\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002<\/p>\n
-\u6587\u732e\u540d-
\nThomas B Casale, et al. Adult pharmacokinetics of self-administration of epinephrine nasal spray 2.0 mg versus manual intramuscular epinephrine 0.3 mg by health care provider. J Allergy Clin Immunol Pract. 2024 Feb;12(2):500-502.e1. doi: 10.1016\/j.jaip.2023.11.006. Epub 2023 Nov 10.<\/p>\n
-\u8981\u7d04-
\n\uff1c\u81e8\u5e8a\u7684\u610f\u7fa9\uff1e
\n\u3000\u9f3b\u8154\u5185\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\uff08\u4ee5\u4e0b\u3001\u30cd\u30d5\u30a3\uff09\u306e\u81ea\u5df1\u6295\u4e0e\u306b\u3088\u308a\u3001\u533b\u7642\u5f93\u4e8b\u8005\u306b\u3088\u308b\u7b4b\u8089\u5185\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6295\u4e0e\u3068\u540c\u7b49\u304b\u305d\u308c\u4ee5\u4e0a\u306e\u85ac\u7269\u52d5\u614b\u304a\u3088\u3073\u85ac\u529b\u5b66\u7684\u53cd\u5fdc\u304c\u5f97\u3089\u308c\u305f\u3002\u91dd\u3092\u4f7f\u308f\u306a\u3044\u4ee3\u66ff\u624b\u6bb5\u304c\u5229\u7528\u3067\u304d\u308b\u3053\u3068\u3067\u3001\u4e0d\u5b89\u304c\u8efd\u6e1b\u3055\u308c\u3001\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6295\u4e0e\u306e\u9045\u308c\u304c\u6e1b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n
\u3000\u9662\u5916\u306b\u304a\u3051\u308b\u91cd\u5ea6\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u52b9\u679c\u7684\u306a\u6cbb\u7642\u306b\u306f\u3001\u60a3\u8005\u3084\u4ecb\u8b77\u8005\u304c\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u3092\u8fc5\u901f\u304b\u3064\u6b63\u78ba\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u81ea\u52d5\u6ce8\u5c04\u5668 (EAI) \u306f\u4e0d\u4fbf\u3067\u6271\u3044\u306b\u304f\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u6700\u5927 83% \u306e\u60a3\u8005\u3084\u4ecb\u8b77\u8005\u304c EAI \u3092\u6295\u4e0e\u3057\u306a\u304b\u3063\u305f\u308a\u3001\u4f7f\u7528\u3092\u9045\u3089\u305b\u305f\u308a\u3057\u3066\u3044\u308b\u3002\u91cd\u5ea6\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u4e8b\u8c61\u306f\u3001\u7279\u306b\u8fc5\u901f\u306b\u6cbb\u7642\u3059\u308c\u3070\u3001\u547d\u306b\u95a2\u308f\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u306a\u3044\u304c\u3001\u6cbb\u7642\u304c\u9045\u308c\u308b\u3068\u3001\u4e8c\u76f8\u6027\u53cd\u5fdc\u3084\u6b7b\u4ea1\u7387\u306a\u3069\u306e\u7f79\u60a3\u7387\u304c\u9ad8\u304f\u306a\u308b\u3002\u30cd\u30d5\u30a3\u306f\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u3092\u542b\u3080 (\u30bf\u30a4\u30d7 I) \u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u7dca\u6025\u6cbb\u7642\u306e\u8ffd\u52a0\u30aa\u30d7\u30b7\u30e7\u30f3\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u91dd\u306a\u3057\u306e\u9f3b\u8154\u5185\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30b9\u30d7\u30ec\u30fc\u3067\u3042\u308a\u3001\u6cbb\u7642\u3078\u306e\u4e0d\u5b89\u3084\u9045\u5ef6\u3092\u8efd\u6e1b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n
\u3000\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u5b9f\u65bd\u3092\u5236\u9650\u3059\u308b\u502b\u7406\u7684\u969c\u58c1\u306e\u305f\u3081\u3001\u30cd\u30d5\u30a3\u306e\u958b\u767a\u6226\u7565\u306f\u85ac\u7269\u52d5\u614b (PK) \u304a\u3088\u3073\u85ac\u529b\u5b66 (PD) \u8a55\u4fa1\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u305f\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u30cd\u30d5\u30a3\u306e PK \u304a\u3088\u3073 PD \u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u627f\u8a8d\u6e08\u307f\u306e\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u88fd\u54c1\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u30021\u578b\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6cbb\u7642\u306b\u51e6\u65b9\u3055\u308c\u308b\u3059\u3079\u3066\u306e\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u88fd\u54c1\u3068\u540c\u69d8\u306b\u3001\u30cd\u30d5\u30a3\u306f\u9662\u5916\u74b0\u5883\u3067\u306e\u4f7f\u7528\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u81ea\u5df1\u6295\u4e0e\u5f8c\u306e\u30cd\u30d5\u30a3\u306e PK \u304a\u3088\u3073 PD \u3092\u793a\u3059\u5fc5\u8981\u304c\u3042\u308b\u3002
\n\u3000\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u533b\u7642\u5f93\u4e8b\u8005\uff08HCP\uff09\u304c\u91dd\u3068\u6ce8\u5c04\u5668\u3067\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3 0.3 mg \u3092\u7b4b\u8089\u5185\uff08IM\uff09\u6ce8\u5c04\u3057\u305f\u5834\u5408\uff08IM 0.3 mg\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u81ea\u5df1\u6295\u4e0e\u3057\u305f\u30cd\u30d5\u30a3 2.0 mg \u306e PK \u3068 PD \u3092\u8a55\u4fa1\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306e\u75c5\u6b74\u3092\u6301\u3064\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u7b2c1\u76f8\u3001\u5358\u56de\u6295\u4e0e\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u8a66\u9a13\u3068\u3057\u3066\u884c\u308f\u308c\u305f\u3002\u60a3\u8005\u306f\u30011\u3064\u306e\u9f3b\u5b54\u306b\u81ea\u5df1\u6295\u4e0e\u3059\u308b\u30cd\u30d5\u30a3 2.0 mg \u306e\u5358\u56de\u6295\u4e0e\u3068\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u65b9\u5f0f\u3067 HCP \u6295\u4e0e\u3055\u308c\u308b 0.3 mg (21 \u30b2\u30fc\u30b8 \u00d7 1 \u30a4\u30f3\u30c1\u91dd) \u306e IM \u5358\u56de\u6295\u4e0e\u3092\u53d7\u3051\u308b\u3088\u3046\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002\u30e9\u30d9\u30eb\u306b\u5f93\u3063\u3066\u3001IM\u6ce8\u5c04\u306f\u5927\u817f\u90e8\u306e\u524d\u9762\u5916\u5074\u306b\u6295\u4e0e\u3055\u308c\u305f\u3002\u6295\u4e0e\u524d\u3068\u6295\u4e0e\u5f8c 360\u5206\u307e\u3067\u306b\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63a1\u53d6\u3057\u305f\u3002\u53ce\u7e2e\u671f\u8840\u5727(SBP)\u3001\u62e1\u5f35\u671f\u8840\u5727 (DBP)\u3001\u8108\u62cd\u6570 (PR) \u306a\u3069\u306e\u85ac\u529b\u5b66\u7684\u6e2c\u5b9a\u5024\u306f\u3001\u6295\u4e0e\u524d\u3068\u6295\u4e0e\u5f8c 120 \u5206\u307e\u3067\u306b\u8a55\u4fa1\u3055\u308c\u305f\u3002\u30bf\u30a4\u30d7 1 \u306e\u8aa4\u5dee\u7387\u304c 5% \u306e\u691c\u51fa\u529b\u8a08\u7b97\u306b\u57fa\u3065\u3044\u3066\u300130 \u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u30b5\u30f3\u30d7\u30eb \u30b5\u30a4\u30ba\u304c\u9069\u5207\u3067\u3042\u308b\u3068\u898b\u306a\u3055\u308c\u305f\u3002
\n\u3000\u3053\u306e\u7814\u7a76\u306f\u3001Novum\u72ec\u7acb\u6a5f\u95a2\u5be9\u67fb\u59d4\u54e1\u4f1a\u306e\u627f\u8a8d\u3092\u53d7\u3051\u3001\u9069\u6b63\u81e8\u5e8a\u5b9f\u8df5\u57fa\u6e96\u304a\u3088\u3073\u30d8\u30eb\u30b7\u30f3\u30ad\u5ba3\u8a00\u306b\u5f93\u3063\u3066\u5b9f\u65bd\u3055\u308c\u305f\u3002\u3059\u3079\u3066\u306e\u60a3\u8005\u306f\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u524d\u306b\u66f8\u9762\u306b\u3088\u308b\u30a4\u30f3\u30d5\u30a9\u30fc\u30e0\u30c9\u30b3\u30f3\u30bb\u30f3\u30c8\u3092\u63d0\u51fa\u3057\u305f\u3002
\n\u3000\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u60a3\u800545\u540d\u304c\u767b\u9332\u3055\u308c\u305f\uff08\u7537\u602757.8%\u3001\u5e74\u9f6223\uff5e53\u6b73\u3001\u5e73\u5747\u00b1SD\u4f53\u91cd81.0\u00b114.4kg\u3001\u5e73\u5747\u00b1SD\u4f53\u683c\u6307\u657027.2\u00b13.1kg\/m2 \uff09\u3002
\n45 \u540d\u306e\u60a3\u8005\u306e\u3046\u3061 41 \u540d (91.1%) \u304c\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u30022 \u540d\u306e\u60a3\u8005\u306f\u671f\u9593 1 \u306b IM 0.3 mg \u3092\u6295\u4e0e\u3055\u308c\u305f\u5f8c\u306b\u8a66\u9a13\u3092\u4e2d\u6b62\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306b\u306f PK \u30c7\u30fc\u30bf\u304c\u306a\u3044\u3002\u3055\u3089\u306b 2\u540d\u306e\u60a3\u8005\u304c\u671f\u9593 1 \u3092\u5b8c\u4e86\u3057\u305f\u304c\u3001\u671f\u9593 2 \u306e\u524d\u306b\u8a66\u9a13\u3092\u4e2d\u6b62\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306e\u3046\u3061 1\u540d\u306f\u671f\u9593 1 \u306b\u30cd\u30d5\u30a3\u3092\u6295\u4e0e\u3055\u308c\u3001\u3082\u3046 1\u540d\u306f IM 0.3 mg \u3092\u6295\u4e0e\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306b\u3064\u3044\u3066\u306f\u671f\u9593 1 \u306e PK \u30c7\u30fc\u30bf\u304c\u53ce\u96c6\u3055\u308c\u305f\u3002\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u4e2d\u3001\u60a3\u8005\u306f\u4f7f\u7528\u8aac\u660e\u66f8\u3001\u30af\u30a4\u30c3\u30af\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u30ac\u30a4\u30c9\u3001\u304a\u3088\u3073\u30d3\u30c7\u30aa\u3092\u78ba\u8a8d\u3057\u3066\u3001\u30cd\u30d5\u30a3\u306e\u4f7f\u7528\u65b9\u6cd5\u306b\u95a2\u3059\u308b 1\u56de\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u30bb\u30c3\u30b7\u30e7\u30f3\u3092\u53d7\u3051\u305f\u3002\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u5f8c\u3001\u60a3\u8005\u306b\u306f\u8ffd\u52a0\u306e\u6307\u793a\u306f\u63d0\u4f9b\u3055\u308c\u306a\u304b\u3063\u305f\u300242\u4eba\u306e\u60a3\u8005\u5168\u54e1\u304c\u30cd\u30d5\u30a3\u3092\u6b63\u3057\u304f\u81ea\u5df1\u6295\u4e0e\u3057\u305f\u3002
\n\u5168\u4f53\u7684\u306b\u3001\u30cd\u30d5\u30a3\u306fIM 0.3 mg\u3068\u6bd4\u8f03\u3057\u3066\u3088\u308a\u9ad8\u3044\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u66dd\u9732\u3092\u3082\u305f\u3089\u3057\u305f\uff08\u56f31\uff09\u3002<\/p>\n
\u3000\u30cd\u30d5\u30a3\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u3001\u6709\u5bb3\u4e8b\u8c61\u3092\u542b\u3081\u3001IM 0.3 mg \u3068\u540c\u69d8\u3060\u3063\u305f\u304c\u3001\u9f3b\u306e\u75c7\u72b6\uff08\u9f3b\u306e\u4e0d\u5feb\u611f\u3084\u9f3b\u6f0f\u306a\u3069\uff09\u306f\u30cd\u30d5\u30a3\u6295\u4e0e\u5f8c\u306b\u591a\u304f\u767a\u751f\u3057\u305f\u3002
\n\u3000\u3053\u308c\u306f\u3001\u81ea\u5df1\u6295\u4e0e\u5f8c\u306e\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306e PK \u3068 PD \u3092\u8abf\u3079\u305f\u6700\u521d\u306e\u7814\u7a76\u3067\u3042\u308b\u3002HCP \u306b\u3088\u308b\u91dd\u3068\u6ce8\u5c04\u5668\u3092\u4f7f\u7528\u3057\u305f\u624b\u52d5\u306e\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6ce8\u5c04\u304c\u3001EAI \u306e\u627f\u8a8d\u306e\u6839\u62e0\u3068\u306a\u3063\u305f\u305f\u3081\u3001\u6bd4\u8f03\u5bfe\u8c61\u3068\u3057\u3066\u9078\u629e\u3055\u308c\u305f\u3002
\n\u3000\u81ea\u5df1\u6295\u4e0e\u5f8c\u3001\u30cd\u30d5\u30a3 2.0 mg \u306f\u3001\u4ee5\u524d\u306e\u7814\u7a76\u3067\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u30cd\u30d5\u30a3\u5f8c\u306e SBP \u306e\u3088\u308a\u9855\u8457\u306a\u4e0a\u6607\u3092\u542b\u3081\u3001\u533b\u7642\u5f93\u4e8b\u8005\u306b\u3088\u308b IM \u6ce8\u5c04\u3068\u540c\u7b49\u304b\u305d\u308c\u4ee5\u4e0a\u306e PK \u304a\u3088\u3073 PD \u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u3082\u305f\u3089\u3057\u305f\u3002\u3053\u306e\u7570\u306a\u308b SBP \u53cd\u5fdc\u306f\u3001\u30cd\u30d5\u30a3\u306e\u9f3b\u8154\u5185\u6295\u4e0e\u306b\u3088\u308a\u3001\u9aa8\u683c\u7b4b\u3078\u306e\u76f4\u63a5\u6ce8\u5c04\u306e\u7d50\u679c\u3068\u3057\u3066\u751f\u3058\u308b \u03b2 2\u5a92\u4ecb\u8840\u7ba1\u62e1\u5f35\u304c\u56de\u907f\u3055\u308c\u3001\u305d\u308c\u306b\u3088\u3063\u3066 DBP \u306e\u4f4e\u4e0b\u304c\u6700\u5c0f\u9650\u306b\u6291\u3048\u3089\u308c\u3001\u7d50\u679c\u3068\u3057\u3066 SBP \u306e\u4e0a\u6607\u304c\u6291\u5236\u3055\u308c\u308b\u305f\u3081\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308b\u3002\u3053\u306e DBP \u306e\u7dad\u6301\u306f\u3001\u51a0\u8840\u6d41\u306e\u3088\u308a\u78ba\u5b9f\u306a\u7dad\u6301\u3092\u3082\u305f\u3089\u3059\u305f\u3081\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u6cbb\u7642\u306b\u6709\u5229\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u305f\u3060\u3057\u3001\u30cd\u30d5\u30a3\u306e\u3088\u308a\u9855\u8457\u306a SBP \u53cd\u5fdc\u306f\u3001\u627f\u8a8d\u3055\u308c\u305f\u6ce8\u5c04\u88fd\u54c1\u306e\u7bc4\u56f2\u5185\u3067\u3042\u308b\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u9ad8\u6fc3\u5ea6\u3067\u3042\u3063\u3066\u3082\u3001\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306e\u5b89\u5168\u6027\u306f 3\u3064\u306e\u7570\u306a\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u652f\u3048\u3089\u308c\u3066\u3044\u308b\u3002(1) \u4e00\u822c\u306b\u3001\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306e\u5fc3\u81d3\u304a\u3088\u3073\u4ee3\u8b1d\u4f5c\u7528\u306f\u7d04 1,000 pg\/mL \u306e\u6fc3\u5ea6\u3067\u5b8c\u5168\u306b\u767a\u73fe\u3057\u3001\u8840\u6f3f\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6fc3\u5ea6\u306e\u3055\u3089\u306a\u308b\u4e0a\u6607\u306f SBP \u306e\u3055\u3089\u306a\u308b\u4e0a\u6607\u306b\u306f\u3064\u306a\u304c\u3089\u306a\u3044\u3002 (2) \u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306e\u8840\u7ba1\u53ce\u7e2e\u4f5c\u7528\u306f\u4e3b\u306b \u03b1 1\u53d7\u5bb9\u4f53\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u3001\u03b2 2\u5a92\u4ecb\u8840\u7ba1\u62e1\u5f35\u306b\u3088\u3063\u3066\u6e1b\u5f31\u3055\u308c\u3001\u8840\u5727\u306e\u8abf\u7bc0\u3092\u3082\u305f\u3089\u3059\u3002(3) \u610f\u56f3\u3057\u306a\u3044\u5b8c\u5168\/\u90e8\u5206\u30dc\u30fc\u30e9\u30b9\u6ce8\u5165\u306e\u5834\u5408\u3092\u9664\u304d\u3001HR \u306e\u4e0a\u6607\u306f\u4ee3\u511f\u6027\u8ff7\u8d70\u795e\u7d4c\u53cd\u5c04\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u308b\u3002
\n\u3000\u3053\u306e\u7814\u7a76\u306e\u5229\u70b9\u306f\u3001\u95a2\u9023\u6027\u306e\u9ad8\u3044\u6bd4\u8f03\u5bfe\u8c61\u8005\u3068\u4ee3\u8868\u7684\u306a\u4f53\u683c\u6307\u6570\u3092\u6301\u3064\u88ab\u9a13\u8005\u3092\u7528\u3044\u3066\u5b9f\u65bd\u3055\u308c\u305f\u3053\u3068\u3060\u304c\u3001\u502b\u7406\u7684\u306a\u5236\u9650\u306b\u3088\u308a\u3001\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u6761\u4ef6\u4e0b\u3067\u306f\u5b9f\u65bd\u3055\u308c\u306a\u304b\u3063\u305f\u3002
\n\u3000\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u30cd\u30d5\u30a3\u306f\u5b89\u5168\u3067\u4f7f\u3044\u3084\u3059\u3044\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6295\u4e0e\u30aa\u30d7\u30b7\u30e7\u30f3\u3067\u3042\u308a\u3001\u91cd\u5ea6\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n
\u3010\u958b\u50ac\u65e5\u30112024\u5e7412\u67084\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"
\u203b\u3053\u306e\u6642\u671f\u306eUpToDate\u306b\u3042\u308b\u201dWhat\u2019s new in family medicine\u201d\u306eTopic\u3067\u53c2\u8003\u306b\u3055\u308c\u3066\u3044\u308b\u6587\u732e\u3067\u3059\u3002 -\u6587\u732e\u540d- Thomas B Casale, et al. Adult pharm … \u7d9a\u304d\u3092\u8aad\u3080 \u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306b\u5bfe\u3059\u308b\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u70b9\u9f3b\u85ac\uff08Epinephrine nasal spray for anaphylaxis\uff09<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33,16],"tags":[],"class_list":["post-2773","post","type-post","status-publish","format-standard","hentry","category-whats-new","category-16"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2773"}],"version-history":[{"count":3,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2773\/revisions"}],"predecessor-version":[{"id":2776,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2773\/revisions\/2776"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}