{"id":2542,"date":"2024-02-21T10:54:41","date_gmt":"2024-02-21T01:54:41","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2542"},"modified":"2024-02-21T10:54:41","modified_gmt":"2024-02-21T01:54:41","slug":"hfpef%e3%81%ab%e5%af%be%e3%81%99%e3%82%8bsglt2%e9%98%bb%e5%ae%b3%e8%96%ac%e3%81%ae%e5%8a%b9%e6%9e%9c%ef%bc%88emperor-preserved%e8%a9%a6%e9%a8%93%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2542","title":{"rendered":"HFpEF\u306b\u5bfe\u3059\u308bSGLT2\u963b\u5bb3\u85ac\u306e\u52b9\u679c\uff08EMPEROR-Preserved\u8a66\u9a13\uff09"},"content":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d<br \/>\nS.D. Anker, J. et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction.<br \/>\nN Engl J Med 2021;385:1451-61.<\/p>\n<p>\uff0d\u8981\u7d04\uff0d<br \/>\n\u3010\u80cc\u666f\u3011<br \/>\nSGLT2\u963b\u5bb3\u85ac\u306f\u3001\u99c6\u51fa\u7387\u304c\u4f4e\u4e0b\u3057\u305f\u5fc3\u4e0d\u5168\uff08HFrEF\uff09\u60a3\u8005\u306e\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u304c\u3001\u99c6\u51fa\u7387\u304c\u7dad\u6301\u3055\u308c\u305f\u5fc3\u4e0d\u5168\uff08HFpEF\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u52b9\u679c\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002<br \/>\n\u3010\u65b9\u6cd5\u3011<br \/>\n23\u30ab\u56fd622\u65bd\u8a2d\u306e\u591a\u65bd\u8a2d\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u300118\u6b73\u4ee5\u4e0a\u306e\u99c6\u51fa\u738740\uff05\u4ee5\u4e0a\u3001NIHA\u30af\u30e9\u30b9II\uff5eIV\u5ea6\u3001NTproBNP300pg\/mL\u4ee5\u4e0a\uff08AF\u304c\u3042\u308b\u5834\u5408\u306f900pg\/mL\u4ee5\u4e0a\uff09\u306e\u5fc3\u4e0d\u5168\u60a3\u80055988\u4f8b\u3092\u3001\u901a\u5e38\u306e\u6cbb\u7642\u306b\u52a0\u3048\u3066\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff0810mg\u30921\u65e51\u56de\u6295\u4e0e\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u5fc3\u8840\u7ba1\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u3068\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795.png\" alt=\"\" width=\"876\" height=\"1338\" class=\"aligncenter size-full wp-image-2543\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795.png 876w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795-196x300.png 196w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795-670x1024.png 670w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/265f61fd15a60d2981b8f07053a17795-768x1173.png 768w\" sizes=\"auto, (max-width: 876px) 100vw, 876px\" \/><\/a><\/p>\n<p>\u3010\u7d50\u679c\u3011<br \/>\n\u4e2d\u592e\u502426.2\u30f5\u6708\u9593\u3067\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa42997\u4f8b\u4e2d415\u4f8b\uff0813.8\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa42991\u4f8b\u4e2d511\u4f8b\uff0817.1\uff05\uff09\u306b\u767a\u73fe\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\u30010.79\uff1b95\uff05\u4fe1\u983c\u533a\u9593[CI]\u30010.69\uff5e0.90\uff1bP<0.001\uff09\u3002\u3053\u306e\u52b9\u679c\u306f\u4e3b\u306b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u306b\u304a\u3051\u308b\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u52b9\u679c\u306f\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u3044\u305f\u3002\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u7dcf\u6570\u306f\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u5c11\u306a\u304b\u3063\u305f\uff08\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4407\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4541\u4f8b\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u30010.73\uff1b95\uff05CI\u30010.61\uff5e0.88\uff1bP\uff1c0.001\uff09\u3002\u5408\u4f75\u75c7\u306e\u306a\u3044\u6027\u5668\u611f\u67d3\u75c7\u304a\u3088\u3073\u5c3f\u8def\u611f\u67d3\u75c7\u3001\u4f4e\u8840\u5727\u306f\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3067\u591a\u304f\u5831\u544a\u3055\u308c\u305f\u3002\n\n<a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/cdffe0381daa80ff49b1062a29921378.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/cdffe0381daa80ff49b1062a29921378.png\" alt=\"\" width=\"978\" height=\"696\" class=\"aligncenter size-full wp-image-2544\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/cdffe0381daa80ff49b1062a29921378.png 978w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/cdffe0381daa80ff49b1062a29921378-300x213.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/cdffe0381daa80ff49b1062a29921378-768x547.png 768w\" sizes=\"auto, (max-width: 978px) 100vw, 978px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936.png\" alt=\"\" width=\"1506\" height=\"860\" class=\"aligncenter size-full wp-image-2545\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936.png 1506w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936-300x171.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936-1024x585.png 1024w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/a4141b1171b33c67bfa54cc7e0649936-768x439.png 768w\" sizes=\"auto, (max-width: 1506px) 100vw, 1506px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517.png\" alt=\"\" width=\"930\" height=\"1336\" class=\"aligncenter size-full wp-image-2546\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517.png 930w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517-209x300.png 209w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517-713x1024.png 713w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/92c05ebf688a9c9bba71f274f8d22517-768x1103.png 768w\" sizes=\"auto, (max-width: 930px) 100vw, 930px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/b2fd7dda1127f7633f498bb7a8cb0d17.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/b2fd7dda1127f7633f498bb7a8cb0d17.png\" alt=\"\" width=\"926\" height=\"622\" class=\"aligncenter size-full wp-image-2547\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/b2fd7dda1127f7633f498bb7a8cb0d17.png 926w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/b2fd7dda1127f7633f498bb7a8cb0d17-300x202.png 300w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2024\/02\/b2fd7dda1127f7633f498bb7a8cb0d17-768x516.png 768w\" sizes=\"auto, (max-width: 926px) 100vw, 926px\" \/><\/a><\/p>\n<p>\u3010\u7d50\u8ad6\u3011<br \/>\n\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\uff0c\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\uff0c\u99c6\u51fa\u7387\u304c\u7dad\u6301\u3055\u308c\u305f\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u6b7b\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002(Boehringer Ingelheim\u793e\u3068Eli Lilly\u793e\u304c\u8cc7\u91d1\u63d0\u4f9b)<br \/>\n\u3010\u8003\u5bdf\u3011<br \/>\n\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3084\u5168\u6b7b\u4ea1\u3067\u306f\u6709\u610f\u5dee\u304c\u51fa\u306a\u304b\u3063\u305f\u3001\u6b7b\u4ea1\u4ee5\u5916\u306e\u6cbb\u7642\u4e2d\u65ad\u4f8b\u304c\u5168\u4f53\u306e23%\u3042\u3063\u305f\u3001\u306a\u3069\u3044\u304f\u3064\u304b\u9650\u754c\u3042\u308a\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112023\u5e747\u67085\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d S.D. Anker, J. et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med 20 &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=2542\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">HFpEF\u306b\u5bfe\u3059\u308bSGLT2\u963b\u5bb3\u85ac\u306e\u52b9\u679c\uff08EMPEROR-Preserved\u8a66\u9a13\uff09<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2542","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2542"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2542\/revisions"}],"predecessor-version":[{"id":2548,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2542\/revisions\/2548"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}