{"id":2587,"date":"2024-03-27T18:39:51","date_gmt":"2024-03-27T09:39:51","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2587"},"modified":"2024-03-27T18:39:51","modified_gmt":"2024-03-27T09:39:51","slug":"%e5%b0%8f%e5%85%90%e3%81%8a%e3%82%88%e3%81%b3%e6%88%90%e4%ba%ba%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e6%8e%a5%e7%a8%ae%e5%be%8c%e3%81%ae%e3%82%a2%e3%83%8a%e3%83%95","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2587","title":{"rendered":"\u5c0f\u5150\u304a\u3088\u3073\u6210\u4eba\u306b\u304a\u3051\u308b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u767a\u751f\u306e\u30ea\u30b9\u30af"},"content":{"rendered":"<p>-\u6587\u732e\u540d-<br \/>\nMcNeil, M. M., Weintraub, E. S., Duffy, J., Sukumaran, L., Jacobsen, S. J., Klein, N. P., Hambidge, S. J., Lee, G. M., Jackson, L. A., Irving, S. A., King, J. P., Kharbanda, E. O., Bednarczyk, R. A., &#038; DeStefano, F.  Risk of anaphylaxis after vaccination in children and adults. The Journal of Allergy and Clinical Immunology, 2016, 137(3), 868\u2013878. https:\/\/doi.org\/10.1016\/j.jaci.2015.07.048<\/p>\n<p>-\u8981\u7d04-<br \/>\nIntroduction\uff1a\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306f\u81f4\u6b7b\u7684\u306b\u306a\u308a\u3046\u308b\u6025\u6027\u306e\u5168\u8eab\u6027\u306e\u904e\u654f\u53cd\u5fdc\u3060\u304c\u3001\u4e88\u9632\u63a5\u7a2e\u5f8c\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u30ea\u30b9\u30af\u3092\u5b9a\u91cf\u5316\u3059\u308b\u306b\u306f\u30c7\u30fc\u30bf\u304c\u9650\u3089\u308c\u3066\u3044\u305f\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u983b\u5ea6\u306f\u4f4e\u3044\u306e\u3067\u3001\u5927\u898f\u6a21\u306a\u96c6\u56e3\u3092\u8abf\u67fb\u3057\u306a\u304f\u3066\u306f\u306a\u3089\u305a\u3001\u30ef\u30af\u30c1\u30f3\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u30ea\u30f3\u30af\uff08The Vaccine Safety Datalink ; VSD\uff09\u304cCDC\u306a\u3069\u3068\u5354\u50cd\u3057\u3066\u305d\u3046\u3057\u305f\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3059\u308b\u7d44\u7e54\u3067\u3042\u308b\u3002\u904e\u53bb\u306bBohlke\u3089\u304c1991\u22121997\u5e74\u306eVSD\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3066\u4eba\u53e3\u30d9\u30fc\u30b9\u306e\u30ef\u30af\u30c1\u30f3\u95a2\u9023\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u30ea\u30b9\u30af\u3092\u8abf\u3079\u305f\u3053\u3068\u306f\u3042\u308b\u304c\u3001\u305d\u306e\u5f8c\u4e88\u9632\u63a5\u7a2e\u306e\u63a8\u5968\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306e\u5909\u66f4\u3084\u3001\u63a8\u5968\u5e74\u9f62\u306e\u62e1\u5927\u3001\u65b0\u3057\u3044\u30ef\u30af\u30c1\u30f3\u3084\u30ef\u30af\u30c1\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u3082\u3044\u304f\u3064\u304b\u5c0e\u5165\u3055\u308c\u305f\u3057\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u75c7\u4f8b\u5b9a\u7fa9\u3084\u30c7\u30fc\u30bf\u53ce\u96c6\u3001\u5206\u6790\u3001\u7d44\u307f\u5165\u308c\u3092\u6a19\u6e96\u5316\u3059\u308b\u305f\u3081\u306e\u30d6\u30e9\u30a4\u30c8\u30f3\u5206\u985e\u3082\u958b\u767a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001VSD\u81ea\u4f53\u3082\u5408\u8a08\uff19\u62e0\u70b9\u306b\u62e1\u5927\u3057\u3001\u3088\u308a\u591a\u304f\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u6027\u3092\u76e3\u8996\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u305d\u3053\u3067\u3001\uff08\uff11\uff09\u3059\u3079\u3066\u306e\u30ef\u30af\u30c1\u30f3\u304a\u3088\u3073\u500b\u3005\u306e\u30ef\u30af\u30c1\u30f3\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u767a\u751f\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3001\uff08\uff12\uff09\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u4eba\u53e3\u7d71\u8a08\u304a\u3088\u3073\u81e8\u5e8a\u7684\u7279\u5fb4\u3092\u8aac\u660e\u3059\u308b\u3001\u306e\uff12\u70b9\u3092\u76ee\u6a19\u306b\u6700\u65b0\u306eVSD\u30c7\u30fc\u30bf\u3092\u8abf\u67fb\u3057\u3001\u30d6\u30e9\u30a4\u30c8\u30f3\u5206\u985e\u3067\u5206\u6790\u3057\u305f\u3002<\/p>\n<p>Method\uff1a\uff19\u30f6\u6240\u306eVSD\u30b5\u30a4\u30c8\u30672009\u5e741\u67081\u65e5\u304b\u30892011\u5e7412\u670831\u65e5\u307e\u3067\u306e\u9593\u306b\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u3092\u53d7\u3051\u305f\u5065\u5eb7\u306a\u5c0f\u5150\u304a\u3088\u3073\u6210\u4eba\u3092\u7d44\u307f\u5165\u308c\u305f\u3002ICD-9-CM\u306b\u57fa\u3065\u3044\u3066\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u75c7\u4f8b\u3092\u7279\u5b9a\u3057\u3001\uff12\u4eba\u306e\u5c02\u9580\u5bb6\u304c\u30ab\u30eb\u30c6\u30ec\u30d3\u30e5\u30fc\u3057\u3001\u30d6\u30e9\u30a4\u30c8\u30f3\u5206\u985e\u306b\u9069\u5408\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u305f\u3002\u5168\u30ef\u30af\u30c1\u30f3\u5408\u8a08\u304a\u3088\u3073\u500b\u5225\u30ef\u30af\u30c1\u30f3\u306b\u3064\u3044\u3066\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u767a\u751f\u4ef6\u6570\u304a\u3088\u3073\u3001\u30ef\u30af\u30c1\u30f3\u306e\u6570\u3067\u8abf\u6574\u3057\u305f\u767a\u751f\u7387\u3092\u4f7f\u3063\u3066\u3001\u30ef\u30af\u30c1\u30f3100\u4e07\u56de\u3042\u305f\u308a\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u767a\u751f\u7387\u304a\u3088\u307395\uff05\u4fe1\u983c\u533a\u9593\u3092\u8a08\u7b97\u3057\u305f\u3002<\/p>\n<p>Results\uff1a2009\u5e741\u67081\u65e5\u304b\u30892011\u5e7412\u670831\u65e5\u307e\u3067\u30012517\u4e073965\u56de\uff08\u5ef6\u3079\u30ef\u30af\u30c1\u30f3\u7a2e\u985e\u30fb\u56de\u6570\u3067\u306f\u306a\u304f\u63a5\u7a2e\u56de\u6570\u306b\u3059\u308b\u30681760\u4e076500\u56de\uff09\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u304c\u884c\u308f\u308c\u305f\u3002\u30ef\u30af\u30c1\u30f3\u95a2\u9023\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306f33\u4ef6\u8a8d\u3081\u3089\u308c\u305f\uff08\u30ef\u30af\u30c1\u30f3100\u4e07\u56de\u3042\u305f\u308a1.31\u4ef6\uff1b\uff19\uff15\uff05CI ,0.90-1.84\u3001\u63a5\u7a2e\u56de\u6570100\u4e07\u4ef6\u3042\u305f\u308a1.87\u4ef6;95%CI,1.29-2.63\uff09\u3002\uff11\u56de\u306e\u63a5\u7a2e\u3067\u8907\u6570\u306e\u30ef\u30af\u30c1\u30f3\u304c\u6295\u4e0e\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u63a5\u7a2e\u56de\u6570\u306b\u57fa\u3065\u304f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u767a\u751f\u306e\u5272\u5408\u306f\u3001\u5ef6\u3079\u63a5\u7a2e\u56de\u6570\u306e\u305d\u308c\u3088\u308a\u591a\u304b\u3063\u305f\u3002\u3059\u3079\u3066\u306e\u75c7\u4f8b\u304c\u30d6\u30e9\u30a4\u30c8\u30f3\u5206\u985e\uff11\u304b\uff12\u3060\u3063\u305f\u300228\u4f8b\u3067\u30a2\u30c8\u30d4\u30fc\u306e\u65e2\u5f80\u304c\u3042\u308a\u3001\u305d\u306e\u3046\u30613\u4f8b\u306f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u65e2\u5f80\u300116\u4f8b\u306f\u5598\u606f\u3082\u3042\u3063\u305f\u3002\u5598\u606f\u3067\u306f\u306a\u3044\u30a2\u30c8\u30d4\u30fc\u306e10\u4f8b\u4e2d9\u4f8b\u306f\u3001\u98df\u7269\u3084\u6297\u83cc\u85ac\u3078\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u65e2\u5f80\u304c\u3042\u3063\u305f\u3002\u6b7b\u4ea1\u4f8b\u306f\u306a\u304f\u3001\u5165\u9662\u3057\u305f\u306e\u306f1\u4ef6\u3060\u3063\u305f\u3002\u5973\u6027\u306e\u65b9\u304c\u7537\u6027\u3088\u308a\u591a\u304b\u3063\u305f\uff08\u5973\u6027\uff12\uff10\u540d\u3001\u7537\u6027\uff11\uff13\u540d\uff09\u3002\u5e74\u9f62\u7bc4\u56f2\u306f4\u221265\u6b73\u3060\u3063\u305f\u3002\u307b\u3068\u3093\u3069\u306e\u30ef\u30af\u30c1\u30f3\u304c\u4ed6\u306e\u30ef\u30af\u30c1\u30f3\u3068\u540c\u6642\u63a5\u7a2e\u3055\u308c\u305f\u305f\u3081\u3001\u7279\u5b9a\u306e\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u30ea\u30b9\u30af\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3060\u3063\u305f\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u767a\u75c7\u6642\u9593\u306f30\u5206\u4ee5\u5185\u304c\uff18\u4f8b\u300130\u5206\u4ee5\u4e0a120\u5206\u672a\u6e80\u304c\uff18\u4f8b\u30012\u6642\u9593\u4ee5\u4e0a4\u6642\u9593\u672a\u6e80\u304c\uff11\uff10\u4f8b\u30014\u6642\u9593\u4ee5\u4e0a8\u6642\u9593\u672a\u6e80\u304c\uff12\u4f8b\u3001\u7fcc\u65e51\u4ef6\u3001\u8a18\u8f09\u306a\u3057\u304c4\u4ef6\u3060\u3063\u305f\u3002<\/p>\n<p>Discussion\uff1a\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u30ef\u30af\u30c1\u30f3100\u4e07\u56de\u3042\u305f\u308a1.31\u4f8b\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3092\u8a8d\u3081\u305f\u3002Bohlke\u3089\u306e\u7814\u7a76\uff08100\u4e07\u56de\u3042\u305f\u308a0.65\u56de\uff09\u3088\u308a\u3082\u308f\u305a\u304b\u306b\u9ad8\u304b\u3063\u305f\u304c\u3001Bohlke\u3089\u306e\u7814\u7a76\u306f\u5c0f\u5150\u3068\u9752\u5c11\u5e74\u306b\u9650\u5b9a\u3055\u308c\u3066\u3044\u305f\u3057\u3001\u591a\u304f\u306e\u5916\u6765\u60a3\u8005\u306b\u3064\u3044\u3066\u306e\u30c7\u30fc\u30bf\u304c\u6b20\u3051\u3066\u3044\u305f\u3002\u8fd1\u5e74\u306e\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u3001\u4e0d\u6d3b\u5316\uff13\u4fa1\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u304c\u3001\u6841\u9055\u3044\u306b\u6700\u3082\u63a5\u7a2e\u3055\u308c\u3066\u3044\u308b\u30ef\u30af\u30c1\u30f3\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u9664\u304f\u3068\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u767a\u751f\u7387\u304c\u4f4e\u3044\u305f\u3081\u3001\u500b\u5225\u30ef\u30af\u30c1\u30f3\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u767a\u751f\u7387\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3002\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u5f8c\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u767a\u75c7\u306f\u7a00\u3060\u3063\u305f\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u30b3\u30fc\u30c9\u306b\u52a0\u3048\u3066\u30a2\u30ec\u30eb\u30ae\u30fc\u30b3\u30fc\u30c9\u3067\u3082\u30c7\u30fc\u30bf\u6355\u6349\u3092\u3057\u305f\u304c\u3001\u305d\u308c\u3067\u3082\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u3092\u4f7f\u308f\u308c\u306a\u304b\u3063\u305f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u75c7\u4f8b\u3092\u898b\u9003\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3092\u8d77\u3053\u3057\u305f33\u4f8b\u4e2d28\u4f8b\u3067\u30a2\u30c8\u30d4\u30fc\u6027\u75be\u60a3\u306e\u65e2\u5f80\u304c\u3042\u308a\u3001\u7279\u306b\u5598\u606f\u306e\u65e2\u5f80\u306f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u30ea\u30b9\u30af\u3067\u3042\u308b\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u304c\u751f\u3058\u305f\u969b\u306b\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u3092\u4f7f\u7528\u3055\u308c\u3066\u3044\u305f\u306e\u306f45\uff05\uff0815\u4f8b\uff09\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u305f\u3002\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306f\u7a00\u3067\u306f\u3042\u308b\u304c\u3001\u6570\u5206\u4ee5\u5185\u306b\u751f\u3058\u308b\u3057\u3001\u8d77\u3053\u3059\u3068\u751f\u547d\u3092\u8105\u304b\u3059\u6027\u8cea\u304c\u3042\u308b\u305f\u3081\u3001\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u8005\u306f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u624b\u9806\u3092\u6e96\u5099\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112023\u5e7410\u67084\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>-\u6587\u732e\u540d- McNeil, M. M., Weintraub, E. S., Duffy, J., Sukumaran, L., Jacobsen, S. J., Klein, N. P., Hambidge, S. 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