{"id":3043,"date":"2026-10-07T09:50:51","date_gmt":"2026-10-07T00:50:51","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=3043"},"modified":"2026-10-07T09:50:51","modified_gmt":"2026-10-07T00:50:51","slug":"%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%81%ae%e5%89%af%e5%8f%8d%e5%bf%9c","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=3043","title":{"rendered":"\u30ef\u30af\u30c1\u30f3\u306e\u526f\u53cd\u5fdc"},"content":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d<br \/>\nColes S. Vaccine Adverse Effects: An Overview. Am Fam Physician. 2026; 113(4): 339-348.<\/p>\n<p>\uff0d\u8981\u7d04\uff0d<br \/>\n<em><strong>Introduction<\/strong><\/em><br \/>\n\u30a2\u30e1\u30ea\u30ab\u3067\u306f2026\u5e74\u306b\u9ebb\u75b9\u306e\u6d41\u884c\u304c\u307f\u3089\u308c\u308b\u306a\u3069\u3001\u4e88\u9632\u63a5\u7a2e\u7387\u306e\u4f4e\u4e0b\u306b\u3088\u3063\u3066\u611f\u67d3\u75c7\u304c\u518d\u3073\u5e83\u304c\u308b\u30ea\u30b9\u30af\u304c\u8868\u9762\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u60a3\u8005\u3055\u3093\u3084\u4fdd\u8b77\u8005\u306e\u65b9\u3005\u304b\u3089\u306f\u300c\u533b\u7642\u8005\u304c\u30ef\u30af\u30c1\u30f3\u306e\u526f\u7406\u89e3\u3092\u5341\u5206\u306b\u6df1\u3081\u3066\u3044\u306a\u3044\u306e\u3067\u306f\u300d\u3068\u3044\u3063\u305f\u4e0d\u5b89\u306e\u58f0\u3082\u3042\u304c\u3063\u3066\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002\u672c\u8ad6\u6587\u3067\u306f\u3001\u666e\u6bb5\u306e\u81e8\u5e8a\u73fe\u5834\u3067\u3088\u304f\u6295\u4e0e\u3055\u308c\u308b\u4e3b\u306a\u30ef\u30af\u30c1\u30f3\u3092\u4e2d\u5fc3\u306b\u3001\u5c40\u6240\u306e\u8efd\u5fae\u306a\u75c7\u72b6\u304b\u3089\u3054\u304f\u7a00\u306b\u751f\u3058\u308b\u91cd\u7be4\u306a\u4e8b\u4f8b\u306b\u81f3\u308b\u307e\u3067\u6700\u65b0\u306e\u77e5\u898b\u3092\u307e\u3068\u3081\u3001\u73fe\u5834\u306e\u533b\u5e2b\u304c\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u4e01\u5be7\u306a\u8aac\u660e\u30fb\u76f8\u8ac7\u3092\u884c\u3048\u308b\u3088\u3046\u60c5\u5831\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><em><strong>Method<\/strong><\/em><br \/>\n\u672c\u8ad6\u6587\u306e\u5f62\u5f0f\u306f\u30ca\u30e9\u30c6\u30a3\u30d6\u30fb\u30ec\u30d3\u30e5\u30fc\uff08\u7dcf\u8aac\uff09\u3067\u3059\u3002<br \/>\nPubMed\u3084Cochrane database\u3001Essential Evidence Plus\u306b\u52a0\u3048\u3001CDC\u3084AAP\u3001AAFP\u3001VAERS\u3068\u3044\u3063\u305f\u5404\u7a2e\u516c\u7684\u6a5f\u95a2\u30fb\u5b66\u4f1a\u306eWeb\u30b5\u30a4\u30c8\u3092\u5bfe\u8c61\u306b\u30012025\u5e746\u6708\u301c7\u6708\u30012025\u5e7412\u6708\u30012026\u5e742\u6708\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u7db2\u7f85\u7684\u306a\u6587\u732e\u691c\u7d22\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u63a1\u7528\u3055\u308c\u305f\u8ad6\u6587\u306b\u306f\u3001\u524d\u5411\u304d\u30fb\u5f8c\u308d\u5411\u304d\u306e\u89b3\u5bdf\u7814\u7a76\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3001\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3001\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306a\u3069\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u81e8\u5e8a\u4e0a\u306e\u63a8\u5968\u4e8b\u9805\u306b\u3064\u3044\u3066\u306f\u3001SORT\uff08Strength of Recommendation Taxonomy\uff09\u306b\u6cbf\u3063\u3066\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\uff08A\uff1a\u8cea\u306e\u9ad8\u3044\u60a3\u8005\u6307\u5411\u30a8\u30d3\u30c7\u30f3\u30b9\u3001B\uff1a\u9650\u5b9a\u7684\u3042\u308b\u3044\u306f\u8cea\u306e\u4e0d\u5341\u5206\u306a\u60a3\u8005\u6307\u5411\u30a8\u30d3\u30c7\u30f3\u30b9\u3001C\uff1a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u3001\u75be\u60a3\u6307\u5411\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u5c02\u9580\u5bb6\u306e\u610f\u898b\uff09\u304c\u5272\u308a\u632f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><em><strong>Results<\/strong><\/em><br \/>\n\u4e3b\u306a\u81e8\u5e8a\u4e0a\u306e\u63a8\u5968\u4e8b\u9805\u3068SORT\u306b\u57fa\u3065\u304f\u30a8\u30d3\u30c7\u30f3\u30b9\u30ec\u30d9\u30eb\u306e\u307e\u3068\u3081\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<br \/>\n<strong>1. \u4e88\u9632\u63a5\u7a2e\u5f8c\u306e\u89e3\u71b1\u93ae\u75db\u85ac\uff08\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\uff09\u306e\u4f7f\u7528\uff08SORT\uff1aC\uff09<\/strong><br \/>\n\u3000\u30fb\u6295\u4e0e\u5f8c\u306b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u514d\u75ab\u7372\u5f97\u3078\u306e\u8457\u660e\u306a\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3055\u305a\u306b\u5c40\u6240\u3084\u5168\u8eab\u306e\u514d\u75ab\u53cd\u5fdc\u75c7\u72b6\u3092\u3084\u308f\u3089\u3052\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff08\u4e88\u9632\u7684\u6295\u4e0e\u306b\u3088\u308b\u71b1\u6027\u3051\u3044\u308c\u3093\u306e\u9632\u6b62\u52b9\u679c\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\uff09\u3002<br \/>\n<strong>2. \u6dfb\u52a0\u7269\u3084\u30a2\u30ec\u30eb\u30b2\u30f3\u6210\u5206\u306e\u8a55\u4fa1\u3068\u5076\u767a\u7684\u63a5\u89e6\u306e\u9632\u6b62\uff08SORT\uff1aC\uff09<\/strong><br \/>\n\u3000\u30fb\u91cd\u5ea6\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u3055\u3093\u3067\u306f\u3001\u88fd\u5264\u306b\u542b\u307e\u308c\u308b\u6dfb\u52a0\u5264\uff08\u30bc\u30e9\u30c1\u30f3\u3001\u6297\u83cc\u85ac\u3001\u30a2\u30eb\u30df\u30cb\u30a6\u30e0\u7b49\uff09\u3092\u78ba\u8a8d\u3057\u3001\u4e0d\u5fc5\u8981\u306a\u66b4\u9732\u3092\u9632\u3050\u5de5\u592b\u304c\u5fc5\u8981\u3067\u3059\u3002<br \/>\n\u3000\u30fb\u306a\u304a\u3001\u5375\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u65e2\u5f80\u306e\u307f\u3067\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u306e\u63a5\u7a2e\u3092\u907f\u3051\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002<br \/>\n<strong>3. MMR\u30ef\u30af\u30c1\u30f3\u3068\u81ea\u9589\u75c7\u306e\u95a2\u9023\u6027\u5426\u5b9a\uff08SORT\uff1aB\uff09<\/strong><br \/>\n\u3000\u30fbMMR\u30ef\u30af\u30c1\u30f3\u304c\u81ea\u9589\u75c7\uff08ASD\uff09\u3092\u8a98\u767a\u3059\u308b\u3068\u3044\u3046\u79d1\u5b66\u7684\u6839\u62e0\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u767a\u71b1\u306b\u4f34\u3046\u3051\u3044\u308c\u3093\u30ea\u30b9\u30af\u304c\u308f\u305a\u304b\u306b\u9ad8\u307e\u308b\uff08\u304a\u3088\u305d1,150\u301c1,700\u56de\u306b1\u4f8b\uff09\u3082\u306e\u306e\u3001\u6a19\u6e96\u7684\u306a\u63a5\u7a2e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306e\u9075\u5b88\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<br \/>\n<strong>4. \u598a\u5a66\u306b\u304a\u3051\u308b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u5ea6\uff08SORT\uff1aC\uff09<\/strong><br \/>\n\u3000\u30fb\u598a\u5a20\u4e2d\u306e\u4e0d\u6d3b\u5316\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u306f\u6d41\u7523\u3084\u80ce\u5150\u7570\u5e38\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3092\u8a8d\u3081\u306a\u3044\u305f\u3081\u3001\u598a\u5a20\u4e2d\u306a\u3089\u3073\u306b\u598a\u5a20\u3092\u8a08\u753b\u4e2d\u306e\u5973\u6027\u3078\u81ea\u767a\u7684\u306a\u63a5\u7a2e\u4fc3\u9032\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n<strong>5. \u65b0\u578b\u30b3\u30ed\u30ca\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308b\u5fc3\u7b4b\u708e\u30fb\u5fc3\u819c\u708e\u306e\u30ea\u30b9\u30af\uff08SORT\uff1aB\uff09<\/strong><br \/>\n\u3000\u30fbmRNA\u30ef\u30af\u30c1\u30f3\u6295\u4e0e\u5f8c\u306b\u82e5\u5e74\u7537\u6027\u3092\u4e2d\u5fc3\u306b\u5fc3\u7b4b\u708e\u7b49\u306e\u767a\u75c7\u5272\u5408\u304c\u308f\u305a\u304b\u306b\u5897\u3048\u307e\u3059\u304c\uff0810\u4e07\u4eba\u3042\u305f\u308a1\u301c3\u4eba\u7a0b\u5ea6\uff09\u3001\u5b9f\u969b\u306e\u611f\u67d3\u306b\u3088\u308b\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\uff0810\u4e07\u4eba\u3042\u305f\u308a150\u301c410\u4eba\uff09\u3068\u6bd4\u8f03\u3059\u308b\u3068\u8efd\u5fae\u3067\u3042\u308a\u3001\u5927\u534a\u304c\u8efd\u75c7\u3067\u56de\u5fa9\u3057\u307e\u3059\u3002<br \/>\n<strong>6. \u305d\u306e\u307b\u304b\u65e5\u5e38\u3067\u906d\u9047\u3059\u308b\u30ef\u30af\u30c1\u30f3\u306e\u5b89\u5168\u9762\u306b\u3064\u3044\u3066\uff1a<\/strong><br \/>\n\u3000\u30fbRSV\u30ef\u30af\u30c1\u30f3\uff1a\u598a\u5a20\u5f8c\u671f\uff0832\u301c36\u9031\uff09\u306e\u6bcd\u4f53\u63a5\u7a2e\u306f\u3001\u80ce\u5150\u3078\u306e\u5b89\u5168\u6027\u3092\u4fdd\u3061\u306a\u304c\u3089\u51fa\u751f\u5f8c\u306e\u4e73\u5150\u3078\u6297\u4f53\u3092\u79fb\u884c\u3055\u305b\u307e\u3059\u3002\u9ad8\u9f62\u8005\u3078\u306e\u63a5\u7a2e\u3067\u306fGBS\uff08\u30ae\u30e9\u30f3\u30fb\u30d0\u30ec\u30fc\u75c7\u5019\u7fa4\uff09\u767a\u751f\u52d5\u5411\u306e\u6ce8\u8996\u304c\u7d9a\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3000\u30fb\u30ed\u30bf\u30a6\u30a4\u30eb\u30b9\u30ef\u30af\u30c1\u30f3\uff1a\u63a5\u7a2e\u5f8c\u306b\u8178\u91cd\u7a4d\u3092\u8d77\u3053\u3059\u983b\u5ea6\u304c\u3054\u304f\u50c5\u304b\u306b\u4e0a\u6607\uff08\u7d0410\u4e07\u4eba\u3042\u305f\u308a1.5\u4f8b\uff09\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3000\u30fb\u30d2\u30c8\u30d1\u30d4\u30ed\u30fc\u30de\u30a6\u30a4\u30eb\u30b9\uff08HPV\uff09\u30ef\u30af\u30c1\u30f3\uff1a\u6ce8\u5c04\u76f4\u5f8c\u306e\u8840\u7ba1\u8ff7\u8d70\u795e\u7d4c\u53cd\u5c04\u306b\u3088\u308b\u7acb\u3061\u304f\u3089\u307f\u3084\u8ee2\u5012\u3092\u9632\u3050\u305f\u3081\u300115\u5206\u7a0b\u5ea6\u306e\u9662\u5185\u5f85\u6a5f\u3068\u89b3\u5bdf\u304c\u52e7\u3081\u3089\u308c\u307e\u3059\u3002<br \/>\n<strong>7. \u6709\u5bb3\u4e8b\u8c61\u306e\u76e3\u8996\u614b\u52e2\u304a\u3088\u3073\u6551\u6e08\u30b9\u30ad\u30fc\u30e0\uff1a<\/strong><br \/>\n\u3000\u30fb\u7c73\u56fd\u3067\u306fVAERS\u3084VSD\u3001V-safe\u3068\u3044\u3063\u305f\u60c5\u5831\u53ce\u96c6\u57fa\u76e4\u3092\u6d3b\u7528\u3057\u3066\u5927\u898f\u6a21\u306a\u8ffd\u8de1\u30fb\u8a55\u4fa1\u304c\u5b9f\u65bd\u3055\u308c\u3066\u304a\u308a\u3001\u4e07\u304c\u4e00\u306e\u5065\u5eb7\u88ab\u5bb3\u306b\u5bfe\u3059\u308b\u7121\u904e\u5931\u6551\u6e08\u306e\u305f\u3081\u306e\u5236\u5ea6\uff08VICP\uff09\u304c\u904b\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><em><strong>Discussion<\/strong><\/em><br \/>\n\u672c\u7dcf\u8aac\u306e\u9650\u754c\uff1a\u591a\u69d8\u306a\u6587\u732e\u3084\u75ab\u5b66\u30c7\u30fc\u30bf\u3092\u4fef\u77b0\u3057\u305f\u30ec\u30d3\u30e5\u30fc\u3067\u3042\u308b\u305f\u3081\u3001\u6839\u62e0\u3068\u306a\u3063\u305f\u500b\u5225\u8ad6\u6587\u306b\u306f\u89b3\u5bdf\u7814\u7a76\u306b\u304a\u3051\u308b\u5404\u7a2e\u504f\u4f4d\u3084\u5831\u544a\u6f0f\u308c\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6b8b\u308a\u307e\u3059\u3002<br \/>\n\u65e5\u5e38\u8a3a\u7642\u3078\u306e\u793a\u5506\uff1a\u6975\u3081\u3066\u983b\u5ea6\u306e\u4f4e\u3044\u6709\u5bb3\u4e8b\u8c61\uff08\u6570\u5341\u4e07\u301c\u6570\u767e\u4e07\u56de\u306e\u63a5\u7a2e\u306b1\u4f8b\u7a0b\u5ea6\uff09\u306f\u500b\u3005\u306e\u8a3a\u7642\u73fe\u5834\u3067\u6349\u3048\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001VSD\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u96c6\u56e3\u30ec\u30d9\u30eb\u306e\u7db2\u7f85\u7684\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u3088\u308b\u7d99\u7d9a\u7684\u306a\u8a55\u4fa1\u30b7\u30b9\u30c6\u30e0\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<br \/>\n\u60a3\u8005\u76f8\u8ac7\u30fb\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\uff1a\u8a3a\u5bdf\u6642\u306b\u306f\u526f\u53cd\u5fdc\u306e\u53ef\u80fd\u6027\u3092\u5168\u9762\u7684\u306b\u6253\u3061\u6d88\u3059\u306e\u3067\u306f\u306a\u304f\u3001\u5c40\u6240\u306e\u75db\u307f\u3084\u4e00\u6642\u7684\u306a\u767a\u71b1\u3068\u3044\u3063\u305f\u4e00\u822c\u7684\u306a\u751f\u4f53\u53cd\u5fdc\u304a\u3088\u3073\u7a00\u306a\u91cd\u75c7\u30ea\u30b9\u30af\u3092\u5ba2\u89b3\u7684\u306b\u5171\u6709\u3057\u3001\u5b9f\u969b\u306e\u75be\u60a3\u306b\u304b\u304b\u3063\u305f\u969b\u306e\u91cd\u75c7\u5316\u4e88\u9632\u52b9\u679c\uff08\u76ca\uff09\u3068\u6bd4\u8f03\u30fb\u5bfe\u8a71\u3057\u306a\u304c\u3089\u8aac\u660e\u3092\u91cd\u306d\u308b\u3053\u3068\u304c\u3001\u826f\u597d\u306a\u95a2\u4fc2\u69cb\u7bc9\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u30112026\u5e7410\u67087\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff0d\u6587\u732e\u540d\uff0d Coles S. Vaccine Adverse Effects: An Overview. Am Fam Physician. 2026; 113(4): 339-348. \uff0d\u8981\u7d04\uff0d Introductio &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=3043\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u30ef\u30af\u30c1\u30f3\u306e\u526f\u53cd\u5fdc<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3043","post","type-post","status-publish","format-standard","hentry","category-5"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3043"}],"version-history":[{"count":3,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3043\/revisions"}],"predecessor-version":[{"id":3046,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3043\/revisions\/3046"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}