{"id":3047,"date":"2026-10-14T12:10:35","date_gmt":"2026-10-14T03:10:35","guid":{"rendered":"https:\/\/www.hcfm.jp\/journal\/?p=3047"},"modified":"2026-10-14T12:10:35","modified_gmt":"2026-10-14T03:10:35","slug":"%e7%89%87%e9%a0%ad%e7%97%9b%e6%88%90%e4%ba%ba%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a2%e3%83%88%e3%82%b2%e3%83%91%e3%83%b3%e3%83%88%e3%81%a8%e3%83%88%e3%83%94%e3%83%a9%e3%83%9e","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=3047","title":{"rendered":"\u7247\u982d\u75db\u6210\u4eba\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u3068\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u306e\u5fcd\u5bb9\u6027\u3001\u5b89\u5168\u6027\u3001\u304a\u3088\u3073\u6709\u52b9\u6027\uff08TEMPLE\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u76f4\u63a5\u6bd4\u8f03\u7b2c3b\u76f8\u8a66\u9a13"},"content":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d
\nUwe Reuter, Annelies Van Dycke, Jan Versijpt,et al. Tolerability, safety, and efficacy of atogepant versus topiramate in adults with migraine (TEMPLE): a randomised, head-to-head, phase 3b trial. Lancet Neurol. 2026; 25: 806\u201317<\/p>\n

\uff0d\u8981\u7d04\uff0d
\nIntroduction\uff1a<\/strong>
\n\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u306a\u3069\u306e\u7d4c\u53e3\u30ab\u30eb\u30b7\u30c8\u30cb\u30f3\u907a\u4f1d\u5b50\u95a2\u9023\u30da\u30d7\u30c1\u30c9\uff08CGRP\uff09\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306f\u3001\u7247\u982d\u75db\u306e\u4e88\u9632\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5f93\u6765\u306e\u7d4c\u53e3\u975e\u7279\u7570\u7684\u4e88\u9632\u6cbb\u7642\u85ac\u3068\u306e\u76f4\u63a5\u6bd4\u8f03\u306f\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u306f\u3001\u7247\u982d\u75db\u306b\u5bfe\u3057\u3066\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u5f93\u6765\u306e\u7d4c\u53e3\u975e\u7247\u982d\u75db\u7279\u7570\u7684\u4e88\u9632\u6cbb\u7642\u85ac\u3060\u304c\u3001\u5fcd\u5bb9\u6027\u304c\u4f4e\u3044\u305f\u3081\u4f7f\u7528\u304c\u5236\u9650\u3055\u308c\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u7247\u982d\u75db\u3092\u6709\u3059\u308b\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u3068\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u306e\u5fcd\u5bb9\u6027\u3001\u5b89\u5168\u6027\u3001\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3057\u3001\u6cbb\u7642\u9078\u629e\u306e\u53c2\u8003\u3068\u306a\u308b\u76f4\u63a5\u7684\u306a\u6bd4\u8f03\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002<\/p>\n

Method\uff1a<\/strong>
\nTEMPLE\u306f\u300112\u304b\u56fd\uff08\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u3001\u30d9\u30eb\u30ae\u30fc\u3001\u30ab\u30ca\u30c0\u3001\u30c1\u30a7\u30b3\u3001\u30d5\u30e9\u30f3\u30b9\u3001\u30c9\u30a4\u30c4\u3001\u30cf\u30f3\u30ac\u30ea\u30fc\u3001\u30a4\u30b9\u30e9\u30a8\u30eb\u3001\u30a4\u30bf\u30ea\u30a2\u3001\u30dd\u30fc\u30e9\u30f3\u30c9\u3001\u30dd\u30eb\u30c8\u30ac\u30eb\u3001\u82f1\u56fd\uff09\u306e\u7247\u982d\u75db\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u7d4c\u9a13\u3092\u6301\u3064\u65bd\u8a2d\u3067\u5b9f\u65bd\u3055\u308c\u305f\u300124\u9031\u9593\u306e\u4e8c\u91cd\u76f2\u691c\u6cbb\u7642\u671f\u9593\u306852\u9031\u9593\u306e\u975e\u76f2\u691c\u6cbb\u7642\u671f\u9593\u304b\u3089\u306a\u308b\u7b2c3b\u76f8\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u30c0\u30df\u30fc\u5b9f\u85ac\u5bfe\u7167\u8a66\u9a13\u3060\u3063\u305f\u3002\u53c2\u52a0\u8005\u306f\u7247\u982d\u75db\u306e\u65e2\u5f80\u6b74\u304c\u3042\u308a\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u524d\u306e3\u304b\u6708\u9593\u3068\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304a\u3088\u3073\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u671f\u9593\u3092\u5408\u308f\u305b\u305f\u671f\u9593\u4e2d\u306b\u3001\u5e73\u5747\u3057\u3066\u6708\u306b\u5c11\u306a\u304f\u3068\u30824\u65e5\u306e\u7247\u982d\u75db\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f\u3001\u30a4\u30f3\u30bf\u30e9\u30af\u30c6\u30a3\u30d6\u5fdc\u7b54\u6280\u8853\u3092\u4f7f\u7528\u3057\u3066\u3001\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\uff081\u65e51\u56de60mg\uff09\u307e\u305f\u306f\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\uff081\u65e550mg\u300175mg\u3001\u307e\u305f\u306f100mg\u306e\u6700\u5927\u8010\u7528\u91cf\uff09\u306b1:1\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5b89\u5168\u6027\u8a55\u4fa1\u5bfe\u8c61\u96c6\u56e3\uff08\u4e8c\u91cd\u76f2\u691c\u671f\u9593\u4e2d\u306b\u6cbb\u9a13\u85ac\u30921\u56de\u4ee5\u4e0a\u6295\u4e0e\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u53c2\u52a0\u8005\uff09\u306b\u304a\u3044\u3066\u3001\u4e8c\u91cd\u76f2\u691c\u671f\u9593\u4e2d\u306b\u6cbb\u7642\u4e2d\u306b\u767a\u751f\u3057\u305f\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u6cbb\u7642\u4e2d\u6b62\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fcd\u5bb9\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u306b\u95a2\u9023\u3059\u308b\u526f\u6b21\u7684\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u4fee\u6b63ITT\u96c6\u56e3\uff08\u6cbb\u9a13\u85ac\u30921\u56de\u4ee5\u4e0a\u6295\u4e0e\u3055\u308c\u3001\u8a55\u4fa1\u53ef\u80fd\u306a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u671f\u9593\u306eeDiary\u30c7\u30fc\u30bf\u304c\u3042\u308a\u3001\u6cbb\u9a13\u85ac\u306e\u521d\u56de\u6295\u4e0e\u5f8c24\u9031\u9593\u4ee5\u5185\uff081\u30f6\u6708\u76ee\u304b\u30896\u30f6\u6708\u76ee\uff09\u306b\u8a55\u4fa1\u53ef\u80fd\u306a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5f8c4\u9031\u9593\uff081\u30f6\u6708\u76ee\uff09\u306eeDiary\u30c7\u30fc\u30bf\u304c1\u3064\u4ee5\u4e0a\u3042\u308b\u3001\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u53c2\u52a0\u8005\u3002\u6cbb\u9a13\u85ac\u6295\u4e0e\u4e2d\u304b\u975e\u6295\u4e0e\u4e2d\u304b\u306f\u554f\u308f\u306a\u3044\uff09\u306b\u304a\u3051\u308b\u30014\uff5e6\u30f6\u6708\u76ee\u306e\u5e73\u5747\u6708\u9593\u7247\u982d\u75db\u65e5\u6570\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e50%\u4ee5\u4e0a\u306e\u6e1b\u5c11\u3001\u304a\u3088\u3073\u5e73\u5747\u6708\u9593\u7247\u982d\u75db\u65e5\u6570\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u3002<\/p>\n

Results\uff1a<\/strong>
\n2023\u5e7410\u67087\u65e5\u304b\u30892025\u5e744\u670828\u65e5\u306e\u9593\u306b\u3001730\u540d\u306e\u53c2\u52a0\u8005\u304c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u3001545\u540d\u304c\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001540\u540d\uff08\u5973\u6027479\u540d\uff3b89\uff05\uff3d\u3001\u7537\u602761\u540d\uff3b11\uff05\uff3d\u3001\u767d\u4eba517\u540d\uff3b96\uff05\uff3d\uff09\u304c\u5b89\u5168\u6027\u89e3\u6790\u5bfe\u8c61\u96c6\u56e3\u306b\u542b\u307e\u308c\u305f\uff08\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4 n=273\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4 n=267\uff09\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a
\n24\u9031\u9593\u306e\u4e8c\u91cd\u76f2\u691c\u671f\u9593\u4e2d\u306b\u6cbb\u7642\u4e2d\u306b\u767a\u73fe\u3057\u305f\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u6295\u4e0e\u4e2d\u6b62\u306f\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4\uff08267\u540d\u4e2d79\u540d\uff3b30\uff05\uff3d\uff09\u3068\u6bd4\u8f03\u3057\u3066\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\uff08273\u540d\u4e2d33\u540d\uff3b12\uff05\uff3d\uff09\u3067\u5c11\u306a\u304b\u3063\u305f\uff08\u76f8\u5bfe\u30ea\u30b9\u30af\uff3bRR\uff3d0.4\u300195\uff05\u4fe1\u983c\u533a\u95930.3\uff5e0.6\u3001p<0.0001\uff09\u3002\n\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee\uff1a\n\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\u3067\u306f\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4\uff0839% [257\u4eba\u4e2d101\u4eba]\u3001\u76f8\u5bfe\u30ea\u30b9\u30af1.6\u300195%\u4fe1\u983c\u533a\u95931.4\uff5e2.0\u3001p<0.0001\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6708\u5e73\u5747\u7247\u982d\u75db\u65e5\u6570\u304c50%\u4ee5\u4e0a\u6e1b\u5c11\u3057\u305f\u53c2\u52a0\u8005\u306e\u5272\u5408\u304c64%\uff08270\u4eba\u4e2d173\u4eba\uff09\u3068\u9ad8\u304b\u3063\u305f\u3002\u307e\u305f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u6708\u5e73\u5747\u7247\u982d\u75db\u65e5\u6570\u306e\u6e1b\u5c11\u306f\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4\uff08-4.5 [0.3]\u3001\u6cbb\u7642\u5dee-1.8 [-2.5\uff5e-1.0]\u3001p<0.0001\uff09\u3088\u308a\u3082\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\uff08\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747-6.3 [\u6a19\u6e96\u8aa4\u5dee0.3]\uff09\u306e\u65b9\u304c\u5927\u304d\u304b\u3063\u305f\u3002\n\n\"\"<\/a><\/p>\n

\u6709\u5bb3\u4e8b\u8c61\u306e\u8a73\u7d30\uff1a
\n\u6cbb\u7642\u306b\u95a2\u9023\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\u306e273\u540d\u4e2d153\u540d\uff0856%\uff09\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4\u306e267\u540d\u4e2d208\u540d\uff0878%\uff09\u3067\u5831\u544a\u3055\u308c\u305f\u3002\u91cd\u7be4\u306a\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\u30676\u540d\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u7fa4\u30673\u540d\u306b\u767a\u751f\u3057\u305f\u3002\u91cd\u7be4\u306a\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306e\u3046\u30611\u4ef6\uff08\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u7fa4\u306b\u304a\u3051\u308b\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u53cd\u5fdc\uff09\u306f\u3001\u6cbb\u9a13\u85ac\u3068\u306e\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u6b7b\u4ea1\u4f8b\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n

\"\"<\/a><\/p>\n

Discussion\uff1a<\/strong>
\n\u30a2\u30c8\u30b2\u30d1\u30f3\u30c860mg\u30921\u65e51\u56de\u6295\u4e0e\u3057\u305f\u5834\u5408\u300124\u9031\u9593\u306b\u308f\u305f\u308a\u3001\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u3068\u6bd4\u8f03\u3057\u3066\u5fcd\u5bb9\u6027\u3068\u6709\u52b9\u6027\u304c\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u3068\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u306f\u3044\u305a\u308c\u3082\u52b9\u679c\u7684\u306a\u7d4c\u53e3\u7247\u982d\u75db\u4e88\u9632\u85ac\u3068\u3057\u3066\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u81e8\u5e8a\u73fe\u5834\u3067\u306e\u6709\u7528\u6027\u306f\u60a3\u8005\u306e\u6cbb\u7642\u8010\u6027\u306b\u5927\u304d\u304f\u5de6\u53f3\u3055\u308c\u308b\u3002\u4eca\u56de\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u533b\u5e2b\u304c\u60a3\u8005\u306b\u6700\u9069\u306a\u4e88\u9632\u7642\u6cd5\u3092\u9078\u629e\u3059\u308b\u969b\u306e\u6307\u91dd\u3068\u306a\u308b\u76f4\u63a5\u7684\u306a\u6bd4\u8f03\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n

\u3010\u958b\u50ac\u65e5\u30112026\u5e7410\u670814\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\uff0d\u6587\u732e\u540d\uff0d Uwe Reuter, Annelies Van Dycke, Jan Versijpt,et al. Tolerability, safety, and efficacy of atogepant vers … \u7d9a\u304d\u3092\u8aad\u3080 \u7247\u982d\u75db\u6210\u4eba\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30c8\u30b2\u30d1\u30f3\u30c8\u3068\u30c8\u30d4\u30e9\u30de\u30fc\u30c8\u306e\u5fcd\u5bb9\u6027\u3001\u5b89\u5168\u6027\u3001\u304a\u3088\u3073\u6709\u52b9\u6027\uff08TEMPLE\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u76f4\u63a5\u6bd4\u8f03\u7b2c3b\u76f8\u8a66\u9a13<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23,17],"tags":[],"class_list":["post-3047","post","type-post","status-publish","format-standard","hentry","category-23","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3047"}],"version-history":[{"count":2,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3047\/revisions"}],"predecessor-version":[{"id":3052,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3047\/revisions\/3052"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}