\u3010\u6587\u732e\u540d\u3011
\n\u2028Shimoli V. Shah and Brian F. Gage. Cost-Effectiveness of Dabigatran for Stroke Prophylaxis in Atrial Fibrillation. (Circulation. 2011;123:2562-2570.)\u2028\u2028<\/p>\n
\u3010\u8981\u7d04\u3011
\n\u2028\uff1cBackground\uff1e
\n\u2028Recent studies have investigated alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost-effective is unknown.<\/p>\n
\u2028\u2028\uff1cMethods and Results\uff1e
\n\u2028On the basis of the results from Randomized Evaluation of Long Term Anticoagulation Therapy\u2028(RE-LY) and other trials, we developed a decision-analysis model to compare the cost and quality-adjusted survival of various antithrombotic therapies. We ran our Markov model in a hypothetical cohort of 70-year-old patients with AF using a cost-effectiveness threshold of $50 000\/quality-adjusted life-year. We estimated the cost of dabigatran as US $9 a day. For a patient with an average risk of major hemorrhage (3%\/y), the most cost-effective therapy depended on stroke risk. For patients with the lowest stroke rate (CHADS 2 stroke score of 0), only aspirin was cost-effective. For patients with a moderate stroke rate (CHADS 2 score of 1 or 2), warfarin was cost-effective unless the risk of hemorrhage was high or quality of international normalized ratio control was poor (time in the therapeutic range 57.1%). For patients with a high stroke risk (CHADS 2 stroke score 3), dabigatran 150 mg (twice daily) was cost-effective unless international normalized ratio control was excellent (time in the therapeutic range\u00a0 72.6%). Neither dabigatran 110 mg nor dual therapy (aspirin and clopidogrel) was cost-effective.\u2028\u2028<\/p>\n
\uff1cConclusions\uff1e
\n\u2028Dabigatran 150 mg (twice daily) was cost-effective in AF populations at high risk of hemorrhage or high risk of stroke unless international normalized ratio control with warfarin was excellent. Warfarin was cost-effective in moderate-risk AF populations unless international normalized ratio control was poor.\u2028\u2028<\/p>\n
\u3010\u958b\u50ac\u65e5\u3011
\n\u20282011\u5e747\u670826\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"