{"id":2428,"date":"2023-09-13T15:49:43","date_gmt":"2023-09-13T06:49:43","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2428"},"modified":"2023-09-13T15:49:43","modified_gmt":"2023-09-13T06:49:43","slug":"%e4%ba%ba%e5%b7%a5%e7%94%98%e5%91%b3%e6%96%99%e3%81%a8%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%81%ae%e3%83%aa%e3%82%b9%e3%82%af","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2428","title":{"rendered":"\u4eba\u5de5\u7518\u5473\u6599\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nCharlotte Debras, 2 Eloi Chazelas, Laury Sellem. Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Sant\u00e9 cohort. BMJ 2022; 378: e071204<\/p>\n

\uff0d\u8981\u7d04\uff0d
\nIntroduction\uff1a
\n\u3000WHO\u306f\u30011\u65e5\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u306e\u3046\u3061\u904a\u96e2\u7cd6\uff08\u5358\u7cd6\u985e\u304a\u3088\u3073\u4e8c\u7cd6\u985e\uff09\u306e\u5272\u5408\u30925\uff05\u672a\u6e80\u306b\u3059\u308b\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u3002\u6dfb\u52a0\u7cd6\u306e\u4ee3\u66ff\u3068\u3057\u3066\u767b\u5834\u3057\u305f\u4eba\u5de5\u7518\u5473\u6599\u306f\u3001\u7802\u7cd6\u3092\u4f7f\u308f\u306a\u304f\u3066\u3082\u7518\u307f\u3092\u518d\u73fe\u3067\u304d\u308b\u305f\u3081\u3001\u904a\u96e2\u7cd6\u306e\u30ab\u30ed\u30ea\u30fc\u3092\u6291\u3048\u3001\u6d88\u8cbb\u8005\u306b\u9ad8\u304f\u8a55\u4fa1\u3055\u308c\u305f\u3002\u5404\u4eba\u5de5\u7518\u5473\u6599\u306e\u8a31\u5bb9\u53ef\u80fd\u306a1\u65e5\u63a5\u7a2e\u91cf\u306f\u3001\u6b27\u5dde\u98df\u54c1\u5b89\u5168\u6a5f\u95a2\uff08EFSA\uff09\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u3001\u307e\u305f\u306f\u98df\u54c1\u6dfb\u52a0\u7269\u306b\u95a2\u3059\u308b\u5408\u540c\u5c02\u9580\u5bb6\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u308c\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u305d\u308c\u3089\u306f\u4f9d\u7136\u3068\u3057\u3066\u8ad6\u4e89\u306e\u7684\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u73fe\u5728EFSA\u3084WHO\u3092\u542b\u3080\u3044\u304f\u3064\u304b\u306e\u4fdd\u5065\u5f53\u5c40\u306b\u3088\u308b\u518d\u8a55\u4fa1\u3092\u53d7\u3051\u3066\u3044\u308b\u3002
\n\u3000\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001\u4eba\u5de5\u7518\u5473\u6599\u3092\u542b\u3080\u98f2\u6599\u306e\u6442\u53d6\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5897\u52a0\u306e\u5f71\u97ff\u304c\u793a\u5506\u3055\u308c\u305f\u304c\u3001\u3053\u308c\u3089\u306e\u95a2\u9023\u6027\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u30ec\u30d9\u30eb\u306fWHO\u306b\u3088\u3063\u3066\u4f4e\u3044\u3068\u898b\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u4eba\u5de5\u7518\u5473\u6599\u5165\u308a\u98f2\u6599\u306f\u4eba\u5de5\u7518\u5473\u6599\u306e\u7dcf\u6442\u53d6\u91cf\u306e\u4e00\u90e8\u306b\u904e\u304e\u306a\u3044\u305f\u3081\u3001\u56e0\u679c\u95a2\u4fc2\u7814\u7a76\u3067\u306f\u3059\u3079\u3066\u306e\u98df\u4e8b\u6e90\u3092\u8003\u5bdf\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002
\n\u3000\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u5b9a\u91cf\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3066\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u3001\u3059\u3079\u3066\u306e\u98df\u4e8b\u6e90\u304b\u3089\u306e\u4eba\u5de5\u7518\u5473\u6599\u306e\u5168\u4f53\u7684\u306a\u95a2\u9023\u6027\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u3068\u3057\u305f\u3002<\/p>\n

Method\uff1a
\n\u3000\u53c2\u52a0\u8005\u306f\u3001\u30a6\u30a7\u30d6\u30d9\u30fc\u30b9\u306eNutriNet-Sant\u00e9\u30b3\u30db\u30fc\u30c8\u306e103,388\u4eba\u306e\u53c2\u52a0\u8005(\u5e73\u5747\u5e74\u9f62 42.2\u00b114.4\u3001\u5973\u6027 79.8%\u3001904,206 \u4eba\u5e74)\u3002\u4eba\u5de5\u7518\u5473\u6599\u306e\u98df\u4e8b\u6442\u53d6\u91cf\u3068\u6d88\u8cbb\u91cf\u306f\u3001\u5de5\u696d\u88fd\u54c1\u306e\u30d6\u30e9\u30f3\u30c9\u540d\u3092\u542b\u3080 24 \u6642\u9593\u306e\u7e70\u308a\u8fd4\u3057\u306e\u98df\u4e8b\u8a18\u9332\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002
\n\u3000\u4e3b\u306a\u7d50\u679c\u306f\u3001\u7518\u5473\u6599 (\u9023\u7d9a\u5909\u6570\u3068\u3057\u3066\u30b3\u30fc\u30c9\u5316\u3055\u308c\u3001log10 \u5909\u63db) \u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027\u3092\u6e2c\u5b9a\u3057\u3001\u591a\u5909\u6570\u8abf\u6574 Cox \u30cf\u30b6\u30fc\u30c9 \u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002<\/p>\n

Results\uff1a
\n\u3000\u4eba\u5de5\u7518\u5473\u6599\u306e\u7dcf\u6442\u53d6\u91cf\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f (1502 \u4ef6\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4 1.09\u300195% \u4fe1\u983c\u533a\u9593 1.01 \uff5e 1.18\u3001P = 0.03)\u3002\u9ad8\u6d88\u8cbb\u8005\uff08\u6027\u5225\u306e\u4e2d\u592e\u5024\u3092\u8d85\u3048\u308b\uff09\u3068\u975e\u6d88\u8cbb\u8005\u306e\u7d76\u5bfe\u767a\u751f\u7387\u306f\u3001\u305d\u308c\u305e\u308c10\u4e07\u4eba\u5e74\u3042\u305f\u308a346\u3068314\u3060\u3063\u305f\u3002\u4eba\u5de5\u7518\u5473\u6599\u306f\u3001\u8133\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3068\u7279\u306b\u95a2\u9023\u3057\u3066\u3044\u305f (777 \u30a4\u30d9\u30f3\u30c8\u30011.18\u30011.06 \uff5e 1.31\u3001P = 0.002; \u767a\u751f\u7387\u306f\u3001\u9ad8\u6240\u5f97\u8005\u304a\u3088\u3073\u975e\u6d88\u8cbb\u8005\u3067\u305d\u308c\u305e\u308c 10 \u4e07\u4eba\u5e74\u3042\u305f\u308a 195 \u304a\u3088\u3073 150)\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306e\u6442\u53d6\u306f\u3001\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f (1.17\u30011.03 \u304b\u3089 1.33\u3001P=0.02; \u9ad8\u5024\u8005\u304a\u3088\u3073\u975e\u6d88\u8cbb\u8005\u306b\u304a\u3051\u308b\u767a\u751f\u7387\u306f\u3001\u305d\u308c\u305e\u308c 100,000 \u4eba\u5e74\u5f53\u305f\u308a 186 \u304a\u3088\u3073 151)\u3002<\/p>\n

Discussion\uff1a
\n\u3000NutriNet-Sant\u00e9 \u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001\u4eba\u5de5\u7518\u5473\u6599\u306e\u7dcf\u6442\u53d6\u91cf\u306f\u3001\u5168\u4f53\u7684\u306a CVD \u304a\u3088\u3073\u8133\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u30a2\u30b9\u30d1\u30eb\u30c6\u30fc\u30e0\u306e\u6442\u53d6\u306f\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3001\u30a2\u30bb\u30b9\u30eb\u30d5\u30a1\u30e0\u30ab\u30ea\u30a6\u30e0\u3068\u30b9\u30af\u30e9\u30ed\u30fc\u30b9\u306f\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u8ffd\u52a0\u306e\u7802\u7cd6\u3092\u4eba\u5de5\u7518\u5473\u6599\u306b\u7f6e\u304d\u63db\u3048\u3066\u3082 CVD \u306e\u7d50\u679c\u306b\u5229\u76ca\u304c\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002
\n\u3000\u3053\u306e\u7814\u7a76\u306f\u3001\u5927\u898f\u6a21\u306a\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba (n=103,388) \u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u3059\u3079\u3066\u306e\u98df\u4e8b\u6e90\u304b\u3089\u306e\u4eba\u5de5\u7518\u5473\u6599\u306e\u6442\u53d6\u3068 CVD \u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u6027\u3092\u524d\u5411\u304d\u306b\u8abf\u67fb\u3057\u305f\u3002\u98df\u4e8b\u6442\u53d6\u91cf\u3092\u5b8c\u5168\u306b\u6e2c\u5b9a\u3059\u308b\u65b9\u6cd5\u306f\u306a\u3044\u305f\u3081\u3001\u5206\u985e\u30d0\u30a4\u30a2\u30b9\u3092\u6392\u9664\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u305f\u3060\u3057\u3001\u3053\u306e\u7814\u7a76\u3067\u884c\u308f\u308c\u305f\u4eba\u5de5\u7518\u5473\u6599\u6d88\u8cbb\u91cf\u306e\u8a55\u4fa1\u306f\u3001\u5927\u898f\u6a21\u306a\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u500b\u4eba\u30ec\u30d9\u30eb\u3067\u306e\u5305\u62ec\u7684\u306a\u8a55\u4fa1\u3060\u3063\u305f\u3002NutriNet-Sant\u00e9 \u7814\u7a76\u306f\u3001\u6b63\u78ba\u3067\u8cea\u306e\u9ad8\u3044\u98df\u4e8b\u30c7\u30fc\u30bf\u3092\u5099\u3048\u305f\u75ab\u5b66\u30b3\u30db\u30fc\u30c8\u3067\u3042\u308b\u3002\u98df\u4e8b\u306e\u8a18\u9332\u306f\u3001\u8a13\u7df4\u3092\u53d7\u3051\u305f\u6804\u990a\u58eb\u3068\u306e\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u306b\u3088\u3063\u3066\u4ee5\u524d\u306b\u691c\u8a3c\u3055\u308c\u3066\u304a\u308a33\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u6804\u990a\u7d20\u306e\u6442\u53d6\u91cf\u306b\u95a2\u3059\u308b\u8840\u6db2\u3068\u5c3f\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u5bfe\u3057\u3066\u691c\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002\u4e16\u754c\u4e2d\u306e\u75ab\u5b66\u7814\u7a76\u3067\u306f\u3001\u4e00\u822c\u7684\u306b\u98df\u4e8b\u983b\u5ea6\u30a2\u30f3\u30b1\u30fc\u30c8(24 \u6642\u9593\u7e70\u308a\u8fd4\u3057\u305f\u98df\u4e8b\u8a18\u9332\u3088\u308a\u3082\u7cbe\u5ea6\u304c\u4f4e\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b)\u3001\u307e\u305f\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306e\u9650\u3089\u308c\u305f\u6570\u306e\u8a18\u9332\u307e\u305f\u306f\u30ea\u30b3\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u3010\u958b\u50ac\u65e5\u30112022\u5e7410\u670812\u65e5(\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Charlotte Debras, 2 Eloi Chazelas, Laury Sellem. Artificial sweeteners and risk of cardiovascular diseas … \u7d9a\u304d\u3092\u8aad\u3080 \u4eba\u5de5\u7518\u5473\u6599\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[],"class_list":["post-2428","post","type-post","status-publish","format-standard","hentry","category-5","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2428"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2428\/revisions"}],"predecessor-version":[{"id":2431,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2428\/revisions\/2431"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}