\u3010\u6587\u732e\u540d\u3011\u3000
\n\u8457\u8005\u540d\uff1aHeike A. Bischoff-Ferrari, MD\u3000et al
\n\u6587\u732e\u30bf\u30a4\u30c8\u30eb\uff1aA Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention
\n\u96d1\u8a8c\u540d\u30fb\u66f8\u7c4d\u540d\uff1aN Engl J Med
\n\u767a\u884c\u5e74\uff1a 2012; 367 : 40 – 9.\u00a0<\/p>\n
\u3010\u8981\u7d04\u3011
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\n\u30d7\u30e9\u30a4\u30de\u30ea\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5e74\u9f62\u5c64\u3001\u6027\u5225\u3001\u4f4f\u5c45\u30bf\u30a4\u30d7\u3001\u8a66\u9a13\u3067\u88dc\u6b63\u3057\u305fCox\u56de\u5e30\u5206\u6790\u3092\u884c\u3044\u3001\u5927\u817f\u9aa8\u9838\u90e8\u3084\u975e\u690e\u4f53\u9aa8\u6298\u306e\u767a\u751f\u7387\u3068\u3057\u305f\u3002\u4e3b\u8981\u76ee\u7684\u306f\uff0c\u3059\u3079\u3066\u306e\u8a66\u9a13\u306e\u6cbb\u7642\u7fa4\u306e\u30d3\u30bf\u30df\u30f3 D \u306e\u5b9f\u969b\u306e\u6442\u53d6\u91cf\uff08\u5404\u88ab\u9a13\u8005\u306e\u6cbb\u7642\u9075\u5b88\u3068\uff0c\u8a66\u9a13\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u5916\u3067\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f7f\u7528\u3092\u542b\u3080\uff09\u306e\u56db\u5206\u4f4d\u7fa4\u306e\u30c7\u30fc\u30bf\u3092\uff0c\u5bfe\u7167\u7fa4\u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3002<\/p>\n
\uff1c\u7d50\u679c\uff1e
\n31022\u4eba\u306e\u4eba(\u5e73\u5747\u5e74\u9f6276\u6b73\u300191%\u304c\u5973\u6027)\u306e\u3046\u30611111\u4eba\u304c\u5927\u817f\u9aa8\u9838\u90e8\u9aa8\u6298\u3092\u767a\u75c7\u3057\u30013770\u4eba\u304c\u975e\u690e\u4f53\u9aa8\u6298\u3092\u767a\u75c7\u3057\u305f\u3002\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u30d3\u30bf\u30df\u30f3D\u6295\u4e0e\u7fa4\u306e\u53c2\u52a0\u8005\u3068\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u53c2\u52a0\u8005\u3068\u306e\u6bd4\u8f03\u3067\u306f\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 0.90\uff0c95%\u4fe1\u983c\u533a\u9593 [CI] 0.80\uff5e1.01\uff09\u304c\u5927\u817f\u9aa8\u9838\u90e8\u9aa8\u6298\u306e\u767a\u75c7\u306e\u30ea\u30b9\u30af\u304c10%\u4f4e\u4e0b\u3057\u3001\u975e\u690e\u4f53\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u306f7%\u306e\u6e1b\u5c11\u3092\u8a8d\u3081\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 0.93\uff0c95% CI 0.87\uff5e0.99\uff09\u3002\u5b9f\u969b\u306e\u6442\u53d6\u91cf\u306e\u56db\u5206\u4f4d\u7fa4\u3067\u306f\uff0c\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u306f\u6442\u53d6\u91cf\u304c\u6700\u5927\u306e\u7fa4\uff08\u4e2d\u592e\u5024 800 IU\/\u65e5\uff0c\u7bc4\u56f2 792\uff5e2,000\uff09\u306b\u306e\u307f\u8a8d\u3081\u3089\u308c\uff0c\u5927\u817f\u9aa8\u8fd1\u4f4d\u90e8\u9aa8\u6298\u30ea\u30b9\u30af\u306f 30%\u4f4e\u304f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 0.70\uff0c95% CI 0.58\uff5e0.86\uff09\uff0c\u3042\u3089\u3086\u308b\u975e\u690e\u4f53\u9aa8\u6298\u30ea\u30b9\u30af\u306f 14%\u4f4e\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 0.86\uff0c95% CI 0.76\uff5e0.96\uff09\u3002\u30d3\u30bf\u30df\u30f3 D \u6442\u53d6\u91cf\u304c\u6700\u5927\u306e\u7fa4\u306b\u304a\u3051\u308b\u6709\u76ca\u6027\u306f\uff0c\u5e74\u9f62\u5c64\uff0c\u4f4f\u5c45\u30bf\u30a4\u30d7\uff0c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e 25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3 D \u5024\uff0c\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8ffd\u52a0\u6442\u53d6\u3067\u898f\u5b9a\u3057\u305f\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u307b\u307c\u4e00\u8cab\u3057\u3066\u3044\u305f\u3002<\/p>\n
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