{"id":2471,"date":"2023-11-09T10:38:21","date_gmt":"2023-11-09T01:38:21","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2471"},"modified":"2023-11-09T10:38:21","modified_gmt":"2023-11-09T01:38:21","slug":"%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%84%9f%e6%9f%93%e7%97%87%e3%81%ae%e9%9d%9e%e5%85%a5%e9%99%a2%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2471","title":{"rendered":"\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u975e\u5165\u9662\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u60a3\u8005\u306b\u304a\u3051\u308b\u30cb\u30eb\u30de\u30c8\u30eb\u30d3\u30eb\u304a\u3088\u3073\u30ea\u30c8\u30ca\u30d3\u30eb\u306e\u7d4c\u53e3\u6295\u4e0e\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015<br \/>\nSarju Ganatra, Sourbha S Dani, Javaria Ahmad, Ashish Kumar, Jui Shah, George M Abraham, Daniel P McQuillen, Robert M Wachter, Paul E Sax, Oral Nirmatrelvir and Ritonavir in Nonhospitalized Vaccinated Patients With Coronavirus Disease 2019 (COVID-19), Clinical Infectious Diseases, 2022;, ciac673<\/p>\n<p>\u2015\u8981\u7d04-<br \/>\nIntroduction\uff1a<br \/>\nCOVID-19\u306e\u6cbb\u7642\u306b\u30cb\u30eb\u30de\u30c8\u30ec\u30eb\u30d3\u30eb\u3068\u30ea\u30c8\u30ca\u30d3\u30eb\uff08NMV-r\uff09\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5165\u9662\u3057\u3066\u3044\u306a\u3044\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u30cf\u30a4\u30ea\u30b9\u30af\u60a3\u8005\u3092\u6cbb\u7642\u3059\u308b\u3068\u3001\u91cd\u75c7\u5316\u3059\u308b\u30ea\u30b9\u30af\u304c\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3051\u308b NMV-r \u306e\u6f5c\u5728\u7684\u306a\u5229\u70b9\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>Method\uff1a<br \/>\nTriNetX \u7814\u7a76\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u7528\u3044\u3066\u3001\u6bd4\u8f03\u5f8c\u65b9\u8996\u7684\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u305f\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3001\u5c11\u306a\u304f\u3068\u30821\u30f6\u6708\u5f8c\u306bCOVID-19\u3092\u767a\u75c7\u3057\u305f18\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\uff082021\u5e7412\u67081\u65e5\u304b\u30892022\u5e744\u670818\u65e5\u306e\u9593\uff09\u3002\u8a3a\u65ad\u5f8c 5 \u65e5\u4ee5\u5185\u306e NMV-r \u306e\u4f7f\u7528\u306b\u57fa\u3065\u3044\u3066\u30b3\u30db\u30fc\u30c8\u3092\u4f5c\u6210\u3057\u305f\u3002\u4e3b\u8981\u8907\u5408\u8ee2\u5e30\u306f\uff0c30 \u65e5\u306e\u8ffd\u8de1\u8abf\u67fb\u6642\u306e\u5168\u539f\u56e0\u6551\u6025\u5ba4\uff08ER\uff09\u53d7\u8a3a\uff0c\u5165\u9662\uff0c\u6b7b\u4ea1\u3068\u3057\u305f\uff0e\u526f\u6b21\u7684\u8ee2\u5e30\u306b\u306f\uff0c\u4e3b\u8981\u8ee2\u5e30\u306e\u500b\u3005\u306e\u8981\u7d20\uff0c\u591a\u7cfb\u7d71\u306e\u75c7\u72b6\uff0cCOVID-19 \u306b\u95a2\u9023\u3059\u308b\u5408\u4f75\u75c7\uff0c\u8a3a\u65ad\u691c\u67fb\u306e\u5229\u7528\u304c\u542b\u307e\u308c\u305f\uff0e\uff08\u8907\u5408\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308b\u5168\u539f\u56e0ER\u53d7\u8a3a\u3001\u5165\u9662\u3001\u6b7b\u4ea1\u306e\u5404\u8981\u7d20\u3002COVID-19\u306e\u8a3a\u65ad\u304b\u308930\u65e5\u4ee5\u5185\u306e\u3055\u307e\u3056\u307e\u306a\u5168\u8eab\u304a\u3088\u3073\u975e\u7279\u7570\u7684\u75c7\u72b6\uff08\u4f53\u8cea\u3001\u5fc3\u80ba\u3001\u6d88\u5316\u5668\u3001\u795e\u7d4c\u7cfb\u304a\u3088\u3073\u7b4b\u9aa8\u683c\u7cfb\u75c7\u72b6\u3001\u306b\u304a\u3044\uff0f\u5473\u899a\u5909\u5316\uff09\u3001\u5168\u8eab\u5408\u4f75\u75c7\uff08\u5fc3\u8840\u7ba1\u7cfb\u3001\u547c\u5438\u5668\u3001\u6d88\u5316\u5668\u3001\u6c17\u5206\u969c\u5bb3\uff09\u3001\u8a3a\u65ad\u691c\u67fb\uff08\u653e\u5c04\u7dda\u8a3a\u65ad\u691c\u67fb\u3001\u5fc3\u8840\u7ba1\u8a3a\u65ad\u691c\u67fb\uff3b\u5fc3\u30a8\u30b3\u30fc\u56f3\u304a\u3088\u3073\u5fc3\u81d3\u30ea\u30ba\u30e0\u30e2\u30cb\u30bf\u30fc\uff3d\uff09\u5b9f\u65bd\u7387\uff09\u3002Figure1<\/p>\n<p>COVID-19\u3092\u767a\u75c7\u3057\u305f\u975e\u5165\u9662\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u60a3\u8005\u3092\uff0c\u8a3a\u65ad\u5f8c5\u65e5\u4ee5\u5185\u306eNMV-r\u306e\u4f7f\u7528\u306b\u57fa\u3065\u3044\u30662\u3064\u306e\u30b3\u30db\u30fc\u30c8\u306b\u5206\u3051\u305f\uff0eNMV-r\u3092\u4f7f\u7528\u3057\u305f\u30b3\u30db\u30fc\u30c8\u3068NMV-r\u3092\u4f7f\u7528\u3057\u306a\u304b\u3063\u305f\u30b3\u30db\u30fc\u30c8\u3067\u3042\u308b\uff0e\u9023\u7d9a\u5909\u6570\u306b\u3064\u3044\u3066\u306f\u72ec\u7acb\u6a19\u672c\u306et\u691c\u5b9a\u3092\u7528\u3044\u3066\u30b3\u30db\u30fc\u30c8\u3092\u6bd4\u8f03\u3057\u3001\u5e73\u5747\u5024\uff08\u7bc4\u56f2\uff09\u3068\u3057\u3066\u5831\u544a\u3057\u305f\u3002\u30ab\u30c6\u30b4\u30ea\u30fc\u5909\u6570\u306f\u30ab\u30a6\u30f3\u30c8\uff08%\uff09\u3067\u5831\u544a\u3057\u3001\u30ab\u30a4\u4e8c\u4e57\uff08\u03c72\uff09\u691c\u5b9a\u3067\u6bd4\u8f03\u3057\u305f\u3002\u60a3\u8005\u30b3\u30db\u30fc\u30c8\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u9055\u3044\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u30010.1\u30d7\u30fc\u30eb\u306e\u6a19\u6e96\u5dee\uff08SD\uff09\u306e\u30ad\u30e3\u30ea\u30d1\u30fc\u3067\u8caa\u6b32\u306a\u6700\u8fd1\u508d\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u4f7f\u7528\u3059\u308b\u7d44\u307f\u8fbc\u307f\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u6d3b\u7528\u3057\u3066\u3001\u81e8\u5e8a\u7684\u306b\u95a2\u9023\u6027\u306e\u3042\u308b\u7279\u6027\u306b\u3064\u3044\u30661\uff1a1 PSM\u304c\u5b9f\u884c\u3055\u308c\u305f\u3002\u30b3\u30db\u30fc\u30c8\u9593\u306e\u6a19\u6e96\u5316\u5e73\u5747\u5dee\u304c0.1\u3088\u308a\u5c0f\u3055\u3044\u7279\u6027\u306f\u3001\u3088\u304f\u30de\u30c3\u30c1\u3057\u3066\u3044\u308b\u3068\u307f\u306a\u3055\u308c\u305f\u3002\u50be\u5411\u30de\u30c3\u30c1\u30f3\u30b0\u5f8c\u3001\u95a2\u9023\u6027\u306e\u5c3a\u5ea6\u3068\u3057\u3066\u03c72\u691c\u5b9a\u3092\u7528\u3044\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u306695\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u4ed8\u304d\u306e\u30aa\u30c3\u30ba\u6bd4\uff08OR\uff09\u3092\u7b97\u51fa\u3057\u305f\u3002\u76f8\u5bfe\u7684\u30ea\u30b9\u30af\u4f4e\u6e1b\u306f\u3001\u6cbb\u7642\u7fa4\uff08NMV-r\uff09\u3068\u5bfe\u7167\u7fa4\uff08\u975eNMV-r\uff09\u306e\u9593\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u4f4e\u6e1b\u3092\u5bfe\u7167\u7fa4\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u3067\u5272\u3063\u305f\u3082\u306e\u3068\u3057\u3066\u7b97\u51fa\u3057\u305f\u3002\u751f\u5b58\u89e3\u6790\u306f\u3001\u30ed\u30b0\u30e9\u30f3\u30af\u691c\u5b9a\u306b\u3088\u308bKaplan-Meier\u66f2\u7dda\u306e\u30d7\u30ed\u30c3\u30c8\u3068\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306e\u7b97\u51fa\u306b\u3088\u308a\u30012\u3064\u306e\u30b3\u30db\u30fc\u30c8\u3092\u6bd4\u8f03\u3057\u305f\u3002\u7d71\u8a08\u7684\u6709\u610f\u6027\u306f\u3001\u4e21\u5074P\u5024\u304c0.05\u672a\u6e80\u3068\u3057\u305f\u3002\u7d71\u8a08\u89e3\u6790\u306f\u3001R for statistical computing\uff08R Foundation for Statistical Computing\uff09\u3092\u4f7f\u7528\u3057\u305fTriNetX\u30aa\u30f3\u30e9\u30a4\u30f3\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3067\u5b8c\u4e86\u3057\u305f\u3002<\/p>\n<p>\u611f\u5ea6\u5206\u6790\u3068\u3057\u3066\u3001\u89b3\u5bdf\u7814\u7a76\u306b\u304a\u3051\u308b\u672a\u6e2c\u5b9a\u306e\u4ea4\u7d61\u56e0\u5b50\u3084\u7701\u7565\u3055\u308c\u305f\u5171\u5909\u91cf\u306b\u3088\u308b\u30d0\u30a4\u30a2\u30b9\u306b\u5bfe\u3059\u308b\u9811\u5065\u6027\u3092\u78ba\u8a8d\u3059\u308b\u6307\u6a19\u3067\u3042\u308bE\u5024\u3092\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u4e21\u65b9\u306b\u3064\u3044\u3066\u6e2c\u5b9a\u3057\u305f[13]\u3002E\u5024\u304c\u9ad8\u3044\u307b\u3069\u3001\u5171\u5909\u91cf\u306e\u52b9\u679c\u63a8\u5b9a\u5024\u3092\u5426\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u3088\u308a\u5f37\u3044\u672a\u6e2c\u5b9a\u306e\u4ea4\u7d61\u56e0\u5b50\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3001\u56e0\u679c\u95a2\u4fc2\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308b\u3002<\/p>\n<p>\u60a3\u8005\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u3092table1\u306b\u793a\u3057\u307e\u3059\u3002PSM \u306e\u5f8c\u30012 \u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u306f\u985e\u4f3c\u3057\u3066\u304a\u308a\u3001\u6b8b\u7559\u4e0d\u5747\u8861\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f (\u542b\u307e\u308c\u308b\u5171\u5909\u91cf\u306e\u6a19\u6e96\u5dee &lt;0.1)<\/p>\n<p>Results\uff1a<br \/>\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0<br \/>\nNMV-r \u30b3\u30db\u30fc\u30c8\u306e 89 \u4eba (7.87%) \u306e\u60a3\u8005\u3068\u975e NMV-r \u30b3\u30db\u30fc\u30c8\u306e 163 \u4eba (14.4%) \u306e\u60a3\u8005\u3067\u300130 \u65e5\u9593\u306e\u3059\u3079\u3066\u306e\u539f\u56e0\u306b\u3088\u308b ER \u8a2a\u554f\u3001\u5165\u9662\u3001\u307e\u305f\u306f\u6b7b\u4ea1\u306e\u4e3b\u8981\u306a\u8907\u5408\u7d50\u679c\u304c\u767a\u751f\u3057\u307e\u3057\u305f (OR: .5; 95% CI: .39\u2013.67; P \u2009&lt; .005)\u300145% \u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u4e00\u81f4\u3057\u307e\u3059(Table 2)\u3002\u3055\u3089\u306b\u3001NMV-r \u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306f\u300130 \u65e5\u9593\u306e\u7121\u75c5\u751f\u5b58\u7387\u304c\u9ad8\u304b\u3063\u305f (88.15% vs 84.16%; HR: .67; 95% CI: .52, .87; P \u2009= .002) (Figure 2).<\/p>\n<p>\u526f\u6b21\u7684\u30a2\u30a6\u30c8\u30ab\u30e0<br \/>\n\u5168\u539f\u56e0\u3001ER\u8a2a\u554f\uff0882 vs 142; OR: .55; 95% CI: .41-.73; P &lt; .05\uff09\u304a\u3088\u3073\u5165\u9662\uff0810 vs 23; OR: .43; 95% CI: .2-.9; P = .02\uff09\u306f\u3001COVID-19\u60a3\u8005\u306b\u304a\u3044\u3066NMV-r\u3092\u53d7\u3051\u305f\u7fa4\u306b\u6709\u610f\u5dee\u304c\u307f\u3089\u308c\u305f\u300210\u4eba\u306e\u6b7b\u4ea1\u304c\u8a8d\u3081\u3089\u308c\u305f\u304c\u3001\u3059\u3079\u3066NMV-r\u3092\u6295\u4e0e\u3057\u3066\u3044\u306a\u3044\u30b3\u30db\u30fc\u30c8\u3067\u3001NMV-r\u3092\u6295\u4e0e\u3057\u305f\u7fa4\u3067\u306f\u6b7b\u4ea1\u306f\u306a\u304b\u3063\u305f\uff08P &lt; .05\uff09(Table 2)\u3002NMV-r\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3067\u306f\u3001\u4f53\u8cea\u3001\u5fc3\u80ba\u3001\u80c3\u8178\u3001\u795e\u7d4c\u3001\u7b4b\u9aa8\u683c\u7cfb\u306e\u75c7\u72b6\u304c\u5c11\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u55c5\u899a\u30fb\u5473\u899a\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u306f\u30012\u3064\u306e\u30b3\u30db\u30fc\u30c8\u9593\u3067\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u4e0b\u6c17\u9053\u611f\u67d3\u75c7\u3001\u4e0d\u6574\u8108\u3001\u4e0d\u5b89\u30fb\u6c17\u5206\u969c\u5bb3\u306a\u3069\u306e\u5168\u8eab\u6027\u5408\u4f75\u75c7\u306f\u3001NMV-r\u306e\u30b3\u30db\u30fc\u30c8\u3067\u306f\u975eNMV-r\u306e\u30b3\u30db\u30fc\u30c8\u306b\u6bd4\u3079\u3066\u3088\u308a\u5c11\u306a\u3044\u983b\u5ea6\u3067\u307f\u3089\u308c\u305f\u3002\u80c3\u8178\u708e\u3001\u5927\u8178\u708e\u3001\u4e0b\u75e2\u306e\u767a\u751f\u306b\u306f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001NMV-r\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306f\u3001NMV-r\u3092\u6295\u4e0e\u3055\u308c\u306a\u304b\u3063\u305f\u60a3\u8005\u306b\u6bd4\u3079\u3001\u653e\u5c04\u7dda\u8a3a\u65ad\u691c\u67fb\u306e\u5229\u7528\u304c\u5c11\u306a\u304b\u3063\u305f\u3002\u5fc3\u8840\u7ba1\u8a3a\u65ad\u691c\u67fb\u306f\u3001\u4e21\u30b3\u30db\u30fc\u30c8\u3067\u307b\u307c\u540c\u3058\u3067\u3042\u3063\u305f(Table 2, Figure 3)\u3002<\/p>\n<p>Discussion\uff1a\u672c\u7814\u7a76\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u304c\u3042\u308b\u3002\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u50be\u5411\u30de\u30c3\u30c1\u30f3\u30b0\u3092\u7528\u3044\u3066\u6cbb\u7642\u7fa4\u3068\u975e\u6cbb\u7642\u7fa4\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5dee\u3092\u614e\u91cd\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u52aa\u529b\u3092\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u6e2c\u5b9a\u4e0d\u80fd\u306a\u4ea4\u7d61\u304c\u7d50\u679c\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u611f\u5ea6\u5206\u6790\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u3053\u306e\u77e5\u898b\u306f\u6e2c\u5b9a\u4e0d\u80fd\u306a\u4ea4\u7d61\u56e0\u5b50\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u53ef\u80fd\u6027\u306f\u6975\u3081\u3066\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u96fb\u5b50\u30ab\u30eb\u30c6\u304b\u3089\u53ce\u96c6\u3055\u308c\u305f\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u30c7\u30fc\u30bf\u306f\u5fc5\u305a\u3057\u3082\u6b63\u78ba\u3067\u306f\u306a\u3044\u304c\u3001\u3088\u308a\u5ba2\u89b3\u7684\u306a\u81e8\u5e8a\u691c\u67fb\u7d50\u679c\u3092\u5165\u624b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3002\u30ef\u30af\u30c1\u30f3\u3084\u81e8\u5e8a\u7d50\u679c\u3092\u542b\u3080\u81e8\u5e8a\u30c7\u30fc\u30bf\u306f\u3001\u3053\u306e\u7814\u7a76\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u53c2\u52a0\u3057\u3066\u3044\u308b\u533b\u7642\u6a5f\u95a2\u4ee5\u5916\u306e\u60a3\u8005\u3067\u3082\u767a\u751f\u3057\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3082\u3057\u305d\u3046\u3067\u3042\u308c\u3070\u3001\u305d\u306e\u3088\u3046\u306a\u60a3\u8005\u306f\u8aa4\u3063\u3066\u5206\u985e\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u5236\u9650\u306f\u3001\u304a\u305d\u3089\u304f\u6cbb\u7642\u7fa4\u3068\u672a\u6cbb\u7642\u7fa4\u306e\u4e21\u65b9\u306b\u9069\u7528\u3055\u308c\u308b\u3067\u3057\u3087\u3046\u3002COVID-19\u306b\u76f4\u63a5\u95a2\u9023\u3059\u308b\u5165\u9662\u3092\u6271\u3063\u305fEPIC-HR\u8a66\u9a13\u3068\u306f\u7570\u306a\u308a\u3001\u3053\u3053\u3067\u306f\u539f\u56e0\u5225\u306e\u8ee2\u5e30\u3067\u306f\u306a\u304f\u3001\u5168\u539f\u56e0\u5165\u9662\u3001ER\u8a2a\u554f\u3001\u6b7b\u4ea1\u7387\u3092\u8a55\u4fa1\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\uff0cCOVID-19\u306b\u95a2\u9023\u3057\u306a\u3044\u75be\u60a3\u306b\u3088\u3063\u3066\u751f\u3058\u305f\u53ef\u80fd\u6027\u3082\u3042\u308b\u304c\uff0c\u81e8\u5e8a\u306e\u73fe\u5834\u3067\u3082\uff0c\u7279\u306b\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u304c\u75c5\u72b6\u3092\u4e0d\u5b89\u5b9a\u306b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u5185\u79d1\u7684\u5408\u4f75\u75c7\u3092\u6301\u3064\u60a3\u8005\u306b\u304a\u3044\u3066\uff0cCOVID-19\u304c\u5165\u9662\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u306e\u304b\uff0c\u5076\u767a\u7684\u306a\u6240\u898b\u306a\u306e\u304b\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u306a\u5834\u5408\u304c\u3042\u308b\u3002ER\u3078\u306e\u8a2a\u554f\u306f\u30d7\u30e9\u30a4\u30de\u30ea\u30fc\u30b1\u30a2\u3078\u306e\u30a2\u30af\u30bb\u30b9\u306b\u5f71\u97ff\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u60a3\u8005\u304cNMV-r\u306e\u51e6\u65b9\u3092\u53d7\u3051\u305f\u5834\u6240\u304b\u3082\u3057\u308c\u306a\u3044\u305f\u3081\u3001\u5165\u9662\u307e\u305f\u306f\u6b7b\u4ea1\u306e\u307f\u3092\u5bfe\u8c61\u3068\u3057\u305f\u611f\u5ea6\u5206\u6790\u3067\u3082NMV-r\u306e\u6709\u76ca\u6027\u306f\u540c\u7b49\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p>\u4ee5\u4e0a\u3088\u308a\uff0cCOVID-19\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u60a3\u8005\u306b\u304a\u3051\u308bNMV-r\u306e\u8a55\u4fa1\u306f\uff0c\u6cbb\u7642\u3068ER\u8a2a\u554f\uff0c\u5165\u9662\uff0c\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u4f4e\u6e1b\u3068\u306e\u9593\u306b\u5f37\u3044\u95a2\u9023\u3092\u793a\u3057\u305f\uff0eCOVID-19\u306e\u75c7\u4f8b\u306f\uff0c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u666e\u53ca\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u4f9d\u7136\u3068\u3057\u3066\u767a\u751f\u3057\u3066\u304a\u308a\uff0c\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\uff0c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\uff0c\u3053\u306e\u8106\u5f31\u306a\u96c6\u56e3\u306b\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\uff0e\u3055\u307e\u3056\u307e\u306a\u60a3\u8005\u96c6\u56e3\u306b\u304a\u3051\u308bNMV-r\u306e\u7d99\u7d9a\u7684\u306a\u524d\u5411\u304d\u81e8\u5e8a\u8a66\u9a13\u306b\u3088\u308a\u3001\u6cbb\u7642\u306e\u5229\u70b9\u3068\u5371\u967a\u6027\u304c\u3088\u308a\u6b63\u78ba\u306b\u5b9a\u7fa9\u3055\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Figure 1<br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2473\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-scaled.jpg\" alt=\"\" width=\"2560\" height=\"2389\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-scaled.jpg 2560w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-300x280.jpg 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-1024x956.jpg 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-768x717.jpg 768w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-1536x1433.jpg 1536w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/744333f10c9f6c125b4add55a226a8fc-2048x1911.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/a><\/p>\n<p>TriNetX \u7814\u7a76\u30cd\u30c3\u30c8\u30ef\u30fc\u30af \uff08n=88,651,969 ; HCO 59)<br \/>\n2021\u5e7412\u67081\u65e5\uff5e2022\u5e744\u670818\u65e5\u306bSARS-CoV-2\u611f\u67d3\u307e\u305f\u306fCovid-19\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\uff08\u63a5\u7a2e\u5f8c\u5c11\u306a\u304f\u3068\u30821\u30f6\u6708\u4ee5\u4e0a\u7d4c\u904e\u3057\u305f\u60a3\u8005\uff09\u306e\u3046\u3061\u3001\u5bfe\u8c61\u57fa\u6e96\u3092\u6e80\u305f\u3055\u306a\u3044\u60a3\u8005\uff08n=88,404,729)<br \/>\n\u226718\u6b73\u4ee5\u4e0a\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u304c\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c1\u30f6\u6708\u4ee5\u4e0a\u7d4c\u904e\u3057\u305f\u6642\u70b9\u3067SARS-CoV-2\u611f\u67d3\u967d\u6027\u307e\u305f\u306fCovid-19\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5834\u5408\uff08n=231,098\u3001HCOs 40)<br \/>\n\u521d\u56de\u5165\u9662\u304c\u5fc5\u8981\u306a\u60a3\u8005\u3001\u307e\u305f\u306f\u56de\u5fa9\u671f\u8840\u6f3f\u3001\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3001\u30e2\u30eb\u30cc\u30d4\u30e9\u30d3\u30eb\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005(n=119,510)<br \/>\n\u5165\u9662\u305b\u305a\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\uff0cSARS-CoV-2\u611f\u67d3\u307e\u305f\u306fCovid-19\u306e\u691c\u67fb\u3067\u967d\u6027\u3068\u306a\u308a\uff0c5\u65e5\u4ee5\u5185\u306bNMV-r\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u306a\u304b\u3063\u305f\u8005\uff08n=110,457; HCO 37)<br \/>\n\u5165\u9662\u305b\u305a\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3001SARS-COV-2\u611f\u67d3\u307e\u305f\u306fCovid-19\u304c\u967d\u6027\u3067\u30015\u65e5\u4ee5\u5185\u306bNMV-r\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\uff08n=1,131\u3001HCO 12)<\/p>\n<p>&nbsp;<\/p>\n<p>Table 1\u3000Baseline Characteristics<br \/>\n\uff08<a href=\"https:\/\/academic.oup.com\/view-large\/396236081\">\u3053\u3061\u3089\u306e\u30ea\u30f3\u30af<\/a>\u3088\u308a\uff09<\/p>\n<p>Table 2.<br \/>\nOutcomes Comparison at 30 Days<br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/b8a6bdcc88924c2978abce4eef696cc9.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2474\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/b8a6bdcc88924c2978abce4eef696cc9.jpeg\" alt=\"\" width=\"520\" height=\"263\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/b8a6bdcc88924c2978abce4eef696cc9.jpeg 520w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/b8a6bdcc88924c2978abce4eef696cc9-300x152.jpeg 300w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/a><\/p>\n<p>Figure 3. This forest plot demonstrates the odds ratios with 95% confidence intervals for primary and secondary &#8230;<br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-2475\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1252\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-scaled.jpg 2560w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-300x147.jpg 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-1024x501.jpg 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-768x376.jpg 768w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-1536x751.jpg 1536w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2023\/11\/41c51bd6f4807077836a10254ba21f4f-2048x1002.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/a><\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112023\u5e742\u67081\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2015\u6587\u732e\u540d\u2015 Sarju Ganatra, Sourbha S Dani, Javaria Ahmad, Ashish Kumar, Jui Shah, George M Abraham, Daniel P McQuill &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=2471\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u975e\u5165\u9662\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u60a3\u8005\u306b\u304a\u3051\u308b\u30cb\u30eb\u30de\u30c8\u30eb\u30d3\u30eb\u304a\u3088\u3073\u30ea\u30c8\u30ca\u30d3\u30eb\u306e\u7d4c\u53e3\u6295\u4e0e\u306b\u3064\u3044\u3066<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,15],"tags":[],"class_list":["post-2471","post","type-post","status-publish","format-standard","hentry","category-19","category-15"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2471"}],"version-history":[{"count":5,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2471\/revisions"}],"predecessor-version":[{"id":2480,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2471\/revisions\/2480"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2471"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}