{"id":27,"date":"2015-06-12T11:24:35","date_gmt":"2015-06-12T02:24:35","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=27"},"modified":"2015-09-10T16:31:11","modified_gmt":"2015-09-10T07:31:11","slug":"%e3%80%90ebm%e3%81%ae%e5%ad%a6%e3%81%b3%e3%80%91%e4%be%bf%e7%a7%98%e3%81%b8%e3%81%ae%e6%bc%a2%e6%96%b9","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=27","title":{"rendered":"\u3010EBM\u306e\u5b66\u3073\u3011\u4fbf\u79d8\u3078\u306e\u6f22\u65b9"},"content":{"rendered":"<p><strong>STEP1\u3000\u81e8\u5e8a\u60a3\u8005\u306b\u5373\u3057\u305fPI(E)CO<\/strong><br \/>\n\u3010\u8a55\u4fa1\u3092\u884c\u3063\u305f\u65e5\u4ed8\u3011<br \/>\n\u30002015\/ 06\/05<br \/>\n\u3010\u81e8\u5e8a\u72b6\u6cc1\u306e\u30b5\u30de\u30ea\u30fc\u3011<br \/>\n\u3000\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3044\u3066\u4fbf\u79d8\u3067\u56f0\u308b\u60a3\u8005\u3068\u51fa\u4f1a\u3046\u3053\u3068\u306f\u975e\u5e38\u306b\u591a\u3044\u3002\u7279\u306b\u865a\u5f31\u9ad8\u9f62\u8005\u306e\u4fbf\u79d8\u306b\u5bfe\u3057\u3066\u3001\u300c\u3068\u308a\u3042\u3048\u305a\u9ebb\u5b50\u4ec1\u4e38\u300d\u3068\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u3092\u6f20\u7136\u3068\u6301\u3063\u3066\u3044\u305f\u304c\u3001\u5b9f\u969b\u306b\u3069\u308c\u307b\u3069\u306e\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u8abf\u3079\u305f\u3053\u3068\u306f\u306a\u304b\u3063\u305f\u3002<br \/>\n\u3000P\uff1b\u6a5f\u80fd\u6027\u4fbf\u79d8\u75c7\u306e\u9ad8\u9f62\u8005<br \/>\n\u3000I(E)\uff1b\u9ebb\u5b50\u4ec1\u4e38\u5185\u670d<br \/>\n\u3000C\uff1b\u30d7\u30e9\u30bb\u30dc<br \/>\n\u3000O\uff1b\u4fbf\u79d8\u304c\u6539\u5584\u3059\u308b<\/p>\n<p><strong>STEP2\u3000\u691c\u7d22\u3057\u3066\u898b\u3064\u3051\u305f\u6587\u732e\u306e\u540d\u524d<\/strong><br \/>\n\u3010\u898b\u3064\u3051\u305f\u8ad6\u6587\u3011<br \/>\n\u3000Chinese herbal medicine for functional constipation: a randomised controlled trial<\/p>\n<p><strong>STEP3\u3000\u8ad6\u6587\u306e\u8a55\u4fa1<br \/>\nSTEP3-1\u3000\u8ad6\u6587\u306ePECO\u306f\u60a3\u8005\u306ePECO\u3068\u5408\u81f4\u3059\u308b\u304b\uff1f<\/strong><br \/>\n\u3000P\uff1b18\u6b73\u304b\u308965\u6b73\u306e\u6a5f\u80fd\u6027\u4fbf\u79d8\u75c7\u60a3\u8005<br \/>\n\u3000I(E)\uff1b\u9ebb\u5b50\u4ec1\u4e38\u5185\u670d<br \/>\n\u3000C\uff1bPlacebo\u5185\u670d<br \/>\n\u3000O\uff1b1\u9031\u9593\u5f53\u305f\u308a\u306e\u81ea\u767a\u6392\u4fbf\u304c\u5897\u52a0\u3059\u308b\u304b\u3069\u3046\u304b<br \/>\n\u3000\u2192\u60a3\u8005\u306ePECO\u3068\u3000(\u5408\u81f4\u3059\u308b\u3000\u30fb\u3000<strong>\u591a\u5c11\u7570\u306a\u308b\u304cOK<\/strong>\u3000\u30fb\u3000\u5927\u304d\u304f\u7570\u306a\u308b\u305f\u3081\u4e0d\u9069\u5207)<br \/>\n\u3000P\u306b\u3064\u3044\u3066\u3001\u81e8\u5e8a\u3067\u306e\u7591\u554f\u306f\u9ebb\u5b50\u4ec1\u4e38\u306e\u51e6\u65b9\u5bfe\u8c61\u3068\u3057\u3066\u6700\u3082\u591a\u3044\u3068\u611f\u3058\u3066\u3044\u305f\u865a\u5f31\u9ad8\u9f62\u8005\u3002\u3057\u304b\u3057\u9ad8\u9f62\u8005\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u306f\u898b\u3064\u304b\u3089\u306a\u304b\u3063\u305f\u3002I,C,O\u306b\u3064\u3044\u3066\u306f\u3001\u5408\u81f4\u3002O\u306b\u3064\u3044\u3066\u3001\u300c\u4fbf\u79d8\u304c\u6539\u5584\u3059\u308b\u300d\u3068\u306f\u3069\u306e\u3088\u3046\u306b\u8a55\u4fa1\u3059\u3079\u304d\u304b\u81ea\u5206\u3067\u3082\u308f\u304b\u3089\u306a\u304b\u3063\u305f\u304c\u3001\u3053\u306e\u8ad6\u6587\u306eO\u3092\u307f\u3066\u3001\u3080\u3057\u308d\u3053\u3046\u3044\u3046\u8a55\u4fa1\u65b9\u6cd5\u304c\u3042\u308b\u306e\u304b\u3068\u7d0d\u5f97\u3002<\/p>\n<p><strong>STEP3-2\u3000\u8ad6\u6587\u306e\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u8a55\u4fa1\uff1b\u5185\u7684\u59a5\u5f53\u6027\u306e\u8a55\u4fa1<\/strong><br \/>\n\u2460\u7814\u7a76\u65b9\u6cd5\u304cRCT\u306b\u306a\u3063\u3066\u3044\u308b\u304b\uff1f\u96a0\u853d\u5316\u3068\u76f2\u691c\u5316\u306f\u3055\u308c\u3066\u3044\u308b\u304b\uff1f<br \/>\n\u3000\u2192\u30e9\u30f3\u30c0\u30e0\u5272\u308a\u4ed8\u3051\u304c\u3000\uff08\u3000<strong>\u3055\u308c\u3066\u3044\u308b<\/strong>\u3000\u30fb\u3000\u3000\u3055\u308c\u3066\u3044\u306a\u3044\u3000\uff09<br \/>\n\u3000\u2192\u96a0\u853d\u5316\u304c\u3000\u3000\u3000\u3000\u3000\u3000\uff08\u3000\u3055\u308c\u3066\u3044\u308b\u3000\u30fb\u3000\u3000<strong>\u3055\u308c\u3066\u3044\u306a\u3044<\/strong>\u3000\uff09<br \/>\n\u3000\u2192\u76f2\u691c\u5316\u304c\u3000\u3000\u3000\u3000\u3000\u3000\uff08\u3000<strong>\u3055\u308c\u3066\u3044\u308b<\/strong>\u3000\u30fb\u3000\u3000\u3055\u308c\u3066\u3044\u306a\u3044\u3000\uff09<br \/>\n\u3000\u5b9f\u969b\u306eTable\u3067\u4ecb\u5165\u7fa4\u3068\u5bfe\u7167\u7fa4\u306f\u540c\u3058\u3088\u3046\u306a\u96c6\u56e3\u306b\u306a\u3063\u3066\u3044\u308b\u304b\uff1f<br \/>\n\u3000\u2192\uff08\u3000<strong>\u306a\u3063\u3066\u3044\u308b<\/strong>\u3000\u30fb\u3000\u306a\u3063\u3066\u3044\u306a\u3044\uff1b\u3069\u3046\u7570\u306a\u308b\u304b\uff1f\uff09<br \/>\n\u2461\u89e3\u6790\u65b9\u6cd5\u306fITT(intention to treat)\u304b\uff1f<br \/>\n\u3000\u2192ITT\u304c\u3000\uff08<strong>\u3055\u308c\u3066\u3044\u308b<\/strong>\u3000\u3000\u30fb\u3000\u3000\u3055\u308c\u3066\u3044\u306a\u3044\uff09<\/p>\n<p><strong>STEP3-3\u8ad6\u6587\u3067\u898b\u3044\u3060\u3055\u308c\u305f\u7d50\u679c\u306e\u8a55\u4fa1<\/strong><br \/>\n\u3000Outcome\u306b\u3064\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u5024\u3092\u78ba\u8a8d\u3059\u308b<br \/>\n\u3010\u2460\u6cbb\u7642\u52b9\u679c\u306e\u6709\u7121\uff1b P\u5024\u3092\u78ba\u8a8d\u3059\u308b\u3011<br \/>\n\u3000Responder rate\uff1a\u9ebb\u5b50\u4ec1\u4e38\u7fa443.3%\u3001\u5bfe\u7167\u7fa48.3%\uff08P<0.001\uff09\n\u3010\u2461\u6cbb\u7642\u52b9\u679c\u306e\u5927\u304d\u3055\uff1b\u6bd4\u306e\u6307\u6a19\u3068\u5dee\u306e\u6307\u6a19\u3092\u78ba\u8a8d\u3059\u308b\u3011\n\u3000\u30fbRR(\u3042\u308b\u3044\u306fHR\u30fbOR)\u3092\u78ba\u8a8d\u3059\u308b\n\u3000\u3000RR 0.618\n\u3000\u30fbARR\u3068NNT\u3092\u8a08\u7b97\u3059\u308b\n\u00a0\u3000 ARR 0.35\n\u00a0 \u3000NNT 2.857\n\u3010\u2462\u6cbb\u7642\u52b9\u679c\u306e\u3086\u3089\u304e\uff1b\u4fe1\u983c\u533a\u9593\u3092\u78ba\u8a8d\u3059\u308b\u3011\n\u3000\u53c2\u8003\uff1a\n\u3000\u3000\u9ebb\u5b50\u4ec1\u4e38\u7fa4\u306e8\u9031\u9593\u5185\u670d\u7d42\u4e86\u5f8cCSBM\/week\u306e\u56de\u6570\u306f\u3001\n\u3000\u3000\u9ebb\u5b50\u4ec1\u4e38\u7fa4\u306e\u5185\u670d\u524d\u3068\u6bd4\u3079\u3066\u512a\u4f4d\u306b\u5897\u52a01.62\u56de(95%CI\u30001.11-2.13)P<0.001\n\u3000\u3000\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e8\u9031\u9593\u5185\u670d\u7d42\u4e86\u5f8c\u3068\u6bd4\u3079\u3066\u512a\u4f4d\u306b\u5897\u52a0\u3000P=0.003\n\n<strong>STEP4\u60a3\u8005\u3078\u306e\u9069\u5fdc<\/strong><br \/>\n\u3010\u2460\u8ad6\u6587\u306e\u60a3\u8005\u3068\u3001\u76ee\u306e\u524d\u306e\u60a3\u8005\u304c\u3001\u7d50\u679c\u304c\u9069\u5fdc\u3067\u304d\u306a\u3044\u307b\u3069\u7570\u306a\u3063\u3066\u3044\u306a\u3044\u304b\uff1f\u3011<br \/>\n\u3000\u77e5\u308a\u305f\u3044\u5bfe\u8c61\u306f\u865a\u5f31\u9ad8\u9f62\u8005\u3067\u3042\u3063\u305f\u304c\u3001\u4eca\u56de\u306f18-65\u6b73\u3002\u3053\u306e\u8ad6\u6587\u306e\u7d50\u679c\u304c\u3001\u65bd\u8a2d\u5165\u5c45\u306a\u3069\u3057\u3066\u3044\u308b\u865a\u5f31\u9ad8\u9f62\u8005\u306b\u9069\u5fdc\u3067\u304d\u308b\u304b\u306f\u308f\u304b\u3089\u306a\u3044\u3002<br \/>\n\u3010\u2461\u6cbb\u7642\u305d\u306e\u3082\u306e\u306f\u5fe0\u5b9f\u306b\u5b9f\u884c\u53ef\u80fd\u304b\uff1f\u3011<br \/>\n\u3000\u9ebb\u5b50\u4ec1\u4e38\u306e\u7528\u91cf\u306f7.5g 1\u65e52\u56de\u3067\u65e5\u672c\u306e\u4e00\u822c\u7684\u306a\u7528\u91cf\u306e\u500d\u3067\u3042\u308a\u3001\u3053\u306e\u70b9\u3082\u8003\u616e\u304c\u5fc5\u8981\u3001\u4fdd\u967a\u9069\u5fdc\u306f\u3042\u308a\u3001\u6295\u85ac\u671f\u9593\u306f8\u9031\u9593\u3067\u3042\u308a\u7d99\u7d9a\u304c\u96e3\u3057\u3044\u671f\u9593\u3067\u306f\u306a\u3044\u3002\u6f22\u65b9\u85ac\u81ea\u4f53\u306e\u98f2\u307f\u3065\u3089\u3055\u3092\u611f\u3058\u306a\u3044\u60a3\u8005\u3067\u3042\u308c\u3070\u3001\u5185\u670d\u53ef\u80fd\u3002<br \/>\n\u3010\u2462\u91cd\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u30b3\u30b9\u30c8\u3084\u5bb3\u3092\u542b\u3081\u3066\u5168\u3066\u8a55\u4fa1\u3055\u308c\u305f\u304b\uff1f \u3011<br \/>\n\u3000\u526f\u4f5c\u7528\u306f\u8179\u75db\u3001\u6d88\u5316\u7ba1\u306e\u6709\u75db\u6027\u75d9\u6523\u3001\u4e0b\u75e2\u3001\u6d6e\u816b\u3001\u304a\u306a\u3089\u306f\u9ebb\u5b50\u4ec1\u4e38\u7fa4\u3067\u591a\u304b\u3063\u305f\u3002<br \/>\n\u3010\u2463\u60a3\u8005\u306e\u8003\u3048\u30fb\u55dc\u597d\u306f\u3069\u3046\u306a\u306e\u304b\uff1f\u3011<br \/>\n\u3000\u4eca\u56de\u306f\u3042\u308b\u500b\u4eba\u75c7\u4f8b\u306b\u3064\u3044\u3066\u306e\u7591\u554f\u3067\u306f\u306a\u304b\u3063\u305f\u3002\u865a\u5f31\u9ad8\u9f62\u8005\u306b\u9ebb\u5b50\u4ec1\u4e38\u3092\u51e6\u65b9\u3057\u3066\u3001\u7279\u306b\u62b5\u6297\u3092\u53d7\u3051\u305f\u7d4c\u9a13\u306f\u306a\u3044\u3002<\/p>\n<p><a href=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2015\/06\/150612.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2015\/06\/150612.png\" alt=\"150612\" width=\"642\" height=\"84\" class=\"alignnone size-full wp-image-825\" srcset=\"https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2015\/06\/150612.png 642w, https:\/\/www.hcfm.jp\/journal\/wp-content\/uploads\/2015\/06\/150612-300x39.png 300w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" \/><\/a><\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n2015\u5e746\u670810\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STEP1\u3000\u81e8\u5e8a\u60a3\u8005\u306b\u5373\u3057\u305fPI(E)CO \u3010\u8a55\u4fa1\u3092\u884c\u3063\u305f\u65e5\u4ed8\u3011 \u30002015\/ 06\/05 \u3010\u81e8\u5e8a\u72b6\u6cc1\u306e\u30b5\u30de\u30ea\u30fc\u3011 \u3000\u65e5\u5e38\u8a3a\u7642\u306b\u304a\u3044\u3066\u4fbf\u79d8\u3067\u56f0\u308b\u60a3\u8005\u3068\u51fa\u4f1a\u3046\u3053\u3068\u306f\u975e\u5e38\u306b\u591a\u3044\u3002\u7279\u306b\u865a\u5f31\u9ad8\u9f62\u8005\u306e\u4fbf\u79d8\u306b\u5bfe\u3057\u3066\u3001\u300c\u3068\u308a\u3042\u3048\u305a\u9ebb\u5b50 &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=27\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u3010EBM\u306e\u5b66\u3073\u3011\u4fbf\u79d8\u3078\u306e\u6f22\u65b9<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-27","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27"}],"version-history":[{"count":5,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/27\/revisions"}],"predecessor-version":[{"id":871,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/27\/revisions\/871"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}