{"id":2899,"date":"2025-08-14T11:55:59","date_gmt":"2025-08-14T02:55:59","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=2899"},"modified":"2025-08-14T11:58:33","modified_gmt":"2025-08-14T02:58:33","slug":"glp-1%e5%8f%97%e5%ae%b9%e4%bd%93%e4%bd%9c%e5%8b%95%e8%96%ac%e3%81%af%e9%ad%94%e6%b3%95%e3%81%ae%e8%96%ac%e3%81%aa%e3%81%ae%e3%81%8b%ef%bc%9f-%e7%9b%ae%e3%81%ae%e5%89%8d%e3%81%ae%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=2899","title":{"rendered":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u9b54\u6cd5\u306e\u85ac\u306a\u306e\u304b\uff1f-\u76ee\u306e\u524d\u306e\u60a3\u8005\u3078\u9069\u7528\u3059\u308b\u969b\u306b\u6ce8\u610f\u3059\u3079\u304d\u3053\u3068\uff0c\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u89b3\u70b9\u304b\u3089-"},"content":{"rendered":"

\u2010\u6587\u732e\u540d-
\nUeda P, S\u00f6derling J, Wintzell V, Svanstr\u00f6m H, Pazzagli L, Eliasson B, Melbye M, Hviid A, Pasternak B.
\nGLP-1 Receptor Agonist Use and Risk of Suicide Death.
\nJAMA Intern Med. 2024 Nov 1;184(11):1301-1312. doi: 10.1001\/jamainternmed.2024.4369. Erratum in: JAMA Intern Med. 2024 Nov 1;184(11):1396. doi: 10.1001\/jamainternmed.2024.6163.
\nPMID: 39226030; PMCID: PMC11372654.
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/39226030\/<\/p>\n

\u2010\u8981\u7d04-\uff08Abstract\uff09
\n\u91cd\u8981\u6027\u30fb\u80cc\u666f \u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4f7f\u7528\u3068\uff0c\u81ea\u6bba\u5ff5\u616e\u304a\u3088\u3073\u81ea\u50b7\u884c\u70ba\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u61f8\u5ff5\u304c\u63d0\u8d77\u3055\u308c\u3066\u3044\u308b\uff0e\u80a5\u6e80\u624b\u8853\u5f8c\u306bGLP-1\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u3042\u3063\u3066\uff08Ann Surg 2009; 250: 234-241\uff09\uff0cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u81ea\u6bba\u5ff5\u616e\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u61f8\u5ff5\u3055\u308c\u3066\u3044\u305f\uff0e2\u578b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u304a\u3088\u3073\u6e1b\u91cf\u306e\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u81ea\u6bba\u5ff5\u616e\u3068\u306e\u95a2\u9023\u306b\u95a2\u3059\u308b\u61f8\u5ff5\u306f\uff0c\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08\u304a\u3088\u3073\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff09\u306b\u63d0\u51fa\u3055\u308c\u305f\u75c7\u4f8b\u5831\u544a\u306b\u7d9a\u3044\u3066\u63d0\u8d77\u3055\u308c\u305f\uff0e
\n\u76ee\u7684 \u65e5\u5e38\u7684\u306a\u81e8\u5e8a\u73fe\u5834\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4f7f\u7528\u3068\u81ea\u6bba\u6b7b\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\uff0e
\n\u30c7\u30b6\u30a4\u30f3\uff0c\u8a2d\u5b9a\uff0c\u53c2\u52a0\u8005 \u3053\u306e\u5b9f\u85ac\u5bfe\u7167\u30fb\u65b0\u898f\u4f7f\u7528\u8005\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u306f\uff0c2013\u5e74\u304b\u30892021\u5e74\u307e\u3067\u306e\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u3068\u30c7\u30f3\u30de\u30fc\u30af\u306e\u5168\u56fd\u7684\u306a\u767b\u9332\u30c7\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u305f\uff0e GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u307e\u305f\u306f\u6bd4\u8f03\u85ac\u3067\u3042\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\uff08SGLT2\uff09\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3092\u958b\u59cb\u3057\u305f18\u6b73\u304b\u308984\u6b73\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\uff0e \u30c7\u30fc\u30bf\u306f2024\u5e743\u6708\u304b\u30896\u6708\u306b\u304b\u3051\u3066\u5206\u6790\u3055\u308c\u305f\uff0e
\n\u66dd\u9732 GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u307e\u305f\u306fSGLT2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u306e\u958b\u59cb\uff0e
\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u6e2c\u5b9a\u9805\u76ee \u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\uff0c\u6b7b\u56e0\u767b\u9332\u306b\u8a18\u9332\u3055\u308c\u305f\u81ea\u6bba\u6b7b\u3067\u3042\u3063\u305f\uff0e \u526f\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\uff0c\u81ea\u6bba\u6b7b\u3068\u975e\u81f4\u6b7b\u7684\u81ea\u50b7\u884c\u70ba\u306e\u8907\u5408\uff0c\u304a\u3088\u3073\u3046\u3064\u75c5\u3068\u4e0d\u5b89\u95a2\u9023\u969c\u5bb3\u306e\u65b0\u898f\u767a\u75c7\u306e\u8907\u5408\u3067\u3042\u3063\u305f\uff0e \u50be\u5411\u30b9\u30b3\u30a2\u91cd\u307f\u4ed8\u3051\u3092\u7528\u3044\u3066\uff0c\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306895% CI\u3092\u4e21\u56fd\u3067\u500b\u5225\u306b\u8a08\u7b97\u3057\uff0c\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u7d71\u5408\u3057\u305f\uff0e
\n\u7d50\u679c \u5408\u8a08\u3067124,517\u4eba\u306e\u6210\u4eba\u304cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\uff0c174,036\u4eba\u304cSGLT2\u963b\u5bb3\u85ac\u3092\u958b\u59cb\u3057\u305f\uff0e GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u4f7f\u7528\u8005\u306e\u4e2d\u3067\uff0c\u5e73\u5747\uff08SD\uff09\u5e74\u9f62\u306f60\uff0813\uff09\u6b73\u3067\u3042\u308a\uff0c45%\u304c\u5973\u6027\u3067\u3042\u3063\u305f\uff0e \u5e73\u5747\uff08SD\uff092.5\uff081.7\uff09\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\uff0cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u4f7f\u7528\u8005\u306777\u4ef6\uff0cSGLT2\u963b\u5bb3\u85ac\u4f7f\u7528\u8005\u306771\u4ef6\u306e\u81ea\u6bba\u6b7b\u304c\u767a\u751f\u3057\u305f\uff0e\u91cd\u307f\u4ed8\u3051\u5f8c\u306e\u767a\u751f\u7387\u306f\uff0c1000\u4eba\u5e74\u3042\u305f\u308a0.23\u4ef6\u5bfe0.18\u4ef6\uff08HR, 1.25; 95% CI, 0.83-1.88\uff09\u3067\u3042\u308a\uff0c\u7d76\u5bfe\u5dee\u306f1000\u4eba\u5e74\u3042\u305f\u308a0.05\uff0895% CI, -0.03\uff5e0.16\uff09\u4ef6\u3067\u3042\u3063\u305f\uff0e \u81ea\u6bba\u6b7b\u3068\u975e\u81f4\u6b7b\u7684\u81ea\u50b7\u884c\u70ba\u306eHR\u306f0.83\uff0895% CI, 0.70-0.97\uff09\u3067\u3042\u308a\uff0c\u65b0\u898f\u767a\u75c7\u306e\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u95a2\u9023\u969c\u5bb3\u306eHR\u306f1.01\uff0895% CI, 0.97-1.06\uff09\u3067\u3042\u3063\u305f\uff0e
\n\u7d50\u8ad6\u3068\u95a2\u9023\u6027 \u4e3b\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u542b\u3080\u3053\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u306f\uff0cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4f7f\u7528\u3068\u81ea\u6bba\u6b7b\uff0c\u81ea\u50b7\u884c\u70ba\uff0c\u307e\u305f\u306f\u65b0\u898f\u767a\u75c7\u306e\u3046\u3064\u75c5\u304a\u3088\u3073\u4e0d\u5b89\u95a2\u9023\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u306e\u95a2\u9023\u306f\u793a\u3055\u308c\u306a\u304b\u3063\u305f\uff0eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u4f7f\u7528\u8005\u306b\u304a\u3051\u308b\u81ea\u6bba\u6b7b\u306f\u7a00\u3067\u3042\u308a\uff0c\u4fe1\u983c\u533a\u9593\u306e\u4e0a\u9650\u306f\uff0c1000\u4eba\u5e74\u3042\u305f\u308a0.16\u4ef6\u4ee5\u4e0b\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u5897\u52a0\u3068\u77db\u76fe\u3057\u306a\u3044\u3082\u306e\u3067\u3042\u3063\u305f\uff0e<\/p>\n

\u2010\u7d50\u679c-
\n\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n

Discussion\uff08\u672c\u6587\u4e2d\u306e\u3082\u306e\u3092\u629c\u7c8b\uff09
\n\u2022\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u4ea4\u7d61\u56e0\u5b50: \u7cbe\u795e\u969c\u5bb3\u3084\u793e\u4f1a\u7d4c\u6e08\u7684\u5730\u4f4d\u306a\u3069\uff0c\u591a\u304f\u306e\u6f5c\u5728\u7684\u306a\u4ea4\u7d61\u56e0\u5b50\u3092\u8abf\u6574\u3057\u305f\u304c\uff0c\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u4ea4\u7d61\u3000
\n\u304c\u7d50\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u305f\u53ef\u80fd\u6027\u306f\u5426\u5b9a\u3067\u304d\u306a\u3044\uff0e
\n\u2022\u4e00\u822c\u5316\u53ef\u80fd\u6027\u306e\u554f\u984c: \u3053\u306e\u7814\u7a76\u306e\u5bfe\u8c61\u306f\u4e3b\u306b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3042\u3063\u305f\uff0e\u305d\u306e\u305f\u3081\uff0c\u7cd6\u5c3f\u75c5\u3067\u306f\u306a\u3044\u80a5\u6e80\u60a3\u8005\u306b\u3053\u306e\u7d50\u679c\u3092\u305d\u306e
\n\u307e\u307e\u5f53\u3066\u306f\u3081\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e
\n\u2022\u85ac\u5264\u3054\u3068\u306e\u5f71\u97ff: \u4f7f\u7528\u3055\u308c\u305f\u85ac\u5264\u306f\u4e3b\u306b\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\uff08\u30d3\u30af\u30c8\u30fc\u30b6\uff09\u3068\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\uff0c\u30a6\u30b4\u30fc\u30d3\uff0c\u30ea\u30d9\u30eb\u30b5
\n\u30b9\uff09\u3067\u3042\u3063\u305f\uff0e\u500b\u3005\u306e\u85ac\u5264\u3054\u3068\u306b\u81ea\u6bba\u5ff5\u616e\u3068\u306e\u95a2\u9023\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u304c\uff0c\u30a4\u30d9\u30f3\u30c8\u6570\u304c\u5c11\u306a\u304b\u3063\u305f\u305f\u3081\uff0c\u85ac\u5264\u3054\u3068\u306e\u8a73\u7d30
\n\u306a\u5206\u6790\u306f\u3067\u304d\u306a\u304b\u3063\u305f\uff0e
\n\u2022\u8ffd\u8de1\u671f\u9593: GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u4f7f\u7528\u8005\u306e\u5e73\u5747\u8ffd\u8de1\u671f\u9593\u306f2.7\u5e74\u3060\u3063\u305f\uff0e\u3088\u308a\u9577\u671f\u9593\u4f7f\u7528\u3057\u305f\u5834\u5408\u306b\u30ea\u30b9\u30af\u304c\u73fe\u308c\u308b\u53ef\u80fd\u6027\u306f\u6b8b
\n\u3063\u3066\u3044\u308b\uff0e
\n\u2022\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u8aa4\u5206\u985e\u3068\u904e\u5c11\u5831\u544a:
\n\u3000o\u4e00\u90e8\u306e\u81ea\u6bba\u6b7b\u304c\u8aa4\u3063\u3066\u5206\u985e\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e
\n\u3000o\u7279\u306b\u30c7\u30f3\u30de\u30fc\u30af\u3067\u306f\uff0c\u81f4\u6b7b\u7684\u3067\u306a\u3044\u81ea\u50b7\u884c\u70ba\u306f\u904e\u5c11\u5831\u544a\u3055\u308c\u308b\u50be\u5411\u304c\u3042\u308a\uff0c\u3053\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u306f\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u3066
\n\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\uff0e
\n\u3000o\u81ea\u6bba\u6b7b\u3084\u533b\u7642\u6a5f\u95a2\u3067\u306e\u8a3a\u65ad\u306b\u81f3\u3089\u306a\u304b\u3063\u305f\u81ea\u6bba\u5ff5\u616e\u3084\u81ea\u50b7\u884c\u70ba\u306f\u8a55\u4fa1\u3067\u304d\u3066\u3044\u306a\u3044\uff0e
\n\u2022\u7d71\u8a08\u7684\u691c\u51fa\u529b\u306e\u9650\u754c: \u81ea\u6bba\u6b7b\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304b\u3063\u305f\u305f\u3081\uff0c\u7814\u7a76\u306e\u691c\u51fa\u529b\u306b\u306f\u9650\u754c\u304c\u3042\u308a\uff0c\u3088\u308a\u5c0f\u3055\u306a\u30ea\u30b9\u30af\u306e\u5dee\u3092\u691c\u51fa\u3059\u308b\u3053\u3068
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