{"id":2597,"date":"2024-04-03T11:09:09","date_gmt":"2024-04-03T02:09:09","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2597"},"modified":"2024-04-03T11:09:09","modified_gmt":"2024-04-03T02:09:09","slug":"%e5%ad%a4%e7%8b%ac%e3%81%a8%e3%83%91%e3%83%bc%e3%82%ad%e3%83%b3%e3%82%bd%e3%83%b3%e7%97%85%e3%83%aa%e3%82%b9%e3%82%af","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2597","title":{"rendered":"\u5b64\u72ec\u3068\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u30ea\u30b9\u30af"},"content":{"rendered":"

\u2015\u6587\u732e\u540d\u2015
\nAntonio T,Martina L,Selin K,et al. Loneliness and Risk of Parkinson Disease. JAMA Neurology. 2023;80(11):1138-1144.<\/p>\n

\u2015\u8981\u7d04\u2015
\nIntroduction
\n\u5b64\u72ec\u611f\u3068\u306f\u3001\u672c\u4eba\u304c\u6c42\u3081\u308b\u793e\u4f1a\u7684\u306a\u95a2\u4fc2\u3068\u5b9f\u969b\u306b\u611f\u3058\u308b\u95a2\u4fc2\u306b\u9694\u305f\u308a\u304c\u3042\u308b\u305f\u3081\u306b\u751f\u3058\u308b\u3001\u4e3b\u89b3\u7684\u306a\u82e6\u3057\u307f\u3068\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u308b\u3002\u8eab\u4f53\u7684\u306a\u5065\u5eb7\u3060\u3051\u3067\u306a\u304f\u8133\u306e\u5065\u5eb7\u306b\u3082\u60aa\u5f71\u97ff\u306f\u53ca\u3073\u3001\u7cbe\u795e\u75be\u60a3\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3002\u5b9f\u969b\u306b\u3001\u5b64\u72ec\u611f\u306e\u5f37\u3044\u4eba\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u5b64\u72ec\u611f\u3068\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u7814\u7a76\u306f\u307e\u3060\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u305d\u3053\u3067\u8457\u8005\u3089\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u5b64\u72ec\u611f\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u4f4f\u6c11\u30d9\u30fc\u30b9\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u306b\u3057\u305f\u3002
\nMethod
\n\u5bfe\u8c61\u306f\u30012006\u5e743\u670813\u65e5\u304b\u30892010\u5e7410\u67081\u65e5\u306b\u3001UK Biobank\u306b\u767b\u9332\u3055\u308c\u305f38\uff5e73\u6b73\u306e\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u300c\u3042\u306a\u305f\u306f\u3057\u3070\u3057\u3070\u5b64\u72ec\u3092\u611f\u3058\u307e\u3059\u304b\u300d\u3068\u3044\u3046\u8a2d\u554f\u306b\u56de\u7b54\u3057\u3066\u3044\u305f\u4eba\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u65e2\u306b\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u305f\u4eba\u3084\u3001\u8a2d\u554f\u306b\u300c\u5206\u304b\u3089\u306a\u3044\u300d\u300c\u7b54\u3048\u305f\u304f\u306a\u3044\u300d\u3068\u56de\u7b54\u3057\u305f\u4eba\u306f\u9664\u5916\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u767a\u75c7\u3068\u3057\u305f\u3002\u8ffd\u8de1\u306f2021\u5e7410\u67089\u65e5\u307e\u3067\u7d99\u7d9a\u3057\u3001\u82f1\u56fdNational Health Service\u306e\u96fb\u5b50\u5065\u5eb7\u8a18\u9332\u3092\u8abf\u3079\u3066\u767a\u75c7\u3092\u78ba\u8a8d\u3057\u305f\u3002\u3000\u5171\u5909\u6570\u3068\u3057\u3066\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u5b66\u6b74\u3001Townsend\u8ca7\u56f0\u6307\u6570\u3001\u55ab\u7159\u72b6\u614b\u3001\u8eab\u4f53\u6d3b\u52d5\u91cf\u3001BMI\u3001\u4f75\u5b58\u75be\u60a3\uff08\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u8133\u5352\u4e2d\u3001\u5fc3\u81d3\u767a\u4f5c\u3001PHQ\u306e\u3046\u3064\u75c5\u30b9\u30b3\u30a2\u3001\u7cbe\u795e\u75be\u60a3\u306a\u3069\uff09\u3001\u540c\u5c45\u5bb6\u65cf\u306e\u4eba\u6570\u3001\u5bb6\u65cf\u3084\u53cb\u4eba\u3068\u306e\u4ea4\u6d41\u983b\u5ea6\u3001\u793e\u4f1a\u6d3b\u52d5\u306e\u53c2\u52a0\u983b\u5ea6\u3001\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30fb\u30ea\u30b9\u30af\u30fb\u30b9\u30b3\u30a2\uff08\u3042\u308b\u500b\u4eba\u304c\u6301\u3064\u3001\u7279\u5b9a\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u30b9\u30b3\u30a2\u5316\u3057\u3066\u3001\u75c5\u6c17\u306e\u767a\u75c7\u3084\u9032\u5c55\u3092\u4e88\u6e2c\u3059\u308b\u624b\u6cd5\uff09\u306a\u3069\u3082\u8abf\u3079\u305f\u3002
\nResults
\n50\u4e072505\u4eba\u306eUK Biobank\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001\u6761\u4ef6\u3092\u6e80\u305f\u3057\u305f49\u4e071603\u4eba\u3092\u5206\u6790\u5bfe\u8c61\u306b\u3057\u305f\u3002\u5e73\u5747\u5e74\u9f62\u306f56.54\u6b73\uff08\u6a19\u6e96\u504f\u5dee8.09\u6b73\uff09\u300154.4\uff05\u304c\u5973\u6027\u3060\u3063\u305f\u3002\u8a2d\u554f\u306b\u5bfe\u3057\u3066\u3001\u5b64\u72ec\u3092\u611f\u3058\u308b\u3068\u56de\u7b54\u3057\u305f\u4eba\u306f9\u4e071186\u4eba\uff0818.5\uff05\uff09\u3001\u5b64\u72ec\u3092\u611f\u3058\u3066\u3044\u306a\u304b\u3063\u305f\u4eba\u306f40\u4e07417\u4eba\uff0881.5\uff05\uff09\u3060\u3063\u305f\u3002\u4e21\u7fa4\u306e\u7279\u6027\u3092\u6bd4\u3079\u308b\u3068\u3001\u5b64\u72ec\u3092\u611f\u3058\u3066\u3044\u305f\u4eba\u306f\u3001\u3084\u3084\u5e74\u9f62\u304c\u82e5\u304f\u3001\u5973\u6027\u304c\u591a\u304f\u3001\u5065\u5eb7\u306b\u597d\u307e\u3057\u304f\u306a\u3044\u7fd2\u6163\uff08\u55ab\u7159\u3084\u4e0d\u6d3b\u767a\u306a\u3069\uff09\u306e\u4eba\u304c\u591a\u304f\u3001\u6162\u6027\u75be\u60a3\uff08\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u306a\u3069\uff09\u306e\u4fdd\u6709\u7387\u304c\u9ad8\u304f\u3001\u7cbe\u795e\u7684\u306a\u5065\u5eb7\u72b6\u614b\u3082\u4e0d\u826f\uff08\u6291\u3046\u3064\u3042\u308a\/\u7cbe\u795e\u79d1\u533b\u53d7\u8a3a\u6b74\u3042\u308a\uff09\u3060\u3063\u305f\u3002\u5e73\u5747\u5024\u306712.33\u5e74\uff081.80\u5e74\uff09\u3001\u5ef6\u3079606\u4e072197\u4eba\u30fb\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u30012822\u4eba\u304c\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u767a\u75c7\u3057\u3066\u3044\u305f\u3002\u767a\u75c7\u7387\u306f10\u4e07\u4eba\u30fb\u5e74\u5f53\u305f\u308a47\u3060\u3063\u305f\u3002\u5185\u8a33\u306f\u3001\u5b64\u72ec\u611f\u304c\u306a\u304b\u3063\u305f40\u4e07417\u4eba\u3067\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u767a\u75c7\u8005\u306f2273\u4eba\uff0810\u4e07\u4eba\u30fb\u5e74\u5f53\u305f\u308a46\uff09\u3067\u3001\u5b64\u72ec\u3092\u611f\u3058\u3066\u3044\u305f9\u4e071186\u4eba\u3067\u306f\u3001549\u4eba\uff0810\u4e07\u4eba\u30fb\u5e74\u5f53\u305f\u308a49\uff09\u3060\u3063\u305f\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u767a\u75c7\u8005\u306f\u3001\u975e\u767a\u75c7\u8005\u306b\u6bd4\u3079\u9ad8\u9f62\u3067\u3001\u7537\u6027\u304c\u591a\u304f\u3001\u904e\u53bb\u306e\u55ab\u7159\u8005\u304c\u591a\u304f\u3001BMI\u304c\u9ad8\u304f\u3001PD\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30fb\u30ea\u30b9\u30af\u30fb\u30b9\u30b3\u30a2\u3082\u9ad8\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3082\u591a\u304f\u3001\u7cbe\u795e\u79d1\u533b\u53d7\u8a3a\u6b74\u3092\u6709\u3059\u308b\u60a3\u8005\u3082\u591a\u304b\u3063\u305f\u3002\u3000\u5b64\u72ec\u3092\u611f\u3058\u3066\u3044\u305f\u4eba\u306e\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u306f\u6709\u610f\u306b\u9ad8\u304f\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f1.37\uff0895\uff05\u4fe1\u983c\u533a\u95931.25-1.51\uff09\u3060\u3063\u305f\u3002\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u8981\u56e0\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u5730\u4f4d\u3001\u793e\u4f1a\u304b\u3089\u306e\u5b64\u7acb\uff08\u72ec\u5c45\u3001\u5bb6\u65cf\u3084\u89aa\u65cf\u3068\u4f1a\u3046\u983b\u5ea6\u304c\u67081\u56de\u672a\u6e80\u3001\u4f59\u6687\u6d3b\u52d5\u3068\/\u307e\u305f\u306f\u793e\u4f1a\u6d3b\u52d5\u306e\u983b\u5ea6\u304c\u90311\u56de\u672a\u6e80\uff09\u3001PD\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30fb\u30ea\u30b9\u30af\u30fb\u30b9\u30b3\u30a2\u3001\u55ab\u7159\u3001\u8eab\u4f53\u6d3b\u52d5\u3001BMI\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u8133\u5352\u4e2d\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u6291\u3046\u3064\u3001\u7cbe\u795e\u79d1\u533b\u53d7\u8a3a\u6b74\u3067\u8abf\u6574\u3057\u3066\u3082\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f1.25\uff081.12-1.39\uff09\u3068\u5f15\u304d\u7d9a\u304d\u6709\u610f\u5dee\u3092\u793a\u3057\u305f\u3002\u5b64\u72ec\u3068\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u767a\u75c7\u306e\u95a2\u4fc2\u306f\u3001\u6027\u5225\uff08\u4ea4\u4e92\u4f5c\u7528\u306e\u30cf\u30b6\u30fc\u30c9\u6bd40.98\uff1a0.81-1.18\uff09\u3001\u5e74\u9f62\uff080.99\uff1a0.98-1.01\uff09\u3001PD\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff080.93\uff1a0.85-1.02\uff09\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u3000\u5b64\u72ec\u3068\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u767a\u75c7\u306e\u95a2\u4fc2\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30895\u5e74\u9593\u306f\u6709\u610f\u306b\u306a\u3089\u305a\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.15\uff1a0.91-1.45\uff09\u30015\uff5e15\u5e74\u5f8c\u306b\u6709\u610f\u306b\u306a\u3063\u305f\uff081.32\uff1a1.19-1.46\uff09\u3002
\nDiscussion
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