{"id":2457,"date":"2023-10-12T09:10:04","date_gmt":"2023-10-12T00:10:04","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2457"},"modified":"2023-10-12T09:10:04","modified_gmt":"2023-10-12T00:10:04","slug":"%e6%9b%b4%e5%b9%b4%e6%9c%9f%e9%9a%9c%e5%ae%b3%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e8%a1%80%e7%ae%a1%e9%81%8b%e5%8b%95%e7%97%87%e7%8a%b6%e3%81%ab%e5%af%be%e3%81%97%e3%81%a6%e3%81%aessri-vs-snri","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2457","title":{"rendered":"\u66f4\u5e74\u671f\u969c\u5bb3\u306b\u304a\u3051\u308b\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u306eSSRI vs SNRI"},"content":{"rendered":"

\u2015\u6587\u732e\u540d-
\nLaura Morton Newhouser. SSRIs vs. SNRIs for Vasomotor Symptoms of Menopause. Am Fam Physician. 2022 Apr 1; 105(4): 430-431.<\/p>\n

\u2015\u8981\u7d04-
\nQ.
\nSSRI\u3068SNRI\u306f\u66f4\u5e74\u671f\u306e\u8840\u7ba1\u904b\u52d5\u6027\u969c\u5bb3\u306e\u6cbb\u7642\u306b\u6709\u52b9\u304b\uff1f
\nA.
\nSSRI\u3068SNRI\u306f\u3069\u3061\u3089\u3082\u66f4\u5e74\u671f\u306e\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u3092\u7de9\u548c\u3059\u308b\u306e\u306b\u6709\u52b9\u3067\u3042\u308b\u3002(\u63a8\u5968\u5ea6A)
\n2\u3064\u306e\u30af\u30e9\u30b9\u306e\u85ac\u7269\u3092\u76f4\u63a5\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u306f\u306a\u3044\u3002SNRI\u306f\u3088\u308a\u591a\u304f\u306e\u6709\u5bb3\u4f5c\u7528\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002SSRI\u306f\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306e\u4ee3\u8b1d\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u4e73\u304c\u3093\u306e\u5973\u6027\u306b\u306f\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3(\u30a4\u30d5\u30a7\u30af\u30b5\u30fc)\u304c\u597d\u307e\u308c\u308b\u3002<\/p>\n

2015\u5e74\u306eSR\u3067\u306f\u300127\u301c78\u6b73\u306e\u5973\u60273490\u540d\u3092\u5bfe\u8c61\u306b\u3001\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u306b\u5bfe\u3059\u308bSSRI\u3068SNRI\u306e\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002\uff08\u300c\u307b\u3066\u308a\u300d\u56de\u6570\u306f0\u301c50\u56de\/\u9031\uff09\u6d3b\u52d5\u6027\u304c\u3093\u60a3\u8005\u3001\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u3001\u6297\u3046\u3064\u85ac\u3001\u7cbe\u795e\u4f5c\u7528\u306e\u3042\u308b\u85ac\u5264\u3092\u5185\u670d\u3057\u3066\u3044\u308b\u4eba\u306f\u9664\u5916\u3055\u308c\u3066\u3044\u308b\u3002\u30d9\u30f3\u30d5\u30a1\u30e9\u30ad\u30b7\u30f3\u304cSNRI\u306e\u7b2c\u4e00\u9078\u629e\u3067\u3001\u52b9\u679c\u767a\u73fe\u304c\u6700\u3082\u65e9\u304f\u3001(1\u9031\u9593\u307e\u3067\u306b\u5358\u72ec\u306741%\u6e1b\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u306626%\u6e1b\u3001P<0.001) \u5410\u304d\u6c17\u3001\u53e3\u6e07\u3001\u4fbf\u79d8\u306a\u3069\u306e\u526f\u4f5c\u7528\u3082\u3088\u308a\u983b\u7e41\u306b\u307f\u3089\u308c\u305f\u3002SSRI\u306e\u30d1\u30ed\u30ad\u30bb\u30c1\u30f3(\u30d1\u30ad\u30b7\u30eb)\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305f\u5834\u5408\u3001\u307b\u3066\u308a\u3092\u6700\u3082\u8efd\u6e1b\u3057\u305f\uff0810mg\u306740.6\uff05\u300120mg\u306751.7\uff05\uff1b\u305d\u308c\u305e\u308cP =0 .0006\u304a\u3088\u3073P = 0.002\uff09\u3002\n\n 2020\u5e74\u306e4\u3064\u306eRCT\u306e\u691c\u8a0e\u3067\u306fSNRI\u3084SSRI\u3092\u542b\u30806\u3064\u306e\u4ecb\u5165\u304c\u691c\u8a0e\u3055\u308c\u305f\u3002\u3082\u3063\u3068\u3082\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u3092\u6539\u5584\u3057\u305f\u306e\u306f\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3060\u3063\u305f\u304c\u3001\u3064\u3044\u3067SNRI\u3067\u3042\u308b\u30d9\u30f3\u30d5\u30a1\u30e9\u30ad\u30b7\u30f3\u304c\u52b9\u679c\u3092\u307f\u3068\u3081\u305f\u3002\n14\u56de\u4ee5\u4e0a\u306e\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\/\u9031\u3092\u6709\u3059\u308b\u9589\u7d4c\u524d\u5f8c\u5973\u60271005\u4eba\u304c\u5bfe\u8c61\u3002\u4ecb\u5165\u306f\u3001\u30a8\u30b9\u30b7\u30bf\u30ed\u30e9\u30e0(\u30ec\u30af\u30b5\u30d7\u30ed)10\uff5e20mg\/\u65e5\u3001\u30e8\u30ac\u3001\u6709\u9178\u7d20\u904b\u52d5\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u91781.8g\/\u65e5\u300117-\u03b2-\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb0.5mg\/\u65e5\u3001\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3XR75mg\/\u65e5\u3001\u4e0d\u7720\u75c7\u306e\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5(CBT-I)\u3067\u3042\u3063\u305f\u3002\u30a2\u30a6\u30c8\u30ab\u30e0\u8a55\u4fa1\u306b\u306f\u3001Menopause-related Quality of Life scale(MENQOL)\u304a\u3088\u3073\u305d\u306e\u30b5\u30d6\u30b9\u30b1\u30fc\u30eb\u3092\u7528\u3044\u305f\u3002\u7d50\u679c\u3068\u3057\u3066\u306f\u3001\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3001\u30a8\u30b9\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u3001\u4e0d\u7720\u75c7\u306e\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5\u3001\u30e8\u30ac\u3067\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306eMENQOL\u5168\u4f53\u306e\u6709\u610f\u306a\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u3082\u3063\u3068\u3082\u52b9\u679c\u304c\u9ad8\u304b\u3063\u305f(\u30b9\u30b1\u30fc\u30eb\u306e\u5927\u304d\u306a\u6539\u5584\u304c\u307f\u3089\u308c\u305f)\u306e\u306f\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3067\u3042\u3063\u305f\u3002\u7d50\u8ad6\u3068\u3057\u3066\u306f\u3001\u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u3001\u66f4\u5e74\u671f\u969c\u5bb3\u306b\u95a2\u9023\u3057\u305fQOL\u6539\u5584\u306e\u305f\u3081\u306b\u3001\u5973\u6027\u306f\u81ea\u8eab\u306e\u75c7\u72b6\u3084\u597d\u307f\u306b\u5fdc\u3058\u3066\u69d8\u3005\u306a\u6cbb\u7642\u6226\u7565\u304b\u3089\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002\n\uff08\u65e5\u672c\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u30a8\u30b9\u30e9\u30b8\u30aa\u30fc\u30eb\u306f\u30a8\u30b9\u30c8\u30e9\u30fc\u30ca\u30c6\u30fc\u30d70.72mg\u30922\u65e5\u3054\u3068\u8cbc\u308a\u66ff\u3048\uff09\n\"\"<\/a><\/p>\n

\u5317\u7c73\u66f4\u5e74\u671f\u5b66\u4f1a\u306e2015\u5e74\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u30dd\u30b8\u30b7\u30e7\u30f3\u30da\u30fc\u30d1\u30fc\u3067\u306f\u3001\u66f4\u5e74\u671f\u306e\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u306e\u6cbb\u7642\u306b\u3064\u3044\u3066\u3001\u3044\u304f\u3064\u304b\u306e\u7570\u306a\u308b\u975e\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u306e\u9078\u629e\u80a2\u3092\u691c\u8a0e\u3057\u305f\u3002\u5b66\u4f1a\u306f\u3001SSRI\u3068SNRI\u306e\u4e21\u65b9\u304c\u751f\u7406\u7684\u66f4\u5e74\u671f\u75c7\u72b6(\u52a0\u9f62\u306b\u3088\u308b\u3082\u306e)\u304a\u3088\u3073\u5916\u79d1\u7684\u66f4\u5e74\u671f\u75c7\u72b6(\u5916\u79d1\u624b\u8853\u5f8c)\u3092\u5927\u5e45\u306b\u7de9\u548c\u3059\u308b\u3068\u7d50\u8ad6\u3065\u3051\u305f\u3002SSRI\u3067\u306f\u30d1\u30ed\u30ad\u30bb\u30c1\u30f3(\u30d1\u30ad\u30b7\u30eb\uff1a10\u301c25mg\/\u65e5)\u3001\u30a8\u30b9\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0(\u30ec\u30af\u30b5\u30d7\u30ed\uff1a10\u301c20mg\/\u65e5)\u3001\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0(\u30bb\u30ec\u30af\u30b5\uff1a10\u301c20mg\/\u65e5)\u304c\u6700\u3082\u75c7\u72b6\u3092\u8efd\u6e1b\u3057\u3001SNRI\u3067\u306f\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3(\u30a4\u30d5\u30a7\u30af\u30b5\u30fc\uff1a37.5\u301c150mg\/\u65e5)\u3068\u30c7\u30b9\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3(\u30d7\u30ea\u30b9\u30c6\u30a3\u30c3\u30af\uff1a100\u301c150mg\/\u65e5)\u304c\u6709\u610f\u306b\u4f5c\u7528\u3057\u305f\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002SSRI\u306f\u521d\u671f\u306e\u526f\u4f5c\u7528\uff08\u7279\u306b\u5410\u304d\u6c17\u3068\u3081\u307e\u3044\uff09\u304c\u5c11\u306a\u3044\u304c\u3001\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306e\u4ee3\u8b1d\u3092\u640d\u306a\u3046\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u305f\u3002\u3053\u306e\u305f\u3081\u3001\u4e73\u764c\u306e\u65e2\u5f80\u304c\u3042\u308b\u5973\u6027\u306b\u306f\u30d9\u30f3\u30e9\u30d5\u30a1\u30ad\u30b7\u30f3\u304c\u597d\u307e\u308c\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u3010\u958b\u50ac\u65e5\u30112022\u5e7412\u670814\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u2015\u6587\u732e\u540d- Laura Morton Newhouser. SSRIs vs. SNRIs for Vasomotor Symptoms of Menopause. Am Fam Physician. 2022 Apr … \u7d9a\u304d\u3092\u8aad\u3080 \u66f4\u5e74\u671f\u969c\u5bb3\u306b\u304a\u3051\u308b\u8840\u7ba1\u904b\u52d5\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u306eSSRI vs SNRI<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-2457","post","type-post","status-publish","format-standard","hentry","category-13"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2457"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2457\/revisions"}],"predecessor-version":[{"id":2460,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2457\/revisions\/2460"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}