\u3010\u6587\u732e\u540d\u3011<\/p>\n
Toothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey
\nCesar de Oliveira, research fellow in epidemiology and public health, Richard Watt, professor and honorary consultant in dental public health, Mark Hamer, senior research fellow in epidemiology and public health
\nBMJ 2010; 340 doi: 10.1136\/bmj.c2451<\/p>\n
\u3010\u8981\u7d04\u3011<\/p>\n
\uff1cObjective\uff1e
\nTo examine if self reported toothbrushing behaviour is associated with cardiovascular disease and
\nmarkers of inflammation (C reactive protein) and coagulation (fibrinogen).<\/p>\n
\uff1cDesign\uff1e
\nNational population based survey.<\/p>\n
\uff1cSetting\uff1e
\nScottish Health Survey, which draws a nationally representative sample of the general population living in
\nhouseholds in Scotland.<\/p>\n
\uff1cParticipants\uff1e
\n11 869 men and women, mean age 50 (SD 11).<\/p>\n
\uff1cMain outcome measures\uff1e\u00a0
\nOral hygiene assessed from self reported frequency of toothbrushing. Surveys were linked prospectively to clinical hospital records, and Cox proportional hazards models were used to estimate the
\nrisk of cardiovascular disease events or death according to oral hygiene. The association between oral hygiene and
\ninflammatory markers and coagulation was examined in a subsample of participants (n=4830) by using general
\nlinear models with adjustments.<\/p>\n
\uff1cResults\uff1e\u00a0
\nThere were a total of 555 cardiovascular disease events over an average of 8.1 (SD 3.4) years of follow-up,
\nof which 170 were fatal. In about 74% (411) of cardiovascular disease events the principal diagnosis
\nwas coronary heart disease. Participants who reported poor oral hygiene (never\/rarely brushed their teeth) had
\nan increased risk of a cardiovascular disease event (hazard ratio 1.7, 95% confidence interval 1.3 to 2.3; P<0.001) in a fully adjusted model. They also had increased concentrations of both C reactive protein (\u03b2 0.04, 0.01 to 0.08) and fibrinogen (0.08, ?0.01 to 0.18).\n\n\uff1cConclusions\uff1e\nPoor oral hygiene is associated with higher levels of risk of cardiovascular disease and low grade\ninflammation, though the causal nature of the association is yet to be determined.\n\n\u3010\u958b\u50ac\u65e5\u3011\n\uff12\uff10\uff11\uff12\u5e74\uff12\u6708\uff12\uff15\u65e5\n<\/p>\n","protected":false},"excerpt":{"rendered":"