{"id":2341,"date":"2023-04-25T09:29:33","date_gmt":"2023-04-25T00:29:33","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2341"},"modified":"2023-04-25T09:29:33","modified_gmt":"2023-04-25T00:29:33","slug":"%e5%bf%83%e8%a1%80%e7%ae%a1%e3%83%aa%e3%82%b9%e3%82%af%e4%bd%8e%e6%b8%9b%e3%81%ae%e3%81%9f%e3%82%81%e3%81%aepcs9%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%8a%e3%82%88%e3%81%b3%e3%82%a8%e3%82%bc%e3%83%81","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2341","title":{"rendered":"\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306ePCS9\u963b\u5bb3\u85ac\u304a\u3088\u3073\u30a8\u30bc\u30c1\u30df\u30d6"},"content":{"rendered":"<p>-\u6587\u732e\u540d-<br \/>\nSafi U Khan, Siva H Yedlapati, Ahmad N Lone. PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis. BMJ 2022; 377: e069116<\/p>\n<p>-\u8981\u7d04-<br \/>\nIntroduction\uff1a<br \/>\nAHA\/ACC\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3001ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3069\u3061\u3089\u3082\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3068\u3057\u3066\u30b9\u30bf\u30c1\u30f3\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u3002\u30a8\u30bc\u30c1\u30df\u30d6\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u75c7\u3001\u307e\u305f\u306f\u6700\u5927\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u76ee\u6a19\u306eLDL-C\u3092\u9054\u6210\u3067\u304d\u306a\u3044\u60a3\u8005\u306e\u4e8c\u6b21\u6cbb\u7642\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002PCSK9\u963b\u5bb3\u85ac\u306fLDL-C\u3092\u3055\u3089\u306b\u4e0b\u3052\u308b\u5fc5\u8981\u304c\u3042\u308b\u5834\u5408\u306e\u30b9\u30c6\u30c3\u30d7\u30a2\u30c3\u30d7\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002<br \/>\n\u3000\u3053\u308c\u307e\u3067\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3068PCSK9\u963b\u5bb3\u85ac\u306e\u3001\u5358\u72ec\u307e\u305f\u306f\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u7d76\u5bfe\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u3092\u691c\u8a0e\u3057\u305f\u5927\u898f\u6a21\u8a66\u9a13\u3084\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u306a\u304b\u3063\u305f\u3002\u3053\u306e\u77e5\u8b58\u30ae\u30e3\u30c3\u30d7\u3092\u57cb\u3081\u308b\u305f\u3081\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3068\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u65bd\u3057\u305f\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u30012\u3064\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u306e\u30ea\u30b9\u30af\u5c64\u5225\u63a8\u5968\u3092\u4f34\u3046\u4e26\u884c\u81e8\u5e8a\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u8ee2\u5e30\u306b\u5bfe\u3059\u308b\u30a8\u30bc\u30c1\u30df\u30d6\u304a\u3088\u3073PCSK9\u963b\u5bb3\u85ac\u306e\u52b9\u679c\u3092\u5b9a\u91cf\u7684\u306b\u901a\u77e5\u3057\u305f\u3002<\/p>\n<p>Method\uff1a<br \/>\n\u30002020\u5e7412\u670831\u65e5\u307e\u3067\u3001Medline\u3001EMBASE\u3001Cochrane library\u3001ClinicalTrials.gov\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u4f7f\u7528\u3057\u3066\u3001\u8a00\u8a9e\u5236\u9650\u306a\u3057\u3067\u8a73\u7d30\u306a\u6587\u732e\u691c\u7d22\u3092\u5b9f\u884c\u3057\u305f\u3002\u8ffd\u52a0\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u30bd\u30fc\u30b9\u306b\u306f\u3001\u4e3b\u8981\u306a\u5fc3\u81d3\u8840\u7ba1\u304a\u3088\u3073\u533b\u5b66\u96d1\u8a8c\u306eWeb\u30b5\u30a4\u30c8\u3001\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u7814\u7a76\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u53c2\u8003\u6587\u732e\u304c\u542b\u307e\u308c\u305f\u3002\u691c\u7d22\u65b9\u6cd5\u306f\u300clipid\u300d\u300cLDL\u300d\u300ccholesterol\u300d\u300cstatin\u300d\u300cezetimibe\u300d\u300cproprotein convertase subtilisin\/kexin type 9 inhibitor\u300d\u3068\u3044\u3046\u5e45\u5e83\u3044\u691c\u7d22\u7528\u8a9e\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002<br \/>\n\u3000\u9078\u629e\u57fa\u6e96\uff1a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u95a2\u4fc2\u306a\u304f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3092\u6c42\u3081\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3LDL-C\u5024\u306e\u4e2d\u592e\u5024\u304c70mg\/dL\u306e\u60a3\u8005\u3092\u30e9\u30f3\u30c0\u30e0\u5316\u3057\u3066\u3001PCSK9\u963b\u5bb3\u85ac\u3068\u5bfe\u7167\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3068\u5bfe\u7167\u3001PCSK9\u963b\u5bb3\u85ac\u3068\u30a8\u30bc\u30c1\u30df\u30d6\u3092\u6295\u4e0e\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3001\u4fe1\u983c\u3067\u304d\u308b\u63a8\u5b9a\u5024\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306e500\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u306e\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u30686\u30f6\u6708\u4ee5\u4e0a\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u3001\u95a2\u5fc3\u306b\u5408\u81f4\u3057\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u8a66\u9a13\u3002\u4ecb\u5165\u7fa4\uff08PCSK9\u963b\u5bb3\u85ac\u307e\u305f\u306f\u30a8\u30bc\u30c1\u30df\u30d6\uff09\u304c\u5bfe\u7167\u7fa4\u3068\u306f\u7570\u306a\u308b\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u91cf\u3092\u4f53\u7cfb\u7684\u306b\u53d7\u3051\u305f\u8a66\u9a13\u306f\u9664\u5916\u3057\u305f\u3002\u91cd\u8907\u3092\u524a\u9664\u3057\u3001\u7814\u7a76\u306e\u9078\u629e\u57fa\u6e96\u306b\u5f93\u3063\u3066\u3001\u6b8b\u308a\u306e\u8a18\u4e8b\u3092\u30bf\u30a4\u30c8\u30eb\u3068\u8981\u7d04\u30ec\u30d9\u30eb\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3001\u6b21\u306b\u5168\u6587\u30ec\u30d9\u30eb\u3067\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u3002\u7814\u7a76\u306e\u691c\u7d22\u3068\u9078\u629e\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u30012\u4eba\u306e\u30ec\u30d3\u30e5\u30fc\u30a2\u30fc\u306b\u3088\u3063\u3066\u72ec\u7acb\u3057\u3066\u5b9f\u884c\u3055\u308c\u305f\u3002\u5bfe\u7acb\u306f\u5168\u3066\u3001\u8a71\u3057\u5408\u3044\u3068\u76f8\u4e92\u306e\u5408\u610f\u306b\u3088\u3063\u3066\u89e3\u6c7a\u3055\u308c\u305f\u3002<br \/>\n\u3000\u7d50\u679c\u6307\u6a19\uff1a\u81f4\u547d\u7684\u3067\u306a\u3044\u5fc3\u7b4b\u6897\u585e\u3001\u81f4\u547d\u7684\u3067\u306a\u3044\u8133\u5352\u4e2d\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u3001\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u7cfb\u306e\u6b7b\u4ea1\u306b\u3064\u3044\u30665\u5e74\u9593\u6cbb\u7642\u3055\u308c\u305f1000\u4eba\u306e\u60a3\u8005\u3042\u305f\u308a\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304a\u3088\u3073\u7d76\u5bfe\u30ea\u30b9\u30af\u304c\u542b\u307e\u308c\u305f\u3002\u69d8\u3005\u306a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7642\u6cd5\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6577\u5c45\u5024\u306b\u308f\u305f\u3063\u3066\u4e00\u5b9a\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u3092\u60f3\u5b9a\u3057\u3066\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u306e\u5dee\u3092\u63a8\u5b9a\u3057\u305f\u3002PREDICT\u30ea\u30b9\u30af\u8a08\u7b97\u306f\u3001\u4e00\u6b21\u304a\u3088\u3073\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3057\u305f\u3002<br \/>\nResults\uff1a<br \/>\n\u3000\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b83,660\u4eba\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u30a8\u30bc\u30c1\u30df\u30d6\u3068PCSK9\u963b\u5bb3\u85ac\u3092\u8a55\u4fa1\u3059\u308b14\u4ef6\u306e\u8a66\u9a13\u3092\u7279\u5b9a\u3057\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u306b\u30a8\u30bc\u30c1\u30df\u30d6\u3092\u8ffd\u52a0\u3059\u308b\u3068\u3001\u5fc3\u7b4b\u6897\u585e\uff08RR 0.87\u300195\uff05\u4fe1\u983c\u533a\u95930.80-0.94\uff09\u304a\u3088\u3073\u8133\u5352\u4e2d\uff08RR 0.82\uff080.71-0.96\uff09\uff09\u304c\u6e1b\u5c11\u3057\u305f\u304c\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\uff08RR 0.99\uff08 0.92-1.06\uff09\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\uff08RR 0.97\uff080.87-1.09\uff09\uff09\u306f\u6e1b\u5c11\u3057\u306a\u304b\u3063\u305f\u3002\u540c\u69d8\u306b\u3001PCSK9\u963b\u5bb3\u85ac\u3092\u30b9\u30bf\u30c1\u30f3\u306b\u8ffd\u52a0\u3059\u308b\u3068\u3001\u5fc3\u7b4b\u6897\u585e\uff08RR 0.81\uff080.76-0.87\uff09\uff09\u304a\u3088\u3073\u8133\u5352\u4e2d\uff08RR 0.74\uff080.64-0.85\uff09\uff09\u304c\u6e1b\u5c11\u3057\u305f\u304c\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\uff08RR 0.95\uff080.87-1.03\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\uff08RR 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\/>\nDiscussion\uff1a<br \/>\n\u3000\u30a8\u30bc\u30c1\u30df\u30d6\u307e\u305f\u306fPCSK9\u963b\u5bb3\u85ac\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044\u307e\u305f\u306f\u9ad8\u3044\u6210\u4eba\u306e\u81f4\u547d\u7684\u3067\u306a\u3044\u5fc3\u7b4b\u6897\u585e\u304a\u3088\u3073\u8133\u5352\u4e2d\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4e2d\u7b49\u5ea6\u307e\u305f\u306f\u4f4e\u3044\u60a3\u8005\u3067\u306f\u52b9\u679c\u304c\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30a8\u30bc\u30c1\u30df\u30d6\u307e\u305f\u306fPCSK9\u963b\u5bb3\u85ac\u3092\u8ffd\u52a0\u3057\u3066\u3082\u3001\u3059\u3079\u3066\u306e\u539f\u56e0\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u6b7b\u4ea1\u7387\u306b\u6709\u610f\u306a\u5f71\u97ff\u306f\u306a\u304b\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u6700\u3082\u91cd\u3044\u60a3\u8005\u3067\u5229\u76ca\u304c\u6700\u3082\u5927\u304d\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u4e2d\u7a0b\u5ea6\u304b\u3089\u4f4e\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u60a3\u8005\u3067\u306e\u81f4\u547d\u7684\u3067\u306a\u3044\u5fc3\u7b4b\u6897\u585e\u304a\u3088\u3073\u8133\u5352\u4e2d\u306e\u6e1b\u5c11\u306f\u308f\u305a\u304b\u3067\u3042\u308b\u3002\u540c\u69d8\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u6027\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30bc\u30c1\u30df\u30d6\u307e\u305f\u306fPCSK9\u963b\u5bb3\u85ac\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044\u60a3\u8005\u3068\u9ad8\u3044\u60a3\u8005\u306e\u5fc3\u7b4b\u6897\u585e\u3068\u8133\u5352\u4e2d\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112022\u5e746\u67088\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>-\u6587\u732e\u540d- Safi U Khan, Siva H Yedlapati, Ahmad N Lone. PCSK9 inhibitors and ezetimibe with or without statin thera &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=2341\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306ePCS9\u963b\u5bb3\u85ac\u304a\u3088\u3073\u30a8\u30bc\u30c1\u30df\u30d6<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2341","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2341"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2341\/revisions"}],"predecessor-version":[{"id":2344,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2341\/revisions\/2344"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}