{"id":528,"date":"2011-11-21T02:37:18","date_gmt":"2011-11-20T17:37:18","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=528"},"modified":"2015-08-06T15:38:30","modified_gmt":"2015-08-06T06:38:30","slug":"%e6%85%a2%e6%80%a7%e9%96%89%e5%a1%9e%e6%80%a7%e8%82%ba%e7%96%be%e6%82%a3%e3%81%ae%e5%a2%97%e6%82%aa%e4%ba%88%e9%98%b2%e3%81%ab%e7%94%a8%e3%81%84%e3%82%8b%e3%82%a2%e3%82%b8%e3%82%b9%e3%83%ad%e3%83%9e","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=528","title":{"rendered":"\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u306e\u5897\u60aa\u4e88\u9632\u306b\u7528\u3044\u308b\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3"},"content":{"rendered":"

\u3010\u6587\u732e\u540d\u3011
\n\u2028R.K. Albert , et al.\u3000Azithromycin for Prevention of Exacerbations of COPD. The NEW\u3000ENGLAND\u3000JOURNAL\u3000of\u3000MEDISINE. 2011;8.25: 689-698.\u2028\u2028<\/p>\n

\u3010\u8981\u7d04\u3011\u2028
\n\uff1c\u80cc\u666f\uff1e
\n\u2028COPD\u6025\u6027\u5897\u60aa\u306b\u3088\u308a\u3001\u8a3a\u7642\u6240\u3084\u6551\u6025\u5916\u6765\u3092\u983b\u7e41\u306b\u53d7\u8a3a\u3057\u3001\u983b\u56de\u306e\u5165\u9662\u306b\u3088\u308b\u5931\u696d\u3084\u6cbb\u7642\u30b3\u30b9\u30c8\u304c\u304b\u304b\u308b\u3002\u307e\u305f\u3001\u6025\u6027\u5897\u60aa\u3092\u5f15\u304d\u8d77\u3053\u3059\u60a3\u8005\u306f\u5f15\u304d\u8d77\u3053\u3055\u306a\u3044\u60a3\u8005\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001\u7a81\u7136\u6b7b\u306e\u30ea\u30b9\u30af\u3084\u65e9\u671f\u306e\u547c\u5438\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3001QOL\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u7cfb\u6297\u83cc\u85ac\u304cCOPD\u6025\u6027\u5897\u60aa\u3092\u6e1b\u3089\u3059\u3068\u3044\u3046\u7814\u7a76\u3068\u6e1b\u3089\u3055\u306a\u3044\u3068\u3044\u3046\u7814\u7a76\u304c\u3042\u308b\u305f\u3081\u306b\uff08\u9650\u754c\u306e\u3042\u308b\u7814\u7a76\u304c\u591a\u304b\u3063\u305f\u305f\u3081\uff09\u3001\u3053\u306e\u6cbb\u7642\u306e\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3046\u3053\u3068\u3068\u3057\u305f\u3002<\/p>\n

\uff1c\u65b9\u6cd5\uff1e
\n\u2028\u5897\u60aa\u30ea\u30b9\u30af\u306f\u9ad8\u3044\u304c\u3001\u8074\u899a\u969c\u5bb3\u30fb\u5b89\u9759\u6642\u983b\u8108\u306f\u8a8d\u3081\u305a\uff0c\u88dc\u6b63 QT \u9593\u9694\u5ef6\u9577\u306e\u660e\u78ba\u306a\u30ea\u30b9\u30af\u3092\u6709\u3057\u306a\u3044 COPD \u60a3\u8005\u3092\u5bfe\u8c61\u306b\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u306b\u3088\u3063\u3066\u5897\u60aa\u306e\u983b\u5ea6\u304c\u4f4e\u4e0b\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3092\u884c\u3063\u305f\u3002<\/p>\n

\u2028\u2028\uff1c\u7d50\u679c\uff1e
\n\u20281,577 \u4f8b\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u3001\u305d\u306e\u4e2d\u3067 1,142 \u4f8b\uff0872%\uff09\u30921 \u5e74\u306b\u308f\u305f\u308a\u6a19\u6e96\u306e\u6cbb\u7642\u3068\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3 250 mg\/\u65e5\u3092\u6295\u4e0e\u3059\u308b\u7fa4\uff08570 \u4f8b\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3059\u308b\u7fa4\uff08572 \u4f8b\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u30021 \u5e74\u9593\u306e\u8ffd\u8de1\u3092\u5b8c\u4e86\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u306f\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4 89%\uff0c\u30d7\u30e9\u30bb\u30dc\u7fa4 90%\u3067\u3042\u3063\u305f\u3002\u521d\u56de\u5897\u60aa\u307e\u3067\u306e\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u3067 266 \u65e5\uff0895%\u4fe1\u983c\u533a\u9593 [CI] 227\uff5e313\uff09\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f 174 \u65e5\uff0895% CI 143\uff5e215\uff09\u3060\u3063\u305f\uff08P\uff1c0.001\uff09\u3002\u5897\u60aa\u306e\u983b\u5ea6\u306f\uff0c\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u3067\u60a3\u8005\u30fb\u5e74\u3042\u305f\u308a 1.48 \u56de\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u60a3\u8005\u30fb\u5e74\u3042\u305f\u308a 1.83 \u56de\u3067\u3042\u308a\uff08P\uff1d0.01\uff09\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u306b\u304a\u3051\u308b\u60a3\u8005\u30fb\u5e74\u3042\u305f\u308a\u306e COPD \u6025\u6027\u5897\u60aa\u767a\u751f\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f 0.73\uff0895% CI 0.63\uff5e0.84\uff09\u3067\u3042\u3063\u305f\uff08P\uff1c0.001\uff09\u3002St. George \u547c\u5438\u5668\u8cea\u554f\u7968\uff080\uff5e100 \u3067\uff0c\u30b9\u30b3\u30a2\u304c\u4f4e\u3044\u307b\u3069\u6a5f\u80fd\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\uff09\u306e\u30b9\u30b3\u30a2\u6539\u5584\u306f\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u306e\u307b\u3046\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u5927\u304d\u304f\uff08\u4f4e\u4e0b\u306e\u5e73\u5747 [\u00b1SD] 2.8\u00b112.8 \u5bfe 0.6\u00b111.4\uff0cP\uff1d0.004\uff09\uff0c\u6700\u5c0f\u6709\u610f\u5dee\u3067\u3042\u308b 4 \u5358\u4f4d\u4ee5\u4e0a\u306e\u4f4e\u4e0b\u304c\u307f\u3089\u308c\u305f\u60a3\u8005\u306e\u5272\u5408\u306f\u3001\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u3067 43%\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f 36%\u3067\u3042\u3063\u305f\uff08P\uff1d0.03\uff09\u3002\u8074\u529b\u4f4e\u4e0b\u306f\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u7fa4\u3067\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u591a\u304f\u8a8d\u3081\u3089\u308c\u305f\uff0825% \u5bfe 20%\uff0cP\uff1d0.04\uff09\u3002\u307e\u305f\u3001\u6c17\u9053\u306b\u304a\u3051\u308b\u30de\u30af\u30ed\u30e9\u30a4\u30c9\u8010\u6027\u83cc\u306f\u512a\u4f4d\u306b\u4e0a\u6607\uff0881\uff05\u5bfe41\uff05\uff09\u3057\u305f\u304c\u3001\u80ba\u708e\u767a\u75c7\u306b\u306f\u95a2\u4e0e\u3057\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u2028\u2028\uff1c\u7d50\u8ad6\uff1e\u2028
\n\u7279\u5b9a\u306e COPD \u60a3\u8005\u3067\u306f\uff0c\u6a19\u6e96\u6cbb\u7642\u306b\u52a0\u3048\u3066\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3092 1 \u5e74\u9593\u9023\u65e5\u670d\u7528\u3059\u308b\u3053\u3068\u3067\uff0c\u5897\u60aa\u306e\u983b\u5ea6\u304c\u4f4e\u4e0b\u3057 QOL \u304c\u6539\u5584\u3057\u305f\u304c\u3001\u3054\u304f\u4e00\u90e8\u306e\u60a3\u8005\u3067\u8074\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u305f\u3002\u3053\u306e\u4ecb\u5165\u306b\u3088\u3063\u3066\u5fae\u751f\u7269\u306e\u85ac\u5264\u8010\u6027\u30d1\u30bf\u30fc\u30f3\u304c\u5909\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\u3001\u305d\u308c\u306b\u3088\u308b\u5f71\u97ff\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u2028\u2028<\/p>\n

\u3010\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3011
\n\u2028\u30a2\u30b8\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u306e1\u5e74\u9593\u9023\u65e5\u6295\u4e0e\u3067\u6025\u6027\u5897\u60aa\u306e\u983b\u5ea6\u304c\u4f4e\u4e0b\u3057\u3066QOL\u306f\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u304c\u3001\u30b8\u30b9\u30ed\u30de\u30c3\u30af250mg\u9320=304\u5186\u306a\u306e\u3067\u30011\u5e74\u9593\u9023\u65e5\u6295\u4e0e\u3060\u3068\u3001\u7d0411\u4e07\u5186\u3002\u3053\u306e\u60a3\u8005\u306e\u7d4c\u6e08\u72b6\u6cc1\u306a\u3069\u8003\u3048\u308b\u3068\u73fe\u5b9f\u7684\u306a\u6cbb\u7642\u3068\u306f\u8a00\u3048\u306a\u3044\u3002\u307e\u305a\u306f\u5438\u5165\u306a\u3069\u306e\u6a19\u6e96\u6cbb\u7642\u306e\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306e\u4e0a\u6607\u3092\u76ee\u6307\u3059\u3053\u3068\u304c1\u756a\u91cd\u8981\u3067\u3042\u308b\u3002\u2028\u5065\u5eb7\u4fdd\u967a\u306e\u30ab\u30d0\u30fc\u3057\u3066\u3044\u306a\u3044\u5229\u7528\u6cd5\u3067\u3042\u308b\u3053\u3068\u3001\u5165\u9662\u30fb\u6b7b\u4ea1\u306a\u3069\u306b\u3064\u3044\u3066\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u6709\u610f\u5dee\u304c\u51fa\u3066\u3044\u306a\u3044\u3053\u3068\u306a\u3069\u3001\u554f\u984c\u306f\u591a\u3044\u3060\u308d\u3046\u3002\u2028\u2028<\/p>\n

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