{"id":2887,"date":"2025-07-10T19:39:52","date_gmt":"2025-07-10T10:39:52","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2887"},"modified":"2025-07-10T19:39:52","modified_gmt":"2025-07-10T10:39:52","slug":"%e4%b8%8d%e5%8d%81%e5%88%86%e3%81%aa%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e5%9f%ba%e3%81%a5%e3%81%8d%e5%95%86%e6%a5%ad%e5%8c%96%e3%81%95%e3%82%8c%e3%81%9f%e3%81%8c%e3%82%93%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2887","title":{"rendered":"\u4e0d\u5341\u5206\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304d\u5546\u696d\u5316\u3055\u308c\u305f\u304c\u3093\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3068\u3069\u3046\u5411\u304d\u5408\u3046\u304b"},"content":{"rendered":"

-\u6587\u732e\u540d-
\nJuntaro Matsuzaki, et al. Prediction of tissue-of-origin of early stage cancers using serum miRNomes. JNCI Cancer Spectrum, 2023, 7(1), pkac080.<\/p>\n

-\u8981\u7d04-<\/p>\n

\u3010\u80cc\u666f\u3011
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\n2014\u5e74\u3088\u308a\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\u306e\u6b21\u4e16\u4ee3\u6cbb\u7642\u30fb\u8a3a\u65ad\u5b9f\u73fe\u306e\u305f\u3081\u306e\u5275\u85ac\u57fa\u76e4\u6280\u8853\u958b\u767a\u4e8b\u696d\u306e\u652f\u63f4\u3092\u53d7\u3051\u3001\u300e\u4f53\u6db2\u4e2d\u30de\u30a4\u30af\u30edRNA\u6e2c\u5b9a\u6280\u8853\u57fa\u76e4\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u300f\u304c\u5b9f\u65bd\u3055\u308c\u305f\u3002
\n\u3010\u65b9\u6cd5\u3011
\n\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3001\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u7b49\u3092\u6d3b\u7528\u3057\u3001\u56fa\u5f62\u304c\u30939,921\u4f8b\uff3b\u4e73\u304c\u3093675\u4f8b\u3001\u8180\u80f1\u304c\u3093399\u4f8b\u3001\u80c6\u9053\u304c\u3093402\u4f8b\u3001\u5927\u8178\u304c\u30931,596\u4f8b\u3001\u98df\u9053\u6241\u5e73\u4e0a\u76ae\u304c\u3093566\u4f8b\u3001\u80ba\u304c\u30931,699\u4f8b\u3001\u80c3\u304c\u30931,418\u4f8b\u3001\u809d\u7d30\u80de\u304c\u3093348\u4f8b\u3001\u81b5\u304c\u3093851\u4f8b\u3001\u524d\u7acb\u817a\u304c\u30931,027\u4f8b\u3001\u5375\u5de3\u304c\u3093400\u4f8b\u3001\u9aa8\u8edf\u90e8\u8089\u816b299\u4f8b\u3001\u8133\u816b\u760d241\u4f8b\uff3d\u3068\u975e\u304c\u3093\u5bfe\u71675,643\u4f8b\u3001\u304a\u3088\u3073\u5404\u7a2e\u826f\u6027\u75be\u60a3626\u4f8b\u306e\u8840\u6e05miRNA\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u89e3\u6790\u3057\u305f\u3002<\/p>\n

\u3010\u7d50\u679c\u3011
\n\u5168\u4f53\u306e5\u5206\u306e4\u306b\u76f8\u5f53\u3059\u308b\u30b5\u30f3\u30d7\u30eb\u6570\u3067\u6a5f\u68b0\u5b66\u7fd2\u30e2\u30c7\u30eb\u306bmiRNA\u30c7\u30fc\u30bf\u3092\u5b66\u7fd2\u3055\u305b\u3001\u6b8b\u308a\u306e5\u5206\u306e1\u306e\u30c7\u30fc\u30bf\u306b\u3088\u3063\u3066\u304c\u3093\u306e\u7a2e\u985e\u3092\u4e88\u6e2c\u3057\u305f\u3068\u3053\u308d\u3001\u8a3a\u65ad\u4e88\u6e2c\u7cbe\u5ea6\u306f\u5168\u30b9\u30c6\u30fc\u30b8\u30670.88\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a0.87-0.90\uff09\u3001\u7279\u306b\u65e9\u671f\u8a3a\u65ad\u306e\u610f\u7fa9\u304c\u9ad8\u3044\u30b9\u30c6\u30fc\u30b80\u304b\u3089II\u306b\u9650\u3063\u3066\u3082\u7cbe\u5ea60.90\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a0.88-0.91\uff09\u3068\u9ad8\u3044\u6027\u80fd\u304c\u5f97\u3089\u308c\u305f\uff08Figure2\uff09\u3002\u6570\u5b57\u306f\u6b63\u3057\u304f\u8a3a\u65ad\u3055\u308c\u305f\u5272\u5408\uff08%\uff09\u3092\u793a\u3059\u3002\u8a3a\u65ad\u30b9\u30c6\u30fc\u30b80\u304b\u3089II\u306b\u304a\u3044\u3066\u3082\u3001\u30b9\u30c6\u30fc\u30b8III\uff5eIV\u3068\u540c\u7b49\u306e\u6027\u80fd\u304c\u307f\u3089\u308c\u3001\u65e9\u671f\u8a3a\u65ad\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306e\u6d3b\u7528\u304c\u671f\u5f85\u3067\u304d\u308b\u3002\u80c6\u9053\u304c\u3093\u306f\u4ed6\u304c\u3093\u306b\u6bd4\u3079\u3066\u8a3a\u65ad\u96e3\u6613\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u3082\u5224\u660e\u3057\u305f\u3002\uff08BR: \u4e73\u304c\u3093\u3001BL: \u8180\u80f1\u304c\u3093\u3001BT: \u80c6\u9053\u304c\u3093\u3001CR: \u5927\u8178\u304c\u3093\u3001ES: \u98df\u9053\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u3001GA: \u80c3\u304c\u3093\u3001GL: \u8133\u816b\u760d\u3001HC: \u809d\u7d30\u80de\u304c\u3093\u3001LU: \u80ba\u304c\u3093\u3001OV: \u5375\u5de3\u304c\u3093\u3001PA: \u81b5\u304c\u3093\u3001PR: \u524d\u7acb\u817a\u304c\u3093\u3001SA: \u9aa8\u8edf\u90e8\u8089\u816b\uff09<\/p>\n

Figure2
\n\"\"<\/a><\/p>\n

\"\"<\/a>
\n\u306a\u304a\u3001\u3053\u306e\u6027\u80fd\u306f\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u3088\u3063\u3066\u5927\u304d\u306a\u5dee\u7570\u304c\u3042\u308a\u3001\u6a5f\u68b0\u5b66\u7fd2\u306e\u6700\u9069\u5316\u306e\u91cd\u8981\u6027\u3082\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u8840\u4e2dmiRNA\u8a3a\u65ad\u306b\u6700\u9069\u306a\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3068\u3057\u3066\u3001\u6df1\u5c64\u5b66\u7fd2\u3092\u542b\u3080\u968e\u5c64\u7684\u30a2\u30f3\u30b5\u30f3\u30d6\u30eb\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0 \uff08the Hierarchical Ensemble Algorithm with Deep learning: HEAD\u30e2\u30c7\u30eb\u3068\u547d\u540d\uff09\u3092\u69cb\u7bc9\u3057\u3001\u4e0a\u8a18\u306e\u8a3a\u65ad\u4e88\u6e2c\u7cbe\u5ea6\u3092\u9054\u6210\u3057\u305f\u304c\u3001\u7528\u3044\u308b\u6a5f\u68b0\u5b66\u7fd2\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u3088\u3063\u3066\u306f\u3001HEAD\u30e2\u30c7\u30eb\u3088\u308a\u3082\u8a3a\u65ad\u6027\u80fd\u304c\u5927\u304d\u304f\u52a3\u3063\u3066\u3044\u305f\u3002\u3055\u3089\u306b\u672c\u7814\u7a76\u3067\u4f5c\u6210\u3057\u305f\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u52a0\u3048\u3066\u3001\u516c\u958b\u3055\u308c\u3066\u3044\u308bmiRNA\u60c5\u5831\u3082\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u4e88\u6e2c\u7cbe\u5ea6\u3092\u5411\u4e0a\u3055\u305b\u308b\u300c\u8ee2\u79fb\u5b66\u7fd2\u300d\u304c\u6d3b\u7528\u3067\u304d\u308b\u3053\u3068\u3084\u3001\u3053\u306e\u7d71\u5408\u60c5\u5831\u3088\u308a\u3001\u304c\u3093\u306e\u7a2e\u985e\u3092\u4e88\u6e2c\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306amiRNA\u306e\u7d5e\u308a\u8fbc\u307f\u3092\u884c\u3063\u305f\u7d50\u679c\u3082\u5831\u544a\u3057\u305f\u3002<\/p>\n

\u3010\u8003\u5bdf\u3011
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-\u6587\u732e\u540d- Juntaro Matsuzaki, et al. Prediction of tissue-of-origin of early stage cancers using serum miRNomes. JN … \u7d9a\u304d\u3092\u8aad\u3080 \u4e0d\u5341\u5206\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304d\u5546\u696d\u5316\u3055\u308c\u305f\u304c\u3093\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3068\u3069\u3046\u5411\u304d\u5408\u3046\u304b<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,17],"tags":[],"class_list":["post-2887","post","type-post","status-publish","format-standard","hentry","category-5","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2887"}],"version-history":[{"count":4,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2887\/revisions"}],"predecessor-version":[{"id":2893,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2887\/revisions\/2893"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}