{"id":2563,"date":"2024-03-07T08:03:36","date_gmt":"2024-03-06T23:03:36","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2563"},"modified":"2024-03-07T08:03:36","modified_gmt":"2024-03-06T23:03:36","slug":"ba-4-5%e3%81%8a%e3%82%88%e3%81%b3ba-1%e4%ba%8c%e4%be%a1mrna%e8%bf%bd%e5%8a%a0%e5%85%8d%e7%96%ab%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e5%ae%89%e5%85%a8%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2563","title":{"rendered":"BA.4-5\u304a\u3088\u3073BA.1\u4e8c\u4fa1mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nNiklas Worm Andersson. Safety of BA.4-5 or BA.1 bivalent mRNA booster vaccines: nationwide cohort study. BMJ. 2023-075015 on 25 July 2023<\/p>\n

-\u8981\u7d04-
\nIntroduction\uff1a
\n2022\u5e74\u521d\u79cb\u306b\u3001\u30d5\u30a1\u30a4\u30b6\u30fcBioNTech\u30ef\u30af\u30c1\u30f3\u30b3\u30df\u30ca\u30c6\u30a3\uff08BNT162b\uff12\u3001\u30aa\u30ea\u30b8\u30ca\u30eb\u682a\u304a\u3088\u3073\u30aa\u30df\u30af\u30ed\u30f3\u5909\u7570\u4f53BA.4-5\u304a\u3088\u3073BA.1\uff09\u3001\u30e2\u30c7\u30eb\u30ca\u30ef\u30af\u30c1\u30f3\u30b9\u30d1\u30a4\u30af\u30d0\u30c3\u30af\u30b9\uff08mRNA-1273\u3001\u30aa\u30ea\u30b8\u30ca\u30eb\u304a\u3088\u3073BA.1\uff09\u306e\u3044\u305a\u308c\u304b\u3092\u4f7f\u7528\u3057\u305f\u4e8c\u4fa1mRNA\u30d6\u30fc\u30b9\u30bf\u30fc\u6295\u4e0e\u304c\u8a8d\u53ef\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u4e8c\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u3092\u9069\u5fdc\u3055\u305b\u305fmRNA \u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306f\u3001\uff08\u5143\u306e\uff09\u4e00\u4fa1\u306e\u6700\u521d\u306e\u8ffd\u52a0\u514d\u75ab\uff08\u3064\u307e\u308a\u30013\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u6295\u4e0e\uff09\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u4e00\u6b21\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u30b7\u30ea\u30fc\u30ba\u306e\u5b8c\u4e86\u5f8c\u306e\u5358\u4e00\u306e\u8ffd\u52a0\u514d\u75ab\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002
\n\u30c7\u30f3\u30de\u30fc\u30af\u3067\u306f\u30012022\u5e749\u670815\u65e5\u306b\u4e8c\u4fa1mRNA\u30d6\u30fc\u30b9\u30bf\u30fc\u306e\u5c55\u958b\u304c\u958b\u59cb\u3055\u308c\u300150\u6b73\u4ee5\u4e0a\u306e\u3059\u3079\u3066\u306e\u6210\u4eba\u3068\u91cd\u75c7\u306e\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u6210\u4eba\u306b\u63a8\u5968\u3055\u308c\u3001\u63d0\u4f9b\u3055\u308c\u305f\u3002\u30c7\u30f3\u30de\u30fc\u30af\u3067\u306f 3 \u56de\u76ee\u306e\u6295\u4e0e (\u3064\u307e\u308a\u30011 \u56de\u76ee\u306e\u8ffd\u52a0\u514d\u75ab) \u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u7387\u304c\u9ad8\u3044\u305f\u3081 (\u5bfe\u8c61\u96c6\u56e3\u306e >90%)\u3001\u4e8c\u4fa1 mRNA\u8ffd\u52a0\u514d\u75ab\u306f\u4e3b\u306b 4 \u56de\u76ee\u306e\u6295\u4e0e (\u3064\u307e\u308a\u30012 \u56de\u76ee\u306e\u8ffd\u52a0\u514d\u75ab) \u3068\u3057\u3066\u6295\u4e0e\u3055\u308c\u3066\u3044\u308b\u3002
\n\u9069\u5fdc\u3055\u308c\u305f\u4e8c\u4fa1mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u306f\u3001\u4e3b\u306b\u5229\u7528\u53ef\u80fd\u306a\u4e8b\u524d\u627f\u8a8d\u81e8\u5e8a\u8a66\u9a13\u3001\u4e00\u4fa1mRNA\u30ef\u30af\u30c1\u30f3\u306e\u5e02\u8ca9\u5f8c\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u3001\u4e8c\u4fa1 mRNA \u30ef\u30af\u30c1\u30f3\u306e\u514d\u75ab\u539f\u6027\u3068\u53cd\u5fdc\u539f\u6027\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002\u7c73\u56fd\u75be\u75c5\u7ba1\u7406\u4e88\u9632\u30bb\u30f3\u30bf\u30fc(CDC)\u304b\u3089\u306e\u6700\u8fd1\u306e\u5831\u544a\u306e 1 \u3064\u306f\u3001v-safe \u304a\u3088\u3073\u4e8c\u4fa1\u30ef\u30af\u30c1\u30f3\u306e\u30ef\u30af\u30c1\u30f3\u6709\u5bb3\u4e8b\u8c61\u5831\u544a\u30b7\u30b9\u30c6\u30e0\u3092\u901a\u3058\u3066\u521d\u671f\u306b\u5831\u544a\u3055\u308c\u305f\u5b89\u5168\u6027\u6240\u898b(\u4e3b\u306b\u53cd\u5fdc\u539f\u6027\u306b\u95a2\u9023\u3059\u308b)\u306b\u95a2\u3059\u308b\u3082\u306e\u3068\u306a\u3063\u3066\u3044\u308b\u3002BA.4-5\u3092\u542b\u3080\u30d6\u30fc\u30b9\u30bf\u30fc\uff083\u56de\u4ee5\u4e0a\u306e\u7528\u91cf\uff09\u306f\u3001\u4e00\u4fa1\u30ef\u30af\u30c1\u30f3\u30d6\u30fc\u30b9\u30bf\u30fc\u3067\u4ee5\u524d\u306b\u89b3\u5bdf\u3055\u308c\u305f\u3082\u306e\u3068\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002\u305d\u308c\u306b\u3088\u308a\u3001\u4e8c\u4fa1 mRNA \u30ef\u30af\u30c1\u30f3\u306b\u95a2\u9023\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u306e\u6f5c\u5728\u7684\u306a\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u9069\u5207\u306b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u30c7\u30fc\u30bf\u304c\u4fdd\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002
\n\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u30014\u56de\u76ee\u306e\u63a5\u7a2e\u3068\u3057\u3066\u4e8c\u4fa1mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u305f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306827\u4ef6\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u8abf\u67fb\u3057\u305f\u3002<\/p>\n

Method\uff1a
\n\u30c7\u30b6\u30a4\u30f3\uff1a\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08\u30c7\u30f3\u30de\u30fc\u30af\uff09\u3002
\n\u53c2\u52a0\u8005\uff1a2021\u5e741\u67081\u65e5\u304b\u30892022\u5e7412\u670810\u65e5\u307e\u3067\u306e\u671f\u9593\u4e2d\u306b3\u56de\u306ecovid-19\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f50\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba2,225,567\u4eba
\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u6e2c\u5b9a\uff1a\u4e8c\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u5bfe\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u30924\u56de\u76ee\u306e\u6295\u4e0e\u3068\u3057\u3066\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3057\u305f\u5f8c\u306e28\u65e5\u9593\u306e\u4e3b\u8981\u30ea\u30b9\u30af\u671f\u9593\u306b\u304a\u3051\u308b27\u306e\u7570\u306a\u308b\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u6765\u9662\u7387\u3092\u30013\u56de\u76ee\u307e\u305f\u306f4\u56de\u76ee\u4ee5\u964d\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304b\u308929\u65e5\u76ee\u4ee5\u964d\u306e\u53c2\u7167\u671f\u9593\u7387\u3068\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n

Results\uff1a
\n\u6210\u4eba1,740,417\u4eba\uff08\u5e73\u5747\u5e74\u9f6267.8\u6b73\u3001\u6a19\u6e96\u504f\u5dee10.7\u6b73\uff09\u304c4\u56de\u76ee\u306e\u63a5\u7a2e\u3068\u3057\u3066\u4e8c\u4fa1mRNA\u30ef\u30af\u30c1\u30f3\u3092\u53d7\u3051\u305f\u3002\u4e8c\u4fa1mRNA\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b4\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306f\u300128\u65e5\u4ee5\u5185\u306e27\u4ef6\u306e\u6709\u5bb3\u8ee2\u5e30\u306e\u3044\u305a\u308c\u306e\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5897\u52a0\u7387\u3068\u3082\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\uff08\u4f8b:
\n\u865a\u8840\u6027\u5fc3\u81d3\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u6bd40.95\u300195\uff05\u4fe1\u983c\u533a\u95930.87\uff5e1.04\u3002\u6bd4\u8f03\u3055\u308c\u305f28\u65e5\u9593\u3068\u53c2\u7167\u671f\u9593\u4e2d\u3067\u3001\u305d\u308c\u305e\u308c672\u5bfe9,992\u306e\u30a4\u30d9\u30f3\u30c8\uff09\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u306b\u5f93\u3063\u3066\u5206\u6790\u3055\u308c\u305f\u5834\u5408\u3001\u307e\u305f\u306f\u4ee3\u66ff\u306e\u5206\u6790\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u4f7f\u7528\u3057\u305f\u5834\u5408\u3002\u305f\u3060\u3057\u3001\u4e8b\u5f8c\u5206\u6790\u3067\u306f\u5fc3\u7b4b\u708e\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\uff08\u5973\u6027\u53c2\u52a0\u8005\u3067\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\uff09\u304c\u3001\u7d50\u679c\u306f\u307e\u308c\u3067\u3042\u308a\u3001\u6240\u898b\u306f\u5c11\u6570\u306e\u75c7\u4f8b\u306b\u57fa\u3065\u3044\u3066\u3044\u305f\u3002\u8133\u6897\u585e\u306e\u30ea\u30b9\u30af\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u767a\u751f\u7387\u6bd4 0.95\u300195%\u4fe1\u983c\u533a\u9593 0.87\uff5e1.05\u3001644\u5bfe9687\uff09\u3002<\/p>\n

\"\"<\/a>
\n\u56f31\uff1a\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u6982\u8981\u3002\u4e3b\u306a\u30ea\u30b9\u30af\u671f\u9593\u306f\u30014\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3068\u3057\u30662\u4fa1\u306ecovid-19 mRNA\u8ffd\u52a0\u63a5\u7a2e\u5f8c0\u65e5\u304b\u308928\u65e5\u3002\u7dcf\u53c2\u7167\u671f\u9593\u306f\u30013\u56de\u76ee\u306e\u6295\u4e0e\u5f8c29\u65e5\u4ee5\u4e0a\uff084\u56de\u76ee\u306e\u6295\u4e0e\u306e\u524d\u65e5\u307e\u3067\uff08\u3064\u307e\u308a\u30010\u65e5\u304b\u30891\u65e5\u3092\u5f15\u3044\u305f\u65e5\uff09\uff09\u304a\u3088\u30734\u56de\u76ee\u306e\u6295\u4e0e\uff082\u56de\u76ee\u306e\u8ffd\u52a0\u514d\u75ab\uff09\u304b\u3089\u69cb\u6210\u3055\u308c\u305f\u3002<\/p>\n

\"\"<\/a>
\n\u56f32\uff1a2022\u5e749\u670815\u65e5\u304b\u30892022\u5e7412\u670810\u65e5\u307e\u3067\u306e50\u6b73\u4ee5\u4e0a\u306e\u30c7\u30f3\u30de\u30fc\u30af\u4eba\u6210\u4eba\u306b\u5bfe\u3059\u308b4\u56de\u76ee\u306e\u63a5\u7a2e\u3068\u3057\u30662\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u9069mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u3092\u63a5\u7a2e\u3057\u3066\u304b\u308928\u65e5\u4ee5\u5185\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3002<\/p>\n

\"\"<\/a>
\n\u56f33\uff1a2022\u5e749\u670815\u65e5\u304b\u30892022\u5e7412\u670810\u65e5\u307e\u3067\u306e50\u6b73\u4ee5\u4e0a\u306e\u30c7\u30f3\u30de\u30fc\u30af\u4eba\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30012\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u9069\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306e4\u56de\u76ee\u63a5\u7a2e\u5f8c28\u65e5\u4ee5\u5185\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3092\u6027\u5225\u5225\u306b\u793a\u3057\u305f\u3002<\/p>\n

\"\"<\/a>
\n\u56f34\uff1a2022\u5e749\u670815\u65e5\u304b\u30892022\u5e7412\u670810\u65e5\u307e\u3067\u306e50\u6b73\u4ee5\u4e0a\u306e\u30c7\u30f3\u30de\u30fc\u30af\u4eba\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30012\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u9069\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306e4\u56de\u76ee\u63a5\u7a2e\u5f8c28\u65e5\u4ee5\u5185\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u3092\u5e74\u9f62\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u5225\u306b\u793a\u3057\u305f\u3002<\/p>\n

\"\"<\/a>
\n\u56f35\uff1a2022\u5e749\u670815\u65e5\u304b\u30892022\u5e7412\u670810\u65e5\u307e\u3067\u306b50\u6b73\u4ee5\u4e0a\u306e\u30c7\u30f3\u30de\u30fc\u30af\u4eba\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u30012\u4fa1\u306e\u30aa\u30df\u30af\u30ed\u30f3\u9069\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u30924\u56de\u76ee\u3068\u3057\u3066\u63a5\u7a2e\u3057\u3066\u304b\u308928\u65e5\u4ee5\u5185\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\uff08\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u5225\uff09\u3002<\/p>\n

Discussion\uff1a
\n\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u5206\u6790\u306b\u304a\u3044\u3066\u3001\u30c7\u30f3\u30de\u30fc\u30af\u306e50\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba1,740,417\u4eba\u3092\u5bfe\u8c61\u306b\u30014\u56de\u76ee\u306e\u63a5\u7a2e\u3068\u3057\u3066\u53d7\u3051\u305f\u4e8c\u4fa1\u30aa\u30df\u30af\u30ed\u30f3\u9069\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306b\u95a2\u9023\u3059\u308b27\u4ef6\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u3092\u8a55\u4fa1\u3057\u305f\u30024\u56de\u76ee\u306e\u6295\u4e0e\u3068\u3057\u3066\u4e8c\u4fa1mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u3064\u3044\u3066\u306e\u88cf\u4ed8\u3051\u306f\u898b\u3064\u304b\u3089\u306a\u304b\u3063\u305f\u3002
\n\u672c\u7814\u7a76\u306e\u9650\u754c\u306e1\u3064\u306f\u3001\u6bd4\u8f03\u3057\u305f\u671f\u9593\u9593\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u78ba\u8a8d\u306b\u304a\u3051\u308b\u5dee\u7570\u3092\u6392\u9664\u3067\u304d\u306a\u3044\u3053\u3068\u3067\u3042\u308b\u30024\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c28\u65e5\u9593\u306e\u5272\u5408\u3092\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c29\u65e5\u76ee\u304b\u3089\u306e\u53c2\u7167\u671f\u9593\u306e\u5272\u5408\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3044\u3046\u6211\u3005\u306e\u30c7\u30b6\u30a4\u30f3\u306e\u7a4d\u6975\u7684\u306a\u6bd4\u8f03\u7279\u6027\u306b\u3088\u308a\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u4e2d\u306e\u5272\u5408\u3068\u306e\u6bd4\u8f03\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u671f\u9593\u306e\u8ee2\u5e30\u306e\u78ba\u8a8d\u306b\u304a\u3051\u308b\u5dee\u7570\u304c\u8efd\u6e1b\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u78ba\u8a3c\u30d0\u30a4\u30a2\u30b9\u3092\u5b8c\u5168\u306b\u6392\u9664\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304b\u3089\u9577\u6642\u9593\u7d4c\u904e\u3057\u305f\u57fa\u6e96\u671f\u9593\u3068\u6bd4\u8f03\u3057\u3066\u30014\u56de\u76ee\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u6570\u9031\u9593\u3067\u65e2\u77e5\u306e\u6709\u5bb3\u4e8b\u8c61\uff08\u4f8b\u3001\u5fc3\u7b4b\u708e\uff09\u306b\u95a2\u9023\u3059\u308b\u75c7\u72b6\u306b\u5bfe\u3059\u308b\u610f\u8b58\u304c\u5897\u52a0\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u89b3\u5bdf\u3055\u308c\u305f\u3082\u306e\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u7d50\u679c\u306f\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u504f\u308b\u3053\u3068\u306b\u306a\u308b\u3002\u6700\u5f8c\u306b\u3001\u8a55\u4fa1\u304a\u3088\u3073\u5b9f\u65bd\u3055\u308c\u305f\u5206\u6790\u306e\u5e83\u7bc4\u306a\u7d50\u679c\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u8907\u6570\u306e\u691c\u67fb\u3092\u8003\u616e\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u507d\u967d\u6027\u6240\u898b\u306e\u78ba\u7387\u306f\u9ad8\u304b\u3063\u305f\u3002\u305f\u3060\u3057\u3001\u4e00\u8cab\u3057\u3066\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u898b\u3064\u304b\u3089\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u7d50\u8ad6\uff1a
\n\u30fb4\u56de\u76ee\u306e\u63a5\u7a2e\u3068\u3057\u3066\u4e8c\u4fa1\u306e\u30aa\u30df\u30af\u30ed\u30f3\u9069\u5fdcmRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u3092\u53d7\u3051\u305f170\u4e07\u4eba\u4ee5\u4e0a\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u30c7\u30f3\u30de\u30fc\u30af\u5168\u56fd\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002
\n\u30fb\u3069\u306e\u6027\u5225\u3001\u5e74\u9f62\u3001\u30ef\u30af\u30c1\u30f3\u306e\u7a2e\u985e\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u3082\u8133\u6897\u585e\u3068\u306e\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002
\n\u30fb\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u4e8c\u4fa1mRNA\u30ef\u30af\u30c1\u30f3\u306e\u4f7f\u7528\u306e\u5b89\u5168\u6027\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n

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-\u6587\u732e\u540d- Niklas Worm Andersson. Safety of BA.4-5 or BA.1 bivalent mRNA booster vaccines: nationwide cohort study. … \u7d9a\u304d\u3092\u8aad\u3080 BA.4-5\u304a\u3088\u3073BA.1\u4e8c\u4fa1mRNA\u8ffd\u52a0\u514d\u75ab\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2563","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2563"}],"version-history":[{"count":3,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2563\/revisions"}],"predecessor-version":[{"id":2571,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2563\/revisions\/2571"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}