{"id":535,"date":"2011-10-17T15:48:45","date_gmt":"2011-10-17T06:48:45","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=535"},"modified":"2015-08-06T15:50:32","modified_gmt":"2015-08-06T06:50:32","slug":"2%e5%9e%8b%e7%b3%96%e5%b0%bf%e7%97%85%e6%82%a3%e8%80%85%e3%81%ab%e5%8e%b3%e5%af%86%e3%81%aa%e8%a1%80%e7%b3%96%e9%99%8d%e4%b8%8b%e6%b2%bb%e7%99%82%e3%81%af%e3%80%81%e3%81%84%e3%81%84%e3%81%ae%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=535","title":{"rendered":"2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306f\u3001\u3044\u3044\u306e\uff1f\u60aa\u3044\u306e\uff1f"},"content":{"rendered":"

\u3010\u6587\u732e\u540d\u3011\u2028
\nEffect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials\u2028\u00a0BMJ 2011;343:d4169 doi: 10.1136\/bmj.d4169\u2028\u2028<\/p>\n

\u3010\u8981\u7d04\u3011
\n\u2028\uff1c\u76ee\u7684\uff1e\u2028
\n2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u3068\u3001\u5168\u6b7b\u4ea1\u53ca\u3073\u8840\u7ba1\u7cfb\u6b7b\u4ea1\u306e\u95a2\u4fc2\u3092\u307f\u308b\u2028\u2028<\/p>\n

\uff1c\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1e
\n\u2028RCT\u306e\u30e1\u30bf\u89e3\u6790\u2028\u2028<\/p>\n

\uff1c\u30c7\u30fc\u30bf\u6e90\uff1e
\n\u2028Medline\u3001Embace\u3001Cochrane\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3001\u6700\u8fd1\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u30ea\u30b9\u30c8\u2028\u2028<\/p>\n

\uff1c\u9078\u629e\u3055\u308c\u305f\u7814\u7a76\uff1e\u2028
\n\uff11\uff18\u6b73\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\u3067\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u5fae\u5c0f\u8840\u7ba1\u5408\u4f75\u75c7\u306b\u304a\u3051\u308b\u3001\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b13\u7de8\u306eRCT\uff085\u3064\u306f\u4e8c\u91cd\u76f2\u691c\u3067Jadad\uff13\u70b9\u4ee5\u4e0a\u30028\u3064\u306f\u975e\u76f2\u691c\u306f\uff13\u70b9\u4ee5\u4e0b\uff09<\/p>\n

\u2028\u2028\uff1c\u30c7\u30fc\u30bf\u306e\u62bd\u51fa\uff1e\u2028
\n\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u5168\u6b7b\u4ea1\u3068\u5fc3\u8840\u7ba1\u7cfb\u6b7b\u4ea1\u3002\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u91cd\u75c7\u306a\u4f4e\u8840\u7cd6\u3068\u3001\u5927\u8840\u7ba1\u304a\u3088\u3073\u5fae\u5c0f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3002<\/p>\n

\u2028\u2028\uff1c\u7d50\u679c\u306e\u7d71\u5408\uff1e\u2028
\n\u7d50\u679c\u306frisk ratio(99\uff05\u4fe1\u983c\u533a\u9593)\u3068\u3057\u3066\u5831\u544a\u3057\u305f\u3002\u7d71\u8a08\u5b66\u7684\u7570\u8cea\u6027\u306f\u30ab\u30a4\u4e8c\u4e57\u691c\u5b9a\u306a\u3069\u3002fixed effect model\u3067\u7d71\u5408\u3057\u305f\u3002\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u3068\u901a\u5e38\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6bd4\u8f03\u306f\u3001fixed effect model\u3067\u8a55\u4fa1\u3057\u305f\u3002\u304b\u304fRCT\u306e\u8cea\u306fJadad score\u3067\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

\u2028\u2028\uff1c\u7d50\u679c\uff1e
\n\u202813\u306e\u7814\u7a76\u304c\u63a1\u7528\u3055\u308c\u305f\u300234533\u4eba\u306e\u60a3\u8005\u306e\u3046\u3061\u300118315\u4eba\u304c\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u3092\u3046\u3051\u300116218\u4eba\u304c\u901a\u5e38\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u3002\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306f\u5168\u6b7b\u4ea1\u306b\u5927\u304d\u306a\u5f71\u97ff\u306f\u3082\u305f\u3089\u3055\u306a\u304b\u3063\u305f(RR\uff1a1.04\u300199\uff05\u4fe1\u983c\u533a\u9593\uff1a0.91?1.19)\u3002\u5fc3\u8840\u7ba1\u7cfb\u6b7b\u4ea1\u3082\u540c\u69d8\u3067\u3042\u3063\u305f(1.11\u30010.86?1.43)\u3002\u3057\u304b\u3057\u3001\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306f\u3001\u975e\u81f4\u6b7b\u7684\u306aAMI\u3092\u6e1b\u5c11\u3055\u305b\u305f(0.85\u30010.74?0.96\u3001P<0.001)\u3002\u307e\u305f\u5fae\u91cf\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3082\u6e1b\u5c11\u3055\u305b\u305f(0.90\u30010.85?0.96\u3001P<0.001)\u3002\u3057\u304b\u3057\u91cd\u75c7\u306a\u4f4e\u8840\u7cd6\u304c2\u500d\u3060\u3063\u305f(2.33\u30011.62?3.36\u3001P<0.001)\u3002\uff15\u5e74\u9593\u3067\u3001\uff11\u4eba\u306e\u5fc3\u7b4b\u6897\u585e\u3092\u9632\u3050\u305f\u3081\u306b117\u4eba?150\u4eba\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u3002\u5fae\u91cf\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3082\u540c\u69d8\u306b32\u4eba?142\u4eba\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u3002\u3057\u304b\u3057\u3053\u308c\u3092\u3059\u308b\u3068\u300115\u4eba?52\u4eba\u306b\uff11\u4eba\u306e\u5272\u5408\u3067\u6bce\u5e74\u91cd\u75c7\u306a\u4f4e\u8840\u7cd6\u304c\u8d77\u304d\u308b(NNH=15?52)\u3002\u8cea\u306e\u9ad8\u3044\u7814\u7a76(Jadad score\u30673\u70b9\u4ee5\u4e0a)\u306b\u9650\u308b\u3068\u3001\u3046\u3063\u8840\u6027\u5fc3\u4e0d\u5168\u306e\u5371\u967a\u6027\u304c47\uff05\u5897\u52a0\u3059\u308b\u3002\n\n\u2028\u2028\uff1c\u7d50\u8ad6\uff1e\n\u2028\u30e1\u30bf\u89e3\u6790\u306e\u7d50\u679c\u304b\u3089\u306f\u3001\u5168\u6b7b\u4ea1\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u306b\u304a\u3051\u308b\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306e\u5229\u76ca\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3002\u7814\u7a76\u8005\u3089\u306f\u3001\u5168\u6b7b\u4ea1\u306e\uff19\uff05\u306e\u6e1b\u5c11\u304a\u3088\u307319\uff05\u306e\u5897\u52a0\u306f\u9664\u5916\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u540c\u69d8\u306b\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u306e14\uff05\u306e\u6e1b\u5c11\u306843\uff05\u306e\u5897\u52a0\u306f\u9664\u5916\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u5927\u8840\u7ba1\u304a\u3088\u3073\u5fae\u5c0f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u304a\u3051\u308b\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306e\u5229\u76ca\uff0f\u4e0d\u5229\u76ca\u306e\u6bd4\u306f\u3001\u4e0d\u660e\u78ba\u306a\u307e\u307e\u3067\u3042\u308b\u3002\u91cd\u75c7\u306a\u4f4e\u8840\u7cd6\u306e\u5bb3\u306f\u3001\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306bcounterbalance\u3057\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u30022\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3078\u306e\u6700\u524d\u306e\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u78ba\u7acb\u3059\u308b\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u4e8c\u91cd\u76f2\u691cRCT\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u2028\u2028\n\n\uff1c\u9650\u754c\uff1e\u2028\n\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u7814\u7a76\u9593\u306b\u6cbb\u7642\u65b9\u6cd5\u3001\u6cbb\u7642\u76ee\u6a19\u3001\u30d5\u30a9\u30ed\u30fc\u306e\u671f\u9593\u306b\u3070\u3089\u3064\u304d\u304c\u3042\u308b\u3002\u2028\u2028\n\n\u3010\u958b\u50ac\u65e5\u3011\n\u20282011\u5e749\u670821\u65e5\n<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u6587\u732e\u540d\u3011\u2028 Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microv … \u7d9a\u304d\u3092\u8aad\u3080 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u53b3\u5bc6\u306a\u8840\u7cd6\u964d\u4e0b\u6cbb\u7642\u306f\u3001\u3044\u3044\u306e\uff1f\u60aa\u3044\u306e\uff1f<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-535","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=535"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/535\/revisions"}],"predecessor-version":[{"id":536,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/535\/revisions\/536"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}