{"id":2420,"date":"2023-09-13T15:46:59","date_gmt":"2023-09-13T06:46:59","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2420"},"modified":"2023-09-13T15:46:59","modified_gmt":"2023-09-13T06:46:59","slug":"%e7%94%9f%e6%b4%bb%e7%bf%92%e6%85%a3%e3%81%a8%e9%9d%9e%e8%aa%8d%e7%9f%a5%e7%97%87%e4%bd%99%e5%91%bd%e3%81%ae%e9%96%a2%e4%bf%82","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2420","title":{"rendered":"\u751f\u6d3b\u7fd2\u6163\u3068\u975e\u8a8d\u77e5\u75c7\u4f59\u547d\u306e\u95a2\u4fc2"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nKlodian Dhana, et al. Healthy lifestyle and life expectancy with and without Alzheimer\u2019s dementia: population based cohort study. BMJ. 2022; 377:e068390. (doi: 10.1136\/bmj-2021-068390) <\/p>\n

\uff0d\u8981\u7d04\uff0d
\nIntroduction:
\n\uf06c\t\u8fd1\u5e74\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7(AD )\u306e\u4e88\u9632\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u306f\u751f\u6d3b\u7fd2\u6163\u304c\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u9045\u3089\u305b\u3001AD\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30c7\u30fc\u30bf\u304c\u5897\u3048\u3066\u304d\u305f\u3053\u3068\u306b\u8d77\u56e0\u3059\u308b
\n\uf06c\t\u3057\u304b\u3057\u3001\u826f\u3044\u751f\u6d3b\u7fd2\u6163\u306f\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3060\u3051\u3067\u306a\u304f\u5bff\u547d\u306e\u5ef6\u9577\u306b\u3082\u3064\u306a\u304c\u308a\u3001\u5bff\u547d\u304c\u5ef6\u3073\u308c\u3070\u9ad8\u9f62\u8005\u304c\u5897\u3048\u308b\u3002\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u306f\u5e74\u9f62\u304c\u4e0a\u304c\u308b\u306b\u3064\u308c\u3066\u6307\u6570\u95a2\u6570\u7684\u306b\u5897\u52a0\u3059\u308b
\n\uf06c\t\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3078\u306e\u4ecb\u5165\u306b\u3088\u3063\u3066\u3001AD\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u306f\u53ef\u80fd\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u5168\u4f53\u306e\u6709\u75c5\u7387\u3084\u8a8d\u77e5\u75c7\u3068\u3068\u3082\u306b\u751f\u304d\u308b\u5e74\u6570\u306f\u5909\u308f\u3089\u306a\u3044\u304b\u3001\u3080\u3057\u308d\u5897\u3048\u308b\u304b\u3082\u3057\u308c\u306a\u3044
\n\uf06c\t\u305d\u3046\u3067\u3042\u308c\u3070\u3001\u533b\u7642\u5c02\u9580\u5bb6\u3001\u653f\u7b56\u7acb\u6848\u8005\u7b49\u306f\u5c06\u6765\u306e\u533b\u7642\u8cbb\u3068\u30cb\u30fc\u30ba\u3092\u5341\u5206\u306b\u8a08\u753b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b<\/p>\n

Method
\n<\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u3001\u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\u3001\u30dd\u30d4\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3>
\n\uf06c\t\u672c\u7814\u7a76\u306f\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u524d\u5411\u304d\u96c6\u56e3\u30d9\u30fc\u30b9\u30b3\u30db\u30fc\u30c8\u7814 \u7a76 \u3067 \u3042\u308bChicago Health and Aging Project\uff08CHAP\uff09\u5185\u3067\u884c\u308f\u308c\u305f
\n–\t1993\u5e74\u304b\u30892012\u5e74\u306e\u9593\u306b\u3001\u30b7\u30ab\u30b4\u5357\u90e8\u306b\u4f4f\u308065\u6b73\u4ee5\u4e0a\u5168\u54e1\u304c\u5bfe\u8c61\u306b\u306a\u308a\u3001\u5168\u5bfe\u8c61\u8005\u306e\u7d0478.7%\u306e6,157\u540d\u304cenroll\u3055\u308c\u30012000\u5e74\u306bsuccessive cohorts\u30674,645\u540d\u304c\u8ffd\u52a0\u3002Total\u306710,802\u540d\u304cenroll\u3055\u308c\u305f
\n\uf06c\t\u8a8d\u77e5\u6a5f\u80fd\u8a55\u4fa1\u306f3\u5e74\u6bce\u306b\u6700\u59276\u56de\u5b9f\u65bd\u3055\u308c\u3001AD free\u306fin home\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u3068\u81e8\u5e8a\u8a55\u4fa1\u306e\u7d50\u679c\u8a8d\u5b9a\u3055\u308c\u305f
\n\uf06c\t\u4eca\u56de\u306e\u89e3\u6790\u3067\u306f2,110\u540d\u306eAD free\u3068339\u540d\u306eAD\u60a3\u8005\u306etotal 2449\u540d\u304c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u3002<\/p>\n

<\u751f\u6d3b\u7fd2\u6163\u56e0\u5b50\u306e\u30a2\u30bb\u30b9\u30e1\u30f3\u30c8>
\n\uf06c\t5\u3064\u306e\u751f\u6d3b\u7fd2\u6163\u56e0\u5b50(\u2460\u98df\u4e8b\uff08Mediterranean-DASH Diet Intervention for Neurodegenerative Delay\uff3bMIND\uff3d\u98df\u4e8b\u30b9\u30b3\u30a2\uff09\u3001\u2461\u8a8d\u77e5\u7684\u6d3b\u52d5\u3001\u2462\u4e2d\uff5e\u5f37\u5ea6\u306e\u8eab\u4f53\u6d3b\u52d5\u3001\u2463\u7981\u7159\u3001\u2464\u4e2d\u7a0b\u5ea6\u4ee5\u4e0b\u306e\u98f2\u9152)\u306b\u3064\u3044\u3066\u3001\u6709\u3059\u308b\u5834\u5408\u306f1\u70b9, \u6709\u3057\u306a\u3044\u5834\u5408\u306f0\u70b9\u3067total 5\u70b9\u3067\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0
\n–\t\u2460\u98df\u4e8b\u306f\u3001MIND score \u4e0a\u4f4d40%(\u6982\u306dMIND score >7.5)\u30921\u70b9\u3068\u3057\u305f
\n–\t\u2461\u8a8d\u77e5\u6d3b\u52d5\u306f\u3001\u904e\u53bb~\u73fe\u5728\u306e\u8aad\u66f8\u3001\u7f8e\u8853\u9928\u8a2a\u554f\u3001\u30ab\u30fc\u30c9\u30b2\u30fc\u30e0\u3001\u30dc\u30fc\u30c9\u30b2\u30fc\u30e0(checkers)\u3001\u30af\u30ed\u30b9\u30ef\u30fc\u30c9\u3001\u30d1\u30ba\u30eb\u304b\u3089\u306a\u308bcognitive activity score\u306b\u57fa\u3065\u3044\u3066\u3001\u4e0a\u4f4d40%\u4ee5\u4e0a\u30921\u70b9\u3068\u3057\u305f
\n–\t\u2462\u8eab\u4f53\u6d3b\u52d5\u306f\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3001\u30ac\u30fc\u30c7\u30cb\u30f3\u30b0\u3001\u4f53\u64cd\u3001\u81ea\u8ee2\u8eca\u3001\u6c34\u6cf3\u3067\u3042\u308b\u3002\u9031150\u5206\u4ee5\u4e0a\u30671\u70b9
\n–\t\u2463\u55ab\u7159\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u5438\u3063\u3066\u3044\u306a\u3051\u308c\u30701\u70b9
\n–\t\u2464\u98f2\u9152\u306f\u3001\u7537\u6027\u306f30g \/\u65e5\u4ee5\u4e0b\u3001\u5973\u6027\u306f15g \/\u65e5\u4ee5\u4e0b\u30671\u70b9(\u7f36\u30d3\u30fc\u30eb\u306a\u30892\u672cor 1\u672c)<\/p>\n

<\u7d71\u8a08\u5b66\u7684\u5206\u6790>
\n\uf06c\tMultistate life table\u3092\u7528\u3044\u305f\u5206\u6790\u3092\u884c\u3063\u305f
\n–\tAD free\u2192AD\u3001AD free\u2192death\u3001AD\u2192death\u306e3\u3064\u306e\u305d\u308c\u305e\u308c\u306etransition\u30d1\u30bf\u30fc\u30f3\u306b\u3064\u3044\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u6bce\u306e\u7537\u5973\u5225\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u751f\u5b58\u5206\u6790\u3067\u5206\u6790
\n–\t\u56de\u5e30\u30e2\u30c7\u30eb\u306f\u5e74\u9f62\u3001\u4eba\u7a2e\u3001\u914d\u5076\u8005\u306e\u6709\u7121\u3001\u6559\u80b2\u3001APOE \u03b54\u5909\u7570\u306e\u6709\u7121\u3001\u4f75\u5b58\u75be\u60a3\u3067\u8abf\u6574
\n–\t\u5168\u4eba\u53e3\u306b\u5bfe\u3059\u308b\u751f\u547d\u8868\u3068 \u3001\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u56e0\u5b50\u306e\u6570\uff080\uff5e1\u30012\uff5e3\u30014\uff5e5\u70b9\uff09\u3054\u3068\u306b3\u3064\u306e\u751f\u547d\u8868\u3092\u4f5c\u6210<\/p>\n

<\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u8a3a\u65ad>
\n\uf06c\tCognitive performance test\u306e 2\u3064\u4ee5\u4e0a\u306e\u6a5f\u80fd\u306e\u969c\u5bb3\u3068\u3001\u795e\u7d4c\u79d1\u533b\u304c\u5224\u65ad\u3059\u308b\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304cAD\u306e\u8a3a\u65ad\u306b\u5fc5\u8981\u3068\u3057\u305f
\n\uf06c\tAD\u8a3a\u65ad\u306f\u3001NINCDS(National institute of Neurological and Communicative Disorders and Stroke)\u304a\u3088\u3073ADRDA(the Alzheimer\u2019s Disease and Related Disorders Association)\u306eprobable Alzheimer’s disease\u306e\u57fa\u6e96\u306b\u3088\u308a\u5224\u5b9a<\/p>\n


\n\uf06c\t\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u304c\u3042\u308b\u5834\u5408\u3068\u306a\u3044 \u5834\u5408\u306e\u5973\u6027\u304a\u3088\u3073\u7537\u6027\u306e\u5e73\u5747\u4f59\u547d<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

(Martha C.M. et al., Alzheimers Dement. 2015 Sep; 11(9): 1015\u20131022. doi: 10.1016\/j.jalz.2015.04.011)<\/p>\n

Result<\/strong><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

Discussion
\n\uf06c\t\u672c\u7814\u7a76\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u56e0\u5b50\u306e\u4f59\u547d\u3060\u3051\u3067\u306a\u304f\u975e\u8a8d\u77e5\u75c7\u4f59\u547d\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8003\u616e\u3059\u308b\u305f\u3081\u306e\u5b9a\u91cf\u7684\u30c7\u30fc\u30bf\u3092\u4f9b\u7d66\u3059\u308b\u3068\u3044\u3046\u610f\u5473\u3067\u4fa1\u5024\u304c\u3042\u308b
\n\uf06c\t\u65e2\u5b58\u7814\u7a76\u3067\u6559\u80b2\u30ec\u30d9\u30eb\u306e\u9ad8\u3044\u4eba\u306e\u975e\u8a8d\u77e5\u75c7\u4f59\u547d\u304c\u9577\u3044\u3068\u3044\u3046study\u3082\u3042\u308b\u304c\u3001\u4eca\u56de\u306f\u6559\u80b2\u30ec\u30d9\u30eb\u3067\u8abf\u6574\u3092\u884c\u3063\u305f\u4e0a\u3067\u3001\u751f\u6d3b\u7fd2\u6163\u7b49\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u306e\u975e\u8a8d\u77e5\u75c7\u4f59\u547d\u3078\u306e\u5f71\u97ff\u306b\u8a00\u53ca\u3057\u305f\u8ad6\u6587\u3067\u3042\u308b\u3053\u3068\u3082\u7279\u5fb4
\n\uf06c\tLimitation\u3068\u3057\u3066\u306f\u3001\u2460\u751f\u6d3b\u7fd2\u6163\u56e0\u5b50\u306e\u8a55\u4fa1\u304cbaseline\u3057\u304b\u3067\u304d\u3066\u304a\u3089\u305a\u3001\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u4e2d\u306b\u306f\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u305d\u306e\u5f8c\u306e\u5909\u5316\u3084\u3001\u8a8d\u77e5\u75c7\u306b\u3088\u308b\u751f\u6d3b\u7fd2\u6163\u306e\u5909\u5316\u3092\u6349\u3048\u3089\u308c\u3066\u3044\u306a\u3044\u3001\u2461\u4e0d\u5065\u5eb7\u306a\u4eba\u306fstudy\u306b\u53c2\u52a0\u3057\u306a\u304b\u3063\u305f\u308a\u53c2\u52a0\u307e\u3067\u306b\u6b7b\u4ea1\u3057\u3066\u3044\u308b\u983b\u5ea6\u304c\u591a\u3044\u3068\u8003\u3048\u3089\u308c\u3001\u4e0d\u5065\u5eb7\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u3082\u3064\u4eba\u3005\u306epopulation\u3092\u904e\u5c0f\u8a55\u4fa1\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3001\u2462\u751f\u6d3b\u7fd2\u6163\u306e\u8a55\u4fa1\u306f\u81ea\u5df1\u7533\u544a\u5236\u3067\u3042\u308b\u3053\u3068\u3001\u7b49\u304c\u3042\u308b<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112022\u5e7410\u670812\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Klodian Dhana, et al. Healthy lifestyle and life expectancy with and without Alzheimer\u2019s dementia: popul … \u7d9a\u304d\u3092\u8aad\u3080 \u751f\u6d3b\u7fd2\u6163\u3068\u975e\u8a8d\u77e5\u75c7\u4f59\u547d\u306e\u95a2\u4fc2<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,11],"tags":[],"class_list":["post-2420","post","type-post","status-publish","format-standard","hentry","category-5","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2420"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2420\/revisions"}],"predecessor-version":[{"id":2427,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2420\/revisions\/2427"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}