{"id":603,"date":"2011-08-17T09:49:57","date_gmt":"2011-08-17T00:49:57","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=603"},"modified":"2015-08-07T09:52:06","modified_gmt":"2015-08-07T00:52:06","slug":"%e5%96%98%e6%81%af%e3%82%b3%e3%83%b3%e3%83%88%e3%83%ad%e3%83%bc%e3%83%ab%e6%b2%bb%e7%99%82%e3%81%ae%e3%83%95%e3%82%a1%e3%83%bc%e3%82%b9%e3%83%88%e3%83%a9%e3%82%a4%e3%83%b3%e3%82%82%e3%81%97%e3%81%8f","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=603","title":{"rendered":"\u5598\u606f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6cbb\u7642\u306e\u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3\u3082\u3057\u304f\u306f\u4f75\u7528\u85ac\u3068\u3057\u3066\u306e\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u62ee\u6297\u85ac"},"content":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011<br \/>\n\u2028David Price et al. Leukotriene\u00a0 Antagonists as First-Line or Add-on Asthma-controller Therapy. The New\u3000England\u3000Journal of\u3000Medicine\uff0cMay 5,2011\u2028\u2028\u2028<\/p>\n<p>\u3010\u8981\u7d04\u3011<br \/>\n\u2028\uff1cBackground\uff1e<br \/>\n\u2028\u5598\u606f\u6cbb\u7642\u7814\u7a76\u306erandomized trialsa\u2028\u2028<\/p>\n<p>\uff1cMethods\uff1e<br \/>\n\u2028\u30fb\u5598\u606f\u6cbb\u7642\u306b\u304a\u3044\u3066<br \/>\n\u2028\u2460\u7b2c\u4e00\u9078\u629e\u3067\u3042\u308b\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u62ee\u6297\u85ac(LTRA)\u2028<br \/>\n\u2461\u3059\u3067\u306b\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u5c0e\u5165\u3057\u3066\u3044\u308b\u60a3\u8005\u3078\u8ffd\u52a0\u6cbb\u7642\u3068\u3057\u3066\u2028\u9577\u6642\u9593\u4f5c\u52d5\u6027\u03b2\u523a\u6fc0\u85ac(LABA)\u3068\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u62ee\u6297\u85ac(LTRA)\u2028\u3068\u3092\u6bd4\u8f03\u3057\u305f\u3002\u2028\u2028<\/p>\n<p>\u30fb12\u6b73\uff5e80\u6b73\u306e\u30d7\u30e9\u30a4\u30de\u30ea\u30b1\u30a2\u60a3\u8005\u3067\u5598\u606f\u95a2\u9023\u306eQOL\u304c\u4f4e\u3044\u4eba(MiniAQLQ\u30b9\u30b3\u30a26\u70b9\u4ee5\u4e0b)\u3082\u3057\u304f\u306f\u4e0d\u9069\u5207\u306a\u5598\u606f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u60a3\u8005(ACQ\u30b9\u30b3\u30a21\u70b9\u4ee5\u4e0a)\u3092\u5bfe\u8c61\u3002\u60a3\u8005\u3092\u30e9\u30f3\u30c0\u30e0\u306b\u4ee5\u4e0b\u306e2\u5e74\u9593\u306eopen-label\u6cbb\u7642\u306b\u632f\u308a\u5206\u3051\u305f\u3002<br \/>\n\u2028\u2460\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u3068\u3057\u3066\u3001LTRA\u4f7f\u7528148\u4eba\u3068\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u4f7f\u7528158\u4eba\u2028<br \/>\n\u2461\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u8ffd\u52a0\u6cbb\u7642\u3068\u3057\u3066\u3001LTRA\u8ffd\u52a0170\u4eba\u3068LABA\u8ffd\u52a0182\u4eba\u2028\u2028<\/p>\n<p>\u30fbOutcome<br \/>\n\u2028\u2460Primary outcome\u3000\uff1bMiniAQLQ\u3000score<br \/>\n\u2028\u2461Secondary outcome\uff1bACQscore\u3001RCP3\u3001MiniRQLQ\u3001\u5598\u606f\u60aa\u5316\u983b\u5ea6\u306a\u3069\u2028\u2028<\/p>\n<p>\uff1cResults\uff1e<br \/>\n\u2028\u4e21\u7814\u7a76\u2460\u2461\u3068\u30822\u5e74\u9593\u3067MiniAQLQ\u30b9\u30b3\u30a2\u306f\u5e73\u57470.8-1.0\u70b9\u4e0a\u6607\u3002\u2028<br \/>\n\u6cbb\u76422\u304b\u6708\u306e\u6642\u70b9\u3067\u2460\u2461\u3068\u3082\u306b\u30012\u3064\u306e\u6cbb\u7642\u9593\u3067\u306f\u52b9\u679c\u540c\u7b49(95%CI-0.3\uff5e0.3)\u3002<br 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\/>\n\u30fb\u30a4\u30ae\u30ea\u30b9\u3067\u306f\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u304c\u7b2c\u4e00\u9078\u629e\u3067\u4f7f\u308f\u308c\u3066\u304a\u308a\u533b\u8005\u306b\u3088\u3063\u3066\u306fLTRA\u3092\u5272\u308a\u5f53\u3066\u3089\u308c\u3066\u3082\u4ed6\u306e\u85ac\u5264\u3078\u306e\u5207\u308a\u66ff\u3048\u3084\u8ffd\u52a0\u304c\u3055\u308c\u3084\u3059\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n<p>\u2028\u2028\u2192\u77ed\u671f\u9593\u3067\u306f\u3001\u5438\u5165\u30b9\u30c6\u30ed\u30a4\u30c9\u3068LTRA\u3068\u306f\u52b9\u679c\u306f\u540c\u7b49\u3067\u3069\u3061\u3089\u3092\u9078\u3093\u3067\u3082\u5dee\u306f\u306a\u3044\u3002\u2028<br \/>\n\u9577\u671f\u7684\u52b9\u679c\u306e\u540c\u7b49\u6027\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u305d\u306e\u5dee\u306f\u5c0f\u3055\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<br \/>\n\u5b9f\u969b\u306e\u81e8\u5e8a\u73fe\u5834\u3067\u306f\u3001\u85ac\u306e\u52b9\u679c\u3060\u3051\u3067\u306a\u304f\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u306a\u3069\u3082\u8907\u96d1\u306b\u304b\u304b\u308f\u3063\u3066\u3044\u308b\u305f\u3081\u2028\u78ba\u5b9f\u306b\u4f7f\u7528\u3067\u304d\u308b\u85ac\u5264\u3092\u9078\u629e\u3059\u308b\u73fe\u5728\u306e\u6cbb\u7642\u65b9\u91dd\u3067\u7279\u306b\u554f\u984c\u306a\u3055\u305d\u3046\u3068\u601d\u308f\u308c\u308b\u3002\u2028\u2028\u2028<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\u20282011\u5e746\u67081\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6587\u732e\u540d\u3011 \u2028David Price et al. Leukotriene\u00a0 Antagonists as First-Line or Add-on Asthma-controller Therapy. The New\u3000 &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=603\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\u5598\u606f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6cbb\u7642\u306e\u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3\u3082\u3057\u304f\u306f\u4f75\u7528\u85ac\u3068\u3057\u3066\u306e\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u62ee\u6297\u85ac<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-603","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=603"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/603\/revisions"}],"predecessor-version":[{"id":604,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/603\/revisions\/604"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}