{"id":463,"date":"2012-03-26T15:12:21","date_gmt":"2012-03-26T06:12:21","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=463"},"modified":"2015-08-06T15:12:47","modified_gmt":"2015-08-06T06:12:47","slug":"psa%e3%81%ab%e3%82%88%e3%82%8b%e5%89%8d%e7%ab%8b%e8%85%ba%e7%99%8c%e3%81%ae%e3%82%b9%e3%82%af%e3%83%aa%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%ef%bc%9a%e5%89%8d%e7%ab%8b%e8%85%ba%e7%99%8c%e6%ad%bb","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=463","title":{"rendered":"PSA\u306b\u3088\u308b\u524d\u7acb\u817a\u764c\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff1a\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u7387\u3092\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3057\u305f11\u5e74\u9593\u306e\u8ffd\u8de1\u7d50\u679c"},"content":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011<\/p>\n<p>Prostate-Cancer Mortality at 11 Years of Follow-up<br \/>\nF.H. Schroder and others\uff08N Engl J Med 2012; 366 : 981 &#8211; 90.\uff09<\/p>\n<p>\u3010\u80cc\u666f\u3011<\/p>\n<p>PSA\u691c\u8a3a\u306f\u7537\u6027\u306e\u304c\u3093\u691c\u8a3a\u3068\u3057\u3066\u3001\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u304c\u3001USPSTF\u3067\u306f\u300c\u6b7b\u4ea1\u7387\u306e\u6e1b\u5c11\u306f\u671f\u5f85\u3067\u304d\u306a\u3044\u300d\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u691c\u67fb\u3067\u306f\u306a\u3044\u3002\u8abf\u3079\u3066\u307f\u308b\u3068\u305d\u306e\u6839\u62e0\u3068\u3057\u3066\u7c73\u56fd\u306eProstate,Lung,Colorectal,and Ovarian Cancer Screening Trial\uff08PLCO\uff09\u3068\u3001\u6b27\u5dde\u306eEuropean Randomized Study of Screening for Prostate Cancer\uff08ERSPC\uff09\u306e2\u3064\u306e\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u5bfe\u7167\u8a66\u9a13\u306b\u304a\u3051\u308b\u7d50\u679c\u304c\u76f8\u53cd\u3059\u308b\u7d50\u679c\u3068\u306a\u3063\u305f\u305f\u3081\u3001USPSTF\u306fPSA\u691c\u8a3a\u5f8c\u306e\u904e\u5270\u6cbb\u7642\u306a\u3069\u306e\u4e0d\u5229\u76ca\u3092\u554f\u984c\u8996\u3059\u3079\u304d\u3060\u3068\u5224\u65ad\u3057\u300c\u63a8\u5968\u3057\u306a\u3044\u300d\u3068\u3044\u3046\u5224\u65ad\u306b\u306a\u3063\u305f\u3088\u3046\u3060\u3063\u305f\u3002\u4eca\u56de\u305d\u306eERSPC\u306e\u3055\u3089\u306b2\u5e74\u8ffd\u8de1\u3057\u305f\u8ad6\u6587\u304c\u51fa\u3066\u3044\u305f\u306e\u3067\u8aad\u3093\u3067\u307f\u308b\u3053\u3068\u3068\u3057\u305f\u3002<\/p>\n<p>\u3010\u8981\u7d04\u3011<\/p>\n<p>\uff1c\u80cc\u666f\uff1e<br \/>\n\u3000\u524d\u7acb\u817a\u764c\u306e\u6b7b\u4ea1\u7387\u306b\u5bfe\u3059\u308bPSA\u691c\u67fb\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u306f\u7570\u306a\u308b\u7d50\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002<br \/>\n\u6b27\u5dde\u524d\u7acb\u817a\u764c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\uff08European Randomized Study of Screening for Prostate Cancer\uff09\u306b\u304a\u3044\u3066\uff0c\u3055\u3089\u306b 2 \u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u306b\u3088\u308b\u6700\u65b0\u306e\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u7387\u3092\u5831\u544a\u3059\u308b\u3002<\/p>\n<p>\uff1c\u65b9\u6cd5\uff1e<br \/>\n\u7814\u7a76\u306f\u30a8\u30f3\u30c8\u30ea\u30fc\u6642\u306b 50\uff5e74 \u6b73\u3067\u3042\u3063\u305f\u7537\u6027 182,160 \u4f8b\u3067\uff0c\u4e8b\u524d\u306b\u898f\u5b9a\u3057\u305f 55\uff5e69 \u6b73\u306e\u30b3\u30a2\u306a\u5e74\u9f62\u7fa4\u306e162,388 \u4f8b\u3067\u884c\u308f\u308c\u305f\uff0e\u3053\u306e\u8a66\u9a13\u306f\u6b27\u5dde 8 \u30f5\u56fd\u3067\u884c\u308f\u308c\u305f\uff0e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u7537\u6027\u306b\u306f PSA \u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3092\u65bd\u884c\u3057\uff0c\u5bfe\u7167\u7fa4\u306e\u7537\u6027\u306b\u306f\u305d\u306e\u3088\u3046\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306f\u65bd\u884c\u3057\u306a\u304b\u3063\u305f\uff0e\u8ee2\u5e30\u306f\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u7387\u3068\u3057\u305f\uff0e<\/p>\n<p>\uff1c\u7d50\u679c\uff1e<br \/>\n\u30b3\u30a2\u306a\u5e74\u9f62\u306b\u304a\u3051\u308b11\u5e74\u306e\u8ffd\u8de1\u8abf\u67fb\u3067\u306f\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7fa4\u306b\u304a\u3051\u308b\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\u306f 21%(rate ratio,0.79; 95% confidence interval [CI], 0.68 to 0.91; P = 0.001)\u3067\u3042\u308a\u3001\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306e\u60aa\u3044\u4eba\u3092\u88dc\u6b63\u3059\u308b\u306829%\u3067\u3042\u3063\u305f\u3002\u6b7b\u4ea1\u6570\u306eAR\u306f1,000 \u4eba\u5e74\u3042\u305f\u308a 0.10 \u4f8b\u3067\uff0c\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u7537\u6027 1,000 \u4f8b\u3042\u305f\u308a 1.07 \u4f8b\u3067\u3042\u3063\u305f\uff0e\u8ffd\u8de1\u8abf\u67fb 10 \u5e74\u76ee\u30fb11 \u5e74\u76ee\u306b\u304a\u3051\u308b\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u306eRR\u306f 0.62\uff0895% CI 0.45\uff5e0.85\uff0cP\uff1d0.003\uff09\u3067\u3042\u3063\u305f\uff0e\u8ffd\u8de1\u8abf\u67fb 11 \u5e74\u306e\u6642\u70b9\u3067\u306e\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u3092 1 \u4f8b\u4e88\u9632\u3059\u308b\u306b\u306f\uff0c1,055 \u4f8b\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3078\u306e\u53c2\u52a0\u3092\u547c\u3073\u304b\u3051\uff08the number of men who would need to be invited (NNI)\uff09\uff0c\u524d\u7acb\u817a\u764c 37 \u500b\u3092\u767a\u898b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff08the number of prostate cancers that would needed to be detected (NND)\uff09\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u306b\u7fa4\u9593\u3067\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff0e<\/p>\n<p>\uff1c\u7d50\u8ad6\uff1e<br \/>\n\u3055\u3089\u306b 2 \u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u306e\u89e3\u6790\u306b\u3088\u308a\uff0cPSA \u691c\u67fb\u306b\u57fa\u3065\u304f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3046\u3053\u3068\u3067\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u306f\u6709\u610f\u306b\u6e1b\u5c11\u3059\u308b\u304c\uff0c\u5168\u6b7b\u56e0\u6b7b\u4ea1\u3078\u306e\u5f71\u97ff\u306f\u306a\u3044\u3068\u3044\u3046\u4ee5\u524d\u306e\u7d50\u679c\u304c\u88cf\u4ed8\u3051\u3089\u308c\u305f\uff0e<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\uff12\uff10\uff11\uff12\u5e74\uff13\u6708\uff12\uff11\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011 Prostate-Cancer Mortality at 11 Years of Follow-up F.H. Schroder and others\uff08N Engl J Med 2012; 366 : 981 &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=463\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">PSA\u306b\u3088\u308b\u524d\u7acb\u817a\u764c\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff1a\u524d\u7acb\u817a\u764c\u6b7b\u4ea1\u7387\u3092\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3057\u305f11\u5e74\u9593\u306e\u8ffd\u8de1\u7d50\u679c<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-463","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=463"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/463\/revisions"}],"predecessor-version":[{"id":464,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/463\/revisions\/464"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}