{"id":2443,"date":"2023-09-27T13:53:32","date_gmt":"2023-09-27T04:53:32","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2443"},"modified":"2023-09-27T13:53:32","modified_gmt":"2023-09-27T04:53:32","slug":"ef%e3%81%ae%e4%bf%9d%e3%81%9f%e3%82%8c%e3%81%9f%e5%bf%83%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85hfpef%e3%81%ab%e5%af%be%e3%81%99%e3%82%8bsglt2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%ae%e5%8a%b9%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2443","title":{"rendered":"EF\u306e\u4fdd\u305f\u308c\u305f\u5fc3\u4e0d\u5168\u60a3\u8005(HFpEF)\u306b\u5bfe\u3059\u308bSGLT2\u963b\u5bb3\u85ac\u306e\u52b9\u679c"},"content":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015<br \/>\nEmpagliflozin in Heart Failure with a Preserved Ejection Fraction Stefan D. Anker N Engl J Med 2021; 385:1451-1461<\/p>\n<p>\u2015\u8981\u7d04\u2015<br \/>\n\u3010\u80cc\u666f\u3011<br \/>\nSGLT2\u963b\u5bb3\u5264\u306f\u3001\u99c6\u51fa\u7387\u4f4e\u4e0b\u3092\u4f34\u3046\u60a3\u8005\u306e\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u304c\u3001\u5fc3\u4e0d\u5168\u3068\u99c6\u51fa\u7387\u306e\u4fdd\u6301\u3092\u4f34\u3046\u60a3\u8005\u3078\u306e\u5f71\u97ff\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002<br \/>\n\u3010\u65b9\u6cd5\u3011<br \/>\n\u3053\u306e\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001NYHA\u30af\u30e9\u30b9 II \uff5e IV \u306eEF40% \u3092\u8d85\u3048\u308b\u5fc3\u4e0d\u5168\u60a3\u8005 5,988 \u4eba\u3092\u3001\u901a\u5e38\u306e\u6cbb\u7642\u306b\u52a0\u3048\u3066\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3 (\u5546\u54c1\u540d\u30b8\u30e3\u30c7\u30a3\u30a2\u30f3\u30b91 \u65e51 \u56de 10 mg) \u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u30a2\u30a6\u30c8\u30ab\u30e0\u3067\u3042\u308b\u3002<br \/>\n\u3010\u7d50\u679c\u3011figure1,figure3,table2<br \/>\n\u4e2d\u592e\u5024 26.2 \u30f6\u6708\u3067\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u306e\u60a3\u8005 2997 \u4eba\u4e2d 415 \u4eba (13.8%)\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u60a3\u8005 2991 \u4eba\u4e2d 511 \u4eba (17.1%) \u3067\u4e3b\u8981\u8ee2\u5e30\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f (\u30cf\u30b6\u30fc\u30c9\u6bd4 0.79\uff1a95% \u4fe1\u983c\u533a\u9593 0.69 \uff5e 0.90\uff1aP < 0.001)\u3002\u3053\u306e\u52b9\u679c\u306f\u4e3b\u306b\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u306e\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u52b9\u679c\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u60a3\u8005\u3067\u4e00\u8cab\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u305f\u3002\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u7dcf\u6570\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u306e\u65b9\u304c\u5c11\u306a\u304b\u3063\u305f (\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067 407 \u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u3067 541 \u4eba; \u30cf\u30b6\u30fc\u30c9\u6bd4 0.73\uff1a95% \u4fe1\u983c\u533a\u9593 0.61 \uff5e 0.88\uff1a P<0.001)\u3002\u5408\u4f75\u75c7\u306e\u306a\u3044\u751f\u6b96\u5668\u304a\u3088\u3073\u5c3f\u8def\u611f\u67d3\u75c7\u3068\u4f4e\u8840\u5727\u304c\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067\u3088\u308a\u983b\u7e41\u306b\u5831\u544a\u3055\u308c\u305f\u3002\n\u3010\u7d50\u8ad6\u3011 \n\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u99c6\u51fa\u7387\u304c\u4fdd\u6301\u3055\u308c\u3066\u3044\u308b\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\n\u3010limitation\u3011\n\u30fb\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3084\u5168\u6b7b\u4ea1\u306b\u306f\u6709\u610f\u5dee\u304c\u306a\u3044\n\u30fb\u4ee5\u524d\u306eARNI\u306eHFpEF\u60a3\u8005\u306b\u5bfe\u3059\u308b\u8a66\u9a13(\u60a3\u8005\u96c6\u56e3\u30fb\u89b3\u5bdf\u671f\u9593\u304c\u540c\u7b49)\u3067\u3082\u5fc3\u8840\u7ba1\u6b7b\u3068\u5fc3\u4e0d\u5168\u5165\u9662\u306e\u7d50\u679c\u306b\u5dee\u304c\u3042\u308b\n\u30fb\u6b7b\u4ea1\u4ee5\u5916\u306e\u4e2d\u65ad\u4f8b\u304c\u5168\u4f53\u306e23%\u3042\u308a\u3001\u6709\u610f\u5dee\u3092\u306a\u304f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\n\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/7b897fa8a118b2ec1ef145eddd8ef134.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/7b897fa8a118b2ec1ef145eddd8ef134.png\" alt=\"\" width=\"532\" height=\"711\" class=\"aligncenter size-full wp-image-2444\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/7b897fa8a118b2ec1ef145eddd8ef134.png 532w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/7b897fa8a118b2ec1ef145eddd8ef134-224x300.png 224w\" sizes=\"auto, (max-width: 532px) 100vw, 532px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/8981fff5c4e437ff3d3c1059f44c1f79.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/8981fff5c4e437ff3d3c1059f44c1f79.png\" alt=\"\" width=\"495\" height=\"349\" class=\"aligncenter size-full wp-image-2445\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/8981fff5c4e437ff3d3c1059f44c1f79.png 495w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/8981fff5c4e437ff3d3c1059f44c1f79-300x212.png 300w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/2df805d4462726d7639cdbac892f5991.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/2df805d4462726d7639cdbac892f5991.png\" alt=\"\" width=\"736\" height=\"457\" class=\"aligncenter size-full wp-image-2446\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/2df805d4462726d7639cdbac892f5991.png 736w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/2df805d4462726d7639cdbac892f5991-300x186.png 300w\" sizes=\"auto, (max-width: 736px) 100vw, 736px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/ab18366668b17ccdb47fcd0d40a6a01d.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/ab18366668b17ccdb47fcd0d40a6a01d.png\" alt=\"\" width=\"517\" height=\"681\" class=\"aligncenter size-full wp-image-2447\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/ab18366668b17ccdb47fcd0d40a6a01d.png 517w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/ab18366668b17ccdb47fcd0d40a6a01d-228x300.png 228w\" sizes=\"auto, (max-width: 517px) 100vw, 517px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/45edf5bc41a8a95b8d2103cd1206fb0c.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/45edf5bc41a8a95b8d2103cd1206fb0c.png\" alt=\"\" width=\"503\" height=\"344\" class=\"aligncenter size-full wp-image-2448\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/45edf5bc41a8a95b8d2103cd1206fb0c.png 503w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/09\/45edf5bc41a8a95b8d2103cd1206fb0c-300x205.png 300w\" sizes=\"auto, (max-width: 503px) 100vw, 503px\" \/><\/a><\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112022\u5e7411\u67089\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015 Empagliflozin in Heart Failure with a Preserved Ejection Fraction Stefan D. Anker N Engl J Med 2021; 385 &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=2443\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">EF\u306e\u4fdd\u305f\u308c\u305f\u5fc3\u4e0d\u5168\u60a3\u8005(HFpEF)\u306b\u5bfe\u3059\u308bSGLT2\u963b\u5bb3\u85ac\u306e\u52b9\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2443","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2443"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2443\/revisions"}],"predecessor-version":[{"id":2450,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2443\/revisions\/2450"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}