{"id":587,"date":"2011-08-31T10:34:34","date_gmt":"2011-08-31T01:34:34","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=587"},"modified":"2015-08-06T16:35:58","modified_gmt":"2015-08-06T07:35:58","slug":"ppi%e3%81%af%e9%aa%a8%e6%8a%98%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e5%a2%97%e5%8a%a0%e3%81%95%e3%81%9b%e3%82%8b%ef%bc%88%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=587","title":{"rendered":"PPI\u306f\u9aa8\u6298\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09"},"content":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011<br \/>\n\u2028Chun-Sick Eom, Sang Min Park, Seung-Kwon Myung, Jae Moon Yun, and Jeong-Soo Ahn. Use of Acid-Suppressive Drugs and Risk of Fracture: A Meta-analysis of Observational Studies. Ann Fam Med . 2011 9: 257-267.\u2028\u2028<\/p>\n<p>\u3010\u8981\u7d04\u3011<br \/>\n\u2028\uff1c\u80cc\u666f\uff1e<br \/>\n\u2028PPI\u306f\u7834\u9aa8\u7d30\u80de\u306e\u9178\u751f\u6210\u3082\u6291\u5236\u3059\u308b\u305f\u3081\u9aa8\u6298\u306b\u4e88\u9632\u7684\u306b\u50cd\u304f\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u304c\u3001\u3080\u3057\u308d\u9aa8\u6298\u304c\u5897\u3048\u308b\u3068\u3044\u3046\u77e5\u898b\u304c\u51fa\u3066\u304d\u3066\u3044\u308b\u3002PPI\u3068\u9aa8\u6298\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306f\u8b70\u8ad6\u306e\u4e00\u81f4\u3092\u307f\u3066\u304a\u3089\u305a\u3001\u3053\u308c\u307e\u3067\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u304c\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u304b\u3089\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u3068\u3057\u305f\u3002<\/p>\n<p>\u2028\u2028\uff1c\u6587\u732e\u691c\u7d22\uff1e<br \/>\n\u2028MEDLINE\u3001EMBASE\u3001Cochrane 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\/>\n\u20281809\u306e\u6587\u732e\u304c\u30d2\u30c3\u30c8\u3057\u305f\u304c\u9078\u5225\u306e\u7d50\u679c\u3001\u6700\u7d42\u89e3\u6790\u306b\u6b8b\u3063\u305f\u306e\u306f5\u3064\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u30013\u3064\u306e\u30b3\u30db\u30fc\u30c8\u5185\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u30013\u3064\u306e\u30b3\u30db\u30fc\u30c8\u3067\u3042\u3063\u305f\u3002RCT\u306f\u6700\u7d42\u9078\u5225\u307e\u3067\u306b\u9664\u5916\u3055\u308c\u6b8b\u3089\u306a\u304b\u3063\u305f\u3002\u2028\u2028\u3000<\/p>\n<p>\u25cf\u4e3b\u89e3\u6790\u7d50\u679c\u2028<br \/>\nPPI\u3067\u9aa8\u6298\u30ea\u30b9\u30af\u4e0a\u6607\u3092\u8a8d\u3081\u305f\uff08adjusted OR 1.29: 95%CI 1.18-1.41, I2 69.8%, n=10\uff09<br \/>\nH2\u30d6\u30ed\u30c3\u30ab\u30fc\u3067\u9aa8\u6298\u30ea\u30b9\u30af\u4e0a\u6607\u8a8d\u3081\u305a\uff08adjusted OR 1.10: 95%CI 0.99-1.23, I2 86.3%, n=7\uff09<\/p>\n<p>\u25cf\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u7d50\u679c<br \/>\nTable.2\u53c2\u7167\u3002\u2028\u2028<\/p>\n<p>\u25cf\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u306e\u8a55\u4fa1<br \/>\n\u7279\u306b\u5f71\u97ff\u306f\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u305f\uff08funnel plot\u3001Egger test\uff09\u3002\u2028\u2028<\/p>\n<p>\uff1cDiscussion\uff1e\u2028<br \/>\nPPI\u3068\u9aa8\u6298\u30ea\u30b9\u30af\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002H2\u30d6\u30ed\u30c3\u30ab\u30fc\u3068\u9aa8\u6298\u30ea\u30b9\u30af\u306b\u306f\u660e\u3089\u304b\u306a\u95a2\u4fc2\u306f\u898b\u3044\u3060\u305b\u306a\u304b\u3063\u305f\u304c\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306fhigh-quality methodology study\u30685\u3064\u4ee5\u4e0a\u306e\u5909\u6570\u306b\u3064\u3044\u3066\u88dc\u6b63\u3057\u305f\u89e3\u6790\u3067\u306f\u9aa8\u6298\u3068\u306e\u95a2\u9023\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u4eca\u5f8c\u306e\u3055\u3089\u306a\u308b4\u7814\u7a76\u304c\u5fc5\u8981\u3002\u2028\u3000\u9650\u754c\u3068\u3057\u3066\u2460\u89b3\u5bdf\u7814\u7a76\u304c\u542b\u307e\u308c\u308b\u306e\u3067\u30d0\u30a4\u30a2\u30b9\u304c\u542b\u307e\u308c\u308b\u53ef\u80fd\u6027\u304c\u308b\u304c\u3001\u3053\u308c\u306b\u3064\u3044\u3066\u306f\u69d8\u3005\u306a\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3092\u884c\u3046\u3053\u3068\u3067\u88dc\u3063\u305f\u3002\u2461Egger test\u306f\u51fa\u7248\u30d0\u30a4\u30a2\u30b9\u8a55\u4fa1\u3068\u3057\u3066\u306f\u4fe1\u983c\u6027\u304c\u52a3\u308b\u3002\u2462\u6804\u990a\u30c7\u30fc\u30bf\u306b\u3064\u3044\u3066\u306f\u8a55\u4fa1\u3057\u3066\u3044\u306a\u3044\u3002\u2463\u80c3\u306e\u75be\u60a3\u306e\u6709\u7121\u306e\u8a55\u4fa1\u3092\u3057\u3066\u3044\u306a\u3044\u3002\u2028\u2028<\/p>\n<p>\uff1c\u307e\u3068\u3081\uff1e<br \/>\n\u2028PPI\u306f\u9aa8\u6298\u30ea\u30b9\u30af\u3092\u4e2d\u7b49\u5ea6\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002H2\u30d6\u30ed\u30c3\u30ab\u30fc\u306b\u95a2\u3057\u3066\u306f\u305d\u306e\u53ef\u80fd\u6027\u306f\u793a\u5506\u3055\u308c\u306a\u304b\u3063\u305f\u3002OR\u306f2\u4ee5\u4e0b\u3067\u50c5\u304b\u306a\u5f71\u97ff\u3068\u8003\u3048\u3089\u308c\u308b\u3082\u306e\u306ecommon disease\u3067\u3082\u3042\u308a\u793e\u4f1a\u3078\u306e\u5f71\u97ff\u306f\u5927\u304d\u3044\u3002\u81e8\u5e8a\u5bb6\u306f\u7279\u306b65\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u306b\u5bfe\u3057\u3066\u3053\u308c\u3089\u306e\u51e6\u65b9\u3059\u308b\u3068\u304d\u306b\u306f\u614e\u91cd\u306b\u8003\u616e\u3092\u3059\u308b\u3079\u304d\u3067\u3042\u308b\u3002\u7528\u91cf\u306b\u3064\u3044\u3066\u3082\u671b\u307e\u3057\u3044\u7d50\u679c\u5f97\u3089\u308c\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u6700\u4f4e\u9650\u306e\u91cf\u306b\u3068\u3069\u3081\u308b\u3053\u3068\u304c\u52e7\u3081\u3089\u308c\u308b\u3002\u2028\u2028<\/p>\n<p>\u3010\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3011<br \/>\n\u2028\u5f31\u3044\u306a\u304c\u3089\u3082PPI\u3068\u9aa8\u6298\u30ea\u30b9\u30af\u4e0a\u6607\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3084\u306f\u308a\u5236\u9178\u85ac\u3092\u4f7f\u7528\u3059\u308b\u969b\u306f\u5fc5\u8981\u6700\u5c0f\u9650\u306e\u3082\u306e\u3068\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3059\u308b\u306e\u304c\u3088\u3055\u305d\u3046\u3067\u3042\u308b\u3002\u2028\u4ee5\u4e0b\u3001\u5168\u4f53\u3067\u306e\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u2028NSAIDS\u306e\u6295\u4e0e\u306b\u3042\u308f\u305b\u3066PPI\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u3082\u591a\u3044\u3002\u3053\u306e\u6587\u732e\u306e\u7d50\u679c\u3092\u53d7\u3051\u3066\u3001\u81ea\u5206\u81ea\u8eab\u306e\u6295\u85ac\u884c\u52d5\u3092\u898b\u76f4\u3059\u6a5f\u4f1a\u3068\u3057\u305f\u3044\u3002\u2028\u2028<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\u20282011\u5e746\u670822\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011 \u2028Chun-Sick Eom, Sang Min Park, Seung-Kwon Myung, Jae Moon Yun, and Jeong-Soo Ahn. Use of Acid-Suppressiv &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=587\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">PPI\u306f\u9aa8\u6298\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\uff08\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff09<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-587","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=587"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/587\/revisions"}],"predecessor-version":[{"id":588,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/587\/revisions\/588"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}