\u3010\u6587\u732e\u540d\u3011
\n\u2028Adriana Buitrago-Lopez et al: Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ 2011; 343:d4488<\/p>\n
\u2028\u2028\u3010\u8981\u7d04\u3011
\n\u2028\uff1cObjective\uff1e
\n\u2028To evaluate the association of chocolate consumption with the risk of developing cardiometabolic disorders.\u2028\u2028<\/p>\n
\uff1cDesign\uff1e
\n\u2028Systematic review and meta-analysis of randomised controlled trials and observational studies.\u2028\u2028<\/p>\n
\uff1cData sources\uff1e\u2028
\nMedline, Embase, Cochrane Library, PubMed, CINAHL, IPA, Web of Science, Scopus, Pascal, reference lists of relevant studies to October 2010, and email contact with authors.\u2028\u2028<\/p>\n
\uff1cStudy selection\uff1e\u2028
\nRandomised trials and cohort, case-control, and cross sectional studies carried out in human adults, in which the association between chocolate consumption and the risk of outcomes related to cardiometabolic disorders were reported.\u2028\u2028<\/p>\n
\uff1cData extraction\uff1e
\nData were extracted by two independent investigators, and a consensus was reached with the involvement of a third. The primary outcome was cardiometabolic disorders, including cardiovascular disease (coronary heart disease and stroke), diabetes, and metabolic syndrome. A meta-analysis assessed the risk of developing cardiometabolic disorders by comparing the highest and lowest level of chocolate consumption.\u2028\u2028<\/p>\n
\uff1cResults\uff1e\u2028
\nFrom 4576 references seven studies met the inclusion criteria (including 114 009 participants). None of the studies was a randomized trial, six were cohort studies, and one a cross sectional study. Large variation was observed between these seven studies for measurement of chocolate consumption, methods, and outcomes evaluated. Five of the seven studies reported a beneficial association between higher levels of chocolate consumption and the risk of cardiometabolic disorders. The highest levels of chocolate consumption were associated with a 37% reduction in cardiovascular disease (relative risk 0.63 (95% confidence interval 0.44 to 0.90)) and a 29% reduction in stroke compared with the lowest levels.\u2028\u2028<\/p>\n
\uff1cConclusions\uff1e
\n\u2028Based on observational evidence, levels of chocolate consumption seem to be associated with a substantial reduction in the risk of cardiometabolic disorders. Further experimental studies are required to confirm a potentially beneficial effect of chocolate consumption.\u2028\u2028<\/p>\n
\u3010\u958b\u50ac\u65e5\u3011\u2028
\n2011\u5e749\u67087\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"