{"id":2610,"date":"2024-04-23T10:00:11","date_gmt":"2024-04-23T01:00:11","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2610"},"modified":"2024-04-23T10:00:11","modified_gmt":"2024-04-23T01:00:11","slug":"%e8%82%a5%e6%ba%80%e3%81%ae%e3%81%82%e3%82%8b%e9%a7%86%e5%87%ba%e7%8e%87%e3%81%8c%e7%b6%ad%e6%8c%81%e3%81%95%e3%82%8c%e3%81%9f%e5%bf%83%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2610","title":{"rendered":"\u80a5\u6e80\u306e\u3042\u308b\u99c6\u51fa\u7387\u304c\u7dad\u6301\u3055\u308c\u305f\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9"},"content":{"rendered":"

\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002
\n-\u6587\u732e\u540d-
\nSemaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity. Kosiborod MN, Abildstr\u00f8m SZ, Borlaug BA,\u3000et al. N Engl J Med. 2023;389(12):1069-1084. \uff08STEP-HFpEF\u8a66\u9a13\uff09<\/p>\n

-\u8981\u7d04-
\n\u3010Introduction\u3011
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\n\u30fb\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08GLP-1\u4f5c\u52d5\u85ac\uff09\u306f\u5927\u5e45\u306a\u4f53\u91cd\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c92.4mg\u306e\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04\u306b\u3088\u308a\u3001\u4f53\u91cd\u6e1b\u5c11\u306e\u307f\u306a\u3089\u305a\u5fc3\u4e0d\u5168\uff08HFpEF\uff09\u306e\u75c7\u72b6\u3084\u8eab\u4f53\u6a5f\u80fd\u5236\u9650\u304c\u6539\u5584\u3067\u304d\u308b\u304b\u3092\u691c\u8a0e\u3057\u305f\u3002
\n\u30fbCOI\uff1aNovo Nordisk\u793e\u306b\u3088\u308b\u7814\u7a76\u52a9\u6210\uff08STEP-HFpEF ClinicalTrials.gov\uff09<\/p>\n

\u3010Method\u3011
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\n\u30fb\u5bfe\u8c61\u60a3\u8005\uff1aBMI\u304c30\u4ee5\u4e0a\u306eHFpEF\uff08EF 45%\u4ee5\u4e0a\u3001NYHA \u2161\u4ee5\u4e0a\uff09\u60a3\u8005529\u4eba
\n\uff08\u4e3b\u306a\u9664\u5916\u57fa\u6e96\uff1a90\u65e5\u4ee5\u5185\u306e5kg\u4ee5\u4e0a\u306e\u4f53\u91cd\u5909\u5316\u3001\u7cd6\u5c3f\u75c5\u306e\u65e2\u5f80\uff09
\n\u30fb\u4ecb\u5165\u7fa4\uff1a\u90311\u56de\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u76ae\u4e0b\u6ce8\uff08\u6700\u521d4\u9031\u9593\u306f0.25mg\u300116\u9031\u76ee\u307e\u3067\u306b2.4mg\u3078\u5897\u91cf\u3059\u308b\u3088\u3046\u6f38\u5897\uff09
\n\u30fb\u5bfe\u7167\u7fa4\uff1a\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e
\n\u30fb\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a52\u9031\u6642\u70b9\u3067\u306e\u4e0b\u8a18\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u8a55\u4fa1
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\n\u30fb\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7fa435\u4eba\uff0813.3%\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa471\u4eba\uff0826.7%\uff09\u3067\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306e\u6295\u4e0e\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u80c3\u8178\u969c\u5bb3\u304c\u591a\u304f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u6709\u5bb3\u4e8b\u8c61\u3068\u3057\u3066\u306f\u5fc3\u81d3\u75be\u60a3\u304c\u591a\u304b\u3063\u305f\u3002
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\n\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

52\u9031\u307e\u3067\u306e\u5e73\u5747\u5909\u5316(\u7387\uff09 \u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7fa4 \u30d7\u30e9\u30bb\u30dc\u7fa4 \u7fa4\u9593\u306e\u63a8\u5b9a\u5dee\uff0895%\u4fe1\u983c\u533a\u9593\uff09
\n\uff08\u4e3b\uff09KCCQ-CSS +16.6\u70b9 +8.7\u70b9 +7.8\u70b9\uff08+4.8\uff5e+10.9\uff1bP<0.001\uff09
\n\uff08\u4e3b\uff09\u4f53\u91cd -13.3% -2.6% -10.7%\uff08-11.9\uff5e-9.4\uff1bP<0.001\uff09
\n6\u5206\u9593\u6b69\u884c\u8ddd\u96e2 +21.5m +1.2m +20.3m\uff088.6\uff5e32.1\uff1bp<0.001\uff09
\n\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u52dd\u5229 60.1% 34.9% \u52dd\u5229\u6bd41.72\uff081.37\uff5e2.15\uff1bP<0.001\uff09
\nCRP\u5024 -43.5% -7.3% \u6cbb\u7642\u6bd40.61\uff080.51\uff5e0.72\uff1bp<0.001\uff09<\/p>\n

\u3010Discussion\u3011
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\n\uff1c\u9650\u754c\uff1e
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\n\u80a5\u6e80\u75c7\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32022\uff08http:\/\/www.jasso.or.jp\/contents\/magazine\/journal.html
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\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002 -\u6587\u732e\u540d- Semaglutide in Patients with Heart … \u7d9a\u304d\u3092\u8aad\u3080 \u80a5\u6e80\u306e\u3042\u308b\u99c6\u51fa\u7387\u304c\u7dad\u6301\u3055\u308c\u305f\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33,17],"tags":[],"class_list":["post-2610","post","type-post","status-publish","format-standard","hentry","category-whats-new","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2610"}],"version-history":[{"count":5,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2610\/revisions"}],"predecessor-version":[{"id":2619,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2610\/revisions\/2619"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}