{"id":2580,"date":"2024-03-27T18:38:39","date_gmt":"2024-03-27T09:38:39","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2580"},"modified":"2024-03-27T18:38:39","modified_gmt":"2024-03-27T09:38:39","slug":"%e6%97%a9%e6%9c%9f%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%ac%e3%82%ab%e3%83%8d%e3%83%9e%e3%83%96","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2580","title":{"rendered":"\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u30ec\u30ab\u30cd\u30de\u30d6"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nC.H. van Dyck, C.J. Swanson, P. Aisen, et al. Lecanemab in Early Alzheimer\u2019s Disease. N Engl J Med. 2023;388(1):9-21.<\/p>\n

-\u8981\u7d04-
\n\u3010Abstract\u3011
\n\uff08\u80cc\u666f\uff09\u53ef\u6eb6\u6027\u304a\u3088\u3073\u4e0d\u6eb6\u6027\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\uff08A\u03b2\uff09\u51dd\u96c6\u4f53\u306e\u84c4\u7a4d\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u75c5\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u958b\u59cb\u307e\u305f\u306f\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u30ec\u30ab\u30cd\u30de\u30d6\u306f\u3001\u53ef\u6eb6\u6027\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30d7\u30ed\u30c8\u30d5\u30a3\u30d6\u30ea\u30eb\u306b\u9ad8\u89aa\u548c\u6027\u3067\u7d50\u5408\u3059\u308b\u30d2\u30c8\u5316IgG1\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308a\u3001\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u3002
\n\uff08\u65b9\u6cd5\uff09\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3088\u308b\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u75c7\uff09\u3067\u3001\u30dd\u30b8\u30c8\u30ed\u30f3\u65ad\u5c64\u64ae\u5f71\uff08PET\uff09\u307e\u305f\u306f\u8133\u810a\u9ac4\u6db2\u691c\u67fb\u3067\u30a2\u30df\u30ed\u30a4\u30c9\u304c\u8a8d\u3081\u3089\u308c\u305f50\uff5e90\u6b73\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u300118\u30f6\u6708\u9593\u306e\u591a\u65bd\u8a2d\u5171\u540c\u4e8c\u91cd\u76f2\u691c\u7b2c3\u76f8\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f\u3001\u30ec\u30ab\u30cd\u30de\u30d6\u9759\u8108\u5185\u6295\u4e0e\u7fa4\uff08\u4f53\u91cd1kg\u3042\u305f\u308a10mg\u30922\u9031\u9593\u3054\u3068\u306b\u6295\u4e0e\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306b1\uff1a1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001CDR-SB\u203b\u6ce81\uff08Clinical Dementia Rating-Sum of Boxes\uff1b0\uff5e18\u70b9\u3001\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u307b\u3069\u969c\u5bb3\u304c\u5927\u304d\u3044\u3053\u3068\u3092\u793a\u3059\uff09\u306e18\u30f6\u6708\u6642\u70b9\u306b\u304a\u3051\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u3067\u3042\u3063\u305f\u3002\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001PET\u306b\u3088\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u84c4\u7a4d\u306e\u5909\u5316\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8a55\u4fa1\u5c3a\u5ea6\uff08ADAS-cog14\uff09\u306e14\u9805\u76ee\u306e\u8a8d\u77e5\u6a5f\u80fd\u30b5\u30d6\u30b9\u30b1\u30fc\u30eb\u306e\u30b9\u30b3\u30a2\uff08ADAS-cog14\u30010\uff5e90\u70b9\u3001\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u307b\u3069\u969c\u5bb3\u304c\u5927\u304d\u3044\u3053\u3068\u3092\u793a\u3059\uff09\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u8907\u5408\u30b9\u30b3\u30a2\uff08ADCOMS\u30010\uff5e1.97\u70b9\uff1b\u30b9\u30b3\u30a2\u304c\u9ad8\u3044\u307b\u3069\u969c\u5bb3\u304c\u5f37\u3044\u3053\u3068\u3092\u793a\u3059\uff09\u3001Alzheimer’s Disease Cooperative Study-Activities of Daily Living Scale for Mild Cognitive Impairment\uff08ADCS-MCI-ADL\uff1b0\uff5e53\u70b9\uff1b\u30b9\u30b3\u30a2\u304c\u4f4e\u3044\u307b\u3069\u969c\u5bb3\u304c\u5f37\u3044\u3053\u3068\u3092\u793a\u3059\uff09\u306e\u30b9\u30b3\u30a2\u3067\u3042\u308b\u3002
\n\uff08\u7d50\u679c\uff09\u5408\u8a081795\u4eba\u304c\u767b\u9332\u3055\u308c\u3001898\u4eba\u304c\u30ec\u30ab\u30cd\u30de\u30d6\u6295\u4e0e\u7fa4\u3001897\u4eba\u304c\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u5e73\u5747CDR-SB\u30b9\u30b3\u30a2\u306f\u4e21\u7fa4\u3068\u3082\u7d043.2\u3067\u3042\u3063\u305f\u300218\u30f6\u6708\u6642\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u8abf\u6574\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5909\u5316\u91cf\u306f\u3001\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u30671.21\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30671.66\u3067\u3042\u3063\u305f\uff08\u5dee-0.45\uff1b95%CI\u3001-0.67\uff5e-0.23\uff1bP<0.001\uff09\u3002698\u4eba\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3067\u306f\u3001\u30ec\u30ab\u30cd\u30de\u30d6\u306e\u65b9\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u84c4\u7a4d\u306e\u6e1b\u5c11\u304c\u5927\u304d\u304b\u3063\u305f\uff08\u5dee-59.1\u30bb\u30f3\u30c1\u30ed\u30a4\u30c9\uff1b95\uff05CI\u3001-62.6\uff5e-55.6\u3000\u203b\u6ce82\uff09\u3002ADAS-cog14\u30b9\u30b3\u30a2\u3067\u306f-1.44\uff0895\uff05CI\u3001-2.27\uff5e-0.61\u3001P<0.001\uff09\u3001ADCOMS\u30b9\u30b3\u30a2\u3067\u306f-0.050\uff0895\uff05CI\u3001-0.074\uff5e-0.027\u3001P<0.001\uff09\u3001ADCS-MCI-ADL\u30b9\u30b3\u30a2\u3067\u306f2.0\uff0895\uff05CI\u30011.2\uff5e2.8\u3001P<0.001\uff09\u3067\u3042\u3063\u305f\u3002\u30ec\u30ab\u30cd\u30de\u30d6\u6295\u4e0e\u306b\u3088\u308a26.4\uff05\u306b\u6025\u6027\u6ce8\u5165\u53cd\u5fdc\uff08\u30a4\u30f3\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u30ea\u30a2\u30af\u30b7\u30e7\u30f3\uff09\u304c\u300112.6\uff05\u306b\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\uff1bARIA-E\uff08\u982d\u90e8MRI\u3067\u306e\u6d6e\u816b\u6027\u5909\u5316\uff09\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\n\uff08\u7d50\u8ad6\uff09\u30ec\u30ab\u30cd\u30de\u30d6\u306f\u3001\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u306e\u30de\u30fc\u30ab\u30fc\u3092\u6e1b\u5c11\u3055\u305b\u300118\u30f5\u6708\u5f8c\u306e\u8a8d\u77e5\u6a5f\u80fd\u3068\u6a5f\u80fd\u306e\u6e2c\u5b9a\u306b\u304a\u3044\u3066\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u4e2d\u7b49\u5ea6\u306e\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u305f\u304c\u3001\u6709\u5bb3\u4e8b\u8c61\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u30ec\u30ab\u30cd\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u3088\u308a\u9577\u671f\u9593\u306e\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\uff08\u8cc7\u91d1\u63d0\u4f9bor\u7814\u7a76\u5354\u529b\uff1a\u30a8\u30fc\u30b6\u30a4(\u65e5)\u3001\u30d0\u30a4\u30aa\u30b8\u30a7\u30f3(\u7c73)\uff09\n\u203b\u6ce81\uff1a\u65e5\u672c\u8a9e\u7248CDR\uff080.5\u70b9\u3092MCI\u30011\u70b9\u4ee5\u4e0a\u3092\u8a8d\u77e5\u75c7\u3068\u3057\u3066\u6349\u3048\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u5404\u30b9\u30b3\u30a2\u306e\u5408\u8a08\uff1dCDR-SB\uff09\n\"\"<\/a>
\n\u203b\u6ce82\uff1a\u30bb\u30f3\u30c1\u30ed\u30a4\u30c9\u306fPET\u306b\u304a\u3051\u308b\u30a2\u30df\u30ed\u30a4\u30c9\u96c6\u7a4d\u91cf\u306e\u8a55\u4fa1\u6cd5\u3002\u82e5\u5e74\u6b63\u5e38\u9670\u6027\u30920\u3001\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u306e\u5178\u578b\u7684\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u5e73\u5747\u30ec\u30d9\u30eb\u3092100\u3068\u3057\u3066\u8868\u73fe\u300250\u30bb\u30f3\u30c1\u30ed\u30a4\u30c9\u4ee5\u4e0a\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u78ba\u5b9a\u8a3a\u65ad\u75c5\u7406\u4f8b\u306b\u76f8\u5f53\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u3010Introduction\u3011
\n\u30fb\u30a2\u30df\u30ed\u30a4\u30c9\u306e\u9664\u53bb\u304c\u8a8d\u77e5\u75c7\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002
\n\u30fb\u6297\u30a2\u30df\u30ed\u30a4\u30c9\u6297\u4f53\u306e\u4e00\u3064\uff08\u30a2\u30c7\u30e5\u30ab\u30cc\u30de\u30d6\u3001\u7c73\u56fd\u5546\u54c1\u540d\uff1a\u30a2\u30c7\u30e5\u30d8\u30eb\u30e0\uff09\u306f\u3001\u7c73\u56fdFDA\u304b\u3089\u65e9\u671f\u627f\u8a8d\u3092\u53d7\u3051\u3066\u3044\u308b\u3002
\n\u30fb\u30ec\u30ab\u30cd\u30de\u30d6\uff08\u7c73\u56fd\u5546\u54c1\u540d\uff1a\u30ec\u30b1\u30f3\u30d3\uff09\u306f\u30d2\u30c8\u5316\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3001\u53ef\u6eb6\u6027\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30d7\u30ed\u30c8\u30d5\u30a3\u30d6\u30ea\u30eb\u306b\u9ad8\u89aa\u548c\u6027\u3067\u7d50\u5408\u3059\u308b\u3002
\n\u30fb\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u30ec\u30ab\u30cd\u30de\u30d6\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3059\u308b\u7b2c3\u76f8\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002<\/p>\n

\u3010Methods\u3011
\n\u30fb\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f18\u30f6\u6708\u9593\u306e\u591a\u65bd\u8a2d\u5171\u540c\u30fb\u4e8c\u91cd\u76f2\u691c\u30fb\u30d7\u30e9\u30bb\u30dc\u6bd4\u8f03\u8a66\u9a13\u3002
\n\u30fb\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\uff0810mg\/\u4f53\u91cdkg\u30922\u9031\u3054\u3068\u6295\u4e0e\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b1:1\u306b\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u3057\u305f\u3002
\n\u5c64\u5225\u5316\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3088\u308b\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u3001\u6297\u8a8d\u77e5\u75c7\u85ac\u306e\u4f7f\u7528\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dE\u03b54\u30ad\u30e3\u30ea\u30a2\u306e\u6709\u7121\u3001\u5730\u7406\u7684\u7279\u6027\u3002
\n\u30fb\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304a\u3088\u3073\u7d71\u8a08\u5b66\u306e\u5c02\u9580\u5bb6\u306b\u3088\u308b\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u304c\u3001\u76f2\u691c\u5316\u3055\u308c\u3066\u3044\u306a\u3044\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u305f\u3002
\n\u72ec\u7acb\u3057\u305f\u533b\u7642\u30c1\u30fc\u30e0\uff08\u8a66\u9a13\u5272\u308a\u5f53\u3066\u30b0\u30eb\u30fc\u30d7\u3092\u77e5\u3089\u306a\u3044\uff09\u304cARIA\u3001\u8f38\u6db2\u95a2\u9023\u53cd\u5fdc\u3001\u904e\u654f\u6027\u53cd\u5fdc\u3092\u691c\u8a0e\u3057\u305f\u3002
\n\u81e8\u5e8a\u8a55\u4fa1\u8005\u306f\u3001\u5b89\u5168\u6027\u8a55\u4fa1\u304a\u3088\u3073\u8a66\u9a13\u5272\u308a\u5f53\u3066\u30b0\u30eb\u30fc\u30d7\u3092\u77e5\u3089\u306a\u304b\u3063\u305f\u3002
\n\u30fb\u9069\u683c\u57fa\u6e96\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3088\u308bMCI\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u75c7\u3092\u6709\u3059\u308b50\uff5e90\u6b73\u3002\u30a2\u30df\u30ed\u30a4\u30c9\u967d\u6027\u306fPET\u307e\u305f\u306f\u8133\u810a\u9ac4\u6db2\u306b\u3088\u308bA\u03b21-42\u6e2c\u5b9a\u306b\u3088\u308a\u5224\u5b9a\u3057\u305f\u3002
\n\u30fb\u8a55\u4fa1\u9805\u76ee\uff1a\u7701\u7565\uff08Abstract\u53c2\u7167\uff09
\n\u30fb\u7d71\u8a08\u89e3\u6790\uff1a\u7121\u76ca\u6027\u3084\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u4e2d\u9593\u89e3\u6790\u306f\u8a08\u753b\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u6709\u52b9\u6027\u306e\u89e3\u6790\u306f\u4fee\u6b63ITT\u89e3\u6790\uff08\u30ec\u30ab\u30cd\u30de\u30d6or\u30d7\u30e9\u30bb\u30dc\u3092\u5c11\u306a\u304f\u3068\u30821\u56de\u6295\u4e0e\u3055\u308c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8a55\u4fa1\u304a\u3088\u3073CDR-SB\u6e2c\u5b9a\u3092\u5c11\u306a\u304f\u3068\u30821\u56de\u5b9f\u65bd\uff09\u306b\u3088\u308a\u5b9f\u65bd\u3057\u305f\u3002\u5b89\u5168\u6027\u306e\u89e3\u6790\u306f\u3001\u30ec\u30ab\u30cd\u30de\u30d6or\u30d7\u30e9\u30bb\u30dc\u3092\u5c11\u306a\u304f\u3068\u30821\u56de\u6295\u4e0e\u3055\u308c\u305f\u53c2\u52a0\u8005\u96c6\u56e3\u3067\u8a55\u4fa1\u3055\u308c\u305f\u3002ARIA\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\uff09\u306f9, 13, 27, 53, 79, 91\u9031\u76ee\u306eMRI\u3067\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3055\u308c\u305f\u3002<\/p>\n

\u3010Result\uff08\u53c2\u52a0\u8005\uff09\u3011\u3000\uff08Figure 1\u3001Table 1\u53c2\u7167\uff09
\n\u30fb\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b05967\u4eba\u3001\u7121\u4f5c\u70ba\u53161795\u4eba\uff08\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4898\u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4897\u4eba\uff09\u3001\u5317\u7c73\u30fb\u6b27\u5dde\u30fb\u30a2\u30b8\u30a2\u306e235\u65bd\u8a2d\u306b\u3066\u3002
\n\u30fb\u8ffd\u8de1\u5b8c\u4e86\u306f\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4729\u4eba\uff0881.2%\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4757\u4eba\uff0884.4%\uff09\u3002\u4fee\u6b63ITT\u89e3\u6790\u306f1734\u4eba\u3067\u5b9f\u65bd\u3002
\n\u30fb\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u53c2\u52a0\u8005\u306e\u7279\u5fb4\u306f2\u7fa4\u3067\u6982\u306d\u985e\u4f3c\uff08\u5e73\u574771\u6b73\u3001CDR-SB 3.2\/18\u70b9\u3001MMSE 25.5\u70b9\uff09\u3002\u975e\u767d\u4eba\u304c20%\u5f37\u3002
\n\u3010Result\uff08\u8a55\u4fa1\u9805\u76ee\uff09\u3011\u3000\uff08Figure 2\u3001Table2\u53c2\u7167\uff09\u203bTable2\u306f\u672c\u30d5\u30a1\u30a4\u30eb\u3067\u306f\u7701\u7565
\n\u30fb\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308bCDR-SB\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u7d043.2\u70b9\u300118\u30f6\u6708\u5f8c\u306e\u5909\u5316\u91cf\u306e\u88dc\u6b63\u5e73\u5747\u306f\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u30671.21\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30671.66\u3067\u3042\u3063\u305f\uff08-0.45\u300195%CI\u3001-0.67\uff5e-0.23\u3001p<0.001\uff09\u3002\u3000\u203b\u300c\u8a8d\u77e5\u75c7\u306e\u9032\u884c\u309227%\u6291\u5236\u300d\u306e\u6570\u7684\u6839\u62e0\u3068\u601d\u308f\u308c\u308b\u3002\n\u30fb\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u95a2\u3057\u3066\u300118\u30f6\u6708\u5f8c\u306e\u5e73\u5747\u5909\u5316\u91cf\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u3063\u305f\u3002\n\u3000(1) PET\u3067\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u84c4\u7a4d\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4-55.48\uff7e\uff9d\uff81\uff9b\uff72\uff84\uff9e\u3001\u30d7\u30e9\u30bb\u30dc\u7fa43.64\uff7e\uff9d\uff81\uff9b\uff72\uff84\uff9e\uff0895%CI\uff1a-62.64\uff5e-55.60\u3001p<0.001\uff09\n\u3000(2) ADAS-cog14\u30b9\u30b3\u30a2\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa44.14\u70b9\u3001\u30d7\u30e9\u30bb\u30dc\u7fa45.58\u70b9\uff0895%CI\uff1a-2.27\uff5e-0.61\u3001p<0.001\uff09\n\u3000(3) ADCOMS\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa40.164\u70b9\u3001\u30d7\u30e9\u30bb\u30dc\u7fa40.214\u70b9\uff0895%CI\uff1a-0.074\uff5e-0.027\u3001p<0.001\uff09\n\u3000(4) ADCS-MCI-ADL Score\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4-3.5\u70b9\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4-5.5\u70b9\uff0895%CI\uff1a1.2\uff5e2.8\u3001p<0.001\uff09\n\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\u3010Result\uff08\u5b89\u5168\u6027\uff09\u3011\uff08Table 3\u53c2\u7167\uff09
\n\u30fb\u6b7b\u4ea1\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa40.7%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa40.8%\u3002\u7814\u7a76\u62c5\u5f53\u533b\u306b\u3088\u308a\u30ec\u30ab\u30cd\u30de\u30d6\u306b\u95a2\u9023\u3059\u308b\u3068\u5224\u65ad\u3055\u308c\u305f\u6b7b\u4ea1\u4f8b\u306f\u306a\u3057\u3002
\n\u30fb\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa414.0%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa411.3%\u3002
\n\u2192\u6025\u6027\u6ce8\u5165\u53cd\u5fdc\uff08\u30a4\u30f3\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u30ea\u30a2\u30af\u30b7\u30e7\u30f3\uff09\uff08\u30ec\u30ab\u30cd\u30de\u30d6\u7fa41.2%\uff0f\u30d7\u30e9\u30bb\u30dc\u7fa40%\uff09\u3001ARIA-E\uff08\u6d6e\u816b\u6027\u5909\u5316\u3092\u4f34\u3046\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\uff09\uff08\u540c0.8%\uff0f0%\uff09\u3001\u5fc3\u623f\u7d30\u52d5\uff08\u540c0.7%\uff0f0.3%\uff09\u3001\u5931\u795e\uff08\u540c0.7%\uff0f0.1%\uff09\u3001\u72ed\u5fc3\u75c7\uff080.7%\uff0f0%\uff09\u3002
\n\u30fb\u5168\u3066\u306e\u6709\u5bb3\u4e8b\u8c61\uff1a\u4e21\u7fa4\u3067\u767a\u751f\u7387\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002
\n\u30fb\u6295\u4e0e\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u30676.9%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30672.9%\u3002
\n\u30fb\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u3067\u591a\u304b\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3002
\n\u30fb\u6025\u6027\u6ce8\u5165\u53cd\u5fdc\uff08\u30a4\u30f3\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u30ea\u30a2\u30af\u30b7\u30e7\u30f3\uff09\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa426.4%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa47.4%\u3002\u5927\u90e8\u5206\u306f\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u3067\u3001\u521d\u56de\u6295\u4e0e\u6642\u3002
\n\u30fbARIA-H\uff08\u51fa\u8840\u6027\u5909\u5316\u3092\u4f34\u3046\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\uff09\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa417.3%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa49.0%
\n\u30fbARIA-E\uff08\u6d6e\u816b\u6027\u5909\u5316\u3092\u4f34\u3046\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\uff09\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa412.6%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa41.7%
\n\u30fb\u982d\u75db\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa411.1%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa48.1%
\n\u30fb\u8ee2\u5012\uff1a\u30ec\u30ab\u30cd\u30de\u30d6\u7fa410.4%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa49.6%
\n\u30fbARIA-E\u306e91%\u306f\u8efd\u5ea6\uff5e\u4e2d\u7b49\u5ea6\u3067\u300178%\u306f\u7121\u75c7\u72b6\u3067\u300181%\u306f\u767a\u898b\u5f8c4\u30f6\u6708\u4ee5\u5185\u306b\u6d88\u5931\u3057\u305f\u3002
\n\u305f\u3060\u3057\u53c2\u52a0\u8005\u306e2.8%\u306b\u75c7\u5019\u6027ARIA-E\u304c\u8a8d\u3081\u3089\u308c\u305f\uff08\u75c7\u72b6\uff1a\u982d\u75db\u3001\u8996\u899a\u969c\u5bb3\u3001\u932f\u4e71\u306a\u3069\uff09\u3002<\/p>\n

\u203b\u6025\u6027\u6ce8\u5165\u53cd\u5fdc\uff08\u30a4\u30f3\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u30ea\u30a2\u30af\u30b7\u30e7\u30f3\uff09\uff1a\u5206\u5b50\u6a19\u7684\u85ac\u306a\u3069\u306e\u70b9\u6ef4\u6642\u306b\u4e00\u904e\u6027\u306e\u708e\u75c7\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u8d77\u3053\u3055\u308c\u308b\u75c5\u614b\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u306b\u3088\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u4e3b\u306a\u75c7\u72b6\u306f\u767a\u71b1\u3001\u60aa\u5bd2\u3001\u982d\u75db\u3001\u767a\u75b9\u3001\u5614\u5410\u3001\u547c\u5438\u56f0\u96e3\u3001\u8840\u5727\u4f4e\u4e0b\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u30b7\u30e7\u30c3\u30af\u306a\u3069\u3002
\n\u203bARIA\uff08Amyloid-related imaging abnormalities\uff09\uff1a\u982d\u90e8MRI\u3067\u306e\u30a2\u30df\u30ed\u30a4\u30c9\u95a2\u9023\u753b\u50cf\u7570\u5e38\u306e\u3053\u3068\u3002\u6d6e\u816b\u6027\u5909\u5316\u3092\u4f34\u3046\u3082\u306e\u3092ARIA-E\uff08edema\/Effusion\uff09\u3001\u51fa\u8840\u6027\u5909\u5316\u3092\u4f34\u3046\u3082\u306e\u3092ARIA-H\uff08Hemosiderin deposition\uff09\u3068\u547c\u3076\u3002
\n\"\"<\/a>
\n\u3010Discussion\u3011
\n\u30fb\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308bCDR-SB\u306e18\u30f6\u6708\u5f8c\u306e\u5909\u5316\u91cf\u306f\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u6709\u5229\u3067\u3042\u3063\u305f\u3002\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3082\u540c\u69d8\u3067\u3042\u3063\u305f\u3002
\n\u30fbCDR-SB\u30b9\u30b3\u30a2\u306e\u81e8\u5e8a\u610f\u7fa9\u306b\u3064\u3044\u3066\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001\u30d7\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u6cbb\u7642\u5dee\u306e\u76ee\u6a19\u3092\u4e0a\u56de\u3063\u3066\u3044\u305f\u3002
\n\u30fb\u8a8d\u77e5\u75c7\u30b9\u30c6\u30fc\u30b8\u306e\u9032\u884c\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u306b\u3064\u3044\u3066\u3082\u3001\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u30ec\u30ab\u30cd\u30de\u30d6\u304c\u6709\u5229\u3067\u3042\u3063\u305f\u3002
\n\u30fb\u30ec\u30ab\u30cd\u30de\u30d6\u7fa4\u306b\u304a\u3051\u308bARIA-E\u306e\u767a\u75c7\u7387\u306f12.6%\u3001ARIA-H\u306e\u767a\u75c7\u7387\u306f17.3%\u3067\u3042\u3063\u305f\u3002
\nARIA-E\u306f\u4e00\u822c\u306b\u6700\u521d\u306e3\u30f6\u6708\u9593\u306b\u767a\u751f\u3057\u3001\u8efd\u5ea6\u3067\u7121\u75c7\u72b6\u3067\u3042\u308a\u30014\u30f6\u6708\u4ee5\u5185\u306b\u6d88\u5931\u3059\u308b\u3053\u3068\u304c\u591a\u304b\u3063\u305f\u3002
\nARIA-E\uff08\u75c7\u5019\u6027\u30fb\u5168\u3066\uff09\u306e\u767a\u751f\u7387\u306f\u3001\u3044\u305a\u308c\u3082ApoE \u03b54\u30db\u30e2\u63a5\u5408\u4f53\u3067\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\u7814\u7a76\u9650\u754c\uff1a18\u30f6\u6708\u9593\u306e\u6cbb\u7642\u30c7\u30fc\u30bf\u3057\u304b\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u3002COVID-19\u6d41\u884c\u306b\u4f34\u3046\u4ecb\u5165\u4e0d\u5b9f\u65bd\u3001\u8a55\u4fa1\u306e\u9045\u5ef6\u3001\u75be\u60a3\u306e\u4f75\u767a\u306a\u3069\u304c\u3042\u308a\u3001\u8131\u843d\u7387\u306f17.2%\u306b\u4e0a\u3063\u305f\u3002ARIA\u306e\u767a\u751f\u306b\u95a2\u3057\u3066\u3001\u53c2\u52a0\u8005\u3084\u6cbb\u9a13\u62c5\u5f53\u533b\u5e2b\u304c\u8a66\u9a13\u7fa4\u306e\u5272\u308a\u4ed8\u3051\u3092\u8a8d\u8b58\u3057\u3066\u3044\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002
\n\u30fb\u73fe\u5728\u3001\u5404\u7a2e\u306e\u8ffd\u52a0\u8a66\u9a13\u304c\u8a08\u753b\u30fb\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\u3002
\n\u30fb\u7d50\u8ad6\uff1a\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30ec\u30ab\u30cd\u30de\u30d6\u306f\u8133\u30a2\u30df\u30ed\u30a4\u30c9\u84c4\u7a4d\u3092\u6e1b\u5c11\u3055\u305b\u300118\u30f6\u6708\u5f8c\u306e\u8a8d\u77e5\u6a5f\u80fd\u304a\u3088\u3073\u5404\u7a2e\u306e\u8a55\u4fa1\u9805\u76ee\u306b\u3064\u3044\u3066\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u4e2d\u7b49\u5ea6\u306e\u4f4e\u4e0b\u30fb\u6291\u5236\u3092\u793a\u3057\u305f\u304c\u3001\u6709\u5bb3\u4e8b\u8c61\u3092\u4f34\u3063\u305f\u3002\u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30ec\u30ab\u30cd\u30de\u30d6\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3088\u308a\u9577\u671f\u9593\u306e\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112023\u5e749\u670813\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

-\u6587\u732e\u540d- C.H. van Dyck, C.J. Swanson, P. Aisen, et al. Lecanemab in Early Alzheimer\u2019s Disease. N Engl J Med. 2023 … \u7d9a\u304d\u3092\u8aad\u3080 \u65e9\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u30ec\u30ab\u30cd\u30de\u30d6<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,11],"tags":[],"class_list":["post-2580","post","type-post","status-publish","format-standard","hentry","category-15","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2580"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2580\/revisions"}],"predecessor-version":[{"id":2586,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2580\/revisions\/2586"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}