{"id":2575,"date":"2024-03-27T18:37:45","date_gmt":"2024-03-27T09:37:45","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2575"},"modified":"2024-03-27T18:37:45","modified_gmt":"2024-03-27T09:37:45","slug":"%e4%bd%8e%e7%94%a8%e9%87%8f%e3%82%a2%e3%82%b9%e3%83%94%e3%83%aa%e3%83%b3%e3%81%ae%e9%80%a3%e6%97%a5%e6%8a%95%e4%b8%8e%e3%81%ab%e3%82%88%e3%82%8b%e9%89%84%e6%ac%a0%e4%b9%8f%e3%81%a8%e8%b2%a7%e8%a1%80","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2575","title":{"rendered":"\u4f4e\u7528\u91cf\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u9023\u65e5\u6295\u4e0e\u306b\u3088\u308b\u9244\u6b20\u4e4f\u3068\u8ca7\u8840"},"content":{"rendered":"

\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002
\n-\u6587\u732e\u540d-
\nZoe K McQuilten, et al. Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly : A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial. Ann Intern Med. 2023; 176(7): 913-921.<\/p>\n

-\u8981\u7d04-
\n\u25cfIntroduction
\n\u30fb\u9ad8\u9f62\u8005\u306e\u8ca7\u8840(\u7537\u6027Hb 12.0 g\/dl\u672a\u6e80\u3001\u5973\u6027Hb 11.0 g\/dl\u672a\u6e80 (WHO\u306e\u5b9a\u7fa9))\u306f\u91cd\u8981\u306a\u5065\u5eb7\u554f\u984c\u3002
\n\u30fb75\u6b73\u4ee5\u4e0a\u306e\u4eba\u306e\u8ca7\u8840\u306e\u5272\u5408\uff1a\u7d0430%(\u5165\u9662\u60a3\u8005\u4f8b)\u3001\u7d0412%(\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u30d9\u30fc\u30b9)\u3002
\n\u30fb\u9ad8\u9f62\u8005\u306e\u8ca7\u8840\u306e\u539f\u56e0\u3068\u3057\u3066\u306f\u3001\u9244\u6b20\u4e4f\u30fb\u814e\u6027\u30fb\u6162\u6027\u708e\u75c7\u6027\u304c\u591a\u3044\u304c\u30011\/3\u306f\u539f\u56e0\u4e0d\u660e\u3002
\n\u30fb\u8ca7\u8840\u306f\u3001\u6a5f\u80fd\u969c\u5bb3\u30fb\u75c5\u7684\u72b6\u614b\u30fb\u6b7b\u4ea1\u7387\u3068\u95a2\u9023\u3002\u305f\u3060\u3057\u56e0\u679c\u95a2\u4fc2\u306f\u4e0d\u660e\u3002\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u3063\u305f\u3068\u3057\u3066\u3001\u8ca7\u8840\u304c\u5065\u5eb7\u306b\u53ca\u307c\u3059\u6f5c\u5728\u7684\u306a\u5f71\u97ff\u304c\u4ecb\u5165\u53ef\u80fd\u306a\u3082\u306e\u306a\u306e\u304b\u3069\u3046\u304b\u3082\u4e0d\u660e\u78ba\u3002<\/p>\n

\u30fb\u7c73\u56fd\u3067\u306f\u7d0450%\u306e\u9ad8\u9f62\u8005\u304c\u4e88\u9632\u7684\u306b\u30a2\u30b9\u30d4\u30ea\u30f3\u5185\u670d\u3057\u3066\u3044\u305f\u304c\u3001\u6700\u8fd1\u306e\u975e\u63a8\u5968\u306b\u4f34\u3044\u6e1b\u5c11\u4e2d\u3002
\n\u30fb\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u5bb3\u306f\u5927\u51fa\u8840\u3001\u3068\u308a\u308f\u3051\u6d88\u5316\u7ba1\u51fa\u8840\u3067\u3001\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u306f\u9ad8\u9f62\u8005\u306b\u591a\u3044\u3002
\n\u30fb\u9855\u6027\u51fa\u8840\u3068\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u95a2\u4fc2\u306f\u660e\u3089\u304b\u3060\u304c\u3001\u8ca7\u8840\u3068\u306e\u95a2\u4fc2\u3092\u7814\u7a76\u3057\u305f\u5831\u544a\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3002
\n\u30fb\u4e0d\u9855\u6027\u51fa\u8840\u306b\u3088\u308a\u9244\u6b20\u4e4f\u3092\u8d77\u3053\u3057\u8ca7\u8840\u3068\u306a\u308b\u53ef\u80fd\u6027\u3001\u4e00\u65b9\u3067\u708e\u75c7\u3092\u6291\u3048\u308b\u6a5f\u5e8f\u3067\u8ca7\u8840\u306b\u6291\u5236\u7684\u306b\u50cd\u304f\u304b\u3082\u3002<\/p>\n

\u30fbThe ASPREE (ASPirin in Reducing Events in the Elderly)\u8a66\u9a13\u306f\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u7121\u4f5c\u70ba\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u300170\u6b73\u4ee5\u4e0a(\uff0a\u7c73\u56fd\u306e\u9ed2\u4eba\u30fb\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u306b\u304a\u3044\u3066\u306f65\u6b73\u4ee5\u4e0a)\u306e\u5065\u5e38\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30b9\u30d4\u30ea\u30f3100 mg\u5185\u670d\u7fa4\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7121\u969c\u5bb3\u751f\u5b58\u671f\u9593\u3092\u5ef6\u9577\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306b\u7f6e\u3044\u305f\u7814\u7a76\u3002\uff08\uff0a\u5927\u7530\u6ce8\uff1a\u7d50\u8ad6\u3068\u3057\u3066\u306f\u5ef6\u9577\u3055\u305b\u306a\u304b\u3063\u305f\u3002N Engl J Med 2018; 379(16): 1519-1528.\uff09
\n\u30fb\u5168\u53c2\u52a0\u8005\u306f\u6bce\u5e74Hb\u5024\u6e2c\u5b9a\u3057\u3001\u4e00\u90e8\u306f\u8a66\u9a13\u958b\u59cb\u6642\u30683\u5e74\u5f8c\u306b\u751f\u5316\u5b66\u63a1\u8840\u3082\u5b9f\u65bd\u3002
\n\u30fbASPREE\u8a66\u9a13\u306epost hoc\u89e3\u6790(\u4e8b\u5f8c\u89e3\u6790)\u306e
\n\u4e3b\u306a\u76ee\u7684\uff09\u5065\u5e38\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u7528\u91cf\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u9023\u65e5\u6295\u4e0e\u304c\u8ca7\u8840\u306e\u767a\u75c7\u7387\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b
\n\u526f\u6b21\u7684\u76ee\u7684\uff09Hb\u5024\u3001Fer\u3001\u9244\u6b20\u4e4f\u306e\u5909\u5316\u306b\u5bfe\u3059\u308b\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u5f71\u97ff\u3092\u63a2\u7d22\u3059\u308b<\/p>\n

\u25cfMethod
\n\u30fbASPREE\u8a66\u9a13\u306b\u3064\u3044\u3066
\n2010\u5e743\u6708\uff5e2014\u5e7412\u6708\u3000\u5e02\u4e2d\u5728\u4f4f\u306e19114\u4eba\u7d44\u307f\u5165\u308c\u3002\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u30d7\u30e9\u30a4\u30de\u30ea\u30fb\u30b1\u30a2\u63d0\u4f9b\u8005or \u7c73\u56fd\u306e\u81e8\u5e8a\u8a66\u9a13\u30bb\u30f3\u30bf\u30fc\u3092\u901a\u3058\u3066\u3002\uff0a\u9664\u5916\uff1a\u8ca7\u8840\u3042\u308a\u3001\u51fa\u8840\u306e\u9ad8\u30ea\u30b9\u30af\u7fa4(\u4f8b\uff1a\u6d88\u5316\u6027\u6f70\u760d\u65e2\u5f80\u3001\u98df\u9053\u9759\u8108\u7624)\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u3092\u4e8c\u6b21\u4e88\u9632\u3067\u4f7f\u7528\u3001\u4ed6\u306e\u6297\u8840\u5c0f\u677f\u85ac\u3084\u6297\u51dd\u56fa\u85ac\u4f7f\u7528\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6b74\u3001Af\u3001\u4e88\u5f8c5\u5e74\u4ee5\u5185\u304c\u60f3\u5b9a\u3055\u308c\u308b\u75be\u60a3\u4f75\u5b58\u3001\u8a8d\u77e5\u75c7\u3002\uff0aNSAIDs\u4f7f\u7528\u306f\u5fc5\u8981\u6700\u5c0f\u9650\u306b\u9650\u308a\u8a31\u53ef\u3055\u308c\u305f\u3002
\n\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u30fb\u30d7\u30e9\u30bb\u30dc\u7fa4\u30921:1\u306b\u632f\u308a\u5206\u3051\u3002\u5e741\u56de\u53d7\u8a3a\u3068\u30ab\u30eb\u30c6\u30ec\u30d3\u30e5\u30fc\u3001\u5b9a\u671f\u7684\u306a\u96fb\u8a71\u3067\u306e\u78ba\u8a8d\u3067\u88dc\u8db3\u3002\u5e741\u56de\u63a1\u8840\u3002<\/p>\n

\u30fb\u30d5\u30a7\u30ea\u30c1\u30f3\uff1a\u5272\u4ed8\u6642\u3068\u30013\u5e74\u5f8c\u30d5\u30a9\u30ed\u30fc\u6642\u306e\u8840\u6db2\u691c\u4f53\u3067\u53ef\u80fd\u306a\u7bc4\u56f2\u3067\u6e2c\u5b9a\u3002<\/p>\n

\u30fb\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5b9a\u7fa9
\n\u30d7\u30e9\u30a4\u30de\u30ea\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u8ca7\u8840\u306e\u767a\u75c7\u7387(\u7537\u6027Hb 12.0 g\/dl\u672a\u6e80\u3001\u5973\u6027Hb 11.0 g\/dl\u672a\u6e80 (WHO\u306e\u5b9a\u7fa9))\u3002
\n\uff0a\u6bce\u5e74\u306eHb\u5024\u6e2c\u5b9a\u30c7\u30fc\u30bf\u3092\u5229\u7528\u3002
\n\u30bb\u30ab\u30f3\u30c0\u30ea\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u5927\u51fa\u8840\uff08\u8133\u51fa\u8840\u3001\u6709\u610f\u306a\u982d\u84cb\u5916\u51fa\u8840(\u8f38\u8840\u30fb\u5165\u9662\u30fb\u5165\u9662\u671f\u9593\u5ef6\u9577\u30fb\u624b\u8853\u3092\u8981\u3057\u305f\u3001\u6b7b\u4ea1\u306b\u3064\u306a\u304c\u3063\u305f)\uff09<\/p>\n

\u30fb\u7d71\u8a08\u5b66\u7684\u89e3\u6790
\n-\u9244\u6b20\u4e4f\u306e\u5b9a\u7fa9\u306f\u3001Fer <45 \u00b5g\/L\u3092\u63a1\u7528(\u7c73\u56fd\u6d88\u5316\u5668\u75c5\u5b66\u4f1a)
\n-\u6bce\u5e74Hb\u5024\u6e2c\u5b9a\u3057\u3001\u8ca7\u8840\u51fa\u73fe\u307e\u3067\u306e\u671f\u9593\u3092\u5206\u6790\u3059\u308b\u305f\u3081\u306b\u30b3\u30c3\u30af\u30b9\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3002
\n-\u7d2f\u7a4d\u767a\u75c7\u7387\u306e\u6e2c\u5b9a\u306b\u306fAalen-Johansen estimator\u3092\u4f7f\u7528(Kaplan\u2013Meier estimator\u306emulti-state (matrix) version)
\n-\u4e00\u6b21\u89e3\u6790\u306f\u8abf\u6574\u306a\u3057\u3001\u4e8c\u6b21\u89e3\u6790\u3067\u306f\u8ca7\u8840\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u5f97\u308b\u4e88\u5f8c\u56e0\u5b50\u3067\u8abf\u6574(\u6027\u5225\u3001\u5e74\u9f62\u3001\u4eba\u7a2e\u3001\u5c45\u4f4f\u72b6\u6cc1\u3001\u55ab\u7159\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u91cf\u3001eGFR\u3001\u764c\u306e\u65e2\u5f80(\u30e1\u30e9\u30ce\u30fc\u30de\u4ee5\u5916\u306e\u76ae\u819a\u816b\u760d\u3092\u9664\u304f))\u3001\u7cd6\u5c3f\u75c5\u3001CKD(\u5c3fAlb\/Cr 30 mg\/gCr\u4ee5\u4e0a or eGFR 60\u672a\u6e80\u3067\u5b9a\u7fa9)\u3001\u9ad8\u8840\u5727\u3001NSAIDs\u4f7f\u7528\u3001PPI\u4f7f\u7528)\u3002
\n-ASPREE\u8a66\u9a13\u306e\u4e00\u6b21\u7d50\u679c\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067\u306f\u764c\u7f79\u60a3\u304a\u3088\u3073\u30b9\u30c6\u30fc\u30b8IV\u306e\u764c\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u2192\u8ca7\u8840\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u52b9\u679c\u304c\u764c\u7f79\u60a3\u3068\u306f\u72ec\u7acb\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u8a66\u9a13\u671f\u9593\u4e2d\u306e\u764c\u30a4\u30d9\u30f3\u30c8\u3092\u7af6\u5408\u30ea\u30b9\u30af\u3068\u3057\u3066\u6271\u3046\u611f\u5ea6\u5206\u6790\u3092\u884c\u3063\u305f\u3002
\n-\u30a2\u30b9\u30d4\u30ea\u30f3\u3068Hb\u5024\u306e\u7d4c\u6642\u7684\u5909\u5316\u306e\u95a2\u9023\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u4e88\u5f8c\u56e0\u5b50\u3067\u8abf\u6574\u3057\u305f\u591a\u5909\u91cf\u7dda\u5f62\u6df7\u5408\u52b9\u679c\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u3002
\n-\u4e88\u5f8c\u56e0\u5b50\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u53c2\u52a0\u8005\u306f\u3001\u89e3\u6790\u304b\u3089\u9664\u5916\u3057\u305f\u3002
\n-\u30a2\u30b9\u30d4\u30ea\u30f3\u3068Fer\u5024\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u7dda\u5f62\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u3002
\n-\u5168\u89e3\u6790\u306fITT\u3067\u3002\u7d71\u8a08\u30bd\u30d5\u30c8\u306fR ver 4.0 or Stata\/SE17\u3092\u7528\u3044\u305f\u3002<\/p>\n

\u25cfResults
\n\u30fb\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u5404\u30b0\u30eb\u30fc\u30d7\u30014.7\u5e74(\u56db\u5206\u4f4d\u7bc4\u56f2(IQR)\uff1a3.6-5.7\u5e74)\u3002
\n\u30fb\u5404\u7fa4\u306e\u7279\u5fb4\uff1a\u5927\u304d\u306a\u5dee\u306f\u306a\u3044\uff08Table\uff09
\n\"\"<\/a>
\n\u5404\u7fa4\u3001\u5e73\u574774\u6b73\u304f\u3089\u3044\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u5728\u4f4f\u306e\u767d\u4eba\u7a2e\u304c8\u5272\u5f37\u3001\u764c\u306e\u65e2\u5f80\u306f2\u5272\u3001\u904e\u53bb\u306e\u30a2\u30b9\u30d4\u30ea\u30f3\u4f7f\u7528\u6b74\u306f1\u5272\u3001CKD 26%\u3001\u30d9\u30fc\u30b9\u306eHb\u502414.2 g\/dl\u3001\u9ad8\u8840\u572774%\u3001NSAIDs\u4f7f\u75281\u5272\u5f31\u3001PPI\u4f7f\u752824%\u3002<\/p>\n

\u30fb\u8ca7\u8840\u306e\u767a\u75c7\u7387\uff1a\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067\u306f1000\u4eba\u5e74\u3042\u305f\u308a51\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f1000\u4eba\u5e74\u3042\u305f\u308a43 \u3068\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067\u6709\u610f\u306b\u9ad8\u3044
\n\u30fb5\u5e74\u4ee5\u5185\u306b\u8ca7\u8840\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u306723.5\uff05\uff0895\uff05\u4fe1\u983c\u533a\u9593:22.4\uff05-24.6\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306720.3\uff05\uff0819.3\uff05-21.4\uff05\uff09\uff1aHR 1.20 (1.12\u20141.29) \u2190 \u764c\u306e\u767a\u75c7\u306b\u95a2\u3059\u308b\u611f\u5ea6\u5206\u6790\u3084\u3001\u8ca7\u8840\u30ea\u30b9\u30af\u3092\u4e0a\u3052\u308b\u8981\u7d20\u306b\u3064\u3044\u3066\u8abf\u6574\u5f8c\u3082\u6709\u610f\u306a\u307e\u307e\u3002(Fig. 2)
\n\"\"<\/a><\/p>\n

\u30fbHb\u5024\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u30795\u5e74\u5f53\u305f\u308a0.6 g\/L\u4f4e\u4e0b\uff080.3-1.0 g\/L\uff09\u3002(Fig. 3)
\n\u30fbFer\u5024\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u30793\u5e74\u76ee\u306eFer\u5024\u304c45\u03bcg\/L\u672a\u6e80\uff0831\u4f8b\uff09\u304a\u3088\u3073100\u03bcg\/L\u672a\u6e80\uff0832\u4f8b\uff09\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304b\u3063\u305f\uff08\u305d\u308c\u305e\u308c\u3001465\u4f8b[13\uff05]\u5bfe350\u4f8b[9.8\uff05]\u30011395\u4f8b[39\uff05]\u5bfe1116\u4f8b[31\uff05]\uff09\u3002(Fig. 4)\u3000\uff08\uff0a\u5927\u7530\u6ce8\uff1aFer<45\u304c\u3001\u672c\u7814\u7a76\u3067\u306e\u9244\u6b20\u4e4f\u306e\u5b9a\u7fa9\uff09
\n\u30fb\u8a66\u9a13\u671f\u9593\u4e2d\u3001465\u4eba\uff082.6\uff05\uff09\u304c\u5c11\u306a\u304f\u3068\u30821\u56de\u306e\u5927\u51fa\u8840\u3092\u7d4c\u9a13\u3057\u305f\uff1a \u30a2\u30b9\u30d4\u30ea\u30f3\u7fa4\u3067273\u4f8b\uff083.0\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067192\u4f8b\uff082.1\uff05\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u25cfDiscussion
\n\u30fb\u611f\u5ea6\u5206\u6790\u306b\u3088\u308a\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u5dee\u306f\u3001\u8ca7\u8840\u306e\u767a\u751f\u3084Fer\u5024\u306e\u6e1b\u5c11\u306e\u5168\u4f53\u7684\u306a\u5dee\u3092\u8aac\u660e\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u2192\u30a2\u30b9\u30d4\u30ea\u30f3\u6295\u4e0e\u7fa4\u306b\u304a\u3051\u308b\u8ca7\u8840\u30ea\u30b9\u30af\u5897\u52a0\u306e\u539f\u56e0\u3068\u3057\u3066\u306f\u3001\u4e0d\u9855\u6027\u51fa\u8840\u304c\u8003\u3048\u3089\u308c\u308b\u3002
\n\u30fb\u4e0d\u9855\u6027\u51fa\u8840\u306e\u6a5f\u5e8f\u3068\u3057\u3066\u306f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u306b\u3088\u308b\u8840\u5c0f\u677f\u51dd\u96c6\u4f4e\u4e0b\u4f5c\u7528\u306e\u307b\u304b\u3001COX-1\u963b\u5bb3\u306b\u3088\u308a\u6d88\u5316\u7ba1\u306e\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u7523\u751f\u3092\u6291\u5236\u3057\u7c98\u819c\u4fdd\u8b77\u4f5c\u7528\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3001\u4e0d\u9855\u6027\u306e\u6d88\u5316\u7ba1\u51fa\u8840\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u60f3\u5b9a\u3055\u308c\u308b\u3002
\n\u30fb\u30a2\u30b9\u30d4\u30ea\u30f3\u5185\u670d\u306f\u901a\u5e38\u9577\u671f\u306b\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u5b9a\u671f\u7684\u306a\u63a1\u8840\u3067\u306e\u8ca7\u8840\u306e\u8a55\u4fa1\u304c\u5fc5\u8981\u3068\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3002<\/p>\n

\u30fb\u672c\u7814\u7a76\u306e\u9650\u754c
\n-\u8ca7\u8840\u304c\u5e741\u56de\u306e\u30ec\u30d3\u30e5\u30fc\u306e\u9593\u306b\u8a66\u9a13\u5916\u306e\u533b\u5e2b\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u6cbb\u7642\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8ca7\u8840\u767a\u751f\u7387\u306e\u904e\u5c0f\u8a55\u4fa1\u306b\u3064\u306a\u304c\u3063\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002
\n-\u81e8\u5e8a\u7684\u306b\u91cd\u5927\u306a\u51fa\u8840\u306e\u5b9a\u7fa9\u306f\u3001\u75c5\u9662\u3067\u306e\u6cbb\u7642\u4f8b\u306e\u307f\u3092\u542b\u3093\u3067\u304a\u308a\u3001\u5916\u6765\u3067\u6cbb\u7642\u3057\u305f\u91cd\u75c7\u306e\u9f3b\u51fa\u8840\u306e\u3088\u3046\u306a\u4ed6\u306e\u51fa\u8840\u4e8b\u8c61\u306f\u8003\u616e\u3057\u3066\u3044\u306a\u3044\u3002
\n-\u8ca7\u8840\u306e\u539f\u56e0\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u306a\u3044\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112023\u5e749\u67086\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002 -\u6587\u732e\u540d- Zoe K McQuilten, et al. Effect of L … \u7d9a\u304d\u3092\u8aad\u3080 \u4f4e\u7528\u91cf\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u9023\u65e5\u6295\u4e0e\u306b\u3088\u308b\u9244\u6b20\u4e4f\u3068\u8ca7\u8840<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33,17,11],"tags":[],"class_list":["post-2575","post","type-post","status-publish","format-standard","hentry","category-whats-new","category-17","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2575"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2575\/revisions"}],"predecessor-version":[{"id":2579,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2575\/revisions\/2579"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}