{"id":2742,"date":"2024-10-09T14:30:57","date_gmt":"2024-10-09T05:30:57","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2742"},"modified":"2024-10-09T14:30:57","modified_gmt":"2024-10-09T05:30:57","slug":"%e8%aa%8d%e7%9f%a5%e7%97%87bpsd%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%ac%ac2%e4%b8%96%e4%bb%a3%ef%bc%88%e9%9d%9e%e5%ae%9a%e5%9e%8b%ef%bc%89%e6%8a%97%e7%b2%be%e7%a5%9e%e7%97%85%e8%96%ac%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2742","title":{"rendered":"\u8a8d\u77e5\u75c7BPSD\u306b\u5bfe\u3059\u308b\u7b2c2\u4e16\u4ee3\uff08\u975e\u5b9a\u578b\uff09\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u6bd4\u8f03"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nL\u00fc W, Liu F, Zhang Y, et al. Efficacy, acceptability and tolerability of second-generation antipsychotics for behavioural and psychological symptoms of dementia: a systematic review and network meta-analysis. BMJ Ment Health. 2024;27:1-8.<\/p>\n

-\u8981\u7d04-
\n\u25cfAbstract\uff08\u5168\u6587\uff09
\n\u3010Background\u3011
\n\u3000BPSD\u306f\u591a\u304f\u306e\u8a8d\u77e5\u75c7\u60a3\u8005\u306b\u8a8d\u3081\u3089\u308c\u308b\u3002BPSD\u306e\u6cbb\u7642\u306b\u306f\u7b2c2\u4e16\u4ee3\uff08\u975e\u5b9a\u578b\uff09\u6297\u7cbe\u795e\u75c5\u85ac\uff08SGAs\uff09\u304c\u3088\u304f\u7528\u3044\u3089\u308c\u308b\u304c\u3001\u305d\u306e\u6709\u52b9\u6027\u3084\u53d7\u5bb9\u6027\u306b\u3064\u3044\u3066\u6bd4\u8f03\u3057\u305f\u969b\u306e\u7279\u5fb4\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002
\n\u3010Methods\u3011
\n\u3000\u6a19\u6e96\u5316\u5e73\u5747\u5dee\uff08SMD\u3001(\u5e73\u5747\u5024\u306e\u5dee)\uff0f(\u5404\u7fa4\u306e\u6a19\u6e96\u504f\u5dee\u306e\u5e73\u5747\u5024)\uff09\u3092\u7528\u3044\u3066\u3001\u9023\u7d9a\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u3066\u306e\u56fa\u5b9a\u52b9\u679c\u3092\u30d7\u30fc\u30eb\u3057\u305f\u3002\u30ab\u30c6\u30b4\u30ea\u5909\u6570\u306b\u5bfe\u5fdc\u3059\u308b\u30aa\u30c3\u30ba\u6bd4\u306895%\u4fe1\u983c\u533a\u9593\u3092\u7b97\u51fa\u3057\u305f\u3002\u53d7\u5bb9\u6027\uff08Acceptability\u3001\u6709\u52b9\u6027\uff0b\u5b89\u5168\u6027\u306e\u6df7\u5408\uff09\u306f\u5168\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u8131\u843d\u7387\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u3001\u5fcd\u5bb9\u6027\uff08Tolerability\uff09\u306f\u6709\u5bb3\u4f5c\u7528\u306b\u3088\u308b\u4e2d\u6b62\u7387\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u6cbb\u7642\u52b9\u679c\u306e\u9806\u4f4d\u306f\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08SUCRA\uff1aSurface Under the Cumulative Ranking Curves\uff09\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3057\u305f\u3002\u6709\u5bb3\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u306f\u3001\u6b7b\u4ea1\u3001\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u3001\u8ee2\u5012\u3001\uff08\u904e\uff09\u93ae\u9759\u3001\u9310\u4f53\u5916\u8def\u75c7\u72b6\u3001\u5c3f\u8def\u75c7\u72b6\u304c\u542b\u307e\u308c\u305f\u3002
\n\u3010Results\u3011
\n\u3000\u3053\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08NMA\uff09\u306b\u306f20\u4ef6\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u304c\u542b\u307e\u308c\u30015\u7a2e\u985e\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\uff09\u306b\u3064\u3044\u3066\u3001\u5408\u8a086374\u4eba\u306e\u7d50\u679c\u304c\u542b\u307e\u308c\u305f\u3002\u4ecb\u5165\u671f\u9593\u306f6\u9031\u9593\u301c36\u9031\u9593\u3067\u3042\u3063\u305f\u3002
\n\u3000\u6709\u52b9\u6027\u306e\u8a55\u4fa1\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u6709\u52b9\u6027\u304c\u9ad8\u304f\uff08SMD=-1.77\u300195%CI:-2.80\uff5e-0.74\uff09\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3088\u308a\u3082\u6709\u52b9\u3067\u3042\u3063\u305f\u3002
\n\u3000\u53d7\u5bb9\u6027\u306e\u8a55\u4fa1\u3067\u306f\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u307f\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u512a\u308c\u3066\u304a\u308a\uff08OR=0.72\u300195%CI:0.54\uff5e0.96\uff09\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3088\u308a\u3082\u512a\u308c\u3066\u3044\u305f\uff08OR 0.61\u300195%CI:0.37\uff5e0.99\uff09\u3002
\n\u3000\u5fcd\u5bb9\u6027\u306e\u8a55\u4fa1\u3067\u306f\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u6700\u3082\u60aa\u304f\uff08OR=6.02\u300195%CI:2.87\uff5e12.66\uff09\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\uff08OR=3.67\u300195%CI:1.66\uff5e8.11\uff09\u3084\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\uff08OR=3.71\u300195%CI:1.46\uff5e9.42\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3082\u60aa\u304b\u3063\u305f\u3002\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u512a\u308c\u3066\u3044\u305f\uff08OR=0.25\u300195%CI:0.08\u301c0.78\uff09\u3002\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u306f\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u306e\u70b9\u3067\u826f\u597d\u306a\u5b89\u5168\u6027\u3092\u793a\u3057\u305f\u3002\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u8ee2\u5012\u3084\uff08\u904e\uff09\u93ae\u9759\u306e\u70b9\u3067\u826f\u597d\u306a\u5b89\u5168\u6027\u3092\u793a\u3057\u305f\u3002
\n\u3010Conclusion\u3011
\n\u3000\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306fBPSD\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u9ad8\u3044\u6709\u52b9\u6027\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u6700\u3082\u53d7\u5bb9\u6027\u304c\u9ad8\u304f\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u306f\u5fcd\u5bb9\u6027\u304c\u6700\u3082\u60aa\u304b\u3063\u305f\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u610f\u601d\u6c7a\u5b9a\u306e\u6307\u91dd\u3068\u3057\u3066\u6d3b\u7528\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n

\u25cfIntroduction
\n\u30fb\u3053\u308c\u307e\u3067\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\u3001\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306fBPSD\u306b\u308f\u305a\u304b\u306a\u6539\u5584\u3092\u3082\u305f\u3089\u3059\u4e00\u65b9\u3001\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\uff08\u7279\u306b\uff08\u904e\uff09\u93ae\u9759\u3001\u9310\u4f53\u5916\u8def\u75c7\u72b6\u3001\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u6b7b\u4ea1\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002FDA\u306f\u4ee5\u524d\u3001\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u4f7f\u7528\u306b\u95a2\u3059\u308b\u8b66\u544a\u3092\u51fa\u3057\u305f\u3002
\n\u30fb\u3057\u304b\u3057\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306f\u3001\u672a\u3060\u306b\u60a3\u8005\u306e12.3\uff5e37.5%\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002
\n\u30fb\u6700\u3082\u6709\u76ca\u304b\u3064\u5b89\u5168\u306a\u6297\u7cbe\u795e\u75c5\u85ac\u3092\u63a2\u308b\u969b\u306b\u3001\u4e00\u5bfe\u4e00\u306e\u6bd4\u8f03\u7814\u7a76\u3092\u57fa\u306b\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u9650\u754c\u304c\u3042\u3063\u305f\u304c\u3001\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08NMA\uff09\u306f\u8907\u6570\u306e\u4ecb\u5165\u8a66\u9a13\u3092\u6bd4\u8f03\u3057\u3066\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u3067\u898b\u8b58\u3092\u6df1\u3081\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002
\n\u30fb\u672c\u7814\u7a76\u3067\u306f\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001BPSD\u306b\u95a2\u3059\u308b\u6bd4\u8f03\u8a66\u9a13\u3092\u8a55\u4fa1\u3057\u3001\u69d8\u3005\u306a\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u6709\u52b9\u6027\u30fb\u53d7\u5bb9\u6027\u30fb\u5fcd\u5bb9\u6027\u306b\u95a2\u3059\u308b\u6700\u521d\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793a\u3059\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u25cfMethods
\n\u30fb\u9069\u683c\u57fa\u6e96
\n\u30fb\u672c\u7814\u7a76\u306f\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u30fb\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u95a2\u3059\u308bPRISMA\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u5247\u3063\u3066\u884c\u308f\u308c\u305f\u3002
\n\u30fb\u3053\u306e\u7814\u7a76\u306b\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3001\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u3001\u6df7\u5408\u578b\u8a8d\u77e5\u75c7\u304c\u542b\u307e\u308c\u305f\uff08\u8a3a\u65ad\u306f\u7814\u7a76\u8457\u8005\u306b\u3088\u3063\u3066\u5b9a\u7fa9\u3055\u308c\u305f\uff09\u3002
\n\u30fb\u60a3\u8005\u306e\u5e74\u9f62\u3084\u8a8d\u77e5\u75c7\u306e\u91cd\u75c7\u5ea6\u306b\u3088\u308b\u5236\u9650\u306f\u8a2d\u3051\u306a\u304b\u3063\u305f\u304c\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u3001\u8a8d\u77e5\u75c7\u306b\u95a2\u4fc2\u306e\u306a\u3044\u305d\u306e\u4ed6\u306e\u7cbe\u795e\u75be\u60a3\uff08\u3046\u3064\u75c5\u3001\u305b\u3093\u5984\u3001\u7d71\u5408\u5931\u8abf\u75c7\u306a\u3069\uff09\u3001\u7ba1\u7406\u4e0d\u826f\u306a\u8eab\u4f53\u75be\u60a3\uff08\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u611f\u67d3\u75c7\u306a\u3069\uff09\u306f\u9664\u5916\u3055\u308c\u305f\u3002
\n\u30fb\u60a3\u8005\u306b\u306f\u3001\u4f55\u3089\u304b\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306b\u3088\u308bBPSD\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u305f\u3002
\n\u30fb\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u6709\u52b9\u6027\u3068\u53d7\u5bb9\u6027\u3067\u3042\u3063\u305f\u3002
\n\u30fb\u6709\u52b9\u6027\u306f\u3001\u6a19\u6e96\u5316\u3055\u308c\u305f\u30b9\u30b1\u30fc\u30eb\uff08\u4f8b\uff1aCMAI\u3001NPI\u3001BPRS\uff09\u3067\u6e2c\u5b9a\u3055\u308c\u305f\u30b9\u30b3\u30a2\u306e\u5909\u5316\u3067\u5b9a\u7fa9\u3055\u308c\u305f\u3002
\n\u30fb\u53d7\u5bb9\u6027\u306f\u5168\u3066\u306e\u539f\u56e0\u306b\u3088\u308b\u8131\u843d\u7387\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u3001\u6709\u52b9\u6027\u3068\u5fcd\u5bb9\u6027\u3092\u5305\u542b\u3057\u305f\u3002
\n\u30fb\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u5fcd\u5bb9\u6027\u3067\u3001\u6709\u5bb3\u4f5c\u7528\u306b\u3088\u308b\u6cbb\u7642\u4e2d\u6b62\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u6709\u5bb3\u4f5c\u7528\u306b\u306f\u6b7b\u4ea1\u7387\u3001\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u3001\u8ee2\u5012\u3001\uff08\u904e\uff09\u93ae\u9759\u3001\u9310\u4f53\u5916\u8def\u75c7\u72b6\u3001\u5c3f\u8def\u75c7\u72b6\u304c\u542b\u307e\u308c\u305f\u3002
\n\u30fb\u3053\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306b\u306f\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306e\u307f\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002
\n\u30fb\u691c\u7d22\u6226\u7565
\n\u30fb\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u3068BPSD\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u3001\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u958b\u59cb\u304b\u30892023\u5e7412\u6708\u307e\u3067\u306b\u3001\u82f1\u8a9e\u3067\u767a\u8868\u3055\u308c\u305f\u6587\u732e\u306b\u3064\u3044\u3066\u3001PubMed\u3001Embase\u3001Web of Science\u3001Cochrane Trial Register\u3067\u691c\u7d22\u3057\u305f\u3002
\n\u30fb2\u540d\u306e\u30ec\u30d3\u30e5\u30a2\u30fc\u304c\u53ce\u96c6\u3084\u8a55\u4fa1\u306b\u95a2\u4e0e\u3057\u305f\u3002
\n\u30fb\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u8ffd\u52a0\u60c5\u5831\u3084\u6b20\u640d\u3057\u305f\u30c7\u30fc\u30bf\u306b\u3064\u3044\u3066\u8457\u8005\u306b\u9023\u7d61\u3092\u53d6\u3063\u305f\u3002
\n\u30fb\u30c7\u30fc\u30bf\u53ce\u96c6
\n\u30fb\u8ad6\u6587\u60c5\u5831\u3001\u53c2\u52a0\u8005\u306e\u60c5\u5831\uff08\u5e74\u9f62\u3001\u6027\u5225\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3001\u8a8d\u77e5\u75c7\u306e\u30bf\u30a4\u30d7\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eMMSE\u306a\u3069\uff09\u3001\u4ecb\u5165\u306e\u7279\u5fb4\uff08\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u7a2e\u985e\u3068\u6295\u4e0e\u91cf\u3001\u6295\u4e0e\u671f\u9593\u306a\u3069\uff09\u3092\u53ce\u96c6\u3057\u305f\u3002
\n\u30fb\u30c7\u30fc\u30bf\u5206\u6790
\n\u30fbStata\/SE\uff08V.15.1\uff09\u3068\u983b\u5ea6\u4e3b\u7fa9\u7684\u30d5\u30ec\u30fc\u30e0\u30ef\u30fc\u30af\u3092\u7528\u3044\u3066\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u30a2\u30ca\u30e9\u30a4\u30b7\u30b9\u3092\u5b9f\u884c\u3057\u305f\u3002
\n\u30fb\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08SUCRA\uff1aSurface Under the Cumulative Ranking Curves\uff09\u3092\u7528\u3044\u3066\u3001\u4eee\u60f3\u6cbb\u7642\u3068\u6bd4\u8f03\u3057\u305f\u5404\u6cbb\u7642\u306e\u6709\u52b9\u6027\u3001\u53d7\u5bb9\u6027\u3001\u5fcd\u5bb9\u6027\u306e\u78ba\u7387\u3092\u8a08\u7b97\u3057\u305f\u3002
\n\u30fb\u30b3\u30af\u30e9\u30f3\u5171\u540c\u8a08\u753b\u304c\u63a8\u5968\u3059\u308b\u300crisk of bias 2\u300d\u3092\u7528\u3044\u3066\u3001\u9078\u629e\u30d0\u30a4\u30a2\u30b9\u3001\u5b9f\u884c\u30d0\u30a4\u30a2\u30b9\u3001\u691c\u51fa\u30d0\u30a4\u30a2\u30b9\u3001\u6e1b\u5c11\u30d0\u30a4\u30a2\u30b9\u3001\u5831\u544a\u30d0\u30a4\u30a2\u30b9\u3001\u305d\u306e\u4ed6\u306e\u30d0\u30a4\u30a2\u30b9\u3092\u8a55\u4fa1\u3057\u305f\u3002\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306b\u3064\u3044\u3066\u306f\u30d5\u30a1\u30f3\u30cd\u30eb\u30d7\u30ed\u30c3\u30c8\u3067\u793a\u3057\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u95a2\u3059\u308b\u611f\u5ea6\u5206\u6790\u306f\u3001\u30d0\u30a4\u30a2\u30b9\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u7814\u7a76\u3092\u9664\u5916\u3057\u3066\u5b9f\u65bd\u3057\u305f\u3002
\n\u30fb\u5404\u7814\u7a76\u306e\u4fe1\u983c\u6027\u306f\u3001CINeMA\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

\u25cfResults
\n\u30fb\u4e00\u6b21\u691c\u7d22\u3067874\u4ef6\u306e\u7814\u7a76\u8ad6\u6587\u304c\u9078\u629e\u3055\u308c\u305f\u304c\u3001\u8ad6\u6587\u306e\u91cd\u8907\u3084\u30bf\u30a4\u30c8\u30eb\u30fb\u6284\u8aad\u306e\u5185\u5bb9\u306a\u3069\u304b\u3089\u9664\u5916\u3057\u300120\u4ef6\uff08\u2192\u53d7\u5bb9\u6027\u3068\u5fcd\u5bb9\u6027\u306e\u8a55\u4fa1\uff0919\u4ef6\uff08\u2192\u6709\u52b9\u6027\u306e\u8a55\u4fa1\uff09\u306eRCT\u3092\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u542b\u3081\u305f\uff08PRISMA\u30d5\u30ed\u30fc\u30c1\u30e3\u30fc\u30c8\u306f\u672c\u6587\u53c2\u7167\uff09\u3002
\n\u30fb\u7814\u7a76\u306e\u7279\u6027
\n\u30fb\u767a\u8868\u671f\u9593\uff1a1999\u5e74\u304b\u30892023\u5e74
\n\u30fb\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\uff1a\u5404\u7814\u7a7640\u4eba\uff5e652\u4eba\u3001\u5408\u8a086374\u4eba
\n\u30fb\u4ecb\u5165\u671f\u9593\uff1a6\u9031\u9593\uff5e36\u9031\u9593
\n\u30fb\u7528\u3044\u3089\u308c\u305f\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\uff1a5\u7a2e\u985e\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\uff09
\n\u30fb\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\uff1aCMAI\u3001NPI\u3001BEHAVE-AD\u3001BPRS\u3001PANSS
\n\u30fb\u30bb\u30c3\u30c6\u30a3\u30f3\u30b0\uff1a\u307b\u3068\u3093\u3069\u304c\u9ad8\u9f62\u8005\u65bd\u8a2d\u3067\u884c\u308f\u308c\u305f
\n\"\"<\/a>\u30fb\u30d0\u30a4\u30a2\u30b9\u306e\u8a55\u4fa1\u3001\u975e\u4e00\u8cab\u6027\u306e\u8a55\u4fa1
\n\u3000\u7565
\n\u30fb\u985e\u4f3c\u6027\u306e\u8a55\u4fa1
\n\u30fb\u53c2\u52a0\u8005\u306e\u5e73\u5747\u5e74\u9f62\u306f79.90\u6b73\u3001\u5973\u6027\u304c67.32%\uff084197\/6234\uff09\u3092\u5360\u3081\u3066\u3044\u305f\u3002
\n\u30fb\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3068\u8a3a\u65ad\u3055\u308c\u3001MMSE\u306e\u5e73\u5747\u306f11.32\u70b9\u3067\u3042\u3063\u305f\u3002
\n\u30fb\u5e73\u5747\u4ecb\u5165\u671f\u9593\u306f11.3\u9031\u9593\u3067\u3042\u3063\u305f\u3002
\n\u30fb\u5e74\u9f62\u3001\u6027\u5225\u3001\u8a3a\u65ad\u306e\u983b\u5ea6\u306f\u5404\u7814\u7a76\u9593\u3067\u540c\u7b49\u3067\u3042\u3063\u305f\uff08\u672c\u6587Table 1\u53c2\u7167\uff09
\n\u30fb\u6709\u52b9\u6027\u306e\u8a55\u4fa1\uff08Table 2\u3001Sup. material 10\uff09
\n\u30fb\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u304c\u6700\u3082\u6709\u52b9\u6027\u304c\u9ad8\u304f\uff08SMD= -1.77\u300195%CI:-2.80\uff5e-0.74\uff09\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3088\u308a\u3082\u6709\u610f\u306b\u512a\u308c\u3066\u3044\u305f\u3002
\n\u30fb\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08SUCRA\uff09\u306b\u3088\u308b\u89e3\u6790\u3067\u306f\u3001\u5168\u3066\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u6709\u52b9\u6027\u306b\u512a\u308c\u3066\u3044\u305f\u30025\u3064\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u4e2d\u3067\u306f\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u304c\u6700\u3082\u512a\u308c\u3066\u304a\u308a\u3001\u6b21\u3044\u3067\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u9806\u3067\u3042\u3063\u305f\u3002\"\"<\/a>\u30fb\u53d7\u5bb9\u6027\u3001\u5fcd\u5bb9\u6027\u306e\u8a55\u4fa1\uff08Table 3\uff1a\u30aa\u30ec\u30f3\u30b8\u304c\u53d7\u5bb9\u6027\u3001\u7070\u8272\u304c\u5fcd\u5bb9\u6027\u3092\u793a\u3059\uff09
\n\u30fb\u53d7\u5bb9\u6027\u306e\u8a55\u4fa1\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u307f\u304c\u512a\u308c\u3066\u304a\u308a\uff08OR=0.72\u300195%CI:0.54\uff5e0.96\uff09\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3082\u6709\u610f\u306b\u512a\u308c\u3066\u3044\u305f\uff08OR=0.61\u300195%CI:0.37\uff5e0.99\uff09\u3002\u307e\u305f\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08SUCRA\uff09\u306b\u3088\u308b\u89e3\u6790\u3067\u306f\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3068\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u53d7\u5bb9\u6027\u306b\u512a\u308c\u3066\u3044\u305f\u3002
\n\u30fb\u5fcd\u5bb9\u6027\u306e\u8a55\u4fa1\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u306f\u6700\u3082\u60aa\u304f\uff08OR=6.02\u300195%CI:2.87\uff5e12.66\uff09\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\uff08OR=3.67\u300195%CI:1.66\uff5e8.11\uff09\u3084\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\uff08OR=3.71\u300195%CI:1.46\uff5e9.42\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3082\u4e0d\u826f\u3067\u3042\u3063\u305f\u3002\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u5fcd\u5bb9\u6027\u304c\u512a\u308c\u3066\u3044\u305f\uff08OR=0.25\u300195%CI:0.08\u301c0.78\uff09\u3002\u307e\u305f\u7d2f\u7a4d\u9806\u4f4d\u66f2\u7dda\u4e0b\u9762\u7a4d\uff08SUCRA\uff09\u306b\u3088\u308b\u89e3\u6790\u3067\u306f\u3001\u5168\u3066\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u5fcd\u5bb9\u6027\u304c\u60aa\u304b\u3063\u305f\u3002\"\"<\/a>\u30fb\u611f\u5ea6\u5206\u6790\u306b\u304a\u3044\u3066\u30d0\u30a4\u30a2\u30b9\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u30442\u4ef6\u306e\u7814\u7a76\u3092\u524a\u9664\u3057\u305f\u5f8c\u3067\u3082\u3001\u6709\u52b9\u6027\u3068\u53d7\u5bb9\u6027\u306e\u7d50\u679c\u306f\u6982\u306d\u4e0a\u8a18\u3068\u4e00\u81f4\u3057\u3066\u3044\u305f\u3002
\n\u30fb\u6709\u5bb3\u4f5c\u7528\u306e\u8a55\u4fa1
\n\u30fb\u6b7b\u4ea1\u7387\u3000
\n\u30004\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u3044\u305a\u308c\u3082\u30d7\u30e9\u30bb\u30dc\u3068\u6709\u610f\u5dee\u304c\u306a\u304f\u3001\u307e\u305f\u4e92\u3044\u306b\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002SUCRA\u306b\u3088\u308b\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u5b89\u5168\u6027\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61
\n\u30005\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u306f\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u3066\u3044\u305f\uff08OR=4.01\u300195%CI:1.48\u301c10.90\uff09\u3002SUCRA\u306b\u3088\u308b\u3068\uff08\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\uff09\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u306e\u5b89\u5168\u6027\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\u8ee2\u5012
\n\u300015\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u3044\u305a\u308c\u3082\u30d7\u30e9\u30bb\u30dc\u3068\u6709\u610f\u5dee\u304c\u306a\u304f\u3001\u307e\u305f\u4e92\u3044\u306b\u6709\u610f\u5dee\u304c\u306a\u304b\u3063\u305f\u3002SUCRA\u306b\u3088\u308b\u3068\uff08\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\uff09\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u5b89\u5168\u6027\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\uff08\u904e\uff09\u93ae\u9759
\n\u300016\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\uff08OR=5.04\u300195%CI:3.24\uff5e7.83\uff09\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\uff08OR=3.68\u300195%CI:2.43\uff5e5.55\uff09\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\uff08OR=2.51\u300195%CI:1.91\uff5e3.31\uff09\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\uff08OR=2.74\u300195%CI:1.25\uff5e6.02\uff09\u3067\u93ae\u9759\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\u3002\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u306f\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u93ae\u9759\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\uff08OR=0.50\u300195%CI:0.32\uff5e0.79\uff09\u3002SUCRA\u306b\u3088\u308b\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u6b21\u3044\u3067\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u5b89\u5168\u6027\u304c\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\u9310\u4f53\u5916\u8def\u75c7\u72b6
\n\u30009\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\uff08OR=2.35\u300195%CI:1.62\uff5e3.39\uff09\u3084\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\uff08OR=2.57\u300195%CI:1.43\uff5e4.63\uff09\u306f\u9310\u4f53\u5916\u8def\u75c7\u72b6\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u3066\u3044\u305f\u3002SUCRA\u306b\u3088\u308b\u3068\uff08\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\uff09\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u306e\u5b89\u5168\u6027\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002
\n\u30fb\u5c3f\u8def\u75c7\u72b6
\n\u300013\u7814\u7a76\u3067\u5831\u544a\u3055\u308c\u305f\uff08\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3092\u542b\u3080\uff09\u3002NMA\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u306f\u5c3f\u8def\u75c7\u72b6\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u3066\u3044\u305f\uff08OR=2.73\u300195%CI:1.34\uff5e5.54\uff09\u3002<\/p>\n

\u25cfDiscussion
\n\u30fb\u672c\u8a66\u9a13\u306e\u7b2c\u4e00\u306e\u5f37\u307f\u306f\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u7d44\u307f\u5165\u308c\u305f\u3053\u3068\u3067\u3042\u308b\u3002
\n\u30fb\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306f\u30d7\u30e9\u30bb\u30dc\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3088\u308a\u3082\u6709\u610f\u306b\u6709\u52b9\u6027\u304c\u9ad8\u3044\u3068\u5206\u304b\u3063\u305f\u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u6709\u52b9\u6027\u304c\uff08\u653b\u6483\u7684\u306a\u884c\u52d5\u3068\u95a2\u4fc2\u3059\u308b\uff09CMAI\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u305f\u3053\u3068\u3067\u3042\u308a\u3001\u4ecb\u8b77\u8005\u3084\u533b\u7642\u30b7\u30b9\u30c6\u30e0\u306b\u3068\u3063\u3066\u6709\u76ca\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002
\n\u30fb\u53d7\u5bb9\u6027\uff08\u6709\u52b9\u6027\uff0b\u5fcd\u5bb9\u6027\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u304c\u30d7\u30e9\u30bb\u30dc\u3084\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3088\u308a\u3082\u6709\u610f\u306b\u512a\u308c\u3066\u3044\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u672c\u7814\u7a76\u306f\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u304c\u6700\u9ad8\u306e\u7b2c2\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac\u3067\u3042\u308b\u3068\u3082\u793a\u3057\u3066\u304a\u308a\u3001BPSD\u6cbb\u7642\u306b\u304a\u3051\u308b\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002
\n\u30fb\u5fcd\u5bb9\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u304c\u30d7\u30e9\u30bb\u30dc\u3001\u30ea\u30b9\u30da\u30ea\u30c9\u30f3\u3001\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3001\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u60aa\u304b\u3063\u305f\u3002
\n\u30fb\u672c\u7814\u7a76\u306f\u3001BPSD\u306b\u5bfe\u3057\u3066\u6700\u3082\u53d7\u5bb9\u6027\u304c\u9ad8\u3044\u306e\u306f\u30a2\u30ea\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u6700\u3082\u52b9\u679c\u304c\u9ad8\u3044\u306e\u306f\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3001\u6709\u5bb3\u4f5c\u7528\u304c\u6700\u3082\u591a\u3044\u306e\u306f\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3067\u3042\u308b\u3068\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u591a\u304f\u306e\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u672c\u7814\u7a76\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u7814\u7a76\u30fb\u30ec\u30d3\u30e5\u30fc\u3068\u307b\u307c\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002
\n\u30fb\u672c\u7814\u7a76\u306e\u9650\u754c\u3068\u3057\u3066\u3001\u2460\u89e3\u6790\u306b\u85ac\u5264\u7528\u91cf\u3092\u8003\u616e\u3057\u306a\u304b\u3063\u305f\uff08\u3067\u304d\u306a\u304b\u3063\u305f\uff09\u3053\u3068\u3001\u2461\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u4ee5\u5916\u306e\u8a8d\u77e5\u75c7\u60a3\u8005\u3092\u542b\u3080\u7814\u7a76\u304c\u3054\u304f\u308f\u305a\u304b\u3067\u3042\u3063\u305f\u3053\u3068\u3001\u2462\u307b\u3068\u3093\u3069\u304c\u9ad8\u9f62\u8005\u65bd\u8a2d\u3067\u884c\u308f\u308c\u305f\u7814\u7a76\u3067\u3042\u3063\u305f\u3053\u3068\u3001\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u308b\u3002<\/p>\n

\u25cfFootnotes\uff08\u811a\u6ce8\uff09
\n\u30fbFunding\uff1a\u56db\u5ddd\u5927\u5b66West China Hospital\u306e1.3.5\u30d7\u30ed\u30b0\u30e9\u30e0\u3001\u304a\u3088\u3073\u4e2d\u56fd\u306e\u56fd\u5bb6\u91cd\u70b9\u7814\u7a76\u958b\u767a\u8a08\u753b\u304b\u3089\u306e\u52a9\u6210\u91d1\u306b\u3088\u308a\u652f\u63f4\u3055\u308c\u305f\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112024\u5e7410\u67089\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"

-\u6587\u732e\u540d- L\u00fc W, Liu F, Zhang Y, et al. Efficacy, acceptability and tolerability of second-generation antipsychotic … \u7d9a\u304d\u3092\u8aad\u3080 \u8a8d\u77e5\u75c7BPSD\u306b\u5bfe\u3059\u308b\u7b2c2\u4e16\u4ee3\uff08\u975e\u5b9a\u578b\uff09\u6297\u7cbe\u795e\u75c5\u85ac\u306e\u6bd4\u8f03<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15,11],"tags":[],"class_list":["post-2742","post","type-post","status-publish","format-standard","hentry","category-15","category-11"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2742"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2742\/revisions"}],"predecessor-version":[{"id":2746,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2742\/revisions\/2746"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}