{"id":716,"date":"2010-10-13T09:56:08","date_gmt":"2010-10-13T00:56:08","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=716"},"modified":"2015-08-07T10:56:30","modified_gmt":"2015-08-07T01:56:30","slug":"%ef%bd%9e%e7%99%ba%e5%a3%b2%e3%81%95%e3%82%8c%e3%81%9f%e3%81%b0%e3%81%8b%e3%82%8a%e3%81%ae%e6%96%b0%e8%96%ac%e3%80%82%e4%bd%bf%e3%81%86%ef%bc%9f%e4%bd%bf%e3%82%8f%e3%81%aa%e3%81%84%ef%bc%9f%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=716","title":{"rendered":"\uff5e\u767a\u58f2\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u65b0\u85ac\u3002\u4f7f\u3046\uff1f\u4f7f\u308f\u306a\u3044\uff1f\uff5e"},"content":{"rendered":"

\u3010\u6587\u732e\u3011
\nPelger S. Underhill J.: Evaluating the safety and effdectiveness of new drugs. Am Fam Physician : 82\uff081\uff0953-57, 2010.<\/p>\n

\u3010\u8981\u7d04\u3011
\n\u300a\u306f\u3058\u3081\u306b\u300b
\n\u767a\u58f2\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u65b0\u3057\u3044\u85ac\u5264\u306f\u65e2\u5b58\u306e\u6cbb\u7642\u6cd5\u306e\u3088\u3046\u306b\u5e45\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u308a\u3001\u52b9\u679c\u3084\u5b89\u5168\u6027\u304c\u5341\u5206\u691c\u8a0e\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3002
\n\u3053\u306e\u554f\u984c\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306bSTEPS\u3068\u3044\u3046\u8a9e\u5442\u5408\u308f\u305b\u304c\u3088\u308a\u3088\u3044\u610f\u5fd7\u6c7a\u5b9a\u3092\u884c\u3046\u305f\u3081\u306b\u6709\u7528\u3067\u3042\u308b\u3002
\n\u300aSafety\uff1a\u3000\u5b89\u5168\u6027\u300b
\n\u5165\u9662\u60a3\u8005\u306e\u7d046.5%\u304c\u85ac\u5264\u306e\u526f\u4f5c\u7528\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308b\u3002
\n\u65b0\u85ac\u306e\u5b89\u5168\u6027\u306e\u554f\u984c\u306f\u6cbb\u9a13\u6bb5\u968e\u3067\u660e\u3089\u304b\u306b\u306a\u3089\u306a\u3044\u3053\u3068\u3082\u3042\u308a\u3001\u660e\u3089\u304b\u306b\u306a\u308b\u306e\u306b\u9577\u671f\u9593\u3092\u8981\u3059\u308b\u3053\u3068\u3082\u591a\u3044\u3002\u7c73\u56fd\u3067\u306f\u8ca9\u58f2\u627f\u8a8d\u5f8c\u306b\u91cd\u5927\u306a\u526f\u4f5c\u7528\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u85ac\u5264\u304c10%\u3082\u3042\u308a\u3001\u65b0\u85ac\u306e\u91cd\u5927\u306a\u526f\u4f5c\u7528\u304c\u5224\u660e\u3059\u308b\u307e\u3067\u306e\u4e2d\u592e\u5024\u304c\uff13\u5e74\u3067\u3042\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308b\u3002
\n\u3053\u3046\u3044\u3063\u305f\u554f\u984c\u306e\u80cc\u666f\u306b\u306f\u65b0\u85ac\u306e\u8ca9\u58f2\u627f\u8a8d\u306e\u6c7a\u5b9a\u304c\u60a3\u8005\u65701500\u4eba\u7a0b\u5ea6\u306e\u77ed\u671f\u9593\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u3088\u308a\u3069\u3053\u308d\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308b\u3002
\n\u300aTolerability\uff1a\u3000\u5fcd\u5bb9\u6027\u300b
\n\u591a\u304f\u306e\u85ac\u5264\u306f\u75c7\u72b6\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u3067\u306f\u306a\u304f\u672a\u6765\u306b\u767a\u751f\u3057\u3046\u308b\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u51e6\u65b9\u3055\u308c\u308b\u3002\u3053\u3046\u3044\u3063\u305f\u85ac\u304c\u60a3\u8005\u306e\u5177\u5408\u3092\u60aa\u304f\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3042\u308c\u3070\u3001\u3082\u306f\u3084\u7d99\u7d9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3002
\n\u300aEffectiveness\uff1a\u3000\u6709\u52b9\u6027\u300b
\n97%\u306e\u65b0\u85ac\u306f\u4ee3\u7528\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u8a2d\u5b9a\u3057\u305f\u77ed\u671f\u9593\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u3088\u308a\u3069\u3053\u308d\u3068\u3057\u3066\u3044\u308b\u3002
\n\u77ed\u671f\u9593\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u5143\u306b\u767a\u58f2\u3055\u308c\u3001\u305d\u306e\u5f8c\u6709\u5bb3\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u85ac\u5264\u3082\u591a\u3044\u3002
\nMilrinone\u306f\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u5fc3\u62cd\u51fa\u91cf\u3092\u5897\u5927\u3055\u305b\u904b\u52d5\u8010\u5bb9\u80fd\u3092\u6539\u5584\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u3082\u3068\u306b\u767a\u58f2\u306b\u306a\u3063\u305f\u304c\u305d\u306e\u5f8c\u3001\u6b7b\u4ea1\u7387\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002
\n\u65b0\u85ac\u306e\u63a1\u7528\u306b\u3064\u3044\u3066\u8003\u3048\u308b\u3068\u304d\u3001\u3044\u3064\u3082\u3053\u3046\u554f\u3046\u3079\u304d\u3067\u3042\u308b\u3002
\n\u300c\u3053\u306e\u85ac\u5264\u306b\u306f\u65e2\u5b58\u306e\u540c\u69d8\u306e\u85ac\u5264\u3068\u6bd4\u8f03\u3057\u3066\u79c1\u306e\u60a3\u8005\u306e\u751f\u547d\u4e88\u5f8c\u3084QOL\u3092\u6539\u5584\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u304b\uff1f\u300d<\/p>\n

\u300aPrice\uff1a\u3000\u4fa1\u683c\u300b
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\n\u4f8b\uff1a \u3042\u308b\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85acA\u306f40%\u306e\u6cbb\u7652\u7387\u3067\u670820$\u304b\u304b\u308b\u3002\u6cbb\u7642\u85acB\u306f50%\u306e\u6cbb\u7652\u7387\u3067\u670850$\u304b\u304b\u308b\u3002\u5370\u8c61\u3067\u306f\u3088\u308a\u591a\u304f\u306e\u60a3\u8005\u3092\u6cbb\u7642\u3067\u304d\u308bB\u3092\u9078\u3076\u3079 \u304d\u3067\u3042\u308b\u3088\u3046\u306b\u898b\u3048\u308b\u304c\u3001\u4eee\u306b\u3053\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u670810\u4e07$\u3057\u304b\u5229\u7528\u3067\u304d\u306a\u3044\u3068\u4eee\u5b9a\u3059\u308b\u3068A\u306f5000\u4eba\u306e\u60a3\u8005\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d2000\u4eba\u306e\u60a3\u8005\u3092\u6551\u3046 \u3053\u3068\u304c\u3067\u304d\u308b\u3002B\u306f2000\u4eba\u306e\u60a3\u8005\u306b\u6295\u4e0e\u30011000\u4eba\u306e\u60a3\u8005\u3057\u304b\u6551\u3046\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3002
\n\u5b9f\u969b\u306f\u3082\u3063\u3068\u8907\u96d1\u3067\u3042\u308a\u3001\u85ac\u5264\u306e\u76f8\u5bfe\u7684\u306a\u30e1\u30ea\u30c3\u30c8\u306f\u305d\u306e\u75be\u60a3\u306b\u4f9d\u5b58\u3059\u308b\u3002
\n\u300aSimplicity\uff1a\u3000\u30b7\u30f3\u30d7\u30eb\u306b\u300b
\n\u6295\u4e0e\u671f\u9593\u306e\u9577\u3044\u85ac\u5264\u306f1\/3\uff5e1\/2\u306e\u85ac\u5264\u304c\u51e6\u65b9\u7b8b\u3069\u304a\u308a\u306b\u670d\u7528\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u3002
\n\u3067\u304d\u308b\u9650\u308a\u5358\u7d14\u306a\u6295\u85ac\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306b\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u306e\u304c\u5e38\u8b58\u3067\u3042\u308b\u304c\u3001\uff11\u65e5\uff11\u56de\u306e\u85ac\u5264\u3084\u5408\u5264\u304cadherence\u3092\u6539\u5584\u3057\u305f\u3068\u3044\u3046\u3088\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3002
\n\u3042\u308b\u8cea\u7684\u7814\u7a76\u3067\u306f\u60a3\u8005\u306b\u3068\u3063\u3066\u306f\u6295\u85ac\u306e\u8907\u96d1\u3055\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u3001\u6295\u85ac\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3092\u751f\u6d3b\u306e\u4e2d\u306b\u53d6\u308a\u8fbc\u3093\u3067\u3044\u304f\u3053\u3068\u304c\u96e3\u3057\u3044\u3088\u3046\u3067\u3042\u308b\u3002
\n\u300aSTEPS\u306b\u52a0\u3048\u3066\u300b
\n\u3000\u30fb\u3000ARR\u304bRRR\u304b
\n\u3000\u65b0\u85ac\u306e\u30d1\u30f3\u30d5\u30ec\u30c3\u30c8\u3084\u81e8\u5e8a\u7814\u7a76\u306e\u7d50\u679c\u306fARR\u3088\u308a\u3082RRR\u3067\u5831\u544a\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002
\n\u3053\u306e\u3053\u3068\u306f\u85ac\u5264\u306e\u52b9\u679c\u3092\u8a87\u5f35\u3057\u3084\u3059\u304f\u3001\u8aa4\u89e3\u306e\u5143\u3068\u306a\u308a\u3084\u3059\u3044\u3002
\n\u85ac\u5264\u306e\u52b9\u679c\u306fARR\uff08NNT\uff09\u3067\u8a55\u4fa1\u3057\u305f\u3044\u3002
\n\u3000\u30fb\u3000\u65e2\u5b58\u306e\u85ac\u5264\u306e\u65b0\u5264\u578b\u306b\u306f\u4ed8\u52a0\u4fa1\u5024\u304c\u3042\u308b\u304b\uff1f
\n\u8fd1 \u5e74\u85ac\u5264\u30e1\u30fc\u30ab\u30fc\u306e\u9593\u3067\u65e2\u5b58\u306e\u85ac\u5264\u306e\u65b0\u3057\u3044\u5264\u578b\uff08\u4f8b\uff1a\u5f90\u653e\u6027\u5264\u3001\u30d7\u30ed\u30c9\u30e9\u30c3\u30b0\u306a\u3069\uff09\u3092\u767a\u58f2\u3059\u308b\u30b1\u30fc\u30b9\u304c\u591a\u3044\u3002\u3053\u3046\u3044\u3063\u305f\u30b1\u30fc\u30b9\u304c\u5b89\u5168\u6027\u3084\u52b9\u679c\u3001 adhereance\u3092\u6539\u5584\u3059\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u4ed8\u52a0\u4fa1\u5024\u3082\u3042\u308d\u3046\u304c\u3001\u591a\u304f\u306e\u5834\u5408\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u85ac\u54c1\u306e\u767b\u5834\u306b\u5bfe\u6297\u3057\u3066\u5e02\u5834\u3092\u5b88\u308b\u305f\u3081\u306e\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\u3002
\n\u5408\u5264\u306b\u3082\u540c\u69d8\u306e\u3053\u3068\u304c\u8a00\u3048\u308b\u304c\u3001\u5546\u54c1\u306b\u3088\u3063\u3066\u306f\u51e6\u65b9\u3092\u5358\u7d14\u306b\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3082\u306e\u3082\u3042\u308b\u3002
\n\u3000\u30fb\u3000\u975e\u52a3\u6027\u8a66\u9a13
\n\u65b0\u85ac\u306b\u306f\u76e3\u67fb\u6a5f\u95a2\u306b\u975e\u52a3\u6027\u8a66\u9a13\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u51fa\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u627f\u8a8d\u3092\u5f97\u305f\u3082\u306e\u3082\u3042\u308b\u3002
\n\u975e \u52a3\u6027\u8a66\u9a13\u306f\u65b0\u85ac\u304c\u65e2\u5b58\u306e\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u85ac\u3068\u6bd4\u8f03\u3057\u3066\u52a3\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u30c6\u30b9\u30c8\u3059\u308b\u3053\u3068\u304c\u76ee\u7684\u3067\u3042\u308b\u3002\u672c\u8cea\u7684\u306b\u306f\u9650\u3089\u308c\u305f\u6642\u9593\u5185\u306b\u985e\u4f3c\u6027\u3092\u8a3c\u660e\u3059\u308b\u3002\u975e\u52a3\u6027\u8a66 \u9a13\u306f\u65b0\u85ac\u306e\u3042\u308b\u75be\u60a3\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u4f4d\u7f6e\u3065\u3051\u306a\u3069\u3092\u691c\u8a0e\u305b\u305a\u85ac\u5264\u306e\u8ca9\u58f2\u3092\u8a31\u53ef\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u306b\u5546\u696d\u76ee\u7684\u306b\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u3053\u3046\u3044\u3063\u305f\u7814\u7a76\u304c\u502b\u7406\u7684\u3067 \u3042\u308b\u304b\u304c\u7591\u554f\u8996\u3055\u308c\u3066\u3044\u308b\u3002
\n\u3053\u3046\u3044\u3063\u305f\u85ac\u5264\u306f\u5f93\u6765\u306e\u85ac\u5264\u306b\u6bd4\u8f03\u3057\u3066\u512a\u4f4d\u3067\u3042\u308b\u3069\u3053\u308d\u304b\u3001\u52b9\u679c\u3084\u5b89\u5168\u6027\u306e\u9762\u3067\u52a3\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3002<\/p>\n

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\u3010\u6587\u732e\u3011 Pelger S. Underhill J.: Evaluating the safety and effdectiveness of new drugs. Am Fam Physician : 82\uff081\uff0953 … \u7d9a\u304d\u3092\u8aad\u3080 \uff5e\u767a\u58f2\u3055\u308c\u305f\u3070\u304b\u308a\u306e\u65b0\u85ac\u3002\u4f7f\u3046\uff1f\u4f7f\u308f\u306a\u3044\uff1f\uff5e<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-716","post","type-post","status-publish","format-standard","hentry","category-9"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=716"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/716\/revisions"}],"predecessor-version":[{"id":717,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/716\/revisions\/717"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}