{"id":781,"date":"2010-06-16T11:15:19","date_gmt":"2010-06-16T02:15:19","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=781"},"modified":"2015-08-07T11:15:42","modified_gmt":"2015-08-07T02:15:42","slug":"%ef%bd%9e%e7%84%a1%e7%97%87%e5%80%99%e6%80%a7%e3%81%aeabi%e4%bd%8e%e4%b8%8b%e6%82%a3%e8%80%85%e3%81%b8%e3%81%ae%e3%82%a2%e3%82%b9%e3%83%94%e3%83%aa%e3%83%b3%e3%81%af%e8%a1%80%e7%ae%a1%e3%82%a4","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=781","title":{"rendered":"\uff5e\u7121\u75c7\u5019\u6027\u306eABI\u4f4e\u4e0b\u60a3\u8005\u3078\u306e\u30a2\u30b9\u30d4\u30ea\u30f3\u306f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u306b\u52b9\u679c\u304c\u306a\u3044\uff5e"},"content":{"rendered":"

\u3010\u6587\u732e\u3011
\nF Gerald R. Fowkes, Jacqueline F. Price Marlene C. W. Stewart at el: Aspirin for\u3000Prevention\u3000of\u3000Cardiovascular\u3000Events\u3000in\u3000a\u3000General\u3000Population\u3000Screened \u3000for\u3000a\u3000Low\u3000Ankle\u3000Brachial\u3000Index.\u3000JAMA; 303 841-848, 2010.<\/p>\n

\u3010\u8981\u7d04\u3011<\/p>\n

\u7d50\u8ad6
\n\u3000\u7121\u75c7\u5019\u6027\u306eABI\u4f4e\u4e0b\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30b9\u30d4\u30ea\u30f3\u306f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u306a\u3044\u3002<\/p>\n

\u8ad6\u6587\u306ePECO
\nP\uff1a
\n50-75\u6b73\u3067\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u7537\u597328980\u4eba\u306bABI\u3092\u884c\u3044\u30010.90\u4ee5\u4e0b\u3060\u3063\u305f3350\u4eba\u3092\u30c8\u30e9\u30a4\u30a2\u30eb\u3078\u3002
\nE\uff1a
\n\u30a2\u30b9\u30d4\u30ea\u30f3100mg
\nC\uff1a
\n\u30d7\u30e9\u30bb\u30dc
\nO\uff1a
\nPrimary\uff1b\u3000\u3000\u3000 \u521d\u56de\u306e\u81f4\u6b7b\u7684\u30fb\u975e\u81f4\u6b7b\u7684\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u8133\u5352\u4e2d\u3001\u8840\u7ba1\u518d\u704c\u6d41\u306e\u6cbb\u7642
\nSecondary\uff1b\u3000\u2460\u4e0a\u8a18\u306ePrimary\uff0b\u72ed\u5fc3\u75c7\uff0b\u9593\u6b20\u6027\u8ddb\u884c\uff0bTIA\u3000\u2461\u7dcf\u6b7b\u4ea1 <\/p>\n

\u59a5\u5f53\u306a\u6587\u732e\u304b\uff1f\u4e8c\u91cd\u76f2\u691c\u306eRCT\u3067ITT\u5206\u6790\u3055\u308c\u3066\u3044\u308b\u3002\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f8.2\u5e74<\/p>\n

\u30e1\u30ea\u30c3\u30c8\u30fb\u30c7\u30e1\u30ea\u30c3\u30c8\u306e\u7a0b\u5ea6\u306f\uff1f
\nPrimary\u3001Secondary\u5171\u306b\u3001\u4ecb\u5165\u7fa4\u3068\u6bd4\u8f03\u90e1\u306b\u3066\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002
\n\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000 Hazard Ratio\u3000\u3000\u3000\u3000RRR\u3000\u3000\u3000\u3000\u3000NNT
\nPrimary endpoint\u3000\u3000\u3000\u3000\u3000\u30001.03(0.84-1.27)\u3000\u3000\u3000\u3000 -0.3\uff05\u3000\u3000\u3000\u3000-333
\nSecondary endpoint
\n\u3000\u2460\u5168\u3066\u306e\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3000\u3000\u30001.00(0.85-1.17)\u3000\u3000\u3000\u3000\u30000.1\uff05\u3000\u3000\u3000\u3000 840
\n\u3000\u2461\u7dcf\u6b7b\u4ea1\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000 0.95(0.77-1.16)\u3000\u3000\u3000\u3000\u30000.6\uff05\u3000\u3000\u3000\u3000 169<\/p>\n

Adverse event\u3068\u3057\u3066\u306f\u3001Major hemorrhage(\u8133\u51fa\u8840\u3001SAH\u3001\u6d88\u5316\u7ba1\u51fa\u8840\u3001\u305d\u306e\u4ed6)\u304c\u4ecb\u5165\u7fa4\u306e\u65b9\u304cHR 1.71(0.99-2.71)\u3067\u591a\u304b\u3063\u305f\u3002
\nNNH\u306f125<\/p>\n

\u3010\u958b\u50ac\u65e5\u3011
\n\uff12\uff10\uff11\uff10\u5e74\uff16\u6708\uff11\uff16\u65e5<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u6587\u732e\u3011 F Gerald R. Fowkes, Jacqueline F. Price Marlene C. W. Stewart at el: Aspirin for\u3000Prevention\u3000of\u3000Cardiovasc … \u7d9a\u304d\u3092\u8aad\u3080 \uff5e\u7121\u75c7\u5019\u6027\u306eABI\u4f4e\u4e0b\u60a3\u8005\u3078\u306e\u30a2\u30b9\u30d4\u30ea\u30f3\u306f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u306b\u52b9\u679c\u304c\u306a\u3044\uff5e<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-781","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=781"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/781\/revisions"}],"predecessor-version":[{"id":782,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/781\/revisions\/782"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}