{"id":2725,"date":"2024-09-11T13:04:43","date_gmt":"2024-09-11T04:04:43","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2725"},"modified":"2024-09-11T13:04:43","modified_gmt":"2024-09-11T04:04:43","slug":"%e7%a6%81%e7%85%99%e3%81%ae%e3%81%9f%e3%82%81%e3%81%ae%e9%9b%bb%e5%ad%90%e3%82%bf%e3%83%90%e3%82%b3","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2725","title":{"rendered":"\u7981\u7159\u306e\u305f\u3081\u306e\u96fb\u5b50\u30bf\u30d0\u30b3"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nReto Auer, Anna Schoeni, Jean-Paul Humair, et al. Electronic Nicotine-Delivery Systems for Smoking Cessation.N Engl J Med. 2024;390(7):601-610.<\/p>\n

-\u8981\u7d04-
\nIntroduction
\n\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u304a\u3088\u3073\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u96fb\u5b50\u30bf\u30d0\u30b3\u306f\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u3088\u308a\u3082\u30bf\u30d0\u30b3\u306e\u7981\u7159\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u304c\u3001\u6a19\u6e96\u6cbb\u7642\u306e\u7981\u7159\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3068\u6bd4\u8f03\u3057\u305f\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u6709\u52b9\u6027\u3001\u304a\u3088\u3073\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u4f7f\u7528\u306b\u95a2\u9023\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u304a\u3088\u3073\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u3067\u6e2c\u5b9a\u3057\u305f\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3002\u55ab\u7159\u8005\u304c\u7981\u7159\u3059\u308b\u3068\u3001\u54b3\u3084\u75f0\u306a\u3069\u306e\u55ab\u7159\u306b\u95a2\u9023\u3057\u305f\u547c\u5438\u5668\u75c7\u72b6\u304c\u8efd\u6e1b\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u304c\u3001\u96fb\u5b50\u30bf\u30d0\u30b3\u3092\u4f7f\u7528\u3057\u3066\u7981\u7159\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u547c\u5438\u5668\u75c7\u72b6\u3082\u8efd\u6e1b\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002
\n\u305d\u3053\u3067\u3001\u7981\u7159\u88dc\u52a9\u3068\u3057\u3066\u306e\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u6709\u52b9\u6027\u3001\u5b89\u5168\u6027\u3001\u6bd2\u6027\u306b\u3064\u3044\u3066\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u96fb\u5b50\u30bf\u30d0\u30b3\u3092\u8ffd\u52a0\u3057\u305f\u5834\u5408\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u3001\u6a19\u6e96\u6cbb\u7642\u5358\u72ec\u3068\u6bd4\u8f03\u3057\u30016\u30f5\u6708\u5f8c\u306e\u7981\u7159\u306b\u95a2\u3057\u3066\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

Method
\n\u30b9\u30a4\u30b9\u306e5\u65bd\u8a2d\u3067\u975e\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u30022018\u5e747\u6708\u304b\u30892021\u5e746\u6708\u306b\u304b\u3051\u3066\u3001\u4e00\u822c\u7d19\u3084\u30bd\u30fc\u30b7\u30e3\u30eb\u30e1\u30c7\u30a3\u30a2\u3067\u306e\u7121\u6599\u30fb\u6709\u6599\u5e83\u544a\u3001\u533b\u7642\u65bd\u8a2d\u3084\u516c\u5171\u4ea4\u901a\u6a5f\u95a2\u3067\u306e\u5e83\u544a\u306b\u3088\u3063\u3066\u53c2\u52a0\u8005\u3092\u52df\u96c6\u3057\u305f\u3002
\n18\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba\u3067\u30011\u65e55\u672c\u4ee5\u4e0a\u306e\u55ab\u7159\u309212\u30f5\u6708\u4ee5\u4e0a\u7d99\u7d9a\u3057\u3001\u767b\u9332\u5f8c3\u30f5\u6708\u4ee5\u5185\u306b\u7981\u7159\u3092\u5e0c\u671b\u3059\u308b\u8005\u3092\u53c2\u52a0\u5bfe\u8c61\u3068\u3057\u305f\u3002\u598a\u5a20\u4e2d\u307e\u305f\u306f\u6388\u4e73\u4e2d\u306e\u8005\u3001\u904e\u53bb3\u30f5\u6708\u9593\u306b\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u307e\u305f\u306f\u4ed6\u306e\u7981\u7159\u88dc\u52a9\u85ac\u3092\u4f7f\u7528\u3057\u305f\u3053\u3068\u306e\u3042\u308b\u8005\u3001\u904e\u53bb3\u30f5\u6708\u9593\u306b\u96fb\u5b50\u30bf\u30d0\u30b3\u307e\u305f\u306f\u30bf\u30d0\u30b3\u52a0\u71b1\u30b7\u30b9\u30c6\u30e0\u3092\u5b9a\u671f\u7684\u306b\u4f7f\u7528\u3057\u305f\u3053\u3068\u306e\u3042\u308b\u8005\u306f\u9664\u5916\u3057\u305f\u3002
\n\u4ecb\u5165\u7fa4\u306f\u7121\u6599\u306e\u96fb\u5b50\u30bf\u30d0\u30b3\u3068\u96fb\u5b50\u30ea\u30ad\u30c3\u30c9\u3001(\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5\u3001\u52d5\u6a5f\u3065\u3051\u9762\u63a5\u3001\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u3084\u7981\u7159\u88dc\u52a9\u85ac\u306a\u3069\u306e\u7981\u7159\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u85ac\u5264\u306e\u4f7f\u7528\u306b\u95a2\u3059\u308b\u5171\u540c\u610f\u601d\u6c7a\u5b9a\u306a\u3069\u3092\u542b\u3080)\u6a19\u6e96\u7684\u306a\u7981\u7159\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3001\u4efb\u610f\uff08\u7121\u6599\u3067\u306f\u306a\u3044\uff09\u306e\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u304c\u63d0\u4f9b\u3055\u308c\u305f\u3002\u5bfe\u7167\u7fa4\u306f\u6a19\u6e96\u7684\u306a\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3068\u3001\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u306e\u8cfc\u5165\u3092\u542b\u3081\u3069\u306e\u3088\u3046\u306a\u76ee\u7684\u306b\u3082\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b50\u30b9\u30a4\u30b9\u30d5\u30e9\u30f3\uff08\u7c73\u30c9\u30eb\u306750\u30c9\u30eb\uff09\u76f8\u5f53\u306e\u30d0\u30a6\u30c1\u30e3\u30fc\u304c\u63d0\u4f9b\u3055\u308c\u305f\u3002
\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u751f\u5316\u5b66\u7684\u306b\u691c\u8a3c\u3055\u308c\u305f(\u5b9a\u7fa9\uff1a\u547c\u6c17\u4e00\u9178\u5316\u70ad\u7d20\u6fc3\u5ea6\u304c9ppm\u4ee5\u4e0b\u3067\u3042\u308b\u3053\u3068)6\u30f5\u6708\u6642\u70b9\u3067\u306e\u7d99\u7d9a\u7684\u7981\u7159\u3067\u3042\u3063\u305f\u3002
\n\u526f\u6b21\u7684\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u53c2\u52a0\u8005\u304c\u81ea\u5df1\u7533\u544a\u3057\u305f6\u30f5\u6708\u6642\u70b9\u306e\u30bf\u30d0\u30b3\u304a\u3088\u3073\u3042\u3089\u3086\u308b\u30cb\u30b3\u30c1\u30f3\uff08\u55ab\u7159\u3001\u96fb\u5b50\u30bf\u30d0\u30b3\u3001\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u3092\u542b\u3080\uff09\u304b\u3089\u306e\u7981\u7159\u3001\u547c\u5438\u5668\u75c7\u72b6\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306a\u3069\u3067\u3042\u3063\u305f\u3002<\/p>\n

Results
\n2027\u4eba\u306e\u55ab\u7159\u8005\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u30011246\u4eba\u3092\u4e00\u6b21\u89e3\u6790\u306b\u7d44\u307f\u5165\u308c\u4ecb\u5165\u7fa4622\u4eba\u3001\u5bfe\u7167\u7fa4624\u4eba\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u3064\u3051\u305f\u3002
\n\"\"<\/a>\u53c2\u52a0\u8005\u306e\u591a\u304f\u306f\u4e2d\u5e74\u3067\u300147\uff05\u304c\u5973\u6027\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6765\u9662\u304b\u3089\u7981\u7159\u76ee\u6a19\u65e5\u307e\u3067\u306e\u5e73\u5747\uff08\u00b1SD\uff09\u65e5\u6570\u306f\u3001\u4ecb\u5165\u7fa46.0\u00b13.6\u65e5\u3001\u5bfe\u7167\u7fa46.0\u00b13.9\u65e5\u3067\u3042\u3063\u305f\u3002\"\"<\/a>\uff1cPrimary Outcomes\uff1e
\n(\u691c\u67fb\u3067)\u691c\u8a3c\u3055\u308c\u305f\u7d99\u7d9a\u7684\u7981\u7159\u306e\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u3001\u4ecb\u5165\u7fa4\u306728.9\uff05\u3001\u5bfe\u7167\u7fa4\u306716.3\uff05\u3067\u3042\u3063\u305f\uff08\u76f8\u5bfe\u30ea\u30b9\u30af\u30011.77\uff1b95\uff05\u4fe1\u983c\u533a\u9593\u30011.43\uff5e2.20\uff09\u3002\"\"<\/a>\uff1cSecondary Outcomes\uff1e
\n\u30fb(\u81ea\u5df1\u7533\u544a\u3067)6\u304b\u6708\u6642\u70b9\u3067\u306e\u30bf\u30d0\u30b3\u3001\u96fb\u5b50\u30bf\u30d0\u30b3\u3001\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u306e\u4f7f\u7528\u72b6\u6cc1
\n6\u30f5\u6708\u306e\u6642\u70b9\u3067\u4ecb\u5165\u7fa4\u3067\u306f59.6\uff05\uff08552\u4eba\u4e2d329\u4eba\uff09\u3001\u5bfe\u7167\u7fa4\u3067\u306f38.5\uff05\uff08504\u4eba\u4e2d194\u4eba\uff09\u304c\u300c\u7981\u7159\u8005\u300d\uff086\u30f5\u6708\u76ee\u306e\u30d5\u30a9\u30ed\u30fc\u65e5\u524d7\u65e5\u9593\u306b\u30bf\u30d0\u30b3\u3092\u4f7f\u7528\u3057\u306a\u304b\u3063\u305f\uff09\u3067\u3042\u3063\u305f\u3002\u4e00\u65b9\uff0c\u4ecb\u5165\u7fa4\u3067\u306f20.1\uff05\uff0c\u5bfe\u7167\u7fa4\u3067\u306f33.7\uff05\u304c\u30cb\u30b3\u30c1\u30f3\u3092\u4e00\u5207\u63a7\u3048\u305f\uff08\u30bf\u30d0\u30b3\uff0c\u30cb\u30b3\u30c1\u30f3\u5165\u308a\u96fb\u5b50\u30bf\u30d0\u30b3\uff0c\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u3092\u7981\u5fcc\uff09\u3002\"\"<\/a>
\n\u30fb\u6709\u5bb3\u4e8b\u8c61
\n\u5bfe\u7167\u7fa4\u3067\u306f\u30011\u4eba\u304c\u8a66\u9a13\u4e2d\u306b\u6b7b\u4ea1\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30896\u30f5\u6708\u306e\u8ffd\u8de1\u8abf\u67fb\u307e\u3067\u306e\u9593\u306b\u3001\u4ecb\u5165\u7fa4\u3067\u306f25\u4eba\uff084.0\uff05\uff09\u3001\u5bfe\u7167\u7fa4\u3067\u306f31\u4eba\uff085.0\uff05\uff09\u306b\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u304c\u767a\u751f\u3057\u305f\uff08\u76f8\u5bfe\u30ea\u30b9\u30af\u30010.81\uff1b95\uff05CI\u30010. 48\uff5e1.35\uff1b\u672a\u8abf\u6574P\uff1d0.49\uff09\u3002
\n\u4ecb\u5165\u7fa4\u306e\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001272\u4eba\uff0843.7\uff05\uff09\u304c425\u4ef6\u306e\u6709\u5bb3\u4e8b\u8c61\u3092\u5831\u544a\u3057\u3001\u5bfe\u7167\u7fa4\u306e\u53c2\u52a0\u8005\u306e\u3046\u3061\u3001229\u4eba\uff0836.7\uff05\uff09\u304c366\u4ef6\u306e\u6709\u5bb3\u4e8b\u8c61\u3092\u5831\u544a\u3057\u305f\uff08\u76f8\u5bfe\u30ea\u30b9\u30af\u30011.19\uff1b95\uff05CI\u30011.04\uff5e1. 37\uff1b\u672a\u8abf\u6574P\uff1d0.01\uff09\u3002
\n\uff08\u8a73\u7d30\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3042\u308a\uff09<\/p>\n

\u30fb\u547c\u5438\u5668\u75c7\u72b6
\nCOPD Assessment Test\u306e\u5e73\u5747\u7dcf\u5f97\u70b9\u306f\u3001\u4ecb\u5165\u7fa44.8\u00b13.9\u70b9\u3001\u5bfe\u7167\u7fa45.7\u00b14.5\u70b9\u3067\u3042\u3063\u305f\uff08\u5e73\u5747\u7dcf\u5f97\u70b9\u306e\u591a\u5909\u91cf\u8abf\u6574\u5dee\u3001-0.66\uff1b95\uff05CI\u3001-1.13\uff5e-0.18\uff09\u3002\u54b3\u304c\u306a\u304b\u3063\u305f\u3068\u56de\u7b54\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u3001\u4ecb\u5165\u7fa441\uff05\u3001\u5bfe\u7167\u7fa434\uff05\u3001\u75f0\u304c\u306a\u304b\u3063\u305f\u3068\u56de\u7b54\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u3001\u4ecb\u5165\u7fa462\uff05\u3001\u5bfe\u7167\u7fa451\uff05\u3001\u80f8\u306e\u3064\u304b\u3048\u304c\u306a\u304b\u3063\u305f\u3068\u56de\u7b54\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u3001\u4ecb\u5165\u7fa473\uff05\u3001\u5bfe\u7167\u7fa472\uff05\u3067\u3042\u3063\u305f\uff1b \u606f\u82e6\u3057\u3055\u3092\u611f\u3058\u306a\u3044\u300d34\uff05\u3001\u300c\u606f\u82e6\u3057\u3055\u3092\u611f\u3058\u306a\u3044\u300d30\uff05\u3001\u300c\u81ea\u5b85\u3067\u306e\u6d3b\u52d5\u306b\u5236\u9650\u304c\u306a\u3044\u300d95\uff05\u3001\u300c\u81ea\u5b85\u3092\u51fa\u308b\u81ea\u4fe1\u304c\u3042\u308b\u300d96\uff05\u3001\u300c\u81ea\u5b85\u3092\u51fa\u308b\u81ea\u4fe1\u304c\u3042\u308b\u300d95\uff05\u3001\u300c\u719f\u7761\u611f\u304c\u3042\u308b\u300d92\uff05\u3001\u300c\u719f\u7761\u611f\u304c\u3042\u308b\u300d90\uff05\u3001\u300c\u5143\u6c17\u304c\u3042\u308b\u300d40\uff05\u3001\u300c\u5143\u6c17\u304c\u3042\u308b\u300d39\uff05\u3067\u3042\u3063\u305f\u3002
\n\uff08\u8a73\u7d30\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3042\u308a\uff09<\/p>\n

Discussion
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\n\u7981\u7159\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u306f\u4ecb\u5165\u7fa4\u3067\u9ad8\u304b\u3063\u305f\u304c\u3001\u30cb\u30b3\u30c1\u30f3\u5165\u308a\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u7d99\u7d9a\u4f7f\u7528\u3082\u9ad8\u304b\u3063\u305f\u3002\u96fb\u5b50\u30cb\u30b3\u30c1\u30f3\u9001\u9054\u30b7\u30b9\u30c6\u30e0\u3068\u6a19\u6e96\u7684\u306a\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u4f75\u7528\u306f\u3001\u5fc5\u305a\u3057\u3082\u30cb\u30b3\u30c1\u30f3\u3092\u65ad\u305f\u305a\u306b\u7981\u7159\u3092\u671b\u3080\u30bf\u30d0\u30b3\u55ab\u7159\u8005\u306b\u3068\u3063\u3066\u306f\u5b9f\u884c\u53ef\u80fd\u306a\u9078\u629e\u80a2\u304b\u3082\u3057\u308c\u306a\u3044\u304c\u3001\u30bf\u30d0\u30b3\u3068\u30cb\u30b3\u30c1\u30f3\u306e\u4e21\u65b9\u3092\u65ad\u3061\u305f\u3044\u55ab\u7159\u8005\u306b\u3068\u3063\u3066\u306f\u3042\u307e\u308a\u9069\u5207\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n

\uff1c\u4eca\u56de\u306e\u7814\u7a76\u306e\u9650\u754c\uff1e
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\n\u7b2c2\u306b\u3001\u4ecb\u5165\u7fa4\u306b\u306f\u7121\u6599\u306e\u96fb\u5b50\u30bf\u30d0\u30b3\u3068\u96fb\u5b50\u30ea\u30ad\u30c3\u30c9\u3092\u63d0\u4f9b\u3057\u305f\u304c\u3001\u5bfe\u7167\u7fa4\u306b\u306f\u4ee5\u524d\u306e\u8a66\u9a13\u3067\u884c\u308f\u308c\u305f\u3088\u3046\u306a\u7121\u6599\u306e\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u306f\u63d0\u4f9b\u3057\u306a\u304b\u3063\u305f(\u96fb\u5b50\u30bf\u30d0\u30b3vs\u30cb\u30b3\u30c1\u30f3\u4ee3\u66ff\u7642\u6cd5\u3092\u6bd4\u8f03\u3059\u308b\u305f\u3081\u3067\u306f\u306a\u304b\u3063\u305f\u305f\u3081)\u3002
\n\u7b2c3\u306b\u3001\u6cbb\u7642\u7d42\u4e86\u8a55\u4fa1\u3092\u5b9f\u65bd\u3059\u308b\u524d\u306b\u3001\u53c2\u52a0\u8005\u306b6\u30f5\u6708\u9593\u7121\u6599\u306e\u96fb\u5b50\u30ea\u30ad\u30c3\u30c9\u3092\u63d0\u4f9b\u3057\u305f\u3002
\n\u7b2c4\u306b\u3001\u53c2\u52a0\u8005\u306e\u5831\u544a\u30c7\u30fc\u30bf\u3088\u308a\u3082\u751f\u5316\u5b66\u7684\u691c\u8a3c\u30c7\u30fc\u30bf\u306e\u6b20\u843d\u304c\u591a\u304f\u3001\u4ecb\u5165\u7fa4\u3088\u308a\u3082\u5bfe\u7167\u7fa4\u3067\u6b20\u843d\u30c7\u30fc\u30bf\u304c\u591a\u304b\u3063\u305f\u3002
\n\u7b2c5\u306b\u3001\u30b9\u30a4\u30b9\u306e\u5916\u6765\u533b\u7642\u74b0\u5883\u3067\u4ecb\u5165\u3092\u8a66\u9a13\u3057\u305f\u305f\u3081\u3001\u8aad\u8005\u306f\u4ed6\u306e\u74b0\u5883\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304c\u5f97\u3089\u308c\u308b\u3068\u4eee\u5b9a\u3059\u308b\u3053\u3068\u306b\u306f\u614e\u91cd\u3067\u3042\u308b\u3079\u304d\u3067\u3042\u308b\u3002
\n\u7b2c6\u306b\u3001\u308f\u308c\u308f\u308c\u306f\u526f\u6b21\u7684\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u3066\u4fe1\u983c\u533a\u9593\u306e\u5e45\u3092\u591a\u91cd\u6027\u306e\u305f\u3081\u306b\u8abf\u6574\u3057\u306a\u304b\u3063\u305f\u306e\u3067\u3001\u3053\u308c\u3089\u306e\u4fe1\u983c\u533a\u9593\u306f\u4eee\u8aac\u691c\u5b9a\u306b\u53d6\u3063\u3066\u4ee3\u308f\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3002<\/p>\n

\u73fe\u5728\u306e\u7d50\u679c\u3067\u306f\u3001\u4e3b\u8981\u8ee2\u5e30\u304c\u305d\u306e\u5f8c\u306e\u6765\u9662\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u6301\u7d9a\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u4e88\u6e2c\u3067\u304d\u306a\u3044\u306e\u3067\u300112\u30f5\u6708\u300124\u30f5\u6708\u300160\u30f5\u6708\u306e\u8ffd\u8de1\u8abf\u67fb\u3092\u7d99\u7d9a\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112024\u5e749\u670811\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"

-\u6587\u732e\u540d- Reto Auer, Anna Schoeni, Jean-Paul Humair, et al. Electronic Nicotine-Delivery Systems for Smoking Cessa … \u7d9a\u304d\u3092\u8aad\u3080 \u7981\u7159\u306e\u305f\u3081\u306e\u96fb\u5b50\u30bf\u30d0\u30b3<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,23],"tags":[],"class_list":["post-2725","post","type-post","status-publish","format-standard","hentry","category-5","category-23"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2725"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2725\/revisions"}],"predecessor-version":[{"id":2730,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2725\/revisions\/2730"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}