19 \u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u5834\u5408\u306e\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002\u7d71\u8a08\u89e3\u6790\u306fSAS\uff08\u30d0\u30fc\u30b8\u30e7\u30f39.4\uff1bSAS Institute\uff09\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002
\n2021\u5e747\u67081\u65e5\u304b\u30892022\u5e741\u670817\u65e5\u306e\u9593\u306b\u300117\u5dde\u306e20\u306e\u5c0f\u5150\u79d1\u75c5\u9662\u306b\u304a\u3044\u3066\u3001483\u4eba\u306e\u5bfe\u8c61\u4e73\u5150\u306e\u3046\u3061\u3001104\u4eba\uff0822\uff05\uff09\u304c\u9664\u5916\u3055\u308c\u300171\u4eba\u306e\u9664\u5916\u4e73\u5150\u306f\u598a\u5a20\u4e2d\u306b\u90e8\u5206\u63a5\u7a2e\u3057\u305f\u6bcd\u89aa\u304b\u3089\u751f\u307e\u308c\u305f\u304b\u51fa\u7523\u5f8c\u306b\u63a5\u7a2e\u3057\u300110\u4eba\u306f\u51fa\u752314\u65e5\u4ee5\u4e0a\u524d\u306b3\u5ea6\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u6295\u4e0e\u3092\u53d7\u3051\u305f\u6bcd\u89aa\u304b\u3089\u751f\u307e\u308c\u300123\u4eba\u306f\u4ed6\u306e\u7406\u7531\u306b\u3088\u308a\u9664\u5916\u3055\u308c\u305f\u3002\u6b8b\u308a\u306e\u5165\u9662\u4e73\u5150379\u4eba\uff08\u75c7\u4f8b\u4e73\u5150176\u4eba\u3001\u5bfe\u7167\u4e73\u5150203\u4eba\uff09\u306e\u5e74\u9f62\u4e2d\u592e\u5024\u306f2\u30ab\u6708\u3067\u300180\u4eba\uff0821\uff05\uff09\u304c\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u57fa\u790e\u75be\u60a3\u3092\u6709\u3057\u300172\u4eba\uff0822\uff05\uff09\u304c\u672a\u719f\u5150\u3068\u3057\u3066\u751f\u307e\u308c\u305f\uff08\u88681\uff09\u3002\u75c7\u4f8b\u5150\u306e\u3046\u3061\u3001\u598a\u5a20\u4e2d\u306bCOVID-19\u30ef\u30af\u30c1\u30f3\u30922\u56de\u63a5\u7a2e\u3057\u305f\u6bcd\u89aa\u306f16\uff05\u3067\u3042\u3063\u305f\u304c\u3001\u5bfe\u7167\u5150\u306e\u6bcd\u89aa\u306f32\uff05\u304c\u63a5\u7a2e\u3057\u3066\u3044\u305f\u3002\u75c7\u4f8b\u5150\u3068\u5bfe\u7167\u5150\u306e\u57fa\u790e\u75be\u60a3\uff08\u305d\u308c\u305e\u308c20\uff05\u306823\uff05\u3001p\uff1d0.42\uff09\u304a\u3088\u3073\u672a\u719f\u5150\uff08\u305d\u308c\u305e\u308c23\uff05\u306821\uff05\u3001p\uff1d0.58\uff09\u306e\u6709\u75c5\u7387\u306f\u307b\u307c\u540c\u3058\u3067\u3042\u3063\u305f\u3002\u75c7\u4f8b\u5150\u306f\u5bfe\u7167\u5150\uff08\u305d\u308c\u305e\u308c9\uff05\u306828\uff05\uff09\u306b\u6bd4\u3079\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u9ed2\u4eba\uff0818\uff05\uff09\u3068\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\uff0834\uff05\uff09\u306e\u5272\u5408\u304c\u9ad8\u304b\u3063\u305f\u3002<\/p>\n

Table 1. COVID-19\uff08\u75c7\u4f8b\u4e73\u5150\uff09\u3067\u5165\u9662\u3057\u3001COVID-19\uff08\u5bfe\u7167\u4e73\u5150\uff09\u3067\u5165\u9662\u3057\u3066\u3044\u306a\u3044\u751f\u5f8c6\u304b\u6708\u672a\u6e80\u306e\u4e73\u5150\u306e\u7279\u5fb4\u2014 20\u306e\u5c0f\u5150\u75c5\u9662\u300117\u306e\u5dde\u3001* 2021\u5e747\u6708\u304b\u30892022\u5e741\u6708<\/p>\n

\"\"<\/a><\/p>\n

\u3000\u75c7\u4f8b\u5150\u306e\u3046\u3061\u300143\u4eba\uff0824\uff05\uff09\u304c\u96c6\u4e2d\u6cbb\u7642\u5ba4\uff08ICU\uff09\u306b\u5165\u9662\u3057\u305f\uff08Table 2\uff09\u300225\u4f8b\uff0815\uff05\uff09\u306e\u4e73\u5150\u306f\u91cd\u75c7\u3067\u3001\u5165\u9662\u4e2d\u306b\u4eba\u5de5\u547c\u5438\u3001\u8840\u7ba1\u4f5c\u52d5\u6027\u8f38\u6db2\u3001\u4f53\u5916\u5f0f\u819c\u9178\u7d20\u7642\u6cd5\uff08ECMO\uff09\u306a\u3069\u306e\u751f\u547d\u7dad\u6301\u7642\u6cd5\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u91cd\u75c7\u4e73\u5150\u306e\u3046\u30611\u4f8b\uff080.4\uff05\uff09\u304c\u6b7b\u4ea1\u3057\u305f\u3002ICU\u306b\u5165\u9662\u3057\u305f43\u4f8b\u306e\u4e73\u5150\u306e\u3046\u3061\u300188\uff05\u306f\u6bcd\u89aa\u304c\u30ef\u30af\u30c1\u30f3\u672a\u63a5\u7a2e\u3067\u3042\u3063\u305f\u3002ECMO\u3092\u5fc5\u8981\u3068\u3057\u305f1\u4f8b\u3068\u6b7b\u4ea1\u3057\u305f1\u4f8b\u306e\u6bcd\u89aa\u306f\u3001\u3044\u305a\u308c\u3082\u30ef\u30af\u30c1\u30f3\u672a\u63a5\u7a2e\u3067\u3042\u3063\u305f\u3002<\/p>\n

Table 2. COVID-19\u3067\u5165\u9662\u3057\u305f6\u304b\u6708\u672a\u6e80\u306e\u4e73\u5150\u306e\u81e8\u5e8a\u8ee2\u5e30\u3068\u91cd\u75c7\u5ea6\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306e\u4e88\u9632\u63a5\u7a2e\u72b6\u6cc1\u5225* \u2014 20\u306e\u5c0f\u5150\u75c5\u9662\u300117\u306e\u5dde\u3001\u2020 2021\u5e747\u6708\u301c2022\u5e741\u6708
\n \"\"<\/a><\/p>\n

\u598a\u5a20\u4e2d\u306b\u6bcd\u89aa\u306e\u4e00\u6b21mRNA COVID-19\u30ef\u30af\u30c1\u30f3\u30b7\u30ea\u30fc\u30ba\u30922\u56de\u63a5\u7a2e\u3057\u305f\u5834\u5408\u306e\u30016\u30ab\u6708\u672a\u6e80\u306e\u4e73\u5150\u306eCOVID-19\u95a2\u9023\u5165\u9662\u306b\u5bfe\u3059\u308b\u6709\u52b9\u7387\u306f61%\uff0895% CI = 31%\uff5e78%\uff09 \u3067\u3042\u3063\u305f\uff08Table 3\uff09\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u6e08\u307f\u3068\u5206\u985e\u3055\u308c\u305f\u6bcd\u89aa93\u4eba\u306e\u3046\u3061\uff0c90\u4eba\uff0897\uff05\uff09\u304c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u65e5\u3092\u8a18\u9332\u3057\u3066\u3044\u305f\u3002\u598a\u5a20\u521d\u671f\uff08\u6700\u521d\u306e20\u9031\uff09\u306e2\u56de\u63a5\u7a2eCOVID-19\u30b7\u30ea\u30fc\u30ba\u306e\u52b9\u679c\u306f32\uff05\uff0895\uff05CI\uff1d-43\uff05\uff5e68\uff05\uff09\u3067\u3042\u3063\u305f\u304c\u3001\u4fe1\u983c\u533a\u9593\u304c\u5e83\u304f\u3001\u614e\u91cd\u306b\u89e3\u91c8\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u3001\u598a\u5a20\u5f8c\u671f\uff0821\u9031\uff5e\u51fa\u752314\u65e5\u524d\uff09\u306f80\uff05\uff0895\uff05CI\uff1d55\uff05\uff5e91\uff05\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

Table 3. \u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u3088\u308b\u30016\u304b\u6708\u672a\u6e80\u306e\u4e73\u5150\u306b\u304a\u3051\u308bCOVID -19\u95a2\u9023\u306e\u5165\u9662\u306b\u5bfe\u3059\u308b\u6bcd\u89aa\u306e2\u56de\u6295\u4e0e\u4e00\u6b21mRNA COVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6709\u52b9\u6027 \u2014 20\u306e\u5c0f\u5150\u75c5\u9662\u300117\u306e\u5dde\u30012021\u5e747\u6708\u301c2022\u5e741\u6708
\n \"\"<\/a><\/p>\n

Discussion
\n\u598a\u5a20\u4e2d\u306eCOVID-19\u306f\u91cd\u75c7\u5316\u304a\u3088\u3073\u6b7b\u4ea1\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001COVID-19\u3092\u6709\u3059\u308b\u598a\u5a66\u306f\u65e9\u7523\u3001\u6b7b\u7523\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u598a\u5a20\u5408\u4f75\u75c7\u3092\u7d4c\u9a13\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u91cd\u75c7\u5316\u3084\u6b7b\u4ea1\u3092\u542b\u3080COVID-19\u306e\u4e88\u9632\u306e\u305f\u3081\u306b\u3001\u598a\u5a66\u3078\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002COVID-19\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306f\u3001\u598a\u5a20\u4e2d\u306b\u884c\u3046\u3053\u3068\u3067\u5b89\u5168\u304b\u3064\u52b9\u679c\u7684\u3067\u3042\u308b\u3002\u598a\u5a20\u4e2d\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306f\u3001\u51fa\u7523\u6642\u306e\u6bcd\u4f53\u8840\u6e05\u3001\u6bcd\u4e73\u304a\u3088\u3073\u6bcd\u4f53\u6297\u4f53\u306e\u79fb\u884c\u3092\u793a\u3059\u4e73\u5150\u8840\u6e05\u3067\u6bcd\u4f53\u6297\u4f53\u304c\u691c\u51fa\u3055\u308c\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u598a\u5a20\u5f8c\u671f\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u5973\u6027\u304b\u3089\u751f\u307e\u308c\u305f\u4e73\u5150\u306eVE\u70b9\u63a8\u5b9a\u5024\u304c\u9ad8\u3044\u3053\u3068\u306f\u3001\u4e73\u5150\u306b\u4fdd\u8b77\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308bSARS-CoV-2\u7279\u7570\u7684\u6297\u4f53\u306e\u7d4c\u80ce\u76e4\u79fb\u52d5\u306e\u53ef\u80fd\u6027\u3068\u4e00\u81f4\u3059\u308b\u3002\u4e73\u5150\u3092\u4fdd\u8b77\u3059\u308b\u6297\u4f53\u304c\u79fb\u884c\u3059\u308b\u305f\u3081\u306e\u6bcd\u89aa\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u306f\u73fe\u5728\u306e\u3068\u3053\u308d\u4e0d\u660e\u3067\u3042\u308a\u3001\u4e73\u5150\u306e\u91cd\u75c7COVID-19\u306e\u4e88\u9632\u306b\u304a\u3051\u308b\u6bcd\u89aa\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u76f4\u63a5\u7684\u52b9\u679c\u306f\u3001\u3053\u308c\u307e\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3055\u3089\u306b\u3001\u73fe\u5728\u3001\u4e73\u5150\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u5bfe\u8c61\u5e74\u9f62\u3067\u306f\u306a\u304f\u3001\u4e73\u5150\u306e\u5165\u9662\u7387\u306f\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u306e\u6700\u9ad8\u30ec\u30d9\u30eb\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u672c\u7814\u7a76\u306f\u3001\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u751f\u5f8c6\u30ab\u6708\u672a\u6e80\u306e\u4e73\u5150\u3092COVID-19\u306b\u3088\u308b\u5165\u9662\u304b\u3089\u5b88\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002<\/p>\n

Limitations\u7b2c\uff11\u306b\u3001\u7279\u5b9a\u306e\u5909\u7570\u4f53\u306b\u5bfe\u3059\u308bVE\u3092\u76f4\u63a5\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\uff0e\u7b2c\uff12\u306b\u3001\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u598a\u5a20\u4e09\u671f\u5225\u306eVE\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u3044\u304f\u3064\u304b\u306e\u63a8\u5b9a\u5024\u306e\u4fe1\u983c\u533a\u9593\u304c\u5e83\u304f\u306a\u308a\u3001\u614e\u91cd\u306b\u89e3\u91c8\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u7b2c\uff13\u306b\u3001\u3053\u306e\u89e3\u6790\u3067\u306f\u3001\u598a\u5a66\u304c\u598a\u5a20\u524d\u307e\u305f\u306f\u598a\u5a20\u4e2d\u306bSARS-CoV-2\u306b\u611f\u67d3\u3057\u3066\u3044\u305f\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3057\u3066\u304a\u3089\u305a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u6bcd\u4f53\u306e\u6297\u4f53\u304c\u5f97\u3089\u308c\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u7b2c\uff14\u306b\u3001\u611f\u67d3\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u3068\u975e\u63a5\u7a2e\u8005\u306e\u6bcd\u89aa\u306e\u884c\u52d5\u306e\u9055\u3044\uff08\u6bcd\u89aa\u304c\u51fa\u751f\u524d\u30b1\u30a2\u3092\u3057\u3066\u3044\u305f\u304b\u3069\u3046\u304b\u306a\u3069\uff09\u306a\u3069\u306e\u4ea4\u7d61\u304c\u6b8b\u3063\u3066\u304a\u308a\u3001\u6f5c\u5728\u7684\u4ea4\u7d61\u56e0\u5b50\uff08\u4f8b\u3048\u3070\u3001\u6bcd\u4e73\u3001\u4fdd\u80b2\u3078\u306e\u51fa\u5e2d\u3001\u672a\u719f\u5150\uff09\u306f\u3001\u3059\u3079\u3066\u306e\u4e73\u5150\u306b\u3064\u3044\u3066\u3053\u306e\u60c5\u5831\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u30e2\u30c7\u30eb\u3067\u8aac\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3002\u7b2c\uff15\u306b\u3001\u3053\u306e\u89e3\u6790\u306b\u306f\u5c11\u6570\u306e\u53c2\u52a0\u8005\u306e\u81ea\u5df1\u5831\u544a\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u308b\u305f\u3081\u3001\u6bcd\u89aa\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u72b6\u6cc1\u304c\u5c11\u6570\u306e\u4e73\u5150\u306b\u3064\u3044\u3066\u8aa4\u3063\u3066\u5206\u985e\u3055\u308c\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u6bcd\u89aa\u304c\u598a\u5a20\u4e2d\u306bCOVID-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u5b8c\u4e86\u3057\u305f\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306e\u8a18\u61b6\u304c\u4e0d\u5b8c\u5168\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u7b2c\uff16\u306b\u3001\u6bcd\u89aa\u304c\u30d7\u30e9\u30a4\u30de\u30ea\u30fc\u30b7\u30ea\u30fc\u30ba\u3092\u5b8c\u4e86\u3059\u308b\u305f\u3081\u306b\u8ffd\u52a0\u306e mRNA COVID-19 \u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u5fc5\u8981\u3068\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u6bcd\u89aa\u306e\u514d\u75ab\u4e0d\u5168\u72b6\u614b\u304c\u53ce\u96c6\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3067\u3042\u308b\uff0e\u6700\u5f8c\u306b\u3001\u598a\u5a20\u4e2d\u306b\u53d7\u3051\u305f\u6bcd\u89aa\u306e\u30d6\u30fc\u30b9\u30bf\u30fc\u7528\u91cf\u306eVE\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u305f\u3081\u3001\u8a55\u4fa1\u3067\u304d\u306a\u304b\u3063\u305f\u3002
\n\u751f\u5f8c6\u30ab\u6708\u672a\u6e80\u306e\u5165\u9662\u4e73\u5150379\u4eba\uff08COVID-19\u3092\u63a5\u7a2e\u3057\u305f176\u4eba\uff3b\u75c7\u4f8b\u4e73\u5150\uff3d\u3001COVID-19\u3092\u63a5\u7a2e\u3057\u306a\u304b\u3063\u305f203\u4eba\uff3b\u5bfe\u7167\u4e73\u5150\uff3d\uff09\u306e\u3046\u3061\u3001\u6708\u9f62\u4e2d\u592e\u5024\u306f2\u30ab\u6708\u300121\uff05\u304c\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u57fa\u790e\u75be\u60a3\u3092\u6301\u3061\u3001\u75c7\u4f8b\u4e73\u5150\u3068\u5bfe\u7167\u4e73\u5150\u306e22\uff05\u304c\u65e9\u7523\uff08\u598a\u5a2037\u9031\u672a\u6e80\uff09\u3067\u751f\u307e\u308c\u305f\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u751f\u5f8c6\u30ab\u6708\u672a\u6e80\u306e\u4e73\u5150\u306eCOVID-19\u5165\u9662\u306b\u5bfe\u3059\u308b\u598a\u5a20\u4e2d\u306e\u6bcd\u89aa\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6709\u52b9\u6027\u306f61\uff05\uff0895\uff05CI\uff1d31\uff05-78\uff05\uff09\u3067\u3042\u3063\u305f\u3002\u598a\u5a20\u4e2d\u306b 2 \u56de\u306e mRNA COVID-19 \u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30b7\u30ea\u30fc\u30ba\u3092\u5b8c\u4e86\u3059\u308b\u3053\u3068\u3067\u3001\u751f\u5f8c 6 \u30f5\u6708\u672a\u6e80\u306e\u4e73\u5150\u306e COVID-19 \u5165\u9662\u3092\u4e88\u9632\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0eCDC\u306f\u3001\u598a\u5a20\u4e2d\u3001\u6388\u4e73\u4e2d\u3001\u73fe\u5728\u598a\u5a20\u3092\u5e0c\u671b\u3059\u308b\u5973\u6027\u3001\u307e\u305f\u306f\u5c06\u6765\u598a\u5a20\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5973\u6027\u304cCOVID-19\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3001\u6700\u65b0\u306e\u72b6\u614b\u3092\u4fdd\u3064\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112022\u5e746\u67081\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002 -\u6587\u732e\u540d- Natasha B. Halasa, MD, Effectivenes … \u7d9a\u304d\u3092\u8aad\u3080 6\u30f6\u6708\u672a\u6e80\u306e\u4e73\u5150\u306b\u304a\u3051\u308bCOVID-19\u95a2\u9023\u5165\u9662\u306b\u5bfe\u3059\u308b\u598a\u5a20\u4e2d\u306emRNACOVID-19\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u6bcd\u4f53\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6709\u52b9\u6027-17\u5dde<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33,13,10],"tags":[],"class_list":["post-2331","post","type-post","status-publish","format-standard","hentry","category-whats-new","category-13","category-10"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2331"}],"version-history":[{"count":4,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2331\/revisions"}],"predecessor-version":[{"id":2338,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2331\/revisions\/2338"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}