{"id":2555,"date":"2024-03-07T08:02:27","date_gmt":"2024-03-06T23:02:27","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2555"},"modified":"2024-03-07T08:02:27","modified_gmt":"2024-03-06T23:02:27","slug":"%e4%bf%9d%e5%ad%98%e6%9c%9f%ef%bc%88%e9%9d%9e%e9%80%8f%e6%9e%90%ef%bc%89%e6%85%a2%e6%80%a7%e8%85%8e%e8%87%93%e7%97%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bhif-ph%e9%98%bb%e5%ae%b3%e5%89%a4%e3%81%a8esa","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2555","title":{"rendered":"\u4fdd\u5b58\u671f\uff08\u975e\u900f\u6790\uff09\u6162\u6027\u814e\u81d3\u75c5\u306b\u304a\u3051\u308bHIF-PH\u963b\u5bb3\u5264\u3068ESA\u88fd\u5264\u306e\u52b9\u679c\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>-\u6587\u732e\u540d-<br \/>\nJunlan Yang, et al. Effects of hypoxia-inducible factor-prolyl hydroxylase inhibitors vs.<br \/>\nerythropoiesis-stimulating agents on iron metabolism in non-dialysis-dependent anemic patients with CKD: A network meta-analysis.<br \/>\nFront Endocrinol (Lausanne). 2023; 14: 1131516.<\/p>\n<p>-\u8981\u7d04-<br \/>\n\u3010\u80cc\u666f\u3011<br \/>\n\u8ca7\u8840\u306f\u6162\u6027\u814e\u81d3\u75c5 (CKD) \u60a3\u8005\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001CKD \u306e\u9032\u884c\u304a\u3088\u3073\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u904e\u53bb 20 \u5e74\u9593\u3001\u8d64\u8840\u7403\u751f\u6210\u523a\u6fc0\u85ac (ESA) \u3068\u9244\u5206\u7642\u6cd5\u306f\u5e38\u306b\u814e\u6027\u8ca7\u8840\u6cbb\u7642\u306e\u57fa\u790e\u3067\u3057\u305f\u3002ESA \u306f\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u306e\u8ca7\u8840\u3092\u52b9\u679c\u7684\u306b\u6539\u5584\u3067\u304d\u307e\u3059\u304c\u3001\u816b\u760d\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306a\u3069\u306e\u6f5c\u5728\u7684\u306a\u526f\u4f5c\u7528\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u9244\u6b20\u4e4f\u3092\u88dc\u6b63\u3057\u3001\u540c\u6642\u306b ESA \u306e\u6295\u4e0e\u91cf\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u305f\u3081\u306b\u9244\u88dc\u7d66\u304c\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u6a5f\u80fd\u7684\u9244\u6b20\u4e4f\u75c7\u306e\u60a3\u8005\u3001\u3064\u307e\u308a\u8caf\u8535\u9244\u306e\u30ec\u30d9\u30eb\u304c\u6bd4\u8f03\u7684\u9ad8\u3044\u60a3\u8005\u3067\u3042\u3063\u3066\u3082\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u30ec\u30d9\u30eb\u304c 500 ng\/ml\u3001\u3055\u3089\u306b\u306f 800 ng\/ml \u672a\u6e80\u3067\u3042\u308b\u9650\u308a\u3001\u8840\u6db2\u900f\u6790\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u306f\u9759\u8108\u5185\u9244\u7642\u6cd5\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u7a2e\u306e\u884c\u70ba\u306f\u60a3\u8005\u3092\u611f\u67d3\u75c7\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u3055\u3089\u306b\u306f\u9244\u904e\u5270\u75c7\u306e\u30ea\u30b9\u30af\u306b\u3055\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50\u30d7\u30ed\u30ea\u30eb\u30d2\u30c9\u30ed\u30ad\u30b7\u30e9\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u963b\u5bb3\u5264 (HIF-PHI) \u306f\u3001\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50 (HIF) \u306e\u5206\u89e3\u3092\u963b\u5bb3\u3057\u3001\u4f4e\u9178\u7d20\u306b\u5bfe\u3059\u308b\u4f53\u306e\u81ea\u7136\u306a\u751f\u7406\u5b66\u7684\u53cd\u5fdc\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u8d64\u8840\u7403\u751f\u6210\u3092\u4fc3\u9032\u3067\u304d\u308b\u65b0\u3057\u3044\u30af\u30e9\u30b9\u306e\u85ac\u5264\u3067\u3059\u3002\u30d7\u30ed\u30ea\u30eb\u30d2\u30c9\u30ed\u30ad\u30b7\u30e9\u30fc\u30bc (PH) \u9175\u7d20\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001HIF-1 \u304a\u3088\u3073 HIF-2 \u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5b89\u5b9a\u5316\u304a\u3088\u3073\u4fc3\u9032\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u4f5c\u7528\u306b\u306f\u3001\u5185\u56e0\u6027\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3 (EPO) \u30db\u30eb\u30e2\u30f3\u306e\u7523\u751f\u306e\u5897\u52a0\u3084\u9244\u306e\u6052\u5e38\u6027\u306e\u8abf\u7bc0\u304c\u542b\u307e\u308c\u3001\u5f8c\u8005\u306e\u80fd\u529b\u306f ESA \u306b\u306f\u306a\u3044\u660e\u78ba\u306a\u5229\u70b9\u3067\u3042\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e HIF-PHI \u304c\u4e16\u754c\u7684\u306a\u81e8\u5e8a\u958b\u767a\u306e\u5f8c\u671f\u6bb5\u968e\u3067\u958b\u767a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u3061\u306e\u3044\u304f\u3064\u304b\u306f\u81e8\u5e8a\u5fdc\u7528\u304c\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8907\u6570\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001HIF- PHI\u304c ESA \u3068\u540c\u7b49\u306e\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3 (Hb) \u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u9244\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b\u305d\u306e\u52b9\u679c\u306f\u660e\u78ba\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u3010\u76ee\u7684\u3011<br \/>\n\u975e\u900f\u6790\u4f9d\u5b58\u6027\u6162\u6027\u814e\u81d3\u75c5\uff08NDD\uff09\u3092\u6709\u3059\u308b\u814e\u6027\u8ca7\u8840\u60a3\u8005\u306e\u9244\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b5\u7a2e\u985e\u306e\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50\u30d7\u30ed\u30ea\u30eb\u30d2\u30c9\u30ed\u30ad\u30b7\u30e9\u30fc\u30bc\u30c9\u30e1\u30a4\u30f3\u963b\u5bb3\u5264\uff08HIF-PHI\uff09\u30012\u7a2e\u985e\u306e\u8d64\u8840\u7403\u751f\u6210\u523a\u6fc0\u85ac\uff08ESA\uff09\u3001\u304a\u3088\u3073\u30d7\u30e9\u30bb\u30dc\u306e\u9244\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3002<\/p>\n<p>\u3010\u65b9\u6cd5\u3011<br \/>\n\u7814\u7a76\u306e\u305f\u3081\u306b 5 \u3064\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304c\u691c\u7d22\u3055\u308c\u307e\u3057\u305f\u3002NDD-CKD\u60a3\u8005\u3092\u5bfe\u8c61\u306bHIF-PHI\u3001ESA\u3001\u30d7\u30e9\u30bb\u30dc\u3092\u6bd4\u8f03\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\u304c\u9078\u629e\u3055\u308c\u307e\u3057\u305f\u3002\u30cd\u30c3\u30c8\u30ef\u30fc\u30af \u30e1\u30bf\u5206\u6790\u306b\u4f7f\u7528\u3055\u308c\u305f\u7d71\u8a08\u30d7\u30ed\u30b0\u30e9\u30e0\u306f Stata\/SE 15.1 \u3067\u3057\u305f\u3002\u4e3b\u306a\u7d50\u679c\u306f\u3001\u30d8\u30d7\u30b7\u30b8\u30f3\u3068\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3 (Hb) \u30ec\u30d9\u30eb\u306e\u5909\u5316\u3067\u3057\u305f\u3002\u4ecb\u5165\u63aa\u7f6e\u306e\u30e1\u30ea\u30c3\u30c8\u306f\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u6cd5\u306b\u3088\u308a\u8868\u9762\u7684\u306b\u4e88\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3010\u7d50\u679c\u3011<br \/>\n\u9078\u629e\u3055\u308c\u305f 1,589 \u306e\u30aa\u30ea\u30b8\u30ca\u30eb \u30bf\u30a4\u30c8\u30eb\u306e\u3046\u3061\u3001\u30c7\u30fc\u30bf\u306f 15 \u4ef6\u306e\u8a66\u9a13 (\u53c2\u52a0\u8005 3,228 \u4eba) \u304b\u3089\u62bd\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e HIF-PHI \u304a\u3088\u3073 ESA \u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u512a\u308c\u305f Hb\u5024\u306e\u4e0a\u6607\u80fd\u529b\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306e\u4e2d\u3067\u3001\u30c7\u30b8\u30c7\u30e5\u30b9\u30bf\u30c3\u30c8\uff08desidusat\uff09 \u306f Hb \u3092\u5897\u52a0\u3055\u305b\u308b\u6700\u3082\u9ad8\u3044\u78ba\u7387 (95.6%) \u3092\u793a\u3057\u307e\u3057\u305f\u3002HIF-PHI \u3068 ESA\u3067\u6bd4\u8f03\u3057\u3066\u3001\u30d8\u30d7\u30b7\u30b8\u30f3 \uff08\u5e73\u5747\u504f\u5dee\uff1aMD = -43.42, 95%CI: -47.08 \uff5e -39.76\uff09\u3001\u30d5\u30a7\u30ea\u30c1\u30f3 (MD= -48.56, 95%CI: -55.21 \uff5e -41.96)\u3001\u304a\u3088\u3073\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30ea\u30f3\u98fd\u548c\u5ea6 (MD = -4.73, 95%CI: -5.52 \uff5e -3.94)\u306f\u6e1b\u5c11\u3092\u793a\u3057 \u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30ea\u30f3 (MD = 0.09\u300195%CI: 0.01 \uff5e 0.18) \u304a\u3088\u3073\u7dcf\u9244\u7d50\u5408\u80fd (MD = 6.34\u300195%CI: 5.71 \uff5e 6.96) \u306f\u5897\u52a0\u3057\u307e\u3057\u305f\u3002 \u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001HIF-PHI \u306e\u30d8\u30d7\u30b7\u30b8\u30f3\u3092\u6e1b\u5c11\u3055\u305b\u308b\u80fd\u529b\u306e\u4e0d\u5747\u4e00\u6027\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u30c0\u30eb\u30d9\u30dd\u30a8\u30c1\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30d8\u30d7\u30b7\u30b8\u30f3\u30ec\u30d9\u30eb\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u306f\u30c0\u30d7\u30ed\u30c7\u30e5\u30b9\u30bf\u30c3\u30c8\uff08daprodustat\uff09 (MD = \u201349.09\u300195% CI: \u201398.13 \uff5e \u20130.05) \u3060\u3051\u3067\u3057\u305f\u3002<\/p>\n<p>\u3010\u8003\u5bdf\u3011<br \/>\n\u3053\u306e\u7814\u7a76\u306f\u3001\u8ca7\u8840\u3068\u9244\u8abf\u7bc0\u7570\u5e38\u306e\u77ef\u6b63\u306b\u5bfe\u3059\u308b 5 \u3064\u306e HIF-PHI\u30012 \u3064\u306e ESA\u3001\u304a\u3088\u3073\u30d7\u30e9\u30bb\u30dc\u306e\u52b9\u679c\u3092\u6bd4\u8f03\u3059\u308b\u6700\u5927\u898f\u6a21\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u306b\u542b\u307e\u308c\u308b5\u3064\u306e HIF-PHI \u306e\u8ca7\u8840\u3092\u88dc\u6b63\u3059\u308b\u80fd\u529b\u306f\u3059\u3079\u3066ESA \u306b\u52a3\u308a\u307e\u305b\u3093\u3002\u3055\u3089\u306b\u3001\u30c7\u30b7\u30c0\u30b9\u30bf\u30c3\u30c8\u306f\u6700\u3082\u5f37\u529b\u306a Hb \u5897\u52a0\u80fd\u529b\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u9244\u4ee3\u8b1d\u306b\u5bfe\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u85ac\u7269\u306e\u8abf\u7bc0\u52b9\u679c\u3092\u5206\u6790\u3059\u308b\u969b\u306b\u30015\u3064\u306e HIF-PHI \u30921\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u30012\u3064\u306e ESA \u3092\u3082\u3046 1\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u53d6\u308a\u4e0a\u3052\u305f\u305f\u3081\u3001\u7d50\u8ad6\u304c\u3088\u308a\u63a8\u5b9a\u7684\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3084ESA\u3068\u6bd4\u8f03\u3057\u3066\u3001HIF-PHI\u306f\u30d8\u30d7\u30b7\u30b8\u30f3\u3001TSAT\u3001\u30d5\u30a7\u30ea\u30c1\u30f3\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30ea\u30f3\u3068TIBC\u3092\u5897\u52a0\u3055\u305b\u308b\u304c\u3001\u8840\u6e05\u9244\u306f\u5909\u5316\u3055\u305b\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790\u3067\u306f\u3001\u7570\u306a\u308b HIF-PHI \u306e\u30d8\u30d7\u30b7\u30b8\u30f3\u3092\u6e1b\u5c11\u3055\u305b\u308b\u80fd\u529b\u306e\u4e0d\u5747\u4e00\u6027\u3082\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\nESA\u306f\u73fe\u5728\u3001\u814e\u6027\u8ca7\u8840\u306e\u6cbb\u7642\u306b\u6700\u3082\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u85ac\u3067\u3059\u3002\u6f5c\u5728\u7684\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3084\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u8003\u616e\u3057\u306a\u304f\u3066\u3082\u3001ESA\u53cd\u5fdc\u4f4e\u4e0b\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u9577\u671f\u9593\u708e\u75c7\u72b6\u614b\u306b\u3042\u308b\u4e00\u90e8\u306e\u60a3\u8005\u306f\u3001ESA\u306b\u53cd\u5fdc\u305b\u305a\u3001\u8ca7\u8840\u3092\u6539\u5584\u3059\u308b\u80fd\u529b\u304c\u7406\u60f3\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u9178\u7d20\u306e\u611f\u77e5\u3068\u9069\u5fdc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u751f\u547d\u306e\u6700\u3082\u91cd\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306e1\u3064\u3067\u3059\u300230\u5e74\u524d\u3001HIF\u306f EPO \u7523\u751f\u3092\u5897\u52a0\u3055\u305b\u3001\u4f4e\u9178\u7d20\u72b6\u614b\u306e\u8ca7\u8840\u3092\u662f\u6b63\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u9178\u7d20\u30ec\u30d9\u30eb\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001HIF-\u03b1 \u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304c\u84c4\u7a4d\u3057\u3001HIF-\u03b2 \u3068\u4e8c\u91cf\u4f53\u5316\u3057\u3066\u6a5f\u80fd\u7684\u306a\u8ee2\u5199\u56e0\u5b50 HIF-1 \u304a\u3088\u3073 HIF-2 \u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u3001EPO \u907a\u4f1d\u5b50\u304a\u3088\u3073\u9244\u5438\u53ce\u95a2\u9023\u306e\u30b3\u30fc\u30c9\u5316\u306b\u95a2\u4e0e\u3059\u308b\u305d\u306e\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u76f4\u63a5\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u305f\u3093\u3071\u304f\u8cea\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u8ca7\u8840\u3092\u6539\u5584\u3057\u307e\u3059\u3002\u5341\u5206\u306a\u9178\u7d20\u306e\u5b58\u5728\u4e0b\u3067\u306f\u3001HIF \u306f HIF-PH \u9175\u7d20\u306b\u3088\u3063\u3066\u6c34\u9178\u5316\u3055\u308c\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u307e\u3059\u3002HIF-PHI \u306f\u3001\u4f4e\u9178\u7d20\u306b\u5bfe\u3059\u308b\u4f53\u306e\u81ea\u7136\u306a\u751f\u7406\u5b66\u7684\u53cd\u5fdc\u3092\u30b7\u30df\u30e5\u30ec\u30fc\u30c8\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066 HIF \u306e\u5206\u89e3\u3092\u963b\u5bb3\u3059\u308b\u3001\u65b0\u3057\u3044\u7a2e\u985e\u306e\u8ca7\u8840\u6cbb\u7642\u85ac\u3067\u3059\u3002\u4ee5\u524d\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790 (2,768 \u4eba\u306e\u60a3\u8005) \u306b\u304a\u3044\u3066\u3001HIF-PHI\u306fESA\u3068\u540c\u69d8\u306e\u8ca7\u8840\u6cbb\u7642\u52b9\u679c\u304c\u3042\u308a\u3001\u3042\u308b\u7a0b\u5ea6\u5b89\u5168\u3067\u3042\u308b\u3068\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u3044\u3053\u3068\u3068\u3001\u7570\u306a\u308b HIF-PHI \u9593\u306e\u76f4\u63a5\u306e\u76f4\u63a5\u6bd4\u8f03\u304c\u6b20\u5982\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u305d\u306e\u7814\u7a76\u7d50\u679c\u306e\u7cbe\u5ea6\u3068\u81e8\u5e8a\u7684\u4fa1\u5024\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790\u306b\u306f\u3001\u65b0\u3057\u304f\u767a\u8868\u3055\u308c\u305f 4\u3064\u306e\u5927\u898f\u6a21\u7814\u7a76 (\u3053\u308c\u3089 4\u3064\u306e\u7814\u7a76\u306b\u306f 1,783 \u4eba\u306e NDD-CKD \u814e\u6027\u8ca7\u8840\u60a3\u8005\u304c\u542b\u307e\u308c\u3066\u3044\u305f) \u304c\u767b\u9332\u3055\u308c\u3001\u7d50\u679c\u306e\u7cbe\u5ea6\u304c\u5411\u4e0a\u3057\u3001\u7d50\u8ad6\u306e\u3055\u3089\u306a\u308b\u5916\u633f\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u542b\u307e\u308c\u3066\u3044\u308b 5\u3064\u306e HIF-PHI \u304c\u8ca7\u8840\u3092\u6539\u5584\u3059\u308b\u80fd\u529b\u306b\u304a\u3044\u3066 ESA \u3088\u308a\u3082\u52a3\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u7d50\u679c\u306b\u3088\u308a\u793a\u3055\u308c\u3001\u30c7\u30b7\u30c0\u30b9\u30bf\u30c3\u30c8\u306f ESA \u3088\u308a\u3082\u5f37\u529b\u306a Hb \u30ec\u30d9\u30eb\u4e0a\u6607\u80fd\u529b\u3055\u3048\u793a\u3057\u307e\u3057\u305f\u3002<br \/>\n\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u5206\u6790\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u5236\u9650\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u7b2c\u4e00\u306b\u3001\u542b\u307e\u308c\u305f\u8a66\u9a13\u306e\u4e00\u90e8\u306f\u4e8c\u91cd\u76f2\u691c\u6cd5\u3092\u4f7f\u7528\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u3053\u306e\u7814\u7a76\u306e\u542b\u307e\u308c\u305f\u7d50\u679c\u306b\u306f\u7d71\u4e00\u3055\u308c\u305f\u57fa\u6e96\u304c\u3042\u308a\u3001\u4e3b\u89b3\u7684\u306a\u8981\u56e0\u306b\u3088\u3063\u3066\u7c21\u5358\u306b\u5909\u66f4\u3055\u308c\u306b\u304f\u3044\u3053\u3068\u3092\u8003\u616e\u3057\u3066\u3001\u975e\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u306f\u9664\u5916\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u7b2c\u4e8c\u306b\u3001\u5bfe\u8c61\u3068\u306a\u3063\u305f\u8a66\u9a13\u9593\u306e\u8ffd\u8de1\u671f\u9593\u306f\u307e\u3063\u305f\u304f\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u6295\u4e0e\u6bb5\u968e\u3067\u306e\u60a3\u8005\u306e\u9244\u4ee3\u8b1d\u3092\u6b63\u78ba\u306b\u89b3\u5bdf\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u307b\u3068\u3093\u3069\u306e HIF-PHI \u304c\u307e\u3060\u81e8\u5e8a\u4f7f\u7528\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u3053\u306e\u7814\u7a76\u306b\u306f\u6295\u4e0e\u671f\u9593\u304c\u77ed\u3044\u3044\u304f\u3064\u304b\u306e\u7b2c II \u76f8\u8a66\u9a13\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b\u3001\u5bfe\u8c61\u3068\u306a\u3063\u305f\u8a66\u9a13\u306e\u88ab\u9a13\u8005\u306eCKD\u72b6\u614b\u306b\u306f\u5dee\u304c\u3042\u308a\u3001\u305d\u308c\u304c\u88ab\u9a13\u8005\u306e\u9244\u4ee3\u8b1d\u72b6\u614b\u3092\u7570\u306a\u308b\u3082\u306e\u306b\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8a08\u7b97\u3057\u3066\u307f\u308b\u3068\u3001\u3053\u306e\u5dee\u306f\u4e0d\u5747\u4e00\u6027\u306b\u95a2\u3059\u308b\u7d71\u8a08\u7684\u57fa\u6e96\u3092\u6e80\u305f\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u5305\u542b\u57fa\u6e96\u3068\u9664\u5916\u57fa\u6e96\u3092\u8abf\u6574\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002<br \/>\n\u7d50\u8ad6\u3068\u3057\u3066\u3001\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u6a5f\u80fd\u7684\u9244\u6b20\u4e4f\u75c7\u306eNDD-CKD\u60a3\u8005\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066HIF-PHI\u304c\u7b2c\u4e00\u9078\u629e\u3068\u306a\u308b\u3079\u304d\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u6cbb\u7642\u8a08\u753b\u3092\u7acb\u3066\u308b\u969b\u306b\u306f\u3001\u9244\u4ee3\u8b1d\u3092\u88dc\u6b63\u3059\u308b\u305f\u3081\u306e HIF-PHI \u306e\u6f5c\u5728\u7684\u306a\u4e0d\u5747\u4e00\u6027\u3092\u5341\u5206\u306b\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112023\u5e748\u67082\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>-\u6587\u732e\u540d- Junlan Yang, et al. Effects of hypoxia-inducible factor-prolyl hydroxylase inhibitors vs. erythropoiesis &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=2555\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u4fdd\u5b58\u671f\uff08\u975e\u900f\u6790\uff09\u6162\u6027\u814e\u81d3\u75c5\u306b\u304a\u3051\u308bHIF-PH\u963b\u5bb3\u5264\u3068ESA\u88fd\u5264\u306e\u52b9\u679c\u306b\u3064\u3044\u3066<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2555","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2555"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2555\/revisions"}],"predecessor-version":[{"id":2556,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2555\/revisions\/2556"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}