{"id":2481,"date":"2023-11-09T11:21:31","date_gmt":"2023-11-09T02:21:31","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2481"},"modified":"2023-11-09T11:21:31","modified_gmt":"2023-11-09T02:21:31","slug":"%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%81%a5%e5%ba%b7%e7%9a%84%e3%81%aa%e3%83%a9%e3%82%a4%e3%83%95%e3%82%b9%e3%82%bf%e3%83%ab%e3%81%a8%e8%a8%98%e6%86%b6%e5%8a%9b%e4%bd%8e","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2481","title":{"rendered":"\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30eb\u3068\u8a18\u61b6\u529b\u4f4e\u4e0b\u306e\u95a2\u9023\u6027\uff1a10\u5e74\u9593\u306e\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76"},"content":{"rendered":"

\u2015\u6587\u732e\u540d-
\nJianping Jia,1 Tan Zhao,1 Zhaojun Liu, et al.
\nAssociation between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.
\nBMJ. 2023; 380: e072691<\/p>\n

\u2015\u8981\u7d04-
\n\u3010\u80cc\u666f\u3011
\n\u308f\u304b\u3063\u3066\u3044\u308b\u3053\u3068\uff1a\u8a18\u61b6\u529b\u306f\u65e5\u5e38\u751f\u6d3b\u306e\u57fa\u672c\u6a5f\u80fd\u3067\u3042\u308a\u3001\u5e74\u9f62\u304c\u4e0a\u304c\u308b\u306b\u3064\u308c\u3066\u7d99\u7d9a\u7684\u306b\u4f4e\u4e0b\u3059\u308b\u3002 \u8a18\u61b6\u529b\u4f4e\u4e0b\u306e \u591a\u56e0\u5b50\u306b\u308f\u305f\u308b\u751f\u7269\u5b66\u7684\u539f\u56e0\u3092\u8003\u3048\u308b\u3068\u3001\u907a\u4f1d\u7684\u306b\u8a18\u61b6\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u4eba\u3067\u3042\u3063\u3066\u3082\u3001\u6700\u9069\u306a\u52b9\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u306f\u3001 \u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u8981\u56e0\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u5fc5\u8981\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u8a18\u61b6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u56e0\u5b50\u3068\u3057\u3066\u3001\u52a0 \u9f62\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d E\uff08APOE\uff09\u03b54 \u907a\u4f1d\u5b50\u578b\u3001\u6162\u6027\u75be\u60a3\u3001\u751f\u6d3b\u30d1\u30bf\u30fc\u30f3\u306a\u3069\u306e\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u4eca\u56de\u308f\u304b\u3063\u305f\u3053\u3068\uff1aAPOE\u03b54 \u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\u4eba\u3092\u542b\u3081\u3001\u8a8d\u77e5\u7684\u306b\u6b63\u5e38\u306a\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001\u5065\u5eb7\u7684\u3067\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u884c \u52d5\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u8a18\u61b6\u306e\u4f4e\u4e0b\u901f\u5ea6\u3092\u9045\u304f\u3059\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u308b \u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u9ad8\u9f62\u8005\u3092\u8a18\u61b6\u306e\u4f4e\u4e0b\u304b\u3089\u5b88\u308b\u305f\u3081 \u306e\u516c\u8846\u885b\u751f\u4e0a\u306e\u53d6\u308a\u7d44\u307f\u306b\u91cd\u8981\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n

\u3010\u76ee\u7684\u3011 \u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u8a18\u61b6\u529b\u4f4e\u4e0b\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306e\u6700\u9069\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002
\n\u3010\u30c7\u30b6\u30a4\u30f3\u3011 \u6bcd\u96c6\u56e3\u306b\u57fa\u3065\u304f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002
\n\u3010\u8a2d\u5b9a\u3011 \u4e2d\u56fd\u306e\u5317\u3001\u5357\u3001\u897f\u306e\u4ee3\u8868\u7684\u306a\u5730\u57df\u304b\u3089\u53c2\u52a0\u8005\u3092\u96c6\u3081\u305f\u3002
\n\u3010\u53c2\u52a0\u8005\u3011 60 \u6b73\u4ee5\u4e0a\u3067\u8a8d\u77e5\u6a5f\u80fd\u304c\u6b63\u5e38\u3067\u3042\u308a\u30012009 \u5e74\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b APOE \u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u3092\u53d7\u3051\u305f\u500b\u4eba\u3002
\n\u3010\u4e3b\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a55\u4fa1\u3011 \u53c2\u52a0\u8005\u306f\u3001\u6b7b\u4ea1\u3001\u4e2d\u6b62\u3001\u307e\u305f\u306f 2019 \u5e74 12 \u6708 26 \u65e5\u307e\u3067\u8ffd\u8de1\u8abf\u67fb\u3055\u308c\u305f\u3002\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9
\n\u30bf\u30a4\u30eb\u306e 6 \u3064\u306e\u8981\u56e0\u3092\u8a55\u4fa1\u3057\u305f\uff1a
\n\u2460\u5065\u5eb7\u7684\u306a\u98df\u4e8b\uff08\u5bfe\u8c61\u98df\u54c1 12 \u54c1\u76ee\u306e\u3046\u3061\u5c11\u306a\u304f\u3068\u3082 7 \u54c1\u76ee\u306e\u63a8\u5968\u6442\u53d6\u91cf\u3092\u9075\u5b88\uff09\u3001
\n\u2461\u5b9a\u671f\u7684\u306a\u8eab\u4f53\u904b\u52d5\uff08\u4e2d\u5f37\u5ea6\u306e 150 \u5206\u4ee5\u4e0a\u307e\u305f\u306f\u5f37\u5ea6\u306e 75 \u5206\u4ee5\u4e0a\u3001\u9031\u3042\u305f\u308a\uff09\u3001
\n\u2462\u6d3b\u767a\u306a\u793e\u4f1a\u63a5\u89e6\uff08\u2267\u9031 2 \u56de\uff09\u3001
\n\u2463\u6d3b\u767a\u306a\u8a8d\u77e5\u6d3b\u52d5\uff08\u2267\u9031 2 \u56de\uff09\u3001
\n\u2464\u55ab\u7159\u3092\u3057\u306a\u3044\u3001\u307e\u305f\u306f\u3057\u305f\u3053\u3068\u304c\u306a\u3044\u3001
\n\u2465\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u98f2\u307e\u306a\u3044\u3002
\n\u53c2\u52a0\u8005\u306f\u3001\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u8981\u56e0\u304c 4\u301c6 \u500b\u3042\u308c\u3070\u597d\u307e\u3057\u3044\u30b0\u30eb\u30fc\u30d7\u306b\u30012\u301c3 \u500b\u3042\u308c\u3070\u5e73\u5747\u7684\u306a\u30b0\u30eb\u30fc\u30d7\u306b\u30010
\n\u301c1 \u500b\u3042\u308c\u3070\u597d\u307e\u3057\u304f\u306a\u3044\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u305f\u3002\u8a18\u61b6\u6a5f\u80fd\u306f WHO\/University of California-Los Angeles Auditory Verbal Learning Test\uff08AVLT\u203b\uff09\u3067\u3001\u30b0\u30ed\u30fc\u30d0\u30eb\u8a8d\u77e5\u6a5f\u80fd\u306f Mini Mental State Examination \u3067 \u8a55\u4fa1\u3057\u305f\u3002\u7dda\u5f62\u6df7\u5408\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u5bfe\u8c61\u8005\u306e\u8a18\u61b6\u306b\u5bfe\u3059\u308b\u751f\u6d3b\u7fd2\u6163\u8981\u56e0\u306e\u5f71\u97ff\u3092\u8abf\u67fb\u3057\u305f\u3002<\/p>\n

\u203bAVLT\uff1a\u5373\u6642\u518d\u751f\u3001\u77ed\u671f\u9045\u5ef6\u81ea\u7531\u518d\u751f\uff083 \u5206\u5f8c\uff09\u3001\u9577\u671f\u9045\u5ef6\u81ea\u7531\u518d\u751f\uff0830 \u5206\u5f8c\uff09\u3001\u9577\u671f\u9045\u5ef6\u8a8d\u8b58\u306e\u6e2c\u5b9a\u3092 \u884c\u3046\u3002\u30c6\u30b9\u30c8\u3067\u306f\u3001\u8a55\u4fa1\u8005\u304c 15 \u500b\u306e\u540d\u8a5e\u304b\u3089\u306a\u308b\u5358\u8a9e\u30ea\u30b9\u30c8\u3092\u8aad\u307f\u3001\u305d\u306e\u76f4\u5f8c\u306b\u3001\u53c2\u52a0\u8005\u306f\u3067\u304d\u308b\u3060\u3051\u591a\u304f\u306e\u5358\u8a9e\u3092\u7e70\u308a \u8fd4\u3057\u3066\u3082\u3089\u3046\u3002\u5373\u6642\u518d\u751f\u306e\u5f97\u70b9\u306f 0\u301c60 \u70b9\u3001\u305d\u306e\u4ed6\u306e\u30c6\u30b9\u30c8\u306e\u5f97\u70b9\u306f 0\u301c15 \u70b9\u3067\u3042\u3063\u305f\u3002\u6a19\u6e96 z \u30b9\u30b3\u30a2\u306f\u3001\u305d\u308c\u305e\u308c\u306e \u5e73\u5747\u5024\u3068\u6a19\u6e96\u504f\u5dee\u306e\u30c6\u30b9\u30c8\u30b9\u30b3\u30a2\u306b\u57fa\u3065\u3044\u3066\u8a08\u7b97\u3055\u308c\u308b\u3002\u8a18\u61b6\u6a5f\u80fd\u306e\u8907\u5408 z \u30b9\u30b3\u30a2\u306f\u3001\u5404\u30c6\u30b9\u30c8\u306e z \u30b9\u30b3\u30a2\u3092\u5e73\u5747\u3059\u308b\u3053\u3068 \u306b\u3088\u3063\u3066\u69cb\u6210\u3055\u308c\u308b\u3002<\/p>\n

\u3010\u7d50\u679c\u3011
\n29,072 \u540d\u306e\u53c2\u52a0\u8005\uff08\u5e73\u5747\u5e74\u9f62 72.23 \u6b73\u3001\u5973\u6027 48.54\uff05\uff08n=14113\uff09\u3001APOE \u03b54 \u30ad\u30e3\u30ea\u30a2 20.43\uff05
\n\uff08n=5939\uff09) \u304c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u300210 \u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\uff082009-19 \u5e74\uff09\u306b\u304a\u3044\u3066\u3001\u597d\u307e\u3057\u3044\u30b0\u30eb\u30fc\u30d7\u306e\u53c2\u52a0\u8005\u306f\u597d\u307e\u3057 \u304f\u306a\u3044\u30b0\u30eb\u30fc\u30d7\u306e\u53c2\u52a0\u8005\u306b\u6bd4\u3079\u3066\u8a18\u61b6\u306e\u4f4e\u4e0b\u304c\u9045\u304b\u3063\u305f\uff080.028 \u30dd\u30a4\u30f3\u30c8\uff0f\u5e74\u300195\uff05\u4fe1\u983c\u533a\u9593 0.023-0.032\u3001P\uff1c 0.001\uff09\u3002APOE \u03b54 \u306e\u30ad\u30e3\u30ea\u30a2\u306e\u4e2d\u3067\u306f\u3001\u597d\u307e\u3057\u3044\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u7fa4\uff080.027\u300195\uff05\u4fe1\u983c\u533a\u9593 0.023 \u304b\u3089 0.031\uff09\u304a \u3088\u3073\u5e73\u5747\u7684\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u7fa4\uff080.014\u30010.010 \u304b\u3089 0.019\uff09\u306f\u3001\u597d\u307e\u3057\u304f\u306a\u3044\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u4eba\u3005\u3088\u308a\u3082\u9045\u3044\u8a18\u61b6\u529b\u4f4e \u4e0b\u3092\u793a\u3057\u3066\u3044\u305f\u3002APOE \u03b54 \u306e\u30ad\u30e3\u30ea\u30a2\u3067\u306a\u3044\u4eba\u3005\u3067\u306f\u3001\u597d\u307e\u3057\u3044\u7fa4\uff080.029 \u30dd\u30a4\u30f3\u30c8\uff0f\u5e74\u300195\uff05\u4fe1\u983c\u533a\u9593 0.019\u301c 0.039\uff09\u304a\u3088\u3073\u5e73\u5747\u7fa4\uff080.019\u30010.011\u301c0.027\uff09\u3067\u3001\u597d\u307e\u3057\u304f\u306a\u3044\u7fa4\u306e\u53c2\u52a0\u8005\u3068\u540c\u69d8\u306e\u7d50\u679c\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002APOE \u03b54 \u306e\u72b6\u614b\u3068\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3001\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b\u306b\u5bfe\u3057\u3066\u6709\u610f\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u793a\u3055\u306a\u304b\u3063\u305f\uff08P=0.52\uff09\u3002 \u8a18\u61b6\u529b\u4f4e\u4e0b\u306b\u5bfe\u3059\u308b\u5404\u751f\u6d3b\u7fd2\u6163\u69cb\u6210\u8981\u7d20\u306e\u5bc4\u4e0e\u3092\u8a55\u4fa1\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u5065\u5eb7\u7684\u306a\u98df\u4e8b\u304c\u8a18\u61b6\u306b\u5bfe\u3057\u3066\u6700\u3082\u5f37\u3044\u5f71\u97ff\u3092\u4e0e\u3048\uff08\u03b2=0.016\u300195\uff05\u4fe1\u983c\u533a\u9593 0.014\u301c0.017\u3001P<0.001\uff09\u3001\u6b21\u306b\u6d3b\u767a\u306a\u8a8d\u77e5\u6d3b\u52d5\uff08\u03b2=0.010\u3001\n0.008\u301c0.012\u3001P<0.001\uff09\u3001\u898f\u5247\u6b63\u3057\u3044\u8eab\u4f53\u7684\u904b\u52d5\uff08\u03b2=0. 007, 0.005\u301c0.009, P<0.001\uff09\u3001\u6d3b\u767a\u306a\u793e \u4f1a\u7684\u63a5\u89e6\uff08\u03b2=0.004, 0.002\u301c0.006, P<0.001\uff09\u3001\u55ab\u7159\u3092\u3057\u306a\u3044\u307e\u305f\u306f\u3057\u305f\u3053\u3068\u304c\u306a\u3044\uff08\u03b2=0.004, 0.000\u301c 0.008, P0.026\uff09\u3001\u98f2\u9152\u3057\u306a\u3044\uff08\u03b2=0.002, 0.000\u301c0.004, P0.048\uff09\u306e\u9806\u3060\u3063\u305f\uff08\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u8868 6\uff09\u3002\n\n\u3010\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3011\n\u5f37\u307f\uff1a\u3053\u306e\u5927\u898f\u6a21\u306a\u7814\u7a76\u306f\u3001\u7570\u306a\u308b\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3001APOE \u03b54 \u306e\u72b6\u614b\u3001\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u300110 \u5e74 \u9593\u306e\u8ffd\u8de1\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u7e26\u65ad\u7684\u306a\u8a18\u61b6\u306e\u8ecc\u8de1\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u63a8\u5b9a\u3057\u305f\u3001\u6211\u3005\u306e\u77e5\u308b\u9650\u308a\u521d\u3081\u3066\u306e\u7814\u7a76\u3067\u3042\u308b\u3002\u305d\u306e\u7d50 \u679c\u3001\u907a\u4f1d\u7684\u306b\u8a18\u61b6\u529b\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u3044\u4eba\u3092\u542b\u3081\u3001\u8a8d\u77e5\u7684\u306b\u6b63\u5e38\u306a\u9ad8\u9f62\u8005\u3067\u306f\u3001\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b \u901f\u5ea6\u306e\u7de9\u3084\u304b\u3055\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002 \u3053\u306e\u3088\u3046\u306a\u5909\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u672c\u7814\u7a76\u3067\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001\u8133\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3001\u8a8d\u77e5\u4e88\u5099\u80fd\u306e\u5411\u4e0a\u3001\u9178\u5316\u30b9\u30c8 \u30ec\u30b9\u3084\u708e\u75c7\u306e\u6291\u5236\u3001\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u306e\u4fc3\u9032\u306a\u3069\u304c\u8003\u3048\u3089\u308c\u308b\u3002\n\n\u5f31\u307f\uff1a\n\u2460\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u8981\u56e0\u306e\u8a55\u4fa1\u306f\u81ea\u5df1\u5831\u544a\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u3057\u305f\u304c\u3063\u3066\u6e2c\u5b9a\u8aa4\u5dee\u304c\u751f\u3058\u3084\u3059\u3044\u3002\n\u2461\u6570\u540d\u306e\u53c2\u52a0\u8005\u306f\u3001\u30c7\u30fc\u30bf\u306e\u6b20\u640d\u3084\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u8a55\u4fa1\u306e\u305f\u3081\u306b\u623b\u3063\u3066\u3053\u306a\u3044\u3068\u3044\u3046\u7406\u7531\u3067\u9664\u5916\u3055\u308c\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u306a \u304c\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\n\u2462\u4e0d\u5065\u5eb7\u306a\u4eba\u306f\u7814\u7a76\u306b\u53c2\u52a0\u3057\u306b\u304f\u3044\u306e\u3067\u3001\u4e0d\u5065\u5eb7\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3092\u6301\u3064\u4eba\u306e\u5272\u5408\u306f\u3001\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u305f \u304b\u3082\u3057\u308c\u306a\u3044\u3002\n\u2463\u6211\u3005\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u6027\u8cea\u4e0a\u3001\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u7dad\u6301\u304c\u3001\u7814\u7a76\u3078\u306e\u767b\u9332\u6642\u70b9\u3067\u65e2\u306b\u8a18\u61b6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u59cb\u3081 \u3066\u3044\u305f\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u304b\u3063\u305f\u3002\n\u2464\u6211\u3005\u306f\u3001\u8a18\u61b6\u6a5f\u80fd\u5168\u4f53\u3092\u5305\u62ec\u7684\u306b\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u5358\u4e00\u306e\u795e\u7d4c\u5fc3\u7406\u5b66\u7684\u691c\u67fb\u3092\u7528\u3044\u3066\u8a18\u61b6\u3092\u8a55\u4fa1\u3057\u305f\u3002\n\n\u3010\u7d50\u8ad6\u3011 \u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306f\u3001APOE \u03b54 \u5bfe\u7acb\u907a\u4f1d\u5b50\u304c\u3042\u308b\u5834\u5408\u3067\u3082\u3001\u3088\u308a\u7de9\u3084\u304b\u306a\u8a18\u61b6\u529b\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044 \u308b\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u9ad8\u9f62\u8005\u3092\u8a18\u61b6\u529b\u4f4e\u4e0b\u304b\u3089\u5b88\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\n\n\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u3010\u958b\u50ac\u65e5\u30112023\u5e742\u67088\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u2015\u6587\u732e\u540d- Jianping Jia,1 Tan Zhao,1 Zhaojun Liu, et al. Association between healthy lifestyle and memory decline i … \u7d9a\u304d\u3092\u8aad\u3080 \u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u5065\u5eb7\u7684\u306a\u30e9\u30a4\u30d5\u30b9\u30bf\u30eb\u3068\u8a18\u61b6\u529b\u4f4e\u4e0b\u306e\u95a2\u9023\u6027\uff1a10\u5e74\u9593\u306e\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,11],"tags":[],"class_list":["post-2481","post","type-post","status-publish","format-standard","hentry","category-15","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2481"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2481\/revisions"}],"predecessor-version":[{"id":2485,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2481\/revisions\/2485"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2481"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2481"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}